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Open research questions in Oral and Maxillofacial Pathology

166 unresolved questions extracted from the limitations and future-work sections of 2,756 Oral and Maxillofacial Pathology papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • loss of presential contact with the patient due to geographical transfer and socioeconomic barriers, - inability to complete the final phase of microvascular reconstruction, - lack of high-resolution postoperative photographic record

    Osteosarcoma condroblástico maxilar post-exodoncia: desafío diagnóstico y manejo quirúrgico. Caso clínico · 2026 · DOI

  • further studies on the diagnostic challenge of differentiating normal post-extraction inflammatory changes from malignant neoplasms, - investigation of the effectiveness of different reconstructive protocols, - research on the optimal follow-up period for osteosarcoma condroblástico maxilar

    Osteosarcoma condroblástico maxilar post-exodoncia: desafío diagnóstico y manejo quirúrgico. Caso clínico · 2026 · DOI

  • Estudio de la efectividad de la planificación virtual en la rehabilitación articular, - Análisis de la relación entre la localización del mixoma odontogénico y la recurrencia

    Mixoma odontogénico en cóndilo mandibular: caso clínico y revisión de literatura · 2026 · DOI

  • The lack of standardized protocol for the treatment of odontogenic myxoma in the mandibular condyle. The limited number of cases reported in the literature. The need for a personalized surgical approach due to the rarity of the condition.

    Mixoma odontogénico en cóndilo mandibular: caso clínico y revisión de literatura · 2026 · DOI

  • La limitación de casos publicados y los aspectos controversiales en torno a su naturaleza subrayan la necesidad de estudios adicionales. Los datos epidemiológicos indican mayor incidencia en la cuarta década de vida, con predominio en el sexo masculino y preferencia por la zona posterior mandibular.

    Ameloblastoma adenoide: un desafío diagnóstico en el estudio de las neoplasias odontogénicas. Reporte de un caso y revisión de la literatura · 2026 · DOI

  • Studios adicionales para comprender su comportamiento y pronóstico, - Investigación sobre la naturaleza subrayan de la lesión

    Ameloblastoma adenoide: un desafío diagnóstico en el estudio de las neoplasias odontogénicas. Reporte de un caso y revisión de la literatura · 2026 · DOI

  • However, the pathogenesis of these cysts remains unclear and is recognized to have multifactorial origins.

    Peri‐implant epidermoid cyst: A case report and literature analysis · 2024 · DOI

  • Sequential dual IHC and molecular testing for BRAFV600E will reduce equivocal results that could exclude some patients from BRAFV600E-inhibitor therapies.

    Comparison of diagnostic methods for detection of BRAFV600E mutation in ameloblastoma · 2024 · DOI

  • Although case studies have reported the management of odontomas and MIH as separate entities, there is a lack of evidence regarding the comprehensive management of patients presenting with a combination of odontoma, dental impaction, and MIH.

    Case Report: Managing Odontoma and Molar-Incisor-Hypomineralization Challenges in Orthodontics · 2024 · DOI

  • Prior studies have not explored the multimodal fusion of CBCT and H&E-stained histopathology for odontogenic lesion analysis. There is a need for a dataset that provides a multi-scale representation of odontogenic lesions.

    Dental Odontogenic Lesion CBCT and Histopathology Integrated Dataset for Benchmarking Deep Learning Algorithms · 2026 · DOI

  • The multimodal classification results demonstrate dataset suitability for multimodal frameworks, but the relatively modest performance gains over single-modality CBCT classifiers suggest opportunities for improved fusion methodologies.

    Dental Odontogenic Lesion CBCT and Histopathology Integrated Dataset for Benchmarking Deep Learning Algorithms · 2026 · DOI

  • The paper identifies the challenge of limited access to early care and systematic reporting of cases. The authors highlight the difficulty of establishing a causal relationship between infectious exposures and tumor development. The paper acknowledges the complexity of considering infectious agents within a broader ecological framework.

    Beyond Burkitt: an emerging maxillofacial tumor pattern in equatorial Africa and a shared ecological context · 2026 · DOI

  • Future research should focus on systematic investigation integrating clinical characterization, environmental assessment, and molecular analysis. The authors suggest the need for improved access to early care and systematic reporting of cases. Further studies should explore the potential connection between infectious exposures and ecological context.

    Beyond Burkitt: an emerging maxillofacial tumor pattern in equatorial Africa and a shared ecological context · 2026 · DOI

  • Odontogenic tumors exhibit a wide spectrum of biological behaviors, making treatment challenging. Recurrence remains a major clinical challenge, particularly in tumors with aggressive histology and large sizes. The study highlights the need for evidence-based management strategies tailored to tumor biology.

