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Open research questions in Organ Transplantation Techniques and Outcomes

194 gap statements mined from Organ Transplantation Techniques and Outcomes papers in our 4.5M-paper local library, which holds 910 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • One limitation of our study was the modest sample size, which resulted in insufficient power to exclude moderate differences in regeneration between the groups. While the study is limited by the lack of portal hemodynamic data and a short follow-up period, its findings provide valuable population-specific insights into LDLT physiology.

    Assessment of liver regeneration in living donor liver transplantation recipients using computed tomography volumetry-an institutional experience · 2026 · DOI

  • The persistent mismatch between organ supply and demand remains a major global challenge. Concerns regarding graft dysfunction and early mortality with the use of extended criteria donors.

    Outcomes of liver transplantation using extended criteria brain-dead donors: a retrospective study with initial experiences from a Vietnamese center · 2026 · DOI

  • The scarcity of deceased donor organs limits liver transplantation worldwide. There is a need to evaluate the clinical outcomes of liver transplantation using extended criteria brain-dead donors.

    Outcomes of liver transplantation using extended criteria brain-dead donors: a retrospective study with initial experiences from a Vietnamese center · 2026 · DOI

  • The study aims to address this gap by investigating the prevalence of ABS and analyzing the outcomes of endoscopic interventions.

    Endoscopic management of post-living donor liver transplant anastomotic biliary strictures: A quaternary care transplant center experience · 2026 · DOI

  • The need to reassess current peri-operative strategies for liver transplantation. The unique risks associated with liver transplantation.

    Peri-operative cardiac arrest guidelines: time to include liver transplantation · 2026 · DOI

  • The 2023 ESAIC guideline does not currently include liver transplantation within its scope. The high incidence of cardiac arrest during liver transplantation is not adequately addressed by current guidelines.

    Peri-operative cardiac arrest guidelines: time to include liver transplantation · 2026 · DOI

  • This was a retrospective cross-sectional study using SRTR data. The study included less than one year of waitlist registry data for evaluating MELD 3.0. Further analyses will be needed to determine causality.

    Sex-based survival disparities persist in liver transplantation: MELD 3.0 fails to improve survival for waitlisted women · 2026 · DOI

  • There is a lack of empirical data evaluating the efficacy of MELD 3.0. Sex-based survival disparities in liver transplantation are not well understood.

    Sex-based survival disparities persist in liver transplantation: MELD 3.0 fails to improve survival for waitlisted women · 2026 · DOI

  • The study does not provide a clear limitation, but it can be inferred that the study's findings may be limited to the Korean context. The study's use of an integrative review method may also be a limitation, as it relies on existing research rather than primary data.

    Adaptation of living donors after liver transplantation in South Korea: an integrative review · 2026 · DOI

  • Future research should investigate the long-term effects of liver transplantation on living donors. Future research should also examine the cultural and social factors that influence the adaptation process of living donors in South Korea.

    Adaptation of living donors after liver transplantation in South Korea: an integrative review · 2026 · DOI

  • The study did not investigate the impact of other factors on rejection outcomes. The study did not provide a clear explanation for the lack of association between donor-specific antibodies and antibody-mediated rejection.

    Impact of donor-specific antibodies on immune rejection rates in liver transplantation: A systematic review and meta-analysis · 2026 · DOI

  • There is a need to investigate the association between MELD scores and in-hospital mortality, LOS, and number of comorbidities in a real-world setting. Prior studies have focused on the prognostic value of the MELD score in specific patient populations.

    Letter to the Editor: Splitting the risk: Interpretable machine learning enters the era of split liver transplantation · 2026 · DOI

  • The risk of cardiac injury during liver core needle biopsy is not well-documented. There is a need for increased awareness and caution among procurement teams to minimize avoidable donor organ loss.

    Donor heart injury caused by liver needle biopsy during multi-organ procurement surgery: A case report · 2026 · DOI

  • Ensuring donor safety remains the foremost ethical and clinical priority in LDLT programs. Limited resources and a maturing healthcare infrastructure pose challenges to developing liver transplant programs. Donor mortality, although rare, remains a critical concern.

    Living donor hepatectomy in a developing transplant system: Early results and one-year outcomes from Nepal · 2026 · DOI

  • There is a lack of comprehensive analyses of living liver donor outcomes from low-and middle-income countries. There is a need to ensure donor safety in developing liver transplant programs.

