Open research questions in Medical Case Reports and Studies
200 gap statements mined from Medical Case Reports and Studies papers in our 4.5M-paper local library, which holds 350 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.
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What the literature leaves open
Ayurvedic classics do not explain any condition exactly resembling the presentation or pathogenesis of BCS. There is a need for alternative treatment options for BCS.
The disease is caused by a deficiency of Agni, the digestive fire. The primary symptom of Grahani Roga is frequent, occasional dry, and occasional wet movements. The therapeutic efficacy of Parpati needs to be increased.
There is a need to understand the clinical importance of Parpati Kalpana in Grahani Roga. There is a lack of discussion on the significance of Parpati preparation and its therapeutic efficacy in treating Grahani Roga.
Clinical examination alone may be insufficient for definitive diagnosis.
Mutrashmari is a complex condition influenced by multiple factors. There is a lack of effective treatment options for Mutrashmari. The condition can cause significant pain and discomfort.
There is a need for clinical evaluation of Kataka Beeja Churna in Mutrashmari. There is a lack of studies on the therapeutic efficacy of Kataka Beeja Churna in managing Mutrashmari.
There is a need for effective management of anorectal disorders such as Arsha, Bhagandara, Gudabhransa, and Parikartika. Current treatments may not be sufficient to address these disorders.
CONTRIBUTION OF SHALYATANTRA IN TREATING ANO-RECTAL DISORDERS, PARTICULARLY ARSHA, BHAGANDARA, GUDABHRAMSA AND PARIKARTIKA · 2026 · DOIFurther studies can be conducted to understand the causes and effects of Kaphaj Yonivyapad. Research can be done to develop effective treatments for the disease.
There is a need to understand the aspects of Kaphaj Yonivyapad in Ayurveda and modern medicine. The knowledge of the disease is essential for its management and treatment.
There is a need to revisit the Ayurvedic anatomical concepts of Janu Sandhi and correlate them with clinical application. The paper identifies a gap in the understanding of applied anatomy in Ayurveda and its relevance to disease manifestation, diagnosis, and management.
There is a need to understand Panduroga through classical Ayurvedic literature. The correlation between Panduroga and Anaemia needs to be established.
There is a lack of studies on the effect of Ayurvedic treatment on hyperthyroidism-related infertility. The current treatments for hyperthyroidism have adverse effects and complications.
BIRD'S-EYE VIEW OF FEMALE INFERTILITY DUE TO HYPERTHYROIDISM (GRAVE'S DISEASE) – A CASE REPORT · 2026 · DOIThere is a need for further studies to validate the effectiveness of the comprehensive Ayurvedic approach in managing recurrent Amavata. The current study is a single case report, and larger studies are needed to establish the efficacy of the treatment protocol.
Ayurvedic Management of Recurrent Amavata Focusing on Ama Pachana and Functional Recovery: A Case Report · 2026 · DOIFuture research should focus on well-designed clinical trials and mechanistic studies to further validate and refine these interventions. While further large-scale randomized controlled trials are warranted, the existing clinical evidence and the rational basis of the therapies make Kayachikitsa a valuable resource in the management of diabetic neuropathy.
The lack of understanding of the hematological and histopathological changes caused by Proteus Mirabilis. The need for further research on the effects of Proteus Mirabilis on the urinary system.
The Alteration of Blood Picture and Histopathological Changes by Proteus Mirabilis in Albino Male Rats · 2026 · DOIThere is a need for comprehensive understanding and management of CKD using Ayurvedic approaches.
PANCHAKARMA INTERVENTION IN CHRONIC KIDNEY DISEASE: A CASE REPORT ON SIGNIFICANT RENAL FUNCTION IMPROVEMENT · 2026 · DOIThere is a need to study the location, function, and application of Marma points in therapy. There is a lack of understanding of the importance of Marma therapy in promoting health and longevity.
The disruption of Agni and pitta can lead to various disorders. Heavy and late-night dinner can cause digestive strain and disrupt the body's natural circadian rhythm. There is a need to develop effective treatments for liver disorders.
Future research can focus on the development of new Ayurvedic herbs for the treatment of liver disorders. Studies can be conducted to investigate the efficacy of Phalatrikadi kwatha in the treatment of liver disorders.
The sudden appearance of the condition can cause concern among patients. There is a need to rule out associated systemic disorders. The integration of Ayurvedic knowledge with modern ophthalmology can be challenging.
There is a need to understand the correlation between Arjuna and Subconjunctival Hemorrhage. The paper identifies a gap in the integration of Ayurvedic knowledge with modern ophthalmology.
