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Open research questions in Dental Erosion and Treatment

338 unresolved questions extracted from the limitations and future-work sections of 5,800 Dental Erosion and Treatment papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Substantial protocol heterogeneity and variable risk of bias in included systematic reviews. Limited evidence on the independent effect of fluoride on tooth sensitivity. Incomplete reporting of treatment parameters for photobiomodulation therapy.

    Interventions for bleaching-induced tooth sensitivity: an umbrella review · 2026 · DOI

  • Substantial protocol heterogeneity and variable risk of bias limited confidence in the findings, - Incomplete reporting of treatment parameters currently preclude recommendation of a standardized clinical regimen, - The certainty of evidence was low, - The overall quality of evidence remained limited

    Interventions for bleaching-induced tooth sensitivity: an umbrella review · 2026 · DOI

  • The lack of standardization in laboratory testing protocols. The difficulty in replicating complex clinical environments in laboratory settings. The need to incorporate patient-specific variables into laboratory testing.

    Tribology of dental materials: from laboratory metrics to clinical durability: review and translational roadmap · 2026 · DOI

  • Development of clinically relevant in vitro models that incorporate patient-specific parameters, - Establishment of a publicly accessible, centralized database for both in vitro and clinical wear data, - Regular inter-laboratory studies to ensure the reproducibility and comparability of wear test results

    Tribology of dental materials: from laboratory metrics to clinical durability: review and translational roadmap · 2026 · DOI

  • Background Ready‐to‐drink (RTD) alcoholic beverages often contain organic acids that lower pH and promote enamel demineralization, yet their erosive potential remains insufficiently explored.

    Analysis of the Surface Morphology of Dental Enamel Exposed to Ready‐to‐Drink Alcoholic Beverages · 2026 · DOI

  • However, limited evidence exists regarding their susceptibility to extrinsic staining and surface degradation when exposed to acidic and chromogenic beverages commonly consumed in modern diets.

    Beverage‐Induced Discoloration and Surface Degradation of Single‐Shade Composite Resin: An In Vitro Investigation · 2026 · DOI

  • Objectives This study aimed to investigate the effect of dentin pretreatment with dimethyl sulfoxide (DMSO) on the interfacial fracture toughness (IFT) of composite resin bonded to dentin under varying collagen hydration conditions, addressing conflicting findings in existing literature.

    Effect of Dentin Pretreatment With Dimethyl Sulfoxide Solution on Interfacial Fracture Toughness of Composite Resin to Wet and Dry Dentin · 2025 · DOI

  • Future studies could investigate the use of silver nanoparticles in combination with other remineralization techniques. Future studies could evaluate the effectiveness of silver nanoparticles with sodium fluoride in vivo. Future studies could assess the long-term effects of using silver nanoparticles with sodium fluoride on the enamel surface.

    Assessment of the microhardness of artificial enamel caries after treatment with a combination of silver nanoparticles and sodium fluoride solution · 2026 · DOI

  • The study identifies a gap in the current methods for treating dental caries, which have limitations. The study notes that new technologies are being developed to allow for the remineralization of newly created enamel caries. The study aims to address this gap by evaluating the effectiveness of silver nanoparticles with sodium fluoride solution on the microhardness of artificially induced demineralization on the enamel surface.

    Assessment of the microhardness of artificial enamel caries after treatment with a combination of silver nanoparticles and sodium fluoride solution · 2026 · DOI

  • There is a lack of robust long-term randomized clinical trial data with patient-centered outcomes for most dental application domains. There is a need for further research on the use of Bioglass 45S5 in dentistry.

    Bioglass 45S5 in dentistry: Current evidence, clinical applications and future perspectives (Review) · 2026 · DOI

  • The future of Bioglass 45S5 in dentistry is likely to be shaped by several converging developments. Additive manufac‑ turing (3D printing) of personalized 45S5‑polymer scaffolds tailored to individual anatomical defects is advancing rapidly from proof‑of‑concept to clinical feasibility, with early case series reporting successful integration in mandibular defect reconstruction (49,50). In parallel, the integration of 3D bioprinting with organoid culture technology holds potential for constructing more physiologically faithful tissue models that better replicate the complex cell‑matrix interactions of oral tissues; recent advances in this domain may inform future scaffold design strategies for dental regeneration (51). The integration of growth factors, including recombinant human BMP‑2, platelet‑derived growth factor‑BB and enamel matrix derivative, into 45S5 mesoporous carriers may enable combi‑ natorial regenerative strategies with synergistic effects that surpass those of individual agents (52). Nano‑scale 45S5 formulations are opening new frontiers in preventive and restorative dentistry. Nano‑45S5‑containing composites, adhesives and glass ionomers that actively remin‑ eralize the tooth‑restoration interface may fundamentally alter secondary caries management and improve restoration longevity. Similarly, smart delivery systems exploiting the pH‑responsive dissolution of 45S5, releasing therapeutic ions selectively in response to acidic cariogenic challenge, represent a promising direction for autonomous preventive materials (53). In regenerative endodontics, 45S5‑based scaffolds supporting dental pulp stem cell (DPSC) homing, proliferation and differentiation may enable biological pulp regeneration in immature teeth with necrotic pulps, providing an alternative to apexification procedures. Since the isolation and character‑ ization of postnatal human DPSCs (54), preliminary studies have shown that these cells cultured on BG scaffolds undergo odontogenic differentiation and form mineralized matrices both in vitro and in vivo. Finally, the integration of antibacterial ion‑doped 45S5 formulations into implant surfaces and regenerative membranes may address the unmet clinical need for infec‑ tion‑resistant biomaterials in peri‑implantitis and post‑surgical infection management, representing one of the most impactful near‑term translational opportunities.

