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Open research questions in Menstrual Health and Disorders

259 unresolved questions extracted from the limitations and future-work sections of 1,024 Menstrual Health and Disorders papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • One challenge is the difficulty in capturing neural responses to social provocation in individuals with PMDD. Another challenge is the potential for variability in ovulation timing among participants, which could affect the results. A third challenge is the need to control for multiple testing in the analysis of the results.

    Escitalopram and brain reactivity to aggressive stimuli in premenstrual dysphoric disorder · 2026 · DOI

  • Further studies are needed to investigate the neural underpinnings of escitalopram efficacy in PMDD. Research should focus on the role of serotonergic transmission in PMDD. Studies should explore the effects of escitalopram on aggressiveness in PMDD patients. Investigations into the relationship between irritability or anger and aggressiveness in PMDD are warranted.

    Escitalopram and brain reactivity to aggressive stimuli in premenstrual dysphoric disorder · 2026 · DOI

  • Investigate the relationship between menstrual pain intensity and postural stability in a larger sample size. Examine the effects of PD on neuromuscular performance in different age groups. Explore the potential impact of PD on daily functioning and academic or professional productivity.

    Postural stability and body composition according to primary dysmenorrhea severity in young women: a cross-sectional study · 2026 · DOI

  • The study faces challenges in blinding participants and practitioners to the Tuina therapy. The study requires careful management of adverse events and emergency situations. The study needs to ensure the accuracy and completeness of clinical data and neuroimaging data.

    Clinical efficacy and neural mechanisms of Tuina for primary dysmenorrhea with cold congestion and blood stasis pattern: a protocol for a randomized controlled fMRI trial · 2026 · DOI

  • Few studies have addressed the possibility of capturing the effect of escitalopram in behavioral, laboratory-based tests. The study aims to investigate the effects of escitalopram on impulsivity and inattention in women with premenstrual irritability and anger.

    The effects of intermittent escitalopram treatment on impulsivity and inattention in women with premenstrual irritability and anger · 2025 · DOI

  • The physiological variability caused by hormonal fluctuations from the menstrual cycle. The lack of research on female athletes, with only 35% of athletes examined being female. The difficulty of conducting studies on women due to hormonal fluctuations.

    Injury Risk and Overall Well-Being During the Menstrual Cycle in Elite Adolescent Team Sports Athletes · 2025 · DOI

  • Investigate the impact of stressors across the life course on symptom reactivity to ovarian hormone fluctuations, - Examine the effects of pre-menarche and post-menarche stressors on cyclical emotional symptoms

    Cumulative stressor exposure predicts menstrual cycle affective changes in a transdiagnostic outpatient sample with past-month suicidal ideation · 2024 · DOI

  • The clinical efficacy of Tuina therapy for primary dysmenorrhea with the cold congestion and blood stasis pattern remains unclear. The central mechanisms of Tuina therapy for primary dysmenorrhea are poorly understood. High-level evidence on the effects of Tuina therapy on brain functional networks is lacking.

    Clinical efficacy and neural mechanisms of Tuina for primary dysmenorrhea with cold congestion and blood stasis pattern: a protocol for a randomized controlled fMRI trial · 2026 · DOI

  • further research is needed to understand the impact of the menstrual cycle on athletic performance and injury risk, - studies should investigate the effects of hormonal fluctuations on well-being and injury susceptibility, - research should focus on developing individualized monitoring and adaptive training strategies

    Injury Risk and Overall Well-Being During the Menstrual Cycle in Elite Adolescent Team Sports Athletes · 2025 · DOI

  • A scoping review was undertaken to explore available global literature on women's experiences of living with PMS or PMDD, highlighting gaps in the literature.

    Women’s experiences of living with premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD): A scoping review · 2026 · DOI

  • A registered systematic review with co-primary frequentist and Bayesian meta-analyses that model these factors as effect modifiers and test any pooled effect against a pre-specified smallest effect size of interest is warranted and introduced (INPLASY202660145).

    Menstrual-Cycle Phase-Based Periodization of Resistance Training and Chronic Gains in Strength and Body Composition: A Discordant Evidence Base in Need of an Uncertainty-Aware Synthesis · 2026 · DOI

  • This opinion argues that the recommendation rests on a small, heterogeneous, and conflicting evidence base and that much of the conflict stems from conflating two questions: acute, within-cycle variation in muscular performance and chronic adaptation to phase-periodized training.

