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Open research questions in Peripheral Neuropathies and Disorders

115 gap statements mined from Peripheral Neuropathies and Disorders papers in our 4.5M-paper local library, which holds 521 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Further studies are needed to confirm the efficacy and safety of efgartigimod in larger patient populations. Studies should evaluate the long-term effects of efgartigimod in GBS patients. Research should focus on optimizing the treatment regimen and dosage of efgartigimod for GBS patients.

    Rapid neurological recovery in Guillain-Barré syndrome treated with efgartigimod · 2026 · DOI

  • Although Borrelia burgdorferi infection may act as a trigger for immune-mediated neuropathies like GBS, definitive causal evidence is lacking, unlike established triggers such as Campylobacter jejuni, cytomegalovirus, and Epstein-Barr virus.

    Tick-Borne Infection as a Precipitant of Guillain-Barré Syndrome: A Case of Lyme Neuroborreliosis · 2026 · DOI

  • Limited understanding of the epidemiology of MS in Australia. Need for improved treatment options for MS patients.

    James Graham McLeod (1932–2022) · 2026 · DOI

  • Integrating Ayurvedic Panchakarma with modern rehabilitative care holds significant promise for improving patient outcomes in GBS, and systematic clinical research is warranted to generate robust evidence for this integrative therapeutic paradigm.

    REVISITING GUILLAIN-BARRE SYNDROME: AYURVEDIC PATHOGENESIS AND PANCHAKARMA-BASED MANAGEMENT · 2026 · DOI

  • Clinical predictors of concomitant stroke in GBS patients are insufficiently characterized. Prior studies have not developed a predictive model for concomitant stroke in GBS patients.

    Machine learning-based identification of concomitant stroke and prognostic analysis in patients with Guillain-Barré syndrome: a retrospective study · 2026 · DOI

  • The lack of standardized assessment tools and rehabilitation protocols for this patient population poses a significant challenge. The complexity of the syndrome's symptoms and the need for tailored therapeutic approaches require careful consideration.

    Efecto del FNP en la independencia y marcha asistida en el síndrome de Miller-Fisher. Reporte de caso · 2026 · DOI

  • Future studies should investigate the effects of PNF on a larger sample of patients with Miller Fisher syndrome. Researchers should explore the potential benefits of PNF in combination with other therapeutic approaches. The development of personalized rehabilitation programs for patients with rare neurological disorders is an area for future research.

    Efecto del FNP en la independencia y marcha asistida en el síndrome de Miller-Fisher. Reporte de caso · 2026 · DOI

  • Early diagnosis of Guillain-Barré Syndrome is challenging due to its non-specific symptoms. The disease's treatment strategies are limited, and there is a need for further research. The disease's economic burden is significant, and there is a need for further research on its impact on healthcare systems.

    SÍNDROME DE GUILLAIN-BARRÉ: REVISÃO ABRANGENTE DOS MECANISMOS FISIOPATOLÓGICOS, PERFIL EPIDEMIOLÓGICO E ESTRATÉGIAS TERAPÊUTICAS · 2026 · DOI

  • The paper does not provide a comprehensive analysis of the disease's economic burden. The review is limited to studies published in Portuguese, English, and Spanish. The paper does not discuss the disease's impact on specific populations, such as children or pregnant women.

    SÍNDROME DE GUILLAIN-BARRÉ: REVISÃO ABRANGENTE DOS MECANISMOS FISIOPATOLÓGICOS, PERFIL EPIDEMIOLÓGICO E ESTRATÉGIAS TERAPÊUTICAS · 2026 · DOI

  • There is a need for a comprehensive understanding of polyneuropathies and their effects on individuals. The role of the peripheral nervous system in polyneuropathies requires further discussion and emphasis.

    Nervensystem und Kommunikation: Polyneuropathie und die Rolle des peripheren Nervensystems · 2026 · DOI

  • Current treatment regimes are often ineffective for patients with neuropathies linked to IgM paraproteins. There is a need for new and effective treatments for patients with treatment-refractory CIPNM.

    Therapeutic effect of T-cell engager in two patients with autoimmune neuropathy · 2026 · DOI

  • This case series highlights the significant therapeutic potential of teclistamab in treatment-refractory CIPNM and provides an important example of ‘off-the-shelf’ BiTE therapy being well tolerated and effective and should be further investigated in neuro-immunological disorders.

    Therapeutic effect of T-cell engager in two patients with autoimmune neuropathy · 2026 · DOI

  • The lack of reported cases of an association of Evans syndrome with POEMS syndrome. The need for a better understanding of the coexistence of these two conditions. The challenges in diagnosing and managing this rare condition.

    Fulminant Evans syndrome and splenic infarction as initial manifestations of POEMS syndrome with monoclonal kappa light chain restriction: a diagnostic and therapeutic challenge · 2026 · DOI

  • Diagnosing PML in patients with liver cirrhosis can be challenging due to the lack of awareness of the condition. Treating PML in patients with liver cirrhosis can be complex due to the underlying liver disease.

