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Open research questions in Neurogenesis and neuroplasticity mechanisms

188 unresolved questions extracted from the limitations and future-work sections of 399 Neurogenesis and neuroplasticity mechanisms papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The study focused on a specific model of astrocytopathy relevant to neuromyelitis optica spectrum disorder, - The study used a limited number of experimental approaches, - The study did not investigate the long-term consequences of astrocyte loss and repopulation

    Focal astrocyte loss reveals nuclear translocation during lesion repopulation · 2026 · DOI

  • Investigating the long-term consequences of astrocyte loss and repopulation, - Examining the effects of different types of astrocyte loss on the spatiotemporal dynamics of astrocyte remodeling and repopulation, - Developing new experimental approaches to study astrocyte biology in vivo

    Focal astrocyte loss reveals nuclear translocation during lesion repopulation · 2026 · DOI

  • The postnatal development of different cIN types is not well understood. The timing and molecular mechanisms underlying the postnatal maturation of SST+ interneurons are not fully characterized. There is a need for detailed molecular and physiological descriptions of the postnatal development of SST+ interneurons.

    SST interneuron maturation extends beyond the second postnatal week and is driven by coordinated transcriptional and functional remodeling · 2026 · DOI

  • Further mechanistic investigation of the Npy regulatory axis and Cntnap2-positive oligodendrocyte-lineage state, - Investigation of hypothalamic metabolic regulation and neuron-glia interactions in diabetes

    Integrated Single-Nucleus and Epigenomic Profiling Reveals Coordinated Neuro-Glial and Chromatin Remodeling in the Type 2 Diabetic Hypothalamus · 2026 · DOI

  • The cellular and regulatory landscape of the hypothalamus in type 2 diabetes remains incompletely understood. The study of diabetes-associated hypothalamic remodeling has been limited to neuronal populations.

    Integrated Single-Nucleus and Epigenomic Profiling Reveals Coordinated Neuro-Glial and Chromatin Remodeling in the Type 2 Diabetic Hypothalamus · 2026 · DOI

  • unraveling the elements contributing to Ca2+ intracellular dynamics in cell proliferation remains a challenging puzzle that requires further investigation

    Calcium and Neural Stem Cell Proliferation · 2024 · DOI

  • Further research into Ca2+ dynamics and the underlying mechanisms in neural stem cells is required. The dynamic nature of calcium and the evolving cell populations during development make understanding its involvement challenging. The paper identifies the need to understand the molecules involved in calcium entry in neural stem cells.

    Calcium and Neural Stem Cell Proliferation · 2024 · DOI

  • How matrix viscoelasticity or stress relaxation regulates primary NPSC stemness, neuronal and glial differentiation, and the associated matrix-cell mechanotransduction pathways are not well understood.

    Matrix Viscoelasticity Regulates the Stemness and Multilineage differentiation of Primary Neural Progenitor-Stem Cells in 3D · 2026 · DOI

  • Systems memory consolidation reorganizes episodic memories from the hippocampus into neocortical networks such as the anterior cingulate cortex (ACC), yet the localized molecular programs supporting this process remain unknown.

    SERINC1-dependent lipid preservation gates neocortical synaptogenesis and remote memory · 2026 · DOI

  • Although adult behavioral and neurobiological alterations following early stress are well documented, the early emerging phenotypes and their underlying cellular and molecular mechanisms during juvenile development remain poorly understood.

    Juvenile behavioral alterations and sex-dependent deficits in hippocampal neurogenesis following early-life stress in rats · 2026 · DOI

  • Yet, because differentiation continues after cell-cycle exit, it remains unclear how far post-mitotic identity can be reshaped by the environment and whether this residual competence varies across neuronal types.

    Transplantation reveals birthdate-dependent post-mitotic competence in cortical neurons · 2026 · DOI

  • Finally, we outline key open questions that define current gaps in our understanding of oligodendroglial autophagy.

