Science AI Journal
Medicine · Research topic

Open research questions in Nitric Oxide and Endothelin Effects

104 gap statements mined from Nitric Oxide and Endothelin Effects papers in our 4.5M-paper local library, which holds 462 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Nitric Oxide and Endothelin Effects? See the ranked Medicine journals.

What the literature leaves open

  • The structural mechanism of electron transfer in iNOS is not well understood. The dynamic movement of the FMND and its role in electron shuttling are not well characterized.

    Structural Mechanism of Electron Shuttling in Inducible Nitric Oxide Synthase · 2026 · DOI

  • The need for rapid and effective therapeutic strategies for treatment-resistant depression. The lack of robust evidence on the use of óxido nitroso in psychiatry.

    ÓXIDO NITROSO COMO ESTRATÉGIA TERAPÊUTICA EM PSIQUIATRIA: EVIDÊNCIAS EM DEPRESSÃO RESISTENTE E IMPLICAÇÕES NEUROBIOLÓGICAS · 2026 · DOI

  • There is a need for a comprehensive review of the evidence on óxido nitroso in psychiatry. The current evidence is not yet robust enough to establish a definitive role for óxido nitroso.

    ÓXIDO NITROSO COMO ESTRATÉGIA TERAPÊUTICA EM PSIQUIATRIA: EVIDÊNCIAS EM DEPRESSÃO RESISTENTE E IMPLICAÇÕES NEUROBIOLÓGICAS · 2026 · DOI

  • Overcoming the limitations of current studies, including the lack of direct causal evidence in human colitic ISCs.

    Nitric Oxide in the Intestinal Stem Cell Niche: A Spatial Model of Nitrosative Stress and Clonal Evolution in Colitis-Associated Colorectal Cancer · 2026 · DOI

  • The mechanisms linking recurrent inflammation to crypt-level dysplasia remain incompletely defined. Direct causal evidence in human colitic ISCs remains limited.

    Nitric Oxide in the Intestinal Stem Cell Niche: A Spatial Model of Nitrosative Stress and Clonal Evolution in Colitis-Associated Colorectal Cancer · 2026 · DOI

  • Future work on SNO in HF should prioritize depth over breadth. Continued expansion of candidate protein lists will be less informative than building reproducible, human-relevant evidence for a smaller number of more robustly supported candidate events.

    Protein S-Nitrosylation in Heart Failure: A Compartment-Resolved Review of Mechanisms, Evidence Boundaries, and Translational Perspectives · 2026 · DOI

  • These findings support the potential of iNOS-targeted nanomedicine as an adjuvant strategy for TNBC treatment and warrant further investigation using in vivo models to evaluate pharmacokinetics, tumor accumulation, and antitumor efficacy of the NPs.

    Controlled delivery of iNOS antagonist, 1400W, for synergistic breast cancer therapy · 2026 · DOI

  • The interactions among NO system components during neurodestruction are not fully elucidated. The effects of colchicine on the nitric oxide system in the basal magnocellular nucleus of rats are not well understood.

    Nitric oxide system parameters in the basal magnocellular nucleus of the rat brain following intracerebroventricular administration of colchicine · 2026 · DOI

  • Future research should focus on large-scale longitudinal studies and adequately powered randomized trials to determine whether oral microbiome-mediated nitrate metabolism influences long-term cardiovascular outcomes.

    The Oral Microbiome–Nitrate–Nitrite–Nitric Oxide Axis and Cardiovascular Health: A Narrative Review · 2026 · DOI

  • The lack of understanding of the molecular mechanisms of transport and substrate recognition of NIPA2. The dearth of structural data on NIPA2 and other DMT proteins.

    Mechanistic studies of the human NIPA2 transporter · 2026 · DOI

  • Human studies also associate menopause with altered blood pressure, arterial stiffness, sympathetic activity, and baroreflex regulation, although direct evidence for estrogen receptor and Nox signaling within the human RVLM remains lacking.

    Sex differences in neurogenic hypertension: estrogen modulation of NADPH oxidase signaling in the rostral ventrolateral medulla · 2026 · DOI

  • The study highlights the need for further research on the role of sGC oxidation in neurodegenerative and cerebrovascular diseases.

    sGC oxidation impairs NO-dependent ophthalmic artery vascular reactivity and alters long-term memory performance in mice · 2026 · DOI

  • More molecular mechanisms should be investigated concerning the pathophysiology of HF after MI since current therapies for reperfusion and clinical guidelines in medicine cannot solve the problem.

    Vericiguat for Post-Myocardial Infarction Heart Failure Prevention: From Molecular Mechanisms to Clinical Translation · 2026 · DOI

  • Dopamine (DA) is clinically employed to improve renal perfusion, but its efficacy remains controversial due to paradoxical vasoconstriction at higher doses.

    The heterogeneity of dopamine-mediated vasodilation in human intrarenal arteries · 2026 · DOI

  • Despite their well‐established physiological relevance, a comprehensive characterization of Kir2 and K ATP channels in freshly isolated human pulmonary vascular cells – particularly within the endothelium – remains lacking.

    Functional expression of inwardly rectifying and ATP‐sensitive potassium channels in human pulmonary artery smooth muscle and endothelial cells · 2026 · DOI

  • The potential therapeutic role of long-term inhaled NO in hypoxia-induced pulmonary hypertension and right ventricular disease has not been determined.

