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Open research questions in Parasitic infections in humans and animals

93 unresolved questions extracted from the limitations and future-work sections of 515 Parasitic infections in humans and animals papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The viability of washed HDCs under long-term storage conditions remains an important area for future work. Washing in this manner was deemed impractical for large scale preparations due to excessive personnel time required for the process. The study did not establish baseline viability for the unwashed control.

    Isolation of Hymenolepis diminuta cysticercoids for therapeutic use: The need for fully disclosed methodology · 2026 · DOI

  • Inconsistent production of therapeutic organisms for helminth therapy. Insufficiently described methods for purification of helminths. Lack of a method for separating large quantities of cysticercoids of the cestode species Hymenolepis diminuta.

    Isolation of Hymenolepis diminuta cysticercoids for therapeutic use: The need for fully disclosed methodology · 2026 · DOI

  • The cellular basis of this remarkable parasite persistence remains poorly understood.

    Persistence of regenerative stem cells provides a cellular basis for the parasitostatic activity of albendazole against Echinococcus multilocularis · 2026 · DOI

  • However, the mechanisms underlying the pathological transition from early inflammation to chronic immunosuppression and fibrosis remain unclear, particularly regarding the spatial regulation of immune–stromal interactions.

    Integrating single-cell RNA sequencing with Visium HD spatial atlas reveals immune–stromal cell interactions in Echinococcus multilocularis metacestode infection · 2026 · DOI

  • The interaction between parasitic infection and the host virome represents a frontier issue in microbial ecology, yet how Echinococcus infection affects the multi-organ virome and whether these alterations hold diagnostic or interventional potential remains poorly understood.

    Systemic remodeling of the multi-organ virome following Echinococcus infection in mice · 2026 · DOI

  • BACKGROUND: Anoplocephala perfoliata is the most prevalent and pathogenic tapeworm (cestode) of horses worldwide, yet it remains molecularly understudied.

    Chromosome-scale nuclear genome and proteome of Anoplocephala perfoliata elucidate lineage-specific features of a ‘neglected’ equine tapeworm · 2026 · DOI

  • multilocularis' immunomodulatory mechanisms are poorly understood and we explored the role of phytic acid, a known component of E.

    Phytic acid impairs macrophage inflammatory response in Echinococcus multilocularis infection · 2025 · DOI

  • Nevertheless, the role of the aforementioned organism in alveolar echinococcosis remains to be elucidated.

    Oxymatrine alleviates Echinococcus multilocularis infection by remodeling the liver immune microenvironment and intestinal flora homeostasis · 2025 · DOI

  • multilocularis infection, which allows us to understand the roles of miRNAs in host-parasite interactions throughout infection and provides a reference for further studies of molecular pathogenesis and new drug or vaccine targets for control of AE.

    MicroRNA expression dynamics in mouse liver at different stages of Echinococcus multilocularis infection · 2025 · DOI

  • Although some studies have examined EW parasites, the prevalence of helminth parasites in free-ranging DDs in Bale Mountains National Park (BMNP) is relatively understudied.

    Incidence of gastrointestinal helminth parasites of free-ranging domestic dogs from the web valley, Bale mountains National park, Ethiopia · 2025 · DOI

  • The Echinococcus gene repertoire required for germinative cell maintenance and differentiation has not been characterised so far.

    Genome-wide transcriptome analysis of Echinococcus multilocularis larvae and germinative cell cultures reveals genes involved in parasite stem cell function · 2024 · DOI

  • EgAgB has a diagnostic value for cystic echinococcosis, but its putative role in the immunobiology of this infection is still poorly understood.

    Modulatory actions of Echinococcus granulosus antigen B on macrophage inflammatory activation · 2024 · DOI

  • Despite its potential public health concern, few studies have been conducted on cardiac cysticercosis in Upper Egypt.

    High Prevalence of Bovine Cardiac Cysticercosis in Upper Egypt: An Epidemiological and Histopathological Study · 2024 · DOI

  • BACKGROUND: The common cat tapeworm, Hydatigera taeniaeformis, is widely distributed across many regions of the world but its global genetic diversity, ecology, and other biological features are not fully understood.

