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Open research questions in Malaria Research and Control

310 unresolved questions extracted from the limitations and future-work sections of 1,037 Malaria Research and Control papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The inability to apply standard epidemiological approaches to routinely collected data due to patient dropout. The lack of methods for calibrating mechanistic transmission models to routinely collected time to recurrence data.

    Identifiability and model misspecification for modelling recurrent infections using routine health care data · 2026 · DOI

  • The study was retrospective and hospital-based, - The sample size was limited to 120 patients, - The study only included patients admitted to one hospital in Shandong Province

    Epidemiological and clinical characteristics of imported malaria patients admitted to a specialized hospital: a retrospective study (2021– June 2026) · 2026 · DOI

  • The lack of detailed clinical characteristics, parasite species distribution, travel history, and treatment patterns among hospitalized malaria patients in Shandong Province. The need to characterize the epidemiological and clinical characteristics of imported malaria patients following China's certification as malaria-free.

    Epidemiological and clinical characteristics of imported malaria patients admitted to a specialized hospital: a retrospective study (2021– June 2026) · 2026 · DOI

  • limited accessibility of Panzi, - high proportion of human DNA in blood limited metagenomic sequencing sensitivity, - no viral taxa were detected in more than half the samples

    Deciphering the etiology of the 2024 outbreak of undiagnosed febrile illness in Panzi, Democratic Republic of the Congo · 2026 · DOI

  • The etiology of the 2024 outbreak of undiagnosed febrile illness in Panzi, Democratic Republic of the Congo, was unknown. There was a need for epidemiological and laboratory investigation to determine the cause of the outbreak. The study aims to address this gap by providing new insights into the etiology of the outbreak.

    Deciphering the etiology of the 2024 outbreak of undiagnosed febrile illness in Panzi, Democratic Republic of the Congo · 2026 · DOI

  • The study only analyzed samples from Uganda, - The sample size for some analyses was limited, - The study did not investigate the mechanisms by which PX1 polymorphisms affect drug susceptibility

    Emergence and spread of Plasmodium falciparum PX1 polymorphisms associated with decreased susceptibility to antimalarials in Uganda · 2026 · DOI

  • Further studies are needed to investigate the mechanisms by which PX1 polymorphisms affect drug susceptibility, - Research should be conducted to determine the prevalence of the PIN haplotype in other African countries, - The impact of the PIN haplotype on malaria control efforts should be investigated

    Emergence and spread of Plasmodium falciparum PX1 polymorphisms associated with decreased susceptibility to antimalarials in Uganda · 2026 · DOI

  • The study did not investigate direct evidence of causality, - Month of sampling was unavailable for controls, - Subgroup numbers were limited for immunophenotype analysis

    A malaria-exposure antibody signature in Rwandan non-Burkitt acute lymphoblastic leukemia · 2026 · DOI

  • Further investigation of malaria-exposure signatures in non-Burkitt ALL, - Analysis of the relationship between malaria exposure and non-Burkitt ALL, - Investigation of the potential mechanisms underlying the observed antibody profile

    A malaria-exposure antibody signature in Rwandan non-Burkitt acute lymphoblastic leukemia · 2026 · DOI

  • Although these survivors have been associated with latency, it remains unclear whether drug treatment induces this state or selectively enriches parasites already predisposed for persistence.

    Environmental stress promotes entry into a pre-existing latent state in Plasmodium falciparum · 2026 · DOI

  • However, the functional significance of this phosphorylation site remains unclear.

    Dynamic phosphorylation of the Plasmodium falciparum Myosin A motor regulates motor speed and is important for asexual replication · 2026 · DOI

  • However, the interaction between hemoglobin genotypes and malaria severity remain poorly defined in endemic African settings, particulary in Angola, where SCA and malaria impose a substantial public health burden.

    Impact of Sickle Cell Hemoglobin Genotypes on Clinical Outcomes Among Plasmodium falciparum Malaria Patients in Luanda, Angola · 2026 · DOI

  • Further empirical studies, particularly on vaccine efficacy in older children, are warranted to inform policy guidance for malaria vaccination implementation.

    Public health impact of catch-up vaccination or additional booster doses with pre-erythrocytic malaria vaccine R21/Matrix-M: a modelling study · 2026 · DOI

  • However, little is known about the progress made in controlling malaria in pregnancy in the Savannah Region.

    Trend of malaria test positivity rate among pregnant women, Savannah Region, Ghana, 2018–2022 · 2025 · DOI

  • While the specific mechanisms remain unknown, findings indicate a potential synergy between innate and adaptive liver responses.

    Leveraging Non-Human Primates to Investigate Malaria Infection and Immunity 4437 · 2025 · DOI

  • Our objective was to investigate influenza coinfection, which is highly understudied in malaria.

    Influenza-induced suppressive alveolar macrophages protect against malarial immunopathology during coinfection 3547 · 2025 · DOI

  • Various hypotheses have been proposed to explain the neurological syndrome associated to cerebral malaria condition, including vascular occlusion and sequestration, cytokine storm or inflammatory response, or a combination of these mechanisms and despite extensive research and a growing range of scientific information, the precise pathophysiological mechanism remains poorly understood.

    Unveiling new perspectives about the onset of neurological and cognitive deficits in cerebral malaria: exploring cellular and neurochemical mechanisms · 2025 · DOI

  • Existing studies have identified individual-level factors as contributors to malaria infection, yet the influence of community-level factors and spatial variations remain underexplored.

    Spatial variation and multilevel determinants of malaria infection among pregnant women in Sub-Saharan Africa: using malaria indicator surveys · 2025 · DOI

  • Although some studies in the Bono East Region have provided valuable insights into the mono-infections of HBV and malaria, their co-infection during pregnancy has not been extensively explored.

    Navigating converging pathways of co-infection: an integrated epidemiological insight into hepatitis B and malaria among pregnant women in the middle belt of Ghana · 2025 · DOI

  • However, the fluctuating ITN coverage and the recent rise in severe cases warrant further investigation.

    Evaluating malaria burden in children under-five and intervention outcomes in Tarkwa-Nsuaem municipality · 2025 · DOI

  • However, the implementation of these malaria interventions and their association with the malaria burden remains unclear.

    Evaluating malaria burden in children under-five and intervention outcomes in Tarkwa-Nsuaem municipality · 2025 · DOI

  • Recent outbreaks-particularly in 2022-along with the rising incidence of Plasmodium falciparum and growing resistance of Anopheles mosquito vector to existing control methods, highlight a critical gap in understanding the effectiveness of current malaria vector control strategies.

    Malaria vector control strategies in Pakistan: a scoping review · 2025 · DOI

  • However, the immune correlates of protection in these people who acquire natural immunity against malaria are poorly understood.

    Malaria exposure remodels the plasma proteome of Ghanaian children · 2025 · DOI

  • Future studies are needed to evaluate whether this dysregulation is associated with neurocognitive sequelae following recovery.

    Prolonged dysregulation of gene expression and biomarkers of coagulation, fibrinolysis, and endothelium in pediatric central nervous system malaria · 2025 · DOI

  • However, the mechanisms governing clinical immunity during asymptomatic infections are not understood.

    Asymptomatic vivax malaria is associated with an IFN-γ-program on adaptive immunity · 2025 · DOI

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310 open questions have been extracted from the limitations and future-work passages of 1,037 Malaria Research and Control papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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