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Open research questions in Reproductive Health and Technologies

697 gap statements mined from Reproductive Health and Technologies papers in our 7.9M-paper local library, which holds 5,327 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Addressing the potential limitations of the study, including the lack of clinical relationship between researchers and participants.

    Fertility protection needs, experiences, and decision-making of women with unintended pregnancies: a qualitative study · 2026 · DOI

  • Given the gaps and variability identified, future efforts in ARTs should prioritize well-designed, large-scale, multicenter, prospective randomized studies. Such studies would help validate the effectiveness, safety, and reproducibility of promising interventions, e.g., PRP-based endometrial preparation, advanced sperm selection, and fertility-preservation protocols in oncological contexts.

    Special Issue “Current Trends and Future Challenges in Assisted Reproduction” · 2026 · DOI

  • The limitations of our study include the retrospective nature of the evaluation, the lack of data regarding semen cryopreservation in pre-pubertal patients (in contrast to other studies, such as), the lack of data regarding hormonal and semen parameters at the first evaluation and during follow-up and the lack of data regarding pregnancies in patients who picked up semen for ART.

    Fertility Preservation in More than 7000 Male Patients: A Single-Center, Tertiary Care Registry Study over 30 Years · 2025 · DOI

  • The number of published studies focusing on AR professional teams is scarce, with a low number of participants and in some instances not really having the AR teams as the main research focus, except in the context of couples dropping out of the AR process.

    Burnout in Assisted Reproduction Professionals: The Influence of Stressors in the Workplace · 2024 · DOI

  • Currently, little is known about reproductive decision-making (RDM) for those affected by or at-risk of genodermatoses.

    Patient Perspectives, Unmet Needs and Dilemmas in Repro ductive Decision-making for Genodermatoses: A Qualitative Interview Study · 2026 · DOI

  • Little is known about male partners’ emotional experience during MAR with their partner.

    A Longitudinal Investigation of the Emotional Experience of Men Using Medically Assisted Reproduction · 2026 · DOI

  • This demonstrates that treating infertility solely as a physical or biological condition is insufficient.

    Assessment of anxiety levels and marital relationships among women undergoing infertility treatment: A descriptive observational study · 2026 · DOI

  • However, the longitudinal evolution trajectory of psychological distress and its key influencing factors have not been systematically clarified.

    A Study of Potential Classes and Trajectories of Psychological Distress in Infertility Patients: A Study Protocol · 2026 · DOI

  • The impact of changes in estradiol (E2) levels prior to human chorionic gonadotropin (hCG) administration during controlled ovarian hyperstimulation (COH) on pregnancy and live birth outcomes remains poorly understood.

    Non-Linear Association Between Serum Estradiol Decline and Clinical Outcomes in IVF/ICSI Cycles: A Retrospective Cohort Study · 2026 · DOI

  • The BRICS countries (Brazil, Russia, India, China, South Africa), representing over 40% of the world's population, have undergone profound social and demographic transitions, yet infertility burden and trends in these countries remain incompletely characterized.

    Modeled Burden and Trends of Infertility Among People Aged 15–49 Years in the Original BRICS Countries: Comparisons with G7 and Global Estimates, 1990–2023, with Projections to 2050 · 2026 · DOI

  • Emotional, relational and socio‐cognitive factors are known to influence decisions; however, these factors have not been examined within a comprehensive framework.

    Parents' Disclosure Intentions in Donor‐Conceived Families: Integrating Attachment Theory and the Theory of Planned Behaviour · 2026 · DOI

  • Luteal phase support (LPS) is widely used in ovarian stimulation–intrauterine insemination (OS-IUI) cycles, but the comparative effectiveness of different LPS strategies remains uncertain.

    Luteal phase support strategies in ovarian stimulation–intrauterine insemination cycles: a systematic review and network meta-analysis of randomized controlled trials · 2026 · DOI

  • However, its role in alleviating depressive symptoms among women failed IVF-ET cycles in China remains insufficiently explored.

    How Resilience Mitigates Depression After IVF-ET Failure: A Moderated Mediation Model of Hope, Social Relations, and Income in China · 2025 · DOI

  • Previous studies have indicated a potential association between reproductive factors and infertility, although the precise nature of this relationship remains unclear.

    Reproductive History and Infertility Risk: Insights from the 2017–2020 National Health and Nutrition Examination Survey · 2025 · DOI

  • It shows that the regulation of SEF remains controversial in Austria, with attitudes towards it being based not only on the right to reproductive autonomy, but also on a wide range of broader social issues in contemporary societies.

    The Discourse on Social Egg Freezing in Austria: Individual Solution to a Societal Problem · 2025 · DOI

  • However, it remains unclear whether and how disparities vary across different stages of the help‐seeking process.

    Social Disparities Across Different Stages of Medical Help‐Seeking to Have a Child in Germany · 2025 · DOI

  • Participants wanted information about fertility from their primary healthcare providers that they felt was lacking.

    Perceptions and Experiences With Healthcare Providers Among People Navigating Reproductive and Fertility Decisions · 2024 · DOI

  • The regulation of information giving in reproductive donation is complex and sensitive. The paper identifies challenges in balancing the needs and rights of different parties involved. The development of a framework for understanding and regulating reproductive donation is a key challenge.

    Conceptualizing Reproductive Donation: Developing Models of Egg and Sperm Donation and the Implications for Regulating Information Giving · 2026 · DOI

  • Further debate is needed on which model of reproductive donation is optimal. Research is needed to develop and refine the typology of models. The paper's findings can inform future research on reproductive donation and its regulation.

    Conceptualizing Reproductive Donation: Developing Models of Egg and Sperm Donation and the Implications for Regulating Information Giving · 2026 · DOI

  • Evidence regarding small-study effects was inconclusive, and publication-bias assessments were difficult to interpret because of the small number of studies and substantial heterogeneity.

    Prevalence of anxiety and depressive symptoms among men attending infertility services in Africa: a systematic review and meta-analysis · 2026 · DOI

  • Anxiety and depression are common comorbidities in individuals with infertility, but their pooled prevalence and study-level sources of heterogeneity among men attending infertility services in Africa are not well defined.

    Prevalence of anxiety and depressive symptoms among men attending infertility services in Africa: a systematic review and meta-analysis · 2026 · DOI

  • Despite infertility affecting one in five women in the United States, few studies have explored the effects of energy intake on fertility status at a population level.

    Does Energy Intake Affect the Fertility Status of Female Adults in the United States? · 2024 · DOI

  • Addressing the “add-on phenotype” requires fundamental shifts in how the medical field evaluates and adopts new technologies. Below are a few relevant points. RIGOROUS PRE-ADOPTION EVALUATIONS Expensive technologies intended to improve patient-important outcomes must undergo adequately powered validation studies before being integrated into standard IVF cycle protocols.

    Paying more for no better outcome: The add-on crisis in modern medicine – using infertility treatment as the primary example · 2026 · DOI

  • Current IVF practices are in need of radical reforms at multiple levels