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Open research questions in Renal Diseases and Glomerulopathies

745 gap statements mined from Renal Diseases and Glomerulopathies papers in our 7.9M-paper local library, which holds 3,286 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Further studies are required to determine the exact mechanism by which R3HDML regulates mesangial phenotypes in vivo. Further research is warranted to fully elucidate the mechanisms and potential clinical role of R3HDML. Research on synthetic serine protease inhibitors similar to R3HDML could be conducted to treat diabetic nephropathy or GBM diseases.

    The secretory peptidase inhibitor R3HDML fine-tunes p38 MAPK signaling to maintain glomerular basement membrane architecture during renal aging and disease · 2026 · DOI

  • The specific function of R3HDML in podocytes is unknown. The role of R3HDML in maintaining glomerular basement membrane architecture during renal aging and disease is unclear.

    The secretory peptidase inhibitor R3HDML fine-tunes p38 MAPK signaling to maintain glomerular basement membrane architecture during renal aging and disease · 2026 · DOI

  • The mechanisms by which NF-κB pathways may affect O-glycosylation in IgA1-producing cells are unknown. Genomic studies identified multiple genetic loci associated with IgAN and suggested a convergence on the NF-κB pathway, including RELA, the gene encoding the NF-κB subunit p65.

    IKK-β inhibitor TPCA-1 increases Gd-IgA1 production and decreases C1GALT1 expression in EBV-immortalized B cells from human donors · 2026 · DOI

  • The pathophysiology and underlying immunological mechanisms of FGN remain poorly understood. There is a need for further research to improve patient outcomes.

    Fibrillary Glomerulonephritis Diagnosis Is Enhanced by DNAJB9: Three Cases with Different Clinical, Anatomopathologic Features and Outcomes · 2025 · DOI

  • There is a lack of understanding of the role of monocytes and macrophages in kidney disease and homeostasis. The paper identifies a gap in the understanding of the pathogenetic roles of monocytes/macrophages in renal disease. There is a need for further research on the potential for novel therapeutic and prognostic biomarkers and targeted therapy.

    Monocytes and Macrophages in Kidney Disease and Homeostasis · 2024 · DOI

  • While over 80 monogenic causes of SRNS have been identified, a significant proportion of affected patients still lack a clear genetic diagnosis, indicating that additional causative genes remain to be discovered.

    Biallelic pathogenic variants in FLNB are associated with paediatric steroid-resistant nephrotic syndrome via podocyte cytoskeletal dysfunction · 2026 · DOI

  • Diabetic nephropathy (DN) pathogenesis remains elusive due to the lack of comprehensive spatial molecular characterization related to tissue pathological signatures.

    Spatial atlas of human diabetic kidney uncovered podocyte-driven metabolic-inflammatory crosstalk via glycerolipid reprogramming and DUSP4/MMP3 axis · 2026 · DOI

  • The clinical significance of the isolated reduction in calculated eGFR therefore remains uncertain.

    Pregnancy Outcomes and Long-Term Kidney Function in Women with Primary Glomerulonephritis · 2026 · DOI

  • Whether pregnancy accelerates long-term kidney function decline in women with primary glomerulonephritis remains unclear.

    Pregnancy Outcomes and Long-Term Kidney Function in Women with Primary Glomerulonephritis · 2026 · DOI

  • However, its safety profile, especially in pediatric and young adults with glomerular diseases, remains to be fully elucidated.

    B-Cell Depletion in Glomerular Diseases: Not Always as Safe as We May Think · 2026 · DOI

  • The efficacy of combination sulfamethoxazole and trimethoprim (Bactrim) prophylaxis for infection prevention in kidney disease with rituximab therapy remains unclear.

    Bactrim Efficacy in Preventing Infections in Glomerular Diseases Receiving Rituximab · 2026 · DOI

  • This report emphasizes the need for further investigation into the mechanism of kidney toxicity following CAR-T cell therapy, and potential benefits and risks of immunosuppressive therapy in this context.

    Minimal Change Disease Following B-Cell Maturation Antigen–Directed Chimeric Antigen Receptor T-Cell Therapy · 2026 · DOI

  • Clinical correlations exist for some MN antigens, whereas others remain poorly characterized because of their rarity.

    Serine Protease HTRA1 Membranous Nephropathy With Polytypic IgG Concurrent With Plasma Cell Dyscrasia · 2026 · DOI

  • The impact of pandemic-related changes in infection exposure on NS epidemiology remains unclear.