    Effects of Continuous Low-dose Nitric Oxide in a Murine Model of Pulmonary Hypertension with Impaired Lung Development · 2026 · DOI

  • However, the immune regulatory role and related mechanisms of NOS1, as well as its impacts on immune therapies such as immune checkpoint blockade (ICB) in melanoma, remain unclear.

    S-nitrosylation of IRF7 induced by NOS1 expression in melanoma suppresses anti-tumor immunity · 2026 · DOI

  • These findings support the therapeutic potential of sGC stimulation in HF, primarily through antioxidative mechanisms, while its effects on cardiac remodeling warrant further investigation.

    Soluble guanylate cyclase as a therapeutic target in heart failure: modulation of oxidative stress and cardiac remodeling pathways with potential implications for heart failure therapy · 2026 · DOI

  • Hemoglobin (Hb), the principal oxygen-transport protein of erythrocytes, is a key intravascular scavenger and target of PN; however, how controlled PN exposure translates into structural remodeling and aggregation of Hb remains poorly understood.

    Peroxynitrite‐induced structural remodeling and aggregation of hemoglobin under nitroxidative stress · 2026 · DOI

  • Additional approaches, such as chemical crosslinking or site-directed mutagenesis, may prove useful for trapping or enriching transient states. The study's findings can be used to inform the development of drugs targeting iNOS.

    Structural Mechanism of Electron Shuttling in Inducible Nitric Oxide Synthase · 2026 · DOI

  • CLTI patients show a wide range of differences in oxidative stress levels, microvascular dysfunction, and hypoxia signaling, making their condition highly heterogeneous.

    Unraveling the association between oxidative stress, nitric oxide signaling, and hypoxia inducible factor in chronic limb-threatening ischemia · 2026 · DOI

  • There is a growing number of reported neurologic complications due to increased recreational nitrous oxide use. Early recognition and treatment of nitrous oxide-related neurologic injury are essential to prevent permanent neurologic injury.

    Nitrous Oxide (“Whippets”)–Induced Subacute Combined Degeneration: A Case Report · 2026 · DOI

  • The widespread availability of nitrite preparations on the market and the underestimated prevalence of recreational nitrite use. The difficulty in diagnosing complications due to nonspecific symptoms.

    Analysis of adverse effects of nitrates and nitrites with particular emphasis on methemoglobinemia and maculopathy based on clinical cases and publicly available literature · 2026 · DOI

  • Further studies on the physiological role of NIPA2 and related proteins, - Investigation of the effects of other mutations on NIPA2 function, - Elucidation of the molecular mechanisms of other members of the Drug/Metabolite Transporter…

    Mechanistic studies of the human NIPA2 transporter · 2026 · DOI

  • These findings support further investigation of prolonged inhaled NO as a potential therapeutic strategy for conditions associated with chronic hypoxia, such as those experienced at high altitude.

    Effects of Continuous Low-dose Nitric Oxide in a Murine Model of Pulmonary Hypertension with Impaired Lung Development · 2026 · DOI

Most-cited papers in Nitric Oxide and Endothelin Effects

Most recent work

Find a gap in your own Nitric Oxide and Endothelin Effects sub-topic

This page shows what the Nitric Oxide and Endothelin Effects literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 4.5M-paper local library and writes the gaps from its rows.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
2,304 open questions
Substance Abuse Treatment and Outcomes
1,956 open questions
Dementia and Cognitive Impairment Research
1,232 open questions
Ferroptosis and cancer prognosis
1,146 open questions
Liver Disease Diagnosis and Treatment
1,049 open questions
Smoking Behavior and Cessation
1,025 open questions
Physical Activity and Health
1,002 open questions
Attention Deficit Hyperactivity Disorder
982 open questions
Open questions raised by papers listed on this page include: (1) The structural mechanism of electron transfer in iNOS is not well understood (“Structural Mechanism of Electron Shuttling in Inducible Nitric Oxide Synthase”, 2026); (2) The lack of robust evidence on the use of óxido nitroso in psychiatry (“ÓXIDO NITROSO COMO ESTRATÉGIA TERAPÊUTICA EM PSIQUIATRIA: EVIDÊNCIAS EM…”, 2026); (3) Overcoming the limitations of current studies, including the lack of direct causal evidence in human colitic ISCs (“Nitric Oxide in the Intestinal Stem Cell Niche: A Spatial Model of Nitrosative…”, 2026); (4) The interactions among NO system components during neurodestruction are not fully elucidated (“Nitric oxide system parameters in the basal magnocellular nucleus of the rat…”, 2026); (5) Future research should focus on large-scale longitudinal studies and adequately powered randomized trials to determine whether oral microbiome-mediated nitrate metabolism influences long-term cardiovascular outcomes (“The Oral Microbiome–Nitrate–Nitrite–Nitric Oxide Axis and Cardiovascular…”, 2026). 104 gap statements have been mined from Nitric Oxide and Endothelin Effects papers in our 4.5M-paper local library, which holds 462 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? Acceptance odds for top, mid and open/emerging journals, in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck for prior publication across 7 sources and our local library.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

How Pre-Check worksHow AI Review works

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.