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Biochemistry, Genetics and Molecular Biology · Research topic

Open research questions in Muscle metabolism and nutrition

271 unresolved questions extracted from the limitations and future-work sections of 733 Muscle metabolism and nutrition papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Testing the effect of LEAA alone, - Assessing the safety of LEAA, - Investigating the long-term benefits of LEAA, - Examining the effect of LEAA in different clinical indications

    Leucine-Enriched Essential Amino Acids in Clinical Practice: A Narrative Review · 2026 · DOI

  • Further research is needed to evaluate the effectiveness of LLM-generated sports nutrition advice in real-world settings, - Studies should investigate the impact of LLMs on the nutritional knowledge and behaviors of recreational female marathon runners, - Research should explore the development of LLMs that can provide personalized sports nutrition advice, - Investigations into the use of LLMs in other areas of sports science and nutrition are warranted

    Evaluating sports nutrition advice provided by general-purpose large language models for recreational female marathon runners: a multidimensional descriptive audit · 2026 · DOI

  • The quality and practical limitations of LLM-generated sports nutrition advice for recreational female marathon runners are unknown. There is a lack of evaluation of LLM configurations for sports nutrition advice. Female-specific considerations in sports nutrition advice are not well-studied.

    Evaluating sports nutrition advice provided by general-purpose large language models for recreational female marathon runners: a multidimensional descriptive audit · 2026 · DOI

  • Investigating the effects of combined diet and physical activity on female recreational athletes with T2DM. Examining the long-term effects of the combined intervention on body composition and biochemical parameters. Studying the impact of different dietary protocols on glycemic control and insulin resistance.

    Effects of combined diet and physical activity on glycemic control and body composition in male recreational athletes with type 2 diabetes mellitus · 2025 · DOI

  • investigate the effects of caffeinated chewing gum on other exercises, - examine the effects of caffeinated chewing gum on different populations, - compare the effects of caffeinated chewing gum to other forms of caffeine intake

    Caffeinated chewing gum enhances maximal strength and muscular endurance during bench press and back squat exercises in resistance-trained men · 2025 · DOI

  • innovative study designs to elucidate causal relationships underlying athletic traits, - further investigation to establish standardized protocols for precision nutrition applications, - more diverse and inclusive studies to refine gender-sensitive research in sports nutrition

    Precision nutrition in sports science: an opinion on omics-based personalization and athletic outcomes · 2025 · DOI

  • The inability to consistently identify significant genetic variants using current GWAS methodologies. The need for innovative study designs to elucidate causal relationships underlying athletic traits. The challenge of translating omics-based findings into practical applications within sports settings, including the development of standardized protocols for personalized dietary planning.

    Precision nutrition in sports science: an opinion on omics-based personalization and athletic outcomes · 2025 · DOI

  • Evidence is lacking for populations with pre-existing kidney conditions, - Evidence is lacking for pregnant women, - Findings from animal studies often cannot be extrapolated to humans, - Methodological limitations of studies compromise their ecological validity

    A short review of the most common safety concerns regarding creatine ingestion · 2025 · DOI

  • Limited evidence on differential anabolic responses to nutritional stimuli in master athletes, - No study has specifically evaluated anabolic responses to nutritional stimuli in master athletes, - Data from clinical studies are limited

    Age-Related Anabolic Resistance: Nutritional and Exercise Strategies, and Potential Relevance to Life-Long Exercisers · 2025 · DOI

  • Systematic understanding of the differences in postprandial anabolic response to varying protein doses in older vs. young athletes, - Evaluation of differential anabolic responses to nutritional stimuli in master athletes

    Age-Related Anabolic Resistance: Nutritional and Exercise Strategies, and Potential Relevance to Life-Long Exercisers · 2025 · DOI

  • Small sample size (eleven young males). Limited to active young males. Short-term BCAA supplementation. No long-term effects of BCAA supplementation were studied.

    Branched-Chain Amino Acid Supplementation Enhances Substrate Metabolism, Exercise Efficiency and Reduces Post-Exercise Fatigue in Active Young Males · 2025 · DOI

  • Investigate the long-term effects of BCAA supplementation on exercise performance and metabolism. Examine the effects of BCAA supplementation on different populations (e.g. females, older adults). Study the effects of BCAA supplementation on different types of exercise (e.g. resistance training, high-intensity interval training).