    Pandemic-Related Reductions in Respiratory Infections and New-Onset Nephrotic Syndrome: A Multicenter Cohort Study in Japan · 2026 · DOI

  • Podocyte injury is a hallmark of chronic kidney disease (CKD) and organ failure, but whether different injury signals perturb unified or distinct molecular targets remains unclear.

    Discovery of kidney disease targets using multimodal human podocyte injury models · 2026 · DOI

  • However, their gluconeogenic potential has not yet been elucidated and the magnitude of this process has not been assessed under high glucose (HG) conditions.

    Activation of phosphoenolpyruvate carboxykinase increases intracellular glucose levels in podocytes under hyperglycemic conditions · 2026 · DOI

  • Ambrisentan, an endothelin receptor antagonist, reduces proteinuria; however, insufficient evidence is available to support its use in IgAN.

    Efficacy and safety of ambrisentan in IgA nephropathy: real-world evidence · 2026 · DOI

  • The clinical presentation and outcome data from India are scarce and largely limited to case reports or series.

    Clinicopathological Features and Outcomes of Fibrillary Glomerulonephritis in an Indian Cohort: A Multicentric Study · 2025 · DOI

  • Although the prognostic significance of hematuria has been established in various kidney diseases, few studies have investigated its role in nephrotic syndrome.

    Association Between Microscopic Hematuria and Proteinuria Remission in Adult Nephrotic Syndrome · 2026 · DOI

  • Few studies have assessed health care resource utilization and costs for IgAN patients with high-risk proteinuria and worsening kidney function in Europe.

    Health Care Resource Utilization and Associated Costs Across Proteinuria and Declining Kidney Function in Patients With IgA Nephropathy: A Retrospective Study in Three European Countries · 2026 · DOI

  • The epidemiologic landscape of biopsy-proven kidney diseases in Romania and its evolution over time are poorly understood.

    Trends of Biopsy-Proven Kidney Diseases in Romania: A Single-Center Registry Report Spanning 28 Years · 2025 · DOI

  • There are no approved therapies for FSGS, and futility of treatment is poorly defined.

    Clinical Decision-Making About Immunosuppressive Treatment in Focal Segmental Glomerulosclerosis · 2025 · DOI

  • The lack of understanding of the coexistence of anti-glomerular basement membrane disease and membranous nephropathy - The need for individualized immunosuppressive strategies to optimize kidney outcomes in complex glomerular…

    Successful treatment of anti-glomerular basement membrane antibody disease combined with membranous nephropathy using rituximab: a case report · 2026 · DOI

  • Developing new therapeutic agents to reduce acute injury by the monocyte-macrophage lineage and thus prevent progression to chronicity. Investigating the role of macrophages in tubulointerstitial and vascular disease in human studies. Elucidating the mechanisms of M1 to M2 macrophage transition in the interstitium of the kidney.

    Monocytes and Macrophages in Kidney Disease and Homeostasis · 2024 · DOI

  • Despite shared podocyte injury, outcomes vary widely, with up to 50% progressing to kidney failure.

    Clinicopathologic Classification of Focal Segmental Glomerulosclerosis to Inform on Outcomes: A Retrospective Cohort Review of Biopsy-Proven Focal Segmental Glomerulosclerosis Cases · 2026 · DOI

Most-cited papers in Renal Diseases and Glomerulopathies

Most recent work

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This page shows what the Renal Diseases and Glomerulopathies literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 7.9M-paper local library and writes the gaps from its rows.

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Open questions raised by papers listed on this page include: (1) Further studies are required to determine the exact mechanism by which R3HDML regulates mesangial phenotypes in vivo (“The secretory peptidase inhibitor R3HDML fine-tunes p38 MAPK signaling to…”, 2026); (2) The mechanisms by which NF-κB pathways may affect O-glycosylation in IgA1-producing cells are unknown (“IKK-β inhibitor TPCA-1 increases Gd-IgA1 production and decreases C1GALT1…”, 2026); (3) While over 80 monogenic causes of SRNS have been identified, a significant proportion of affected patients still lack a clear genetic diagnosis, indicating that additional causative genes remain to be discovered (“Biallelic pathogenic variants in FLNB are associated with paediatric…”, 2026); (4) Diabetic nephropathy (DN) pathogenesis remains elusive due to the lack of comprehensive spatial molecular characterization related to tissue pathological signatures (“Spatial atlas of human diabetic kidney uncovered podocyte-driven…”, 2026); (5) Whether pregnancy accelerates long-term kidney function decline in women with primary glomerulonephritis remains unclear (“Pregnancy Outcomes and Long-Term Kidney Function in Women with Primary…”, 2026). 745 gap statements have been mined from Renal Diseases and Glomerulopathies papers in our 7.9M-paper local library, which holds 3,286 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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