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Open research questions in Periodontal Regeneration and Treatments

439 unresolved questions extracted from the limitations and future-work sections of 3,580 Periodontal Regeneration and Treatments papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Substantial heterogeneity among the included studies, particularly regarding exosome sources, inflammatory induction methods, culture conditions, outcome assessment techniques, and data reporting formats. The lack of standardized frameworks for in vitro evidence. The need to develop methods to overcome the inhibitory effects of inflammation on osteogenesis.

    Exosome-mediated modulation of osteogenesis under inflammatory conditions: a systematic review of in vitro studies on human periodontal ligament stem cells · 2026 · DOI

  • Substantial heterogeneity across studies. Limited evidence also suggested a reduction in pro-inflammatory mediators, although this outcome remains insufficiently explored. Key methodological limitations were identified, particularly related to the lack of reporting on sample randomization, sample size justification, and blinding of outcome assessment.

    Exosome-mediated modulation of osteogenesis under inflammatory conditions: a systematic review of in vitro studies on human periodontal ligament stem cells · 2026 · DOI

  • The study design and sample size may limit the interpretation of the results. The semiquantitative results suggested only limited between-group differences. The study was conducted in a private dental practice with a specific patient population

    Histological evaluation of the soft tissue response to plasma-activated healing abutments: A prospective controlled clinical trial · 2026 · DOI

  • Further studies with larger sample sizes are needed to confirm the results. Investigation of the long-term effects of plasma-activated healing abutments on peri-implant soft tissue. Comparison of different surface treatments and their effects on peri-implant soft tissue

    Histological evaluation of the soft tissue response to plasma-activated healing abutments: A prospective controlled clinical trial · 2026 · DOI

  • The lack of effective treatments for COPD and chronic hypersensitivity pneumonitis. The limited understanding of the use of platelet-rich plasma in pulmonary disease. The need for further research on the potential benefits of PRP in lung injury and chronic respiratory disease.

    Case Report: Nebulized autologous platelet-rich plasma associated with quantitative CT and clinical changes in a patient with COPD and chronic hypersensitivity pneumonitis · 2026 · DOI

  • The study only evaluated the antibacterial activity of PRP, PPP, and Fro-PRP in vitro. The study did not investigate the effects of PRP on wound healing in vivo. The study had a limited sample size of 19 biological replicates.

    In vitro antibacterial activity of platelet-rich plasma against Gram-positive and Gram-negative pathogens · 2026 · DOI

  • Further studies with larger sample sizes and control groups - Investigation of PRP's effects on different types of surgical wounds - Research on the optimal timing and dosage of PRP application

    Intraoperative Platelet-Rich Plasma Application Improves Scar Healing After Cesarean Section: A Prospective Observational Pilot Study · 2025 · DOI

  • The variability in preparation techniques, patient selection criteria, and outcome measures limits the generalizability of PRP therapy results. The lack of defined protocols and controlled trials for PRP therapy in DOR and POI. The potential risks and side effects of PRP therapy, such as ovarian hyperstimulation syndrome (OHSS).

    Platelet-Rich Plasma (PRP) in Reproductive Medicine: A Critical Review of PRP Therapy in Low-Reserve and Premature Ovarian Insufficiency · 2025 · DOI

  • The lack of defined protocols and controlled trials for PRP therapy in DOR and POI. The limited understanding of the molecular mechanisms underlying the clinical effects of PRP therapy. The need for long-term safety data and standardized methodologies for PRP therapy.

    Platelet-Rich Plasma (PRP) in Reproductive Medicine: A Critical Review of PRP Therapy in Low-Reserve and Premature Ovarian Insufficiency · 2025 · DOI

  • Clinical outcomes remain inconsistent, - Short follow-up times and small sample sizes limit understanding of the long-term safety and efficacy of PRP, - Heterogeneity in preparation, in addition to inadequate documentation of processes, - Limited regulatory oversight, commercial kit validation, and overall quality control related to PRP

    Dual-Action Regenerative Therapies: Regeneration and Antimicrobial Effects of Platelet- and Marrow-Derived Biologics · 2025 · DOI

  • Need for consensus-building, standardized procedures, and robust research to optimize clinical integration, - Need for standardization in the use of PRP in regenerative medicine, - Further studies on the long-term safety and efficacy of PRP

    Dual-Action Regenerative Therapies: Regeneration and Antimicrobial Effects of Platelet- and Marrow-Derived Biologics · 2025 · DOI

  • Conventional meta-analyses cannot determine the independent contribution of individual components in alveolar ridge preservation interventions. The most effective combination of biomaterials and adjunctive approaches for alveolar ridge preservation remains unclear.

    Component network meta-analysis of scaffold materials, platelet-rich fibrin and barrier membranes for alveolar ridge preservation · 2026 · DOI

  • CONCLUSION: Within the limitations of this study, the tunneling technique, regardless of membrane use, appears to be a clinically viable alternative to the conventional flap method for horizontal alveolar ridge augmentation.

    Flap Versus Tunneling for Horizontal Ridge Augmentation With FDBA and i‐ PRF : A Randomized Controlled Clinical Trial · 2026 · DOI

  • Future translational study is warranted to explore GT as an alternative source of MSCs for periodontal regeneration.

    Intra‐Tissue Bacteriome and Cellular Profiles in Periodontal Granulation Tissue From Osseous Defects and Extraction Sockets · 2026 · DOI

  • CONCLUSION: Within the limitations of the present study, chitosan improved early palatal wound healing, while the addition of i-PRF enhanced patient comfort.

    Palatal Donor‐Site Healing and Patient‐Reported Outcome Measures Following Chitosan and Injectable Platelet‐Rich Fibrin‐Enriched Chitosan Application Compared with Gelatine Sponge: A Three‐Arm Randomised Controlled Clinical Trial · 2026 · DOI

  • Objective Leukocyte‐ and platelet‐rich fibrin (L‐PRF) has emerged as a bioactive scaffold with regenerative and immunomodulatory properties, though its antimicrobial potential remains underexplored.

    Antimicrobial Effect of Platelet‐Rich Fibrin Membranes on Oral Pathogens: An In Vitro Evaluation · 2026 · DOI

  • Preliminary data indicate potential utility in non-healing cutaneous ulcers, though evidence remains sparse.

    Three Decades of Enamel Matrix Derivative: From Dental Innovation to Extra‐Oral Applications · 2026 · DOI

  • Histological evidence was sparse and was not interchangeable with RFA or radiographic surrogate outcomes.

    Platelet‐Rich Fibrin and Its Derivatives as Adjuncts to Dental Implant Osseointegration: A Scoping Review · 2026 · DOI

  • Although traditional oral prosthetic approaches such as dental implants and fixed bridges have been widely applied, they are limited by the absence of proprioception and periodontal ligament–mediated buffering.

    Tissue-engineering strategies, prosthodontic potential and clinical-translation challenges of regenerative teeth · 2026 · DOI

  • Future research will focus on developing multifunctional, personalized smart scaffold materials through continuous international and interdisciplinary collaboration and integrating them into comprehensive regenerative therapies, aiming to improve the clinical results of periodontal therapy.

    Evolution of scaffold materials for periodontal therapeutics over two decades (2005–2025): A bibliometric mapping analysis · 2026 · DOI

  • Although causality cannot be established from a single case, the findings across multiple outcome domains warrant further investigation in prospectively designed studies.

    Case Report: Nebulized autologous platelet-rich plasma associated with quantitative CT and clinical changes in a patient with COPD and chronic hypersensitivity pneumonitis · 2026 · DOI

  • This heterogeneity, driven by differences in centrifugation parameters, anticoagulants, activation methods, tube types, and patient characteristics, explains inconsistent results across studies and hinders evidence consolidation.

    The role of platelet derivatives in regenerative medicine: biological foundations and translational perspectives · 2026 · DOI

  • Abstract Objectives Postoperative pain and discomfort remain common concerns in periodontal plastic surgery involving gingival grafts; however, the influence of individual pain sensitivity on postoperative outcomes remains poorly understood.

    Does individual pain threshold influence postoperative pain after connective tissue graft surgery? · 2026 · DOI

  • However, the effects on the long-term survival and early stability of dental implants remain unknown and warrant further investigation with long-term follow-up.

    Sinus Floor Elevation With Platelet‐Rich Fibrin From Horizontal Centrifugation and Xenograft: Randomized Clinical Trial · 2025 · DOI

  • However, reports on the effects of FGF-2 on soft-tissue wound healing after periodontal surgery are scarce.

    Recombinant human fibroblast growth factor-2 promotes surgical-wound healing in the rat gingiva · 2025 · DOI

Most-cited papers in Periodontal Regeneration and Treatments

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439 open questions have been extracted from the limitations and future-work passages of 3,580 Periodontal Regeneration and Treatments papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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