Science AI Journal
Medicine · Research topic

Open research questions in Multiple Sclerosis Research Studies

1,241 gap statements mined from Multiple Sclerosis Research Studies papers in our 7.9M-paper local library, which holds 6,227 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Multiple Sclerosis Research Studies? See the ranked Medicine journals.

What the literature leaves open

  • The transition of fluid biomarkers to clinical translation remains uneven across settings. As a scoping review, this work is hypothesis-generating and does not allow causal inference. Definitions and operational criteria for PIRA were not fully uniform across studies. The studies were heterogeneous in cohort characteristics, biomarker assessment, follow-up duration, and analytical approach.

    Impact of age, BMI, and renal function adjustment on interpretation of serum NfL and GFAP in multiple sclerosis progression: a scoping review · 2026 · DOI

  • The complexity of bladder and bowel dysfunction in MS requires a comprehensive tool for screening. The need for validation studies to establish clinical utility and potential refinement of the tool.

    Screening bladder and bowel disfunction in multiple sclerosis: the role of proms (rebuttal letter) · 2026 · DOI

  • The interplay between altered glutamatergic neurotransmission and oxidative stress in MS is not fully understood. There is a need for biomarkers that can capture metabolic and excitotoxic components of disease activity in MS.

    Cerebrospinal fluid amino acid alterations are associated with oxidative stress and neuronal injury markers in multiple sclerosis · 2026 · DOI

  • The paper mentions the biological heterogeneity of MS, which may pose a challenge in identifying disease-associated molecular patterns. The study had to deal with the complexity of the salivary proteome and the need to identify significant changes after six months of therapy.

    Salivary Proteomics Reveals Disease- and Therapy-Associated Molecular Patterns in Relapsing-Remitting Multiple Sclerosis · 2026 · DOI

  • There is a need for non-invasive biomarkers to detect these changes. Prior work has focused on CSF and blood, leaving a gap in the investigation of saliva as a biofluid.

    Salivary Proteomics Reveals Disease- and Therapy-Associated Molecular Patterns in Relapsing-Remitting Multiple Sclerosis · 2026 · DOI

  • There is a need to evaluate the effect of family-centered empowerment interventions on health-promoting lifestyle and psychological well-being in patients with MS. The study identifies a gap in the literature regarding the involvement of primary family caregivers in empowerment interventions.

    Impact of the Family‐Centered Empowerment Model on Health‐Promoting Lifestyle and Psychological Well‐Being in Patients With Multiple Sclerosis: A Randomized Controlled Clinical Trial · 2026 · DOI

  • The frequency and clinical relevance of immune-mediated comorbidities in people with MS remain incompletely characterized. Prior studies have reported variable associations between MS and various immune-mediated diseases, highlighting the need for a comprehensive review.

    Immune-mediated comorbidities in multiple sclerosis: a scoping review · 2026 · DOI

  • The effect of cladribine on cognition is not well known. There is a need to investigate the impact of cladribine tablets on cognition in multiple sclerosis.

    The Impact of Cladribine Tablets on Cognition Over One Year in Patients With Multiple Sclerosis: A Preliminary Study · 2026 · DOI

  • Identity and meaning are central to living with MS yet remain underrecognized in clinical care.

    Existential Disruption in Multiple Sclerosis Care: An Integrative Review of Identity and Meaning · 2026 · DOI

  • Emerging evidence suggests that plasma proteins may serve as genetically supported candidate targets, yet their underlying mechanisms in MS remain poorly understood.

    Proteome-wide Mendelian Randomization and Colocalization Nominate CD58, PARP1, and Immune Co-stimulatory Pathways as Genetically Supported Targets for Multiple Sclerosis · 2026 · DOI

  • However, their capacity to modulate Th17/Treg dynamics within the CNS and to exert sustained immunoregulatory effects has not been fully elucidated.

    Effect of Adipose-derived Stem Cell Exosomes in Alleviating Experimental Autoimmune Encephalomyelitis by Reducing the Th17-related Immune Response in the Central Nervous System · 2026 · DOI

  • This may reflect a stable immunoregulatory state maintaining Treg function independently of continued exosome presence, although the precise mechanisms remain unclear.

    Effect of Adipose-derived Stem Cell Exosomes in Alleviating Experimental Autoimmune Encephalomyelitis by Reducing the Th17-related Immune Response in the Central Nervous System · 2026 · DOI

  • However, how differences in testing frequency bear on comparisons between disease-modifying therapies (DMTs) in real-world cohorts has not been fully explored.

    More tests, higher scores: Testing frequency and SDMT differences between natalizumab and rituximab · 2026 · DOI

  • Endurance training is recommended to help manage MS symptoms, but its immediate impact on functional mobility and spasticity is not well understood.

    Transient and Immediate Motor Effects of Endurance Training in People With Multiple Sclerosis: The Exploratory TIME Study · 2026 · DOI

  • Racial differences in Multiple Sclerosis (MS) and fatigue may be influenced by stress related biological and structural factors, yet the relationships among race, cumulative stress, cognition, and fatigue remain unclear.