    Branched-Chain Amino Acid Supplementation Enhances Substrate Metabolism, Exercise Efficiency and Reduces Post-Exercise Fatigue in Active Young Males · 2025 · DOI

  • The variability in study designs and populations across the included research. The limited understanding of the role of functional foods and personalized nutrition in post-exercise recovery. The risk of overuse and potential regulatory oversight gaps in the use of supplements.

    From Food Supplements to Functional Foods: Emerging Perspectives on Post-Exercise Recovery Nutrition · 2024 · DOI

  • There is a lack of evidence on the impact of creatine supplementation on specific populations, including pregnant women and individuals with pre-existing kidney conditions. The current evidence on the safety of creatine monohydrate supplementation is largely based on studies of healthy individuals. Further research is needed to fully understand the safety profile of creatine monohydrate supplementation.

    A short review of the most common safety concerns regarding creatine ingestion · 2025 · DOI

  • There is limited research on the nutrition knowledge of Reserve Officers’ Training Corps (ROTC) cadets compared to their adherence to recommended dietary guidelines.

    Evaluating The Relationship Between Nutrition Knowledge And Dietary Guideline Adherence In ROTC Cadets · 2026 · DOI

  • Spermidine and spermine support cellular homeostasis and mitochondrial function across species, but their relevance to physical and mitochondrial function in humans remains unclear.

    Polyamines, cardiorespiratory fitness, body composition, and mitochondrial function in older patients with coronary artery disease · 2026 · DOI

  • Background Evidence is limited regarding whether assigned protein targets modify responses to resistance training (RT) alone or to the same RT program plus cycling (concurrent training [CT]) in middle-aged and older women.

    Resistance versus concurrent training with three assigned protein targets in middle-aged and older women: a randomized 2 × 3 factorial trial · 2026 · DOI

  • Background Red meats such as lean beef can be an important source of dietary protein, however, high-quality evidence on its role in stimulating the muscle protein synthetic response and potentially augmenting adaptations to resistance exercise (RTEX) is scarce.

    Effects of lean beef on resistance training-induced strength and body composition adaptations: a randomized controlled trial protocol. · 2026 · DOI

  • While physical activity and dietary modifications are established interventions, their combined effects in active male populations remain underexplored.

    Effects of combined diet and physical activity on glycemic control and body composition in male recreational athletes with type 2 diabetes mellitus · 2025 · DOI

  • Introduction Caffeinated chewing gum, known for its rapid absorption, has not been previously studied for its effects on maximal strength and muscular endurance in resistance exercise.

    Caffeinated chewing gum enhances maximal strength and muscular endurance during bench press and back squat exercises in resistance-trained men · 2025 · DOI

  • The impact of exercise on human metabolism has been extensively studied, yet limited research exists on the effects of high-intensity racing on equine metabolism.

    Plasma Lipidomics and Proteomics Analyses Pre- and Post-5000 m Race in Yili Horses · 2025 · DOI

  • Dietary protein sources provide the amino acids needed, but protein sources vary widely in amio acid composition.

    Determining amino acid requirements in humans · 2024 · DOI

  • The importance of meal distribution of dietary protein to optimize muscle mass and body remains unclear, and the findings are intertwined with age, physical activity, and the total quantity and quality of protein consumed.

    Impacts of protein quantity and distribution on body composition · 2024 · DOI

  • The efficacy of fucoxanthin in alleviating lipid metabolic disorders in skeletal muscle remains poorly understood.

    Fucoxanthin Mitigates High-Fat-Induced Lipid Deposition and Insulin Resistance in Skeletal Muscle through Inhibiting PKM1 Activity · 2024 · DOI

  • Findings underscore the need for further research into nutrient interactions, dosage optimization, and long-term effects on athletic performance.

    From Food Supplements to Functional Foods: Emerging Perspectives on Post-Exercise Recovery Nutrition · 2024 · DOI

Most-cited papers in Muscle metabolism and nutrition

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271 open questions have been extracted from the limitations and future-work passages of 733 Muscle metabolism and nutrition papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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