Science AI Journal
Biochemistry, Genetics and Molecular Biology · Research topic

Open research questions in Nuclear Structure and Function

96 gap statements mined from Nuclear Structure and Function papers in our 4.5M-paper local library, which holds 265 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

What the literature leaves open

  • The disruption of calcium homeostasis can lead to severe conditions, including neurodegenerative diseases, pathological calcification, and rhabdomyolysis. The regulation of calcium concentration is critical for cellular homeostasis. The detailed mechanism of calcium-induced cell death remains unknown.

    The Impact of Calcium Overload on Cellular Processes: Exploring Calcicoptosis and Its Therapeutic Potential in Cancer · 2024 · DOI

  • The definition of calcicoptosis remains controversial within the research community. The detailed mechanism of calcium-induced cell death remains unknown. There is a need to understand the connections between calcium dynamics and cell death pathways.

    The Impact of Calcium Overload on Cellular Processes: Exploring Calcicoptosis and Its Therapeutic Potential in Cancer · 2024 · DOI

  • histolytica and reveal NPC-associated networks that combines recognizable conserved components with extensively remodeled and poorly characterized proteins.

    Evolutionary diversification of the nuclear pore complex in Entamoeba histolytica reveals conserved and lineage-specific nucleoporins · 2026 · DOI

  • Nuclear Envelope Membrane Protein 1 (NEMP1) is highly expressed in oocytes and required for fertility, yet its meiotic function remains poorly understood.

    NEMP1 organizes the meiotic telomere LINC interface to control chromosome movement and telomere integrity · 2026 · DOI

  • The direction of this structural skin response is consistent with the previously reported biological activity of Progerinin in progerin-driven experimental models and provides an initial translational signal supporting further investigation of progerin-targeted approaches in human skin.

    Short-Term Changes in Dermal Density Following Topical Application of a Progerinin-Containing Serum: An Exploratory Clinical Study · 2026 · DOI

  • Because this exploratory study did not include a vehicle or placebo control and the formulation contained additional active skincare ingredients, the specific contribution of Progerinin remains to be established.

    Short-Term Changes in Dermal Density Following Topical Application of a Progerinin-Containing Serum: An Exploratory Clinical Study · 2026 · DOI

  • These preliminary findings support further investigation of XPO1 inhibition combined with R-CHOP, with priority given to dose optimization.

    Selinexor combined with R-CHOP achieved a high response rate in newly diagnosed double/triple-hit lymphoma · 2026 · DOI

  • The molecular mechanisms by which LMNA sequence variations lead to EDMD remain unknown.

    WNT5a-Mediated Aberrant Actin Filament Dynamics Drive Cardiac Pathogenic Phenotypes in LMNA -Related Emery-Dreifuss Muscular Dystrophy · 2026 · DOI

  • IMPORTANCELike most other positive-sense RNA viruses, Zika virus (ZIKV) replicates in the cytoplasm; however, the mechanisms by which it recruits host factors for efficient proliferation remain elusive.

    Zika virus recruits karyopherin α6 for efficient replication via NS2B · 2026 · DOI

  • IMPORTANCEEfficient nuclear export of hepatitis B virus (HBV) RNAs is essential for viral replication, yet the regulatory mechanisms controlling this process remain poorly defined.

    RANBP3 and RAN orchestrate CRM1-mediated nuclear export of hepatitis B virus RNAs · 2026 · DOI

  • However, the mechanisms that govern tethering of heterochromatin to the NE are not fully understood.

    Phosphorylation of Barrier-to-Autointegration Factor (BAF) regulates anchoring of centromeric heterochromatin to the nuclear envelope (NE) · 2026 · DOI

  • Despite recent diagnostic advancements and expanded screening modalities, the underlying cause of DCM remains elusive in over 50% of pediatric cases.

    Homozygous PPP1R13L Mutation Associated with Dilated Cardiomyopathy in a 1-Year-Old Child · 2026 · DOI

  • The mechanisms coordinating NE remodelling, MTOC dynamics, and flagellum assembly remain poorly understood.

    A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei · 2025 · DOI

  • The influence of LMNA variant type/localization on late gadolinium enhancement (LGE) patterns and clinical outcomes remains unclear.