    Beyond perceived stress: Hair cortisol is linked with cognition and fatigue in black and white patients with multiple sclerosis · 2026 · DOI

  • Despite achieving complete peripheral B cell deletion after over 6 months of rituximab therapy, a clinically significant minority of neuromyelitis optica spectrum disorder (NMOSD) patients experience breakthrough relapses, yet the underlying mechanism remains unclear.

    Synergistic Interaction Between MALAT1/miR‐30b‐5p/BAFF Axis and Inflammatory Cytokines Underlies Rituximab‐Refractory NMOSD · 2026 · DOI

  • Dysfunction of the neurovascular unit (NVU) and impaired neurovascular coupling (NVC) may be related to cognitive performance in MS, but this pathway remains insufficiently studied.

    Prefrontal Neurovascular Coupling Abnormalities Associated With Cognitive Performance in Multiple Sclerosis · 2026 · DOI

  • Cognitive impairment is a prevalent and debilitating feature in multiple sclerosis (MS), yet its pathophysiology remains incompletely understood.

    Prefrontal Neurovascular Coupling Abnormalities Associated With Cognitive Performance in Multiple Sclerosis · 2026 · DOI

  • Limited use of high-efficacy agents due to age-related restrictions.

    Age-Onset-Related Particularities of Pediatric MS—Understanding the Spectrum: A Tertiary Center Experience · 2025 · DOI

  • The performance in clinical gait tests showed mixed results with negligible, small and moderate effects at the end of the treatment.

    Investigating the Effects of Repeated Transcutaneous Spinal Cord Stimulation on Spasticity and Gait in Multiple Sclerosis: A Case Series · 2026 · DOI

  • The study had a limited sample size of 50 in the phase 2 trial and 43 in the expanded access cohort, - The study only analyzed CSF biomarkers and did not examine other potential biomarkers, - The study did not investigate the long-term effects of MSC-NP…

    Effect of intrathecal injection of mesenchymal stem cell-neural progenitors on cerebrospinal fluid biomarkers in progressive multiple sclerosis · 2026 · DOI

  • The therapeutic gap in addressing disease progression in progressive MS, - The need for a better understanding of the biological response to MSC-NP treatment, - The lack of identified biomarkers that could help define the pharmacodynamic response to MSC-NP…

    Effect of intrathecal injection of mesenchymal stem cell-neural progenitors on cerebrospinal fluid biomarkers in progressive multiple sclerosis · 2026 · DOI

  • Investigate the effects of treatment on amino acid levels and oxidative stress, - Examine the relationship between amino acid alterations and disease progression, - Study the potential of Gly as a modulatory and protective factor…

    Cerebrospinal fluid amino acid alterations are associated with oxidative stress and neuronal injury markers in multiple sclerosis · 2026 · DOI

  • Investigate the long-term impact of cladribine tablets on cognition, - Examine the effects of cladribine tablets on cognitive function in a larger sample size, - Explore the relationship between cladribine therapy and whole brain GM…

    The Impact of Cladribine Tablets on Cognition Over One Year in Patients With Multiple Sclerosis: A Preliminary Study · 2026 · DOI

  • The number of comparative studies remains limited, - Several estimates were imprecise, - The evidence base was relatively small for some…

    Immune-mediated comorbidities in multiple sclerosis: a scoping review · 2026 · DOI

Most-cited papers in Multiple Sclerosis Research Studies

Most recent work

Find a gap in your own Multiple Sclerosis Research Studies sub-topic

This page shows what the Multiple Sclerosis Research Studies literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 7.9M-paper local library and writes the gaps from its rows.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
4,200 open questions
Dementia and Cognitive Impairment Research
2,789 open questions
Substance Abuse Treatment and Outcomes
2,285 open questions
Cancer Immunotherapy and Biomarkers
2,273 open questions
Liver Disease Diagnosis and Treatment
2,102 open questions
Sports Performance and Training
1,952 open questions
Parkinson's Disease Mechanisms and Treatments
1,915 open questions
Mosquito-borne diseases and control
1,849 open questions
Open questions raised by papers listed on this page include: (1) The interplay between altered glutamatergic neurotransmission and oxidative stress in MS is not fully understood (“Cerebrospinal fluid amino acid alterations are associated with oxidative stress…”, 2026); (2) There is a need for non-invasive biomarkers to detect these changes (“Salivary Proteomics Reveals Disease- and Therapy-Associated Molecular Patterns…”, 2026); (3) There is a need to evaluate the effect of family-centered empowerment interventions on health-promoting lifestyle and psychological well-being in patients with MS (“Impact of the Family‐Centered Empowerment Model on Health‐Promoting Lifestyle…”, 2026); (4) The frequency and clinical relevance of immune-mediated comorbidities in people with MS remain incompletely characterized (“Immune-mediated comorbidities in multiple sclerosis: a scoping review”, 2026); (5) There is a need to investigate the impact of cladribine tablets on cognition in multiple sclerosis (“The Impact of Cladribine Tablets on Cognition Over One Year in Patients With…”, 2026). 1,241 gap statements have been mined from Multiple Sclerosis Research Studies papers in our 7.9M-paper local library, which holds 6,227 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 1,100,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? Acceptance odds for top, mid and open/emerging journals, in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck for prior publication across 7 sources and our local library.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

How Pre-Check worksHow AI Review works

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.