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Open research questions in Nail Diseases and Treatments

46 unresolved questions extracted from the limitations and future-work sections of 481 Nail Diseases and Treatments papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Ingrown toenails are associated with significant pain, erythema, and purulent discharge. The condition can substantially impair quality of life. There is a lack of understanding of the underlying causes of ingrown toenails.

    Narrow ungual tuberosity associated with ingrown toenail: a case-control study based on foot imaging · 2026 · DOI

  • The underlying causes of ingrown toenails are unclear. There is a lack of understanding of the relationship between the morphology of the ungual tuberosity and the occurrence of ingrown toenails.

    Narrow ungual tuberosity associated with ingrown toenail: a case-control study based on foot imaging · 2026 · DOI

  • There is a need for a comprehensive overview of onychomycosis. There is a need for a discussion on various treatment approaches used for managing onychomycosis.

    ONYCHOMYCOSIS: AN UPDATED REVIEW ON DIAGNOSIS, TREATMENT, AND NOVEL FORMULATIONS · 2026 · DOI

  • Tinea infection is a significant public health problem in Mosul City. Rural residents and children are disproportionately affected. There is a lack of data on the prevalence and demographic distribution of tinea infection in Mosul City.

    PREVALENCE OF TINEA AMONG PATIENTS ATTENDING DERMATOLOGY CONSULTATION UNITS IN MOSUL CITY · 2026 · DOI

  • Comparative evidence on the efficacy of systemic and topical antifungal therapies for pityriasis versicolor is limited.

    Comparative Efficacy of Low-Dose Short-Course Oral Fluconazole versus Topical 1% Clotrimazole in the Treatment of Pityriasis Versicolor: A Randomized Controlled Trial · 2026 · DOI

  • The difficulty in diagnosing Tinea incognito due to its similarity to other conditions. The need for a simple and cheap diagnostic test.

    KOH Mount: A busy doctor's best diagnostic ally: A case series of tinea incognito <span style="font-size: 1rem;">confirmed with this simple tool</span> · 2026 · DOI

  • The paper highlights the importance of recognizing id reaction, which is often overlooked or misdiagnosed.

    Id reaction following impetiginized contact dermatitis · 2026 · DOI

  • The mechanisms by which mechanical microtraumas progress to non-healing ulcerative defects due to dysbiosis remain poorly understood.

    Aspects of the Pathogenesis of Skin Complications in the Stump–Prosthesis System in Dynamics: The Role of Bacterial and Mycological Dysbiosis · 2026 · DOI

  • The relationship between seborrhoeic dermatitis and seborrhoea is not fully understood. Prior studies have given conflicting results on the relationship between seborrhoeic dermatitis and seborrhoea.

    Seborrhoea is not a feature of seborrhoeic dermatitis. · 1983 · DOI

  • While the analysis identified footwear (52.0%), orthopedic deformities (92.0%), and injuries (84.0%) as contributing factors to nail problems, the study did not investigate the specific mechanisms by which biomechanical forces cause nail dystrophy.

    Assessment of the effectiveness of podiatric nail cleaning in terms of patient health and quality of life: prospective observational study · 2026 · DOI

  • The study reported fungal species distribution for onychomycosis but did not conduct antifungal susceptibility testing or clinical treatment outcome follow-up. Future research must incorporate in vitro susceptibility testing against azoles and other antifungal agents alongside clinical efficacy monitoring to guide empirical therapy and track resistance patterns.

    Epidemiology and fungal species distribution of onychomycosis and other superficial mycoses in the coastal city of Ningbo, China · 2026 · DOI

  • The retrospective study design prevented systematic collection of concomitant diseases and potential risk factors for onychomycosis and superficial fungal infections. Future prospective studies should systematically document patient comorbidities, occupational exposures, and demographic risk factors to enable determinant analysis in coastal populations.

    Epidemiology and fungal species distribution of onychomycosis and other superficial mycoses in the coastal city of Ningbo, China · 2026 · DOI

  • Fungal contaminations in indoor swimming pools are a challenge to control. Cutaneous fungal infections can have serious health consequences. There is a need for effective control measures to prevent fungal contaminations.

    Significance of Fungal Contaminations Control in Indoor Swimming Pools during Summer Season in Yazd Province · 2026 · DOI

  • There is a limited comparison of the clinical efficacy of oxiconazole vs ciclopirox olamine in treating dermatophyte infections. The study aims to address this gap by evaluating the efficacy and safety of oxiconazole cream compared with ciclopirox olamine cream.