    Menstrual-Cycle Phase-Based Periodization of Resistance Training and Chronic Gains in Strength and Body Composition: A Discordant Evidence Base in Need of an Uncertainty-Aware Synthesis · 2026 · DOI

  • The role of sexism in the menopausal process and symptoms has not been thoroughly investigated in the literature.

    The mediating role of negative attitudes toward menopause between benevolent sexist attitudes and irritability of perimenopausal women · 2025 · DOI

  • Despite extensive research, the underlying causes of these disorders remain elusive.

    The role of the neuroinflammation and stressors in premenstrual syndrome/premenstrual dysphoric disorder: a review · 2025 · DOI

  • Future research could explore its long-term impact on public perception and menstrual hygiene practices, while expanding demographic representation, enhancing context sensitivity, and integrating multimodal and voice-based interactions to improve accessibility across diverse user groups.

    Menstrual Health Education Using a Specialized Large Language Model in India: Development and Evaluation Study of MenstLLaMA · 2025 · DOI

  • Despite affecting half of the population, the intersection of menstruation and diabetes is largely understudied.

    1660-P: Examining the Effects of Menstruation on Diabetes Management among People with Diabetes in the U.S. and EU · 2025 · DOI

  • Future research should explore the hormonal mechanisms influencing blood glucose and the impact of different menstrual cycle stages on glycemic control.

    1660-P: Examining the Effects of Menstruation on Diabetes Management among People with Diabetes in the U.S. and EU · 2025 · DOI

  • As a result, students are susceptible to stress, and their academic success is influenced by various factors, including their menstrual cycle, and the long-term outcomes and consequences are poorly researched.

    Determinants of premenstrual dysphoric disorder and associated factors among regular undergraduate students at Hawassa University Southern, Ethiopia, 2023: institution-based cross-sectional study · 2024 · DOI

  • Even though PMDD has a significant negative impact on student's academic achievement and success limited research has been conducted in low- and middle-income countries including Ethiopia, especially in the study setting.

    Determinants of premenstrual dysphoric disorder and associated factors among regular undergraduate students at Hawassa University Southern, Ethiopia, 2023: institution-based cross-sectional study · 2024 · DOI

  • Background There are few studies on the correlation between energy availability (EA) and subclinical menstrual disorders (SMD) in female athletes.

    Study on the correlation between energy availability and subclinical menstrual disorders · 2024 · DOI

  • Despite the expanded research in recent years on premenstrual dysphoric disorder and premenstrual syndrome, premenstrual exacerbation remains underexplored and poorly defined.

    Understanding premenstrual exacerbation: navigating the intersection of the menstrual cycle and psychiatric illnesses · 2024 · DOI

  • However, specific recommendations for treating and preventing this condition are lacking.

    Dietary and Lifestyle Management of Functional Hypothalamic Amenorrhea: A Comprehensive Review · 2024 · DOI

  • Importance: Premenstrual disorders (PMDs) adversely affect the quality of life of millions of women worldwide, yet research on the long-term consequences of PMDs is limited, and the risk of mortality has not been explored.

    Mortality Risk Among Women With Premenstrual Disorders in Sweden · 2024 · DOI

  • A number of different physical and mental illnesses must be ruled out in order to diagnose PMS and PMDD, requiring comprehensive differential diagnosis protocols.

    ETHNIC HERBAL MEDICINE IN THE TREATMENT OF PREMENSTRUAL SYNDROME: ETIOLOGY, CLINICAL MANIFESTATIONS AND OTHER MEDICAL INTERVENTIONS · 2026 · DOI

  • There is a need for non-pharmacological solutions to overcome dysmenorrhea. The current study aims to fill this gap by examining the effect of abdominal effleurage massage on reducing dysmenorrhea pain.

    Pengaruh Massage Effleurage Abdomen Terhadap Penurunan Nyeri Dismenore Pada Mahasiswi Kebidanan Di Poltekes TNI AU Ciumbuleuit · 2026 · DOI

Most-cited papers in Menstrual Health and Disorders

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259 open questions have been extracted from the limitations and future-work passages of 1,024 Menstrual Health and Disorders papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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