    Recurrence Patterns and Prognostic Determinants of Odontogenic Tumors Following Radical Surgical Management: A Retrospective Cohort Study · 2026 · DOI

  • The diagnostic challenge of PODF. The need for repeat biopsy and histopathologic reassessment in recurrent gingival lesions. The relatively high rate of recurrence of PODF.

    Peripheral Odontogenic Fibroma with Calcification After Previous Excision of a Lesion Diagnosed as Pyogenic Granuloma: A Case Report and Clinicopathologic Consideration · 2026 · DOI

  • The diagnostic challenge of PODF. The need for awareness of the clinical presentation and histopathological features of PODF.

    Peripheral Odontogenic Fibroma with Calcification After Previous Excision of a Lesion Diagnosed as Pyogenic Granuloma: A Case Report and Clinicopathologic Consideration · 2026 · DOI

  • The exact etiology of POF remains unclear. There is a need for more research on the pathogenesis of POF.

    Peripheral Ossifying Fibroma in an Uncommon Location: A Case Report of Mandibular Anterior Lingual Gingiva · 2026 · DOI

  • The lack of comparative studies in pre-prosthetic orthodontics limits the scientific support for PGO. Maintaining tooth position with clear aligner therapy can be complex due to the controlling corrective forces. The treatment of odontomas requires careful consideration of the surrounding tissues and the potential for tooth malposition.

    Digital prosthetically guided orthodontics with clear aligners in the rehabilitation of anterior partial edentulism: a case report · 2026 · DOI

  • The lack of comparative studies in pre-prosthetic orthodontics limits the scientific support for PGO. Further clinical studies are required to evaluate long-term stability and predictability of PGO.

    Digital prosthetically guided orthodontics with clear aligners in the rehabilitation of anterior partial edentulism: a case report · 2026 · DOI

  • The study is limited to a retrospective analysis of 112 patients. The study does not provide long-term follow-up data. The study is conducted in a single tertiary care setting.

    Clinical and histopathological features of maxillary and mandibular cystic lesions: a retrospective clinico-statistical study · 2026 · DOI

  • There is a need for a comprehensive overview of demographic distribution, anatomical localization, radiological characteristics, and postoperative outcomes of benign cystic lesions of the jaws. There is a lack of understanding of the epidemiological and clinico-pathological features of these lesions.

    Clinical and histopathological features of maxillary and mandibular cystic lesions: a retrospective clinico-statistical study · 2026 · DOI

  • As a single case report, this study cannot repre- sent the full range of clinical presentations of FCOD. In addition, the follow-up period was limited to six months. Careful documentation and reporting of additional cases with longer follow-up are required to support evidence-based diagnostic and manage- ment protocols for FCOD and similar fibro-osseous lesions. CONCLUSION FCOD can be challenging to diagnose when re- lying solely on clinical findings, as these lesions are often asymptomatic and may occasionally mimic pulpo-periapical pathology. In the present case, CBCT contributed to a more detailed assessment of the multifocal mandibular lesions, while the discre- pancy between the clinical and radiographic fin- dings was resolved through histopathological exa- integrated diagnostic approach, mination. An combining clinical examination, advanced imaging, and histopathological assessment when indicated, is Romanian JouRnal of Stomatology – Volume 72, no. 2, 2026 200 essential for establishing an accurate diagnosis and avoiding unnecessary or inappropriate treatment.

    Incidental diagnosis of florid cemento-osseous dysplasia: a case report · 2026 · DOI

  • Future studies can investigate the use of other advanced imaging techniques, such as cone-beam computed tomography, in differentiating between ameloblastomas and odontogenic keratocysts. Further research can explore the application of fractal dimension and pixel intensity analyses in other types of lesions.

    Trabecular patterns and pixel intensity in ameloblastomas and odontogenic keratocysts · 2026 · DOI

  • There is a need for more accurate and detailed radiographic descriptions of ameloblastomas and odontogenic keratocysts. The current imaging techniques have limitations in differentiating between these two lesions.

    Trabecular patterns and pixel intensity in ameloblastomas and odontogenic keratocysts · 2026 · DOI

  • The overlap or combination of morphologic patterns recognized in other odontogenic disorders. The lack of understanding of the WNT/β-catenin pathway in these entities.

    Immunohistochemical Expression of CK13 and Molecular Analysis of KRT13 and APC in Odontogenic Ghost Cell Lesions, Adenoid Ameloblastoma, and Conventional Ameloblastoma · 2026 · DOI

Most-cited papers in Oral and Maxillofacial Pathology

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166 open questions have been extracted from the limitations and future-work passages of 2,756 Oral and Maxillofacial Pathology papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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