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Open research questions in Dental Erosion and Treatment

493 gap statements mined from Dental Erosion and Treatment papers in our 7.9M-paper local library, which holds 6,125 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The methodological suitability of SCASS as a behavioral scale has not been studied yet and requires further research.

    The use of pain scales in scientific studies on dentin hypersensitivity: A scoping study · 2026 · DOI

  • This suggests that there might be a competitive interaction between SnCl2/NaF/AmF and the proteins at certain calcium sites on the dentine surface, although the specifics of this interaction remain to be elucidated.

    Proteomic profile of the dentine pellicle modified with plant polyphenols and fluoride · 2026 · DOI

  • Within the limitations of this study, smoking history and bleaching activation method were both associated with the local (GCF) and whole-mouth (salivary) cytokine response to in-office dental bleaching, with evidence suggesting a differential temporal pattern between non-smokers and long-term ex-smokers.

    Periodontal Indices and Cytokines of Ex-Smokers/Non-Smokers After Bleaching · 2026 · DOI

  • The current literature provides limited evidence that NCCLs arise from abrasion alone, indicating that these lesions are typically multifactorial in origin.

    Clinical Management of Cervical Restorations with Closing Gap Technique: A Follow-Up of Two Cases · 2026 · DOI

  • Further research is needed to fully elucidate the mechanisms of action of PHS, particularly its direct antimicrobial potential and its interaction with the acquired salivary pellicle under dynamic intraoral conditions. Limitations of the present study should be acknowledged.

    Impact of phytosphingosine-enriched experimental toothpaste on dental enamel integrity: a combined in vitro and in situ investigation · 2026 · DOI

  • The evidence supporting the whitening effectiveness of some tray-and-gel-based systems is still derived predominantly from in vitro studies. There is a need to evaluate the color stability of whitened teeth following exposure to different staining media.

    Whitening Efficacy and Post-Whitening Color Stability of an LED-Assisted Over-the-Counter Whitening System: An In Vitro Study · 2026 · DOI

  • However, there is still no consensus on the optimal treatment approach; moreover, with the introduction of new biomimetic materials, it is important to investigate their remineralizing and camouflage effects in order to promote understanding of possible long-term esthetic outcomes.

    Color Change and Color Stability of White Spot Lesions Treated with Resin Infiltration, Microabrasion, or Nano-Hydroxyapatite Remineralization: An In Vitro Study · 2025 · DOI

  • Future studies should consider longitudinal designs and expanded analytical methodologies to fully characterize the impact and recovery potential of various bleaching systems on enamel integrity.

    In Vitro Evaluation of Chemical and Microhardness Alterations in Human Enamel Induced by Three Commercial In-Office Bleaching Agents · 2025 · DOI

  • However, the specific age-related factors contributing to this condition remain unclear. Despite its evident impact, the prevalence and epidemiology of DH remain relatively understudied, particularly within the Saudi population.

    The Prevalence and Impact of Dentinal Hypersensitivity on Adults’ Quality of Life in Saudi Arabia · 2025 · DOI

  • Further research is needed to confirm its long-term safety, define optimal usage protocols, and better understand its interactions with enamel over prolonged use. Within significant limitations of this study, the findings suggest that zirconia at moderate levels could be a viable alternative for daily whitening toothpaste.

    Evaluation of Tooth Color Changes at Different Concentrations of Zirconia Toothpaste: A Pilot In Vitro Study · 2025 · DOI

  • Future in vivo studies are warranted to confirm these findings under clinically relevant conditions and to assess the cumulative effect of repeated or long-term syrup use on enamel integrity.

    Erosive Potential of Pediatric Syrup Medications on the Human Enamel: Ex Vivo Study · 2025 · DOI

  • The study identifies a need to assess the effect of different interproximal reduction methods on enamel surface microhardness. There is a lack of knowledge on how various stripping instruments affect enamel microhardness.

    Comparative Evaluation of Dental Enamel Microhardness Following Various Methods of Interproximal Reduction: A Vickers Hardness Tester Investigation · 2024 · DOI

  • The diversity of treatment approaches underscores the lack of standardized guidelines.

    Risk factors and diverse management approaches for intertrigo: analysis of the “All of Us” research cohort · 2026 · DOI

  • These findings are limited to controlled in vitro conditions and should not be directly extrapolated to clinical performance without further in vivo and clinical validation Author Contributions: Conceptualization, C.

    Enamel Remineralization Potential of Conventional and Biomimetic Toothpaste Formulations: A Comparative In Vitro Study · 2026 · DOI

  • The experimental model focused exclusively on bleaching and did not account for common clinical discoloration challenges such as staining beverages or tobacco smoke exposure.