    Autophagy-lysosome networks in oligodendrocytes: a dynamic framework for myelin integrity · 2026 · DOI

  • Although these evolutionary changes are thought to be crucial for the acquisition of higher cognitive functions, the molecular and cellular mechanisms underlying the development and evolution of the mammalian cerebrum are still not fully understood.

    Investigation of the mechanisms underlying the development and evolution of the mammalian cerebrum using gyrencephalic ferrets · 2026 · DOI

  • The molecular mechanisms underlying the transition from cortical neurogenesis to gliogenesis, and the subsequent fate determination of cortical astrocytes, oligodendrocytes, and olfactory bulb interneurons, remain unclear.

    NOTCH, ERK, and SHH signaling respectively control the fate determination of cortical glia and olfactory bulb interneurons · 2025 · DOI

  • Introduction: Prolactin (PRL) is a pleiotropic hormone implicated in various physiological processes; however, its contribution to neurodevelopment, particularly early corticogenesis, remains insufficiently characterized.

    Prolactin drives cortical neuron maturation and dendritic development during murine embryonic stem cell differentiation · 2025 · DOI

  • While early differentiation of adult radial glia-like cells (RGLs) has been studied extensively, the molecular mechanisms guiding the maturation of postmitotic neurons remain unknown.

    Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus · 2024 · DOI

  • Furthermore, the transcriptional regulation of Olig2 and Egfr has not been explored.

    A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex · 2024 · DOI

  • Calcitonin gene-related peptide (CGRP) is a neuropeptide that causes anxiety behavior; however, the underlying mechanisms remain unclear.

    CGRP causes anxiety via HP1γ–KLF11–MAOB pathway and dopamine in the dorsal hippocampus · 2024 · DOI

  • The direct effects of dopamine on human hippocampal progenitor cells are not well understood. The role of the dopamine D4 receptor in regulating human hippocampal neurogenesis is unclear.

    High dopamine impairs early neuronal identity and morphology in human hippocampal progenitor cells · 2026 · DOI

  • Most human evidence remains correlative, with few definitive proofs that OL pathology initiates neurodegeneration. Most mechanistic data are from rodent models, with partial validation in human iPSC-derived OLs and limited in vivo human evidence.

    Oligodendrocyte dysfunction in neurodegenerative diseases: pathological features, underlying mechanisms and therapeutic targeting · 2026 · DOI

  • The mechanisms underlying oligodendrocyte dysfunction in neurodegenerative diseases are not fully understood. The relationship between oligodendrocyte dysfunction and neurodegeneration is not fully elucidated.

    Oligodendrocyte dysfunction in neurodegenerative diseases: pathological features, underlying mechanisms and therapeutic targeting · 2026 · DOI

  • Cell-type-specific manipulations can test the hypothesis that δ-catenin is required in both cell types to instruct astrocyte transcription. Future studies targeting Ctnnd2 in each cell type are needed to dissect the respective contributions of these cell types to the ODP phenotype.

    δ-catenin controls layer-specific transcriptional maturation of astrocytes via Zbtb20 · 2026 · DOI

  • The study uses a limited number of human post-mortem brain slices. The culturing period is limited to 20 days. The study does not investigate the effects of different concentrations of lysophosphatidylcholine.

    Focal and subtle myelin damage in multiple sclerosis-derived post-mortem human brain slice cultures · 2026 · DOI

  • Investigating the effects of different concentrations of lysophosphatidylcholine on myelin damage. Studying the effects of other demyelinating agents on human brain slice cultures. Developing therapeutic strategies based on the findings of this study.

    Focal and subtle myelin damage in multiple sclerosis-derived post-mortem human brain slice cultures · 2026 · DOI

  • The basal ganglia (BG) form anatomically and functionally segregated yet integrative parallel circuits, but the molecular mechanisms specifying them remain unclear.

    Complementary δ2-protocadherin expression delineates parallel basal ganglia circuits in primates · 2026 · DOI

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188 open questions have been extracted from the limitations and future-work passages of 399 Neurogenesis and neuroplasticity mechanisms papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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