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Open research questions in Pancreatic and Hepatic Oncology Research

279 unresolved questions extracted from the limitations and future-work sections of 622 Pancreatic and Hepatic Oncology Research papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • investigating the pathways most relevant to immune exclusion - studying the interaction between different metabolic pathways - examining the relative importance of different pathways in varying tumor states

    KRAS-driven cytokine–metabolic crosstalk shapes immune exclusion in pancreatic ductal adenocarcinoma · 2026 · DOI

  • Ampullary cancer presents unique clinical challenges due to its rarity and diagnostic complexities. The diagnosis and clinical management of ampullary cancer are particularly challenging. The study identifies the challenge of limited current data addressing ampullary cancer therapy.

    Clinicopathological features and treatment paradigms exploration in advanced ampullary cancer · 2026 · DOI

  • Current data addressing ampullary cancer therapy are limited. There is a lack of high-quality therapeutic evidence and insufficient consensus in clinical decision-making. The study aims to fill this gap by exploring the clinicopathological features and treatment paradigms of advanced ampullary cancer.

    Clinicopathological features and treatment paradigms exploration in advanced ampullary cancer · 2026 · DOI

  • Detecting and stratifying the risk of PanIN poses challenges. Differentiating between PanIN 2 and PanIN 3 is clinically significant. The lack of early biomarkers and effective treatment options for PDAC contributes to the high mortality rate.

    Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challenges · 2025 · DOI

  • Current imaging techniques are insufficient for distinguishing PanIN, - Detecting and stratifying the risk of PanIN poses challenges, - Limited research on PDAC CSCs, - Lack of early diagnosis and effective treatment options for PDAC

    Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challenges · 2025 · DOI

  • Comprehensive genomic profiling (CGP) is crucial in precision oncology, yet its real-world utility remains unclear.

    Real-world clinical utility of comprehensive genomic profiling in advanced solid tumors · 2026 · DOI

  • Abstract Introduction The benefits of neoadjuvant therapy (NAT) for pancreatic cancer (PC) with portal venous involvement remain debated.

    Upfront surgery vs. neoadjuvant therapy in pancreatic cancer with venous involvement: a multicenter retrospective analysis · 2026 · DOI

  • Aging is a critical yet understudied determinant in pancreatic ductal adenocarcinoma (PDAC) risk and outcomes.

    The Aging Microenvironment Is a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer · 2025 · DOI

  • Pancreatic cancer is related to gut microbiota, but the associations between its treatment and microbial abundance as well as genetic variations remain unclear.

    A comprehensive multi-omics analysis uncovers the associations between gut microbiota and pancreatic cancer · 2025 · DOI

  • " While this morphology has been well characterized, it remains unknown whether the tumor stroma is functionally active.

    Mucinous cystic neoplasms of the pancreas demonstrate in situ production of estrogen · 2025 · DOI

  • Conclusions: The rising burden of PC, particularly among younger populations, highlights the need for targeted prevention strategies, early detection efforts, and further research into the underlying mechanisms driving these trends.

    Unraveling the Burden of Pancreatic Cancer in the 21st Century: Trends in Incidence, Mortality, Survival, and Key Contributing Factors · 2025 · DOI

  • Although FP has been associated with metabolic syndromes such as obesity and diabetes, its clinical significance remains unclear.

    Fatty Pancreas: Its Potential as a Risk Factor for Pancreatic Cancer and Clinical Implications · 2025 · DOI

  • PURPOSE: Pancreatic neoplasms are rare in children, resulting in limited data on pancreatectomy within this population.

    Pediatric pancreatectomy for neoplasms: indications, outcomes, and implementation of minimally invasive surgery in a Ukrainian tertiary center · 2025 · DOI

  • BACKGROUND: Pediatric pancreatic acinar cell carcinoma (PACC) is an exceptionally rare and poorly understood malignancy with a challenging prognosis.

    Pediatric pancreatic acinar cell carcinoma with a non-canonical BRAF-KMT2C fusion and a classic SND1-BRAF fusion: a case report and literature review · 2025 · DOI

  • These findings suggest a potential therapeutic benefit, although impact on clinical prognosis remains to be established.

    ITGB5-mediated biomechanical regulation in pancreatic ductal adenocarcinoma stroma impacts tumor progression and prognosis · 2025 · DOI

  • However, the mechanisms sustaining stemness and chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC) remain unclear.

    BICC1 drives pancreatic cancer stemness and chemoresistance by facilitating tryptophan metabolism · 2024 · DOI

  • It has been known that poor tumor perfusion and dysregulated cancer cell metabolism give rise to tumor microenvironments with unphysiologic nutrient levels, but the precise alterations in metabolite abundance are not well defined.

    Nutrient Levels and Nutrient Sources in Pancreatic Tumors · 2024 · DOI

  • Although pancreatic cancer is a systemic disease that metastasizes early in its course, the signaling systems that promote this behavior remain incompletely understood.

    Macrophages Under the Influence of Tumor Mesothelin Weaken Host Defenses against Pancreatic Cancer Metastasis · 2024 · DOI

  • However, their impact on multidrug resistance (MDR) in pancreatic cancer (PC) chemotherapy remains unclear.

    PFOS and Its Commercial Alternative, 6:2 Cl-PFESA, Induce Multidrug Resistance in Pancreatic Cancer · 2024 · DOI

  • Introduction: Pancreatic neoplasms are rare among children and very few studies have reported on surgical outcomes for pediatric pancreatic neoplasms.

    Surgical management of pancreatic neoplasms in children: a single-institution experience over 15 years · 2024 · DOI

  • Therapeutic options for cure remain scarce and rely on combination chemotherapy with limited sustainability.

    Role of SGLT2 Inhibitors, DPP-4 Inhibitors, and Metformin in Pancreatic Cancer Prevention · 2024 · DOI

  • There are mixed data regarding the relationship between GLP-1 RA and DPP-4 inhibitors and pancreatic cancer, with some trials suggesting that they might increase the risk.

    Role of SGLT2 Inhibitors, DPP-4 Inhibitors, and Metformin in Pancreatic Cancer Prevention · 2024 · DOI

  • The malignant progression of pancreatic cystic lesions (PCLs) remains understudied with a knowledge gap, yet its exploration is pivotal for effectively stratifying patient risk and detecting cancer at its earliest stages.

    Molecular Pathology of Pancreatic Cystic Lesions with a Focus on Malignant Progression · 2024 · DOI

  • Careful patient selection, financial toxic effects consideration, and direct comparison between FOLFIRINOX and NALIRIFOX are warranted.

    NALIRIFOX, FOLFIRINOX, and Gemcitabine With Nab-Paclitaxel as First-Line Chemotherapy for Metastatic Pancreatic Cancer · 2024 · DOI

  • Analyses comparing NALIRIFOX and GEM-NABP with fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) have not yet been reported.

    NALIRIFOX, FOLFIRINOX, and Gemcitabine With Nab-Paclitaxel as First-Line Chemotherapy for Metastatic Pancreatic Cancer · 2024 · DOI

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279 open questions have been extracted from the limitations and future-work passages of 622 Pancreatic and Hepatic Oncology Research papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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