    Effects of At-Home Bleaching on Color Stability and Surface Roughness of Single-Shade, ORMOCER-Based, and Conventional Resin Composites · 2026 · DOI

  • However, it remains unclear to what extent the differences in fluoride concentration over time observed in the present study translate into clinically meaningful anticaries effects. Although the abrasive-free toothpaste maintained higher fluoride concentrations for a longer period than the other toothpastes, the clinical significance of this finding remains to be determined in future studies.

    Effect of Silica-Based Abrasive Ingredients on Fluoride Concentration in Toothpaste: An In Vitro and In Vivo Study · 2026 · DOI

  • Another limitation of this study is that full blinding could not be ensured during outcome assessment due to the visible black staining in some treatment groups.

    Green-Synthesized Nano-Silver Fluoride for Remineralization of Enamel Lesions in Primary Teeth: A Comparative In Vitro Study with SDF and SDF/KI · 2025 · DOI

  • Although it contains hydrogen peroxide in its composition, studies that have tested the whitening efficiency of Crest 3D White Pearl Glow or other pearl powder-based toothpaste are lacking.

    Comparative Analysis of Whitening Outcomes of Over-the-Counter Toothpastes: An In Vitro Study · 2025 · DOI

  • One of the limitations of this study is sampling bias. However, to date, there is insufficient scientific data to support the discrimination of tooth color or acceptance of color differences.

    Assessing Discrimination and Acceptance for Lightness and Chroma During Shade Selection: A Comparison of Dental and Non-Dental Professionals · 2025 · DOI

  • These findings provide preliminary evidence that shell-derived CaO treatment is associated with enamel-surface deposition and reduced hue alteration under in vitro conditions, warranting further investigation using quantitative subsurface remineralization methods.

    Enamel remineralization and color stability induced by biogenic calcium oxide from eggshell and snail shell under pH cycling: An in vitro study · 2026 · DOI

  • However, studies evaluating the likelihood of tooth erosion from carbonated beverages containing alternative sugars are lacking.

    Evaluation of Tooth Erosion Potential of Zero and Carbonated Beverages in Korea: A Laboratory‐Based Study Focused on pH · 2026 · DOI

  • Considering the limitations of this study, the conclusions we should obtain from this study as clinicians are as follows: 1.

    Effect of Bleaching on Surface Roughness of Universal Composite Resins After Chlorhexidine-Induced Staining · 2025 · DOI

  • The absence of independent container-level replication precluded valid inferential comparisons between staining media, - Lack of independent container-level replication, - Small sample…

    Whitening Efficacy and Post-Whitening Color Stability of an LED-Assisted Over-the-Counter Whitening System: An In Vitro Study · 2026 · DOI

  • Step 1: Icon-etch Step 2: Icon-dry Step 3: Icon-infiltrant Appendix A.2 Apply Icon-etch with the tip; Let it set for 2 min with periodic smearing; Rinse with water for 30 s; Dry with oil/water-free air spray. Apply Icon-dry with the tip; Let it set for 30 s; Dry with oil/water-free air spray.

    The Effect of Different White Spot Lesion Treatments on the Enamel Microhardness—An In Vitro Pilot Study · 2025 · DOI

  • Within the limitations of this study, all restorative materials exhibited color changes exceeding established clinical acceptability thresholds after repeated at-home bleaching, with the magnitude of change varying by material.

    Effects of At-Home Bleaching on Color Stability and Surface Roughness of Single-Shade, ORMOCER-Based, and Conventional Resin Composites · 2026 · DOI

Most-cited papers in Dental Erosion and Treatment

Most recent work

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Open questions raised by papers listed on this page include: (1) The methodological suitability of SCASS as a behavioral scale has not been studied yet and requires further research (“The use of pain scales in scientific studies on dentin hypersensitivity: A…”, 2026); (2) This suggests that there might be a competitive interaction between SnCl2/NaF/AmF and the proteins at certain calcium sites on the dentine surface, although the specifics of this interaction remain to be elucidated (“Proteomic profile of the dentine pellicle modified with plant polyphenols and…”, 2026); (3) Further research is needed to fully elucidate the mechanisms of action of PHS, particularly its direct antimicrobial potential and its interaction with the acquired salivary pellicle under dynamic intraoral conditions (“Impact of phytosphingosine-enriched experimental toothpaste on dental enamel…”, 2026); (4) There is a need to evaluate the color stability of whitened teeth following exposure to different staining media (“Whitening Efficacy and Post-Whitening Color Stability of an LED-Assisted…”, 2026); (5) The diversity of treatment approaches underscores the lack of standardized guidelines (“Risk factors and diverse management approaches for intertrigo: analysis of the…”, 2026). 493 gap statements have been mined from Dental Erosion and Treatment papers in our 7.9M-paper local library, which holds 6,125 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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