    First molecular characterisation of Hydatigera taeniaeformis (Cestoda: Taeniidae) from Rattus rattus in urban market centres from Tamale, Ghana · 2024 · DOI

  • There is a lack of awareness and understanding of orbital CE in children, particularly in non-endemic areas. There is a need for early involvement of CE reference centers to prevent complications and optimize management.

    Disseminated cystic echinococcosis presenting as orbital swelling in a child — case report and literature review · 2026 · DOI

  • NCC is considered rare in Saudi Arabia due to the Islamic prohibition on pork ingestion. The incidence of NCC is growing due to the increase in immigrants.

    Neurocysticercosis Presenting With Status Epilepticus in a Young South African Male Patient in Saudi Arabia: A Case Report and Review of the Literature · 2026 · DOI

  • The study had a limited sample size of 100 patients. The study was retrospective, which may have introduced biases in the data collection and analysis.

    KEPENŲ ECHINOKOKOZĖ: 20 METŲ RETROSPEKTYVINĖ DIAGNOSTIKOS IR GYDYMO REZULTATŲ ANALIZĖ UNIVERSITETINĖJE LIGONINĖJE · 2026 · DOI

  • There is a need for a comprehensive analysis of the diagnosis and treatment of liver echinococcosis. There is a lack of studies on the long-term outcomes of patients with liver echinococcosis.

    KEPENŲ ECHINOKOKOZĖ: 20 METŲ RETROSPEKTYVINĖ DIAGNOSTIKOS IR GYDYMO REZULTATŲ ANALIZĖ UNIVERSITETINĖJE LIGONINĖJE · 2026 · DOI

  • The predictive model had substantial uncertainty and limitations, with widening 95% confidence intervals and the appearance of negative projected values in later years. The national dataset was aggregated, and organ-specific localization of echinococcosis was not available. Records with incomplete information, duplicate entries, or unclear classification of admission type were excluded from the analysis.

    Trends and Regional Disparities in the Treatment of Echinococcosis in Kazakhstan: A Nationwide Retrospective Study (2017–2024) · 2026 · DOI

  • The decline in treated echinococcosis cases may reflect improvements in disease control, but may also be associated with underdiagnosis or reduced access to healthcare services. Significant regional disparities in surgical management were identified.

    Trends and Regional Disparities in the Treatment of Echinococcosis in Kazakhstan: A Nationwide Retrospective Study (2017–2024) · 2026 · DOI

  • Future studies can investigate the immune microenvironment in other diseases using imaging mass cytometry. Future research can explore the development of new treatments for AE based on the study's findings. Future studies can investigate the role of M2 macrophages in immune evasion in AE.

    Imaging mass cytometry of the immune microenvironment in alveolar echinococcosis · 2026 · DOI

  • There is a need to understand the immune response to cystic echinococcosis. There is a lack of studies on the hematological and pro-inflammatory immune profiles in patients with cystic echinococcosis.

    Hematological and Pro-inflammatory Immune Profiles in Patients with Cystic Echinococcosis: A Comparative Study of Total and Differential White Blood Cell Counts · 2026 · DOI

  • Diagnostic challenges due to non-specific symptoms. Management challenges due to the need for prompt surgical intervention. The presence of multiple life-threatening injuries can complicate the management of the condition.

    Traumatic rupture of a hepatic hydatid cyst in a polytrauma patient: a case report highlighting diagnostic and management challenges · 2026 · DOI

  • There is a lack of awareness about traumatic rupture of hepatic hydatid cysts in non-endemic regions. The diagnosis may be delayed in polytrauma patients due to competing injuries.

    Traumatic rupture of a hepatic hydatid cyst in a polytrauma patient: a case report highlighting diagnostic and management challenges · 2026 · DOI

  • There is a lack of reported cases of sparganosis localized exclusively to Tenon’s capsule. The diagnosis of ocular sparganosis can be challenging due to its nonspecific presentation.

    A Case Report of Sparganosis Mansoni Parasitic Infection of Tennon's Capsule · 2026 · DOI

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93 open questions have been extracted from the limitations and future-work passages of 515 Parasitic infections in humans and animals papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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