    Bioglass 45S5 in dentistry: Current evidence, clinical applications and future perspectives (Review) · 2026 · DOI

  • Current measures to contain dental caries have not been sufficient. There is a need to evaluate alternative varnishes for non-invasive control of carious lesions.

    Effect of a Propolis/Chitosan Varnish on Demineralized Primary Tooth Enamel: An In Vitro Study · 2026 · DOI

  • The need for a natural, biocompatible, and cost-effective alternative to synthetic hydroxyapatite. The lack of sustainable utilization of biological waste in the development of remineralizing toothpastes.

    DEVELOPMENT AND EVALUATION OF FISH BONE–DERIVED HYDROXYAPATITE BASED REMINERALIZING TOOTHPASTE · 2026 · DOI

  • The lack of studies examining the efficacy of desensitizing agents in mouthwash formulations. The need for effective treatments for dentin hypersensitivity.

    Use of Ionized Monocalcium Phosphate and Enameline Derivatives to Reduce Dentin Hypersensitivity After Periondontal Therapy · 2026 · DOI

  • The biological risks associated with dental bleaching, such as pulp toxicity and co-carcinogenic potential of peroxides. The lack of awareness among students about these risks and the importance of anamnesis. The inefficacy of natural methods, such as activated charcoal and turmeric.

    PROTOCOLO DE CLAREAMENTO DENTAL EXTERNO PARA ACADÊMICOS DE ODONTOLOGIA · 2026 · DOI

  • There is a lack of knowledge about the biological risks and clinical protocols for dental bleaching. The gap is particularly concerning in the academic context, where students may neglect crucial steps and be unaware of risks.

    PROTOCOLO DE CLAREAMENTO DENTAL EXTERNO PARA ACADÊMICOS DE ODONTOLOGIA · 2026 · DOI

  • Future studies should investigate the long-term effectiveness of 38% silver diamine fluoride in treating dentine hypersensitivity. Future studies should compare the effectiveness of 38% silver diamine fluoride with other desensitizing agents. Future studies should evaluate the optimal application protocol for 38% silver diamine fluoride.

    38% silver diamine fluoride for dentine hypersensitivity treatment: an in situ study · 2026 · DOI

  • Limited evidence is available to guide the optimal application protocol for silver diamine fluoride. There is a need to investigate the effectiveness of 38% silver diamine fluoride in treating dentine hypersensitivity. The elemental composition of the occluding materials is not well understood.

    38% silver diamine fluoride for dentine hypersensitivity treatment: an in situ study · 2026 · DOI

  • Preserving enamel during veneer removal. Ensuring future rehabilitations after veneer removal. Developing effective techniques and instruments for veneer removal.

    Critérios clínicos e considerações para a remoção de facetas dentárias: revisão de literatura. · 2026 · DOI

  • The study identifies a gap in the understanding of the effect of Rexidin SRS mouthwash on the corrosion resistance of Ni-Cr alloy orthodontic wires. There is a need to investigate the corrosion resistance of orthodontic wires in artificial saliva with and without the addition of Rexidin SRS mouthwash.

    Impact of Rexidin SRS mouthwash on the corrosion characteristics of Ni-Cr orthodontic wire submerged in artificial saliva · 2026 · DOI

  • The paper identifies a research gap in the understanding of the antimicrobial effectiveness of silver nanoparticles in traditional glass ionomer cements. The study highlights the need for further research on the clinical applications of silver nanoparticles in dental settings. The paper notes that the optimal concentration of silver nanoparticles for clinical applications is still unknown.

    Gümüş Nanopartikülle Modifiye Edilmiş Geleneksel Cam İyonomer Simanların Antimikrobiyal Etkinliği: Sistematik Derleme · 2026 · DOI

  • There is a need to develop orthodontic materials with enhanced antimicrobial properties to manage oral bacterial colonization. The current orthodontic materials may not effectively prevent tooth decay and other adverse effects. The incorporation of ZnO nanoparticles into orthodontic cement addresses this gap.

    Caries Direction Antimicrobial Activity of Zinc Oxide Nanoparticles Containing Cement for the Management of Orthodontic Teeth against Streptococcus mutans and Lactobacillus casei · 2026 · DOI

  • Future research should focus on in vivo validation, long-term antimicrobial efficacy, and comparative studies with other nanoparticles or antibacterial agents to optimize clinical application in orthodontics. However, the findings are limited to in vitro conditions and do not account for factors such as salivary flow, dietary variations, and long-term ion release in the oral cavi- ty.

    Caries Direction Antimicrobial Activity of Zinc Oxide Nanoparticles Containing Cement for the Management of Orthodontic Teeth against Streptococcus mutans and Lactobacillus casei · 2026 · DOI

  • Future studies should investigate the long-term effects of cyanoacrylate and dentin bonding on reducing dental sensitivity. Future research should explore the use of other substances in reducing sensitivity. The study's findings can inform the development of new treatments for dental sensitivity.

    Cyanoacrylate vs. dentin bonding on reducing dental sensitivity · 2026 · DOI

  • There is a need for new treatments for dental sensitivity. The effectiveness of cyanoacrylate and dentin bonding in reducing sensitivity is not well understood. The study aims to address this gap by comparing the effect of these substances on reducing dental sensitivity.

    Cyanoacrylate vs. dentin bonding on reducing dental sensitivity · 2026 · DOI

Most-cited papers in Dental Erosion and Treatment

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338 open questions have been extracted from the limitations and future-work passages of 5,800 Dental Erosion and Treatment papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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