The lack of effective treatment options for Ekakushta is a significant challenge.
There is a need to evaluate the effectiveness of Panchakarma and Śamana Chikitsa in the management of Ekakushta. The study aims to fill this gap by reporting a case of a patient with Ekakushta who was treated with Panchakarma and Śamana Chikitsa.
Managing migraine with aura can be challenging due to its complex pathophysiology. Conventional treatment modalities may have limited efficacy or adverse effects.
There is a lack of understanding of the concept of Daivavyapashraya Chikitsa - There is a need to explore its application in women's reproductive health and disease…
WOMEN'S DIVINE CARE: NARRATIVE REVIEW ON DAIVAVYAPASHRAYA CHIKITSA FOR REPRODUCTIVE HEALTH AND DISEASES · 2026 · DOI
Most-cited papers in Medical Case Reports and Studies
- An Operation for Displaced Semilunar Cartilage · BMJ · 1885 · 138 citations
- Treatment of TMJ ankylosis in Jordanian children – a comparison of two surgical techniques · Journal of Cranio-Maxillofacial Surgery · 2005 · 62 citations
- Sushruta: The father of surgery · National Journal of Maxillofacial Surgery · 2017 · 59 citations
- The Goddess Śītalā and Epidemic Smallpox in Bengal · The Journal of Asian Studies · 1981 · 37 citations
- ALEKSİTİMİ: KURAMSAL ÇERÇEVE TEDAVİ YAKLAŞIMLARI ve İLGİLİ ARAŞTIRMALAR · Ankara Universitesi Egitim Bilimleri Fakultesi Dergisi · 2002 · 35 citations
- Dentistry and Ayurveda - IV: Classification and management of common oral diseases · Indian Journal of Dental Research · 2008 · 26 citations
- Pahari and Tibetan Polyandry Revisited · Ethnology · 1978 · 24 citations
- Pseudoachalasia: A review · Nigerian Journal of Clinical Practice · 2016 · 19 citations
- TMJ Ankylosis Management: Our Experience · Journal of Maxillofacial and Oral Surgery · 2019 · 14 citations
- Shin-byung (Divine Illness) in a Korean woman · Culture Medicine and Psychiatry · 2000 · 12 citations
Most recent work
- REVIEW ARTICLE ON GUDARSHA (HAEMORRHOIDS) AND ITS MANAGEMENT · Zenodo (CERN European Organization for Nuclear Research) · 2026
- AYURVEDIC MANAGEMENT OF BUDD CHIARI SYNDROME – A CASE STUDY · Zenodo (CERN European Organization for Nuclear Research) · 2026
- AYURVEDIC MANAGEMENT OF SANDHIGATVATA W.S.R. TO OSTEODARTHRITIS -A CASE STUDY · Zenodo (CERN European Organization for Nuclear Research) · 2026
- ASSESSMENT OF EFFECTIVENESS OF PERUNGAYA CHOORANAM IN TREATING SOOTHAGA SOOLAI (DUE TO ENDOMETRIOSIS) AMONG PATIENTS ATTENDING OPD, GOVERNMENT SIDDHA MEDICAL COLLEGE AND HOSPITAL, PALAYAMKOTTAI - A CASE SERIES · Zenodo (CERN European Organization for Nuclear Research) · 2026
- CLINICAL IMPORTANCE OF PARPATI KALPANA IN GRAHANI ROGA · Zenodo (CERN European Organization for Nuclear Research) · 2026
- ROLE OF CLINICAL EXAMINATION AND INVESTIGATION IN DIFFERENTIAL DIAGNOSIS · Zenodo (CERN European Organization for Nuclear Research) · 2026
- MANAGEMENT OF TAMAKA SHWASA: A CASE STUDY · EPRA International Journal of Multidisciplinary Research (IJMR) · 2026
- CLINICAL EVALUATION OF KATAKA BEEJA CHURNA IN MUTRASHMARI: A CASE REPORT · Zenodo (CERN European Organization for Nuclear Research) · 2026
- CONTRIBUTION OF SHALYATANTRA IN TREATING ANO-RECTAL DISORDERS, PARTICULARLY ARSHA, BHAGANDARA, GUDABHRAMSA AND PARIKARTIKA · Zenodo (CERN European Organization for Nuclear Research) · 2026
- MANAGEMENT OF CORNEAL FOREIGN BODY (AKSHI-SHALYA) REMOVAL THROUGH AYURVEDA - A CASE STUDY · Zenodo (CERN European Organization for Nuclear Research) · 2026
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