    Variant‐Specific Late Gadolinium Enhancement Patterns Influence Clinical Outcomes in LMNA ‐Related Cardiomyopathy · 2025 · DOI

  • In contrast, the role of ESCRT-III for nuclear egress of betaherpesviruses, including human cytomegalovirus (HCMV) and human herpesvirus 6A (HHV-6A), has not been elucidated.

    ESCRT-III is recruited by human herpesvirus 6A nuclear egress complex to promote nuclear egress of the nucleocapsid · 2025 · DOI

  • However, the role of DDX56 in teleost antiviral immunity remains poorly characterized.

    DEAD-box helicase gcDDX56 disrupts IRF3 nuclear import complex and promotes nuclear IRF3 degradation for enhancing GCRV replication · 2025 · DOI

  • HASTY (HST), a karyopherin protein, has been implicated in miRNA biogenesis and movement, though its role in non-cell-autonomous miRNA movement remains unclear.

    The nuclear pore complex acts as a hub for pri-miRNA transcription and processing in plants · 2025 · DOI

  • ABSTRACT: Previously, we reported that targeting immunoglobulin superfamily member 9 (IGSF9) could enhance antitumor T-cell activity and sensitivity to anti-PD-1 immunotherapy, although the detailed mechanism remains unclear.

    IGSF9-targeted therapy inhibits the progression of acute myeloid leukemia · 2025 · DOI

  • Despite progress in understanding the perturbations emanating fromLMNAmutations, an integrative understanding of the pathogenesis underlying cardiac dysfunction remains elusive.

    Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute toLMNAcardiomyopathy · 2024 · DOI

  • 378 + 1G > A homozygous mutation has not been previously reported and the report of this patient expands the spectrum of MTX2 mutations.

    Case report: A novel splice-site mutation of MTX2 gene caused mandibuloacral dysplasia progeroid syndrome: the first report from China and literature review · 2024 · DOI

  • 378 + 1G > A in the MTX2 gene, which has not been previously reported in the literature.

    Case report: A novel splice-site mutation of MTX2 gene caused mandibuloacral dysplasia progeroid syndrome: the first report from China and literature review · 2024 · DOI

  • Nonetheless, due to the constraint imposed by the stochastic nature of rupture events, a precise characterization of the initial stage of nuclear repair remains elusive.

    A new microscopy pipeline for studying the initial stages of nuclear and micronuclear rupture and repair · 2024 · DOI

  • However, data on its prevalence and associated factors is scarce among children and adolescents who live in developing countries like Ethiopia.

    Prevalence and associated factors of lipodystrophy in type 1 diabetic children and adolescents at Ayder Comprehensive Specialized Hospital, Tigray, Ethiopia · 2024 · DOI

  • Currently, more than 15 different genes are known to cause distinct forms of LD; however, the genetic etiology of over 50% of familial partial and about 30% of congenital generalized LD cases remains unknown.

    1402-P: Novel Lipodystrophy Genotype Correlations Identified through the Rare and Atypical Diabetes Network (RADIANT) · 2024 · DOI

  • Besides Kapβs, several other types of transport components have been linked to NCT impairments in R-DPR-expressed cells, but the molecular origin of these observations has not been clarified.

    C9orf72 polyPR directly binds to various nuclear transport components · 2024 · DOI

Most-cited papers in Nuclear Structure and Function

Most recent work

Find a gap in your own Nuclear Structure and Function sub-topic

This page shows what the Nuclear Structure and Function literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 4.5M-paper local library and writes the gaps from its rows.

Open the Research Gap Finder →

Related topics in Biochemistry, Genetics and Molecular Biology

Gut microbiota and health
2,259 open questions
Single-cell and spatial transcriptomics
824 open questions
Antibiotic Resistance in Bacteria
676 open questions
Extracellular vesicles in disease
640 open questions
Genetic Associations and Epidemiology
605 open questions
Inflammatory Bowel Disease
516 open questions
RNA modifications and cancer
502 open questions
Mitochondrial Function and Pathology
465 open questions
96 gap statements have been mined from Nuclear Structure and Function papers in our 4.5M-paper local library, which holds 265 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? Acceptance odds for top, mid and open/emerging journals, in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck for prior publication across 7 sources and our local library.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.