    Living donor hepatectomy in a developing transplant system: Early results and one-year outcomes from Nepal · 2026 · DOI

  • The study suggests that future research should incorporate dynamic postoperative variables. The study suggests that future research should clarify the underlying biological mechanisms.

    Letter to the Editor: Early complications in split liver transplantation: An interpretable machine learning model requires multicenter validation · 2026 · DOI

  • Future research should focus on the long-term outcomes of liver transplantation. Future research should also focus on the development of new imaging methods for evaluating postoperative complications.

    Preoperative Evaluation and Postoperative Complications in Liver Transplantation · 2026 · DOI

  • Limited understanding of the effectiveness of extracorporeal therapies in ALF management. Need for larger, randomized controlled trials to confirm the findings of this study.

    Standard-Volume Therapeutic Plasma Exchange Followed by High-Dose Continuous Renal Replacement Therapy in Patients With Hepatitis A Virus-Related Acute Liver Failure · 2026 · DOI

  • The cautionary lesson of IMbrave050— where adjuvant immunotherapy benefit observed at interim analysis was not sustained—underscores that extrapolation from non-transplant settings is insufficient.

    Advances in liver transplant oncology: Biology-driven selection, systemic therapy integration, and future trial frameworks · 2026 · DOI

  • The first intended use of a bioprinted hepatic graft remains insufficiently defined. The field lacks a clear definition of the intended use of 3D bioprinted hepatic grafts.

    3D bioprinting in liver transplantation: from organ replacement to transplantable functional support · 2026 · DOI

  • Vascular complications are a major concern in pediatric liver transplant patients. Children are particularly vulnerable to thrombosis due to their immature coagulation system. The lack of a standardized protocol for thromboprophylaxis makes it challenging to prevent thrombotic events.

    Heparin continuous infusion for thromboprophylaxis in pediatric liver transplant recipients · 2026 · DOI

  • There is no standardized protocol for thromboprophylaxis in pediatric liver transplant recipients. The effectiveness of continuous infusion of unfractionated heparin for thromboprophylaxis in this population is unknown.

    Heparin continuous infusion for thromboprophylaxis in pediatric liver transplant recipients · 2026 · DOI

  • Finally, only in-hospital outcomes were available, and the long-term prognostic impact of the HH-compatible outcome could not be assessed.

    Development and internal validation of a prediction model for hypoxic hepatitis after coronary artery bypass grafting with cardiopulmonary bypass · 2026 · DOI

  • Although preemptive VV-ECMO has rarely been reported in liver transplantation for BCS, our case demonstrates that it can be a safe and effective strategy to maintain intraoperative hemodynamic stability in selected high-risk patients.

    Managing High-Risk Liver Transplantation: A Case of Budd-Chiari Syndrome With Preemptive Venovenous Extracorporeal Membrane Oxygenation (ECMO) · 2026 · DOI

  • The study identifies a gap in the understanding of postoperative complications after liver transplantation. The study also identifies a gap in the understanding of normal findings after liver transplantation.

    Preoperative Evaluation and Postoperative Complications in Liver Transplantation · 2026 · DOI

Most-cited papers in Organ Transplantation Techniques and Outcomes

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Open questions raised by papers listed on this page include: (1) While the study is limited by the lack of portal hemodynamic data and a short follow-up period, its findings provide valuable population-specific insights into LDLT physiology (“Assessment of liver regeneration in living donor liver transplantation…”, 2026); (2) There is a need to evaluate the clinical outcomes of liver transplantation using extended criteria brain-dead donors (“Outcomes of liver transplantation using extended criteria brain-dead donors: a…”, 2026); (3) There is a lack of empirical data evaluating the efficacy of MELD 3.0 (“Sex-based survival disparities persist in liver transplantation: MELD 3.0 fails…”, 2026); (4) Future research should investigate the long-term effects of liver transplantation on living donors (“Adaptation of living donors after liver transplantation in South Korea: an…”, 2026); (5) The study did not provide a clear explanation for the lack of association between donor-specific antibodies and antibody-mediated rejection (“Impact of donor-specific antibodies on immune rejection rates in liver…”, 2026). 194 gap statements have been mined from Organ Transplantation Techniques and Outcomes papers in our 4.5M-paper local library, which holds 910 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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