    Comparative Efficacy of Oxiconazole Cream Versus Ciclopirox Olamine Cream in the Management of Localized Cutaneous Dermatophytosis: A Randomized Controlled Trial. · 2026 · DOI

  • IJDDT, Volume 16 Issue 27s, 2026 Page: 5 Comparative Efficacy of Oxiconazole Cream Versus Ciclopirox Olamine Cream in the Management of Localized Cutaneous Dermatophytosis: A Randomized Controlled Trial. The principal limitations of this study include: (i) the relatively small sample size (n=40), which, although adequate for detecting the primary outcome, may limit generalizability; (ii) the open-label design, which precludes blinding of patients and treating physicians, though outcome assessors were blinded; (iii) the conduct at a single centre, which may restrict external validity; (iv) the short four-week treatment and absence of post-treatment follow- up, which preclude assessment of recurrence rates and long- term durability; (v) the moderate baseline score imbalance between groups, which, while statistically non-significant, could partially influence percentage-reduction analyses; and (vi) the absence of species-level identification of causative dermatophytes, which limits assessment of species-specific treatment responses.

    Comparative Efficacy of Oxiconazole Cream Versus Ciclopirox Olamine Cream in the Management of Localized Cutaneous Dermatophytosis: A Randomized Controlled Trial. · 2026 · DOI

  • There is a need for a natural alternative to chemical-based treatments for dandruff. There is a lack of studies on the antifungal activity of polyherbal extracts against Malassezia globosa.

    Polyherbal Extracts and its Potential Impact on Dandruff Causative Agent of Malassezia globosa · 2026 · DOI

  • The diagnosis of P. glomerata can be challenging due to its similarity to other fungi. There is a lack of literature on the use of MALDI-TOF MS and DNA sequencing for the diagnosis of P. glomerata.

    Phoma glomerata Kaynaklı Non-Dermatofitik Onikomikoz: Türkiye’den İlk Olgu · 2026 · DOI

  • The study aims to address the gap in understanding the variety, incidence, and clinical distribution of dermatological lesions in patients with hematologic malignancies. The study highlights the need for routine follow-up for hematologic patients to include a dermatological evaluation.

    Evaluation of Dermatological Lesions in Patients With Hematologic Malignancy · 2026 · DOI

  • There is a need for enhanced clinical vigilance and awareness of dermatophyte infections. There is a lack of effective treatment options for dermatophytosis, particularly against emerging drug-resistant strains.

    In Vitro Antifungal Activity of Octenidine Against Emerging Dermatophyte Species · 2026 · DOI

  • The diagnostic approach is complicated by the similarity between tinea incognita and other inflammatory dermatoses. Pregnancy adds further complexity to the diagnostic and therapeutic approach.

    Extensive Pustular Tinea Incognita During Late Pregnancy: A Case Report · 2026 · DOI

  • The incidence of dermatophytoses is rising, partly due to increased use of antimicrobials and immunosupressants. There is a need for effective and safe treatments for tinea corporis.

    COMPARING THE EFFECTIVENESS AND SAFETY OF CLOTRIMAZOLE AND SERTACONAZOLE FOR TREATING TINEA CORPORIS · 2026 · DOI

  • There is a need for non-invasive methods to evaluate microvascular changes in rheumatological diseases. Current diagnostic methods may not provide sufficient information for disease monitoring and treatment.

    Investigation of Nailfold Capillary Structures Using Digital Dermatoscopy in Rheumatological Diseases · 2026 · DOI

  • Although the factors triggering vasculopathy, the initial stage of SSc, are not clearly known, it is thought that cytomegalovirus (CMV), whose epitopes resemble endothelial cell surface molecules, anti-endothelial cell antibodies, or free oxygen radicals cause endothelial cell damage, leading to apoptosis in endothelial cells.

    Investigation of Nailfold Capillary Structures Using Digital Dermatoscopy in Rheumatological Diseases · 2026 · DOI

  • The epidemiologic landscape in Indonesian regional hospitals has not been adequately explored. There is a lack of understanding of how dermatologic emergencies manifest in populations where diseases such as leprosy remain endemic.

    Profile of Dermatologic Emergencies At The Emergency Department of RSUD Jombang: A Three-Year Retrospective Study (2023 To 2025) · 2026 · DOI

  • The 14-day follow-up allowed assessment of the early clinical response but was insufficient to determine completion of the planned antifungal course, mycological cure, definitive hair regrowth, recurrence, scarring alopecia, or adverse events occurring after day 14.

    Severe Adult Kerion Celsi With Rapid Improvement During Systemic Antifungal and Adjunctive Secretome Therapy: A Case Report · 2026 · DOI

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46 open questions have been extracted from the limitations and future-work passages of 481 Nail Diseases and Treatments papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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