    Cerebellar-onset Progressive Multifocal Leukoencephalopathy (PML) Associated with Hepatitis B-related Liver Cirrhosis · 2026 · DOI

  • There is a lack of awareness of PML in patients with liver cirrhosis. The relationship between liver cirrhosis and PML is not well understood.

    Cerebellar-onset Progressive Multifocal Leukoencephalopathy (PML) Associated with Hepatitis B-related Liver Cirrhosis · 2026 · DOI

  • There is a need for early recognition and treatment of neurosyphilis. There is a lack of awareness among clinicians about the symptoms and treatment options for neurosyphilis.

    A case report of transverse myelitis in a young man with neurosyphilis · 2026 · DOI

  • The mediators responsible for driving early autoimmune injury in the most common GBS variant, acute inflammatory demyelinating polyradiculoneuropathy (AIDP), remain incompletely understood.

    Nerve-targeting and pain-promoting transcriptomic signatures in early Guillain-Barre syndrome · 2026 · DOI

  • The diagnosis of Miller Fisher Syndrome with Guillain-Barré Syndrome overlap can be challenging. There is a lack of understanding of the condition in early childhood.

    Miller Fisher Syndrome With Guillain-Barré Syndrome Overlap in a 20-Month-Old Girl: A Case Report · 2026 · DOI

  • The case presentation is limited to a single patient. The diagnosis of AMSAN is based on clinical examination and diagnostic tests, which may not be comprehensive.

    A CASE OF ACUTE MOTOR AND SENSORY AXONAL NEUROPATHY (AMSAN) VARIANT OF GUILLAIN-BARRÉ SYNDROME PRESENTING WITH PARADOXICAL HYPERREFLEXIA AND INVERTED SUPINATOR REFLEX · 2026 · DOI

  • Systematic comparisons between hEDS and idiopathic SFN (iSFN) are lacking. Prior studies have pointed out a high rate of SFN in hEDS, but the distinct clinical/instrumental phenotype of hEDS/SFN is not well understood.

    Distinct sensory and autonomic involvement in hypermobile Ehlers–Danlos syndrome compared with idiopathic small fiber neuropathy: a multimodal study · 2026 · DOI

  • It is nevertheless worth noting that the small percentage of positive patients identified is insufficient to confirm a characteristic clinical phenotype, although it is intriguing and warrants further investigation by identifying additional positive cases.

    Autoantibodies in small fiber neuropathy: frequency and clinical features associated with antibodies to the novel targets MX1 and DBNL · 2026 · DOI

  • Retrospective analysis may be subject to bias. Limited follow-up period of 3 months.

    Rapid neurological recovery in Guillain-Barré syndrome treated with efgartigimod · 2026 · DOI

  • The diagnosis of AMSAN can be challenging due to its rarity and unusual presentation. The presence of hyperreflexia in AMSAN can create a diagnostic dilemma.

    A CASE OF ACUTE MOTOR AND SENSORY AXONAL NEUROPATHY (AMSAN) VARIANT OF GUILLAIN-BARRÉ SYNDROME PRESENTING WITH PARADOXICAL HYPERREFLEXIA AND INVERTED SUPINATOR REFLEX · 2026 · DOI

  • Further research on the epidemiology of MS. Development of new treatments for MS. Investigation of the risks of pregnancy for women with MS.

    James Graham McLeod (1932–2022) · 2026 · DOI

  • Diagnosing pure sensory ganglionopathy can be challenging - There is a need for increased awareness of the association between this condition and anti-Yo…

    Anti-Yo related pure sensory ganglionopathy: a rare paraneoplastic entity · 2026 · DOI

Most-cited papers in Peripheral Neuropathies and Disorders

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Open questions raised by papers listed on this page include: (1) Further studies are needed to confirm the efficacy and safety of efgartigimod in larger patient populations (“Rapid neurological recovery in Guillain-Barré syndrome treated with efgartigimod”, 2026); (2) The lack of standardized assessment tools and rehabilitation protocols for this patient population poses a significant challenge (“Efecto del FNP en la independencia y marcha asistida en el síndrome de…”, 2026); (3) The disease's treatment strategies are limited, and there is a need for further research (“SÍNDROME DE GUILLAIN-BARRÉ: REVISÃO ABRANGENTE DOS MECANISMOS FISIOPATOLÓGICOS,…”, 2026); (4) There is a need for a comprehensive understanding of polyneuropathies and their effects on individuals (“Nervensystem und Kommunikation: Polyneuropathie und die Rolle des peripheren…”, 2026); (5) There is a need for new and effective treatments for patients with treatment-refractory CIPNM (“Therapeutic effect of T-cell engager in two patients with autoimmune neuropathy”, 2026). 115 gap statements have been mined from Peripheral Neuropathies and Disorders papers in our 4.5M-paper local library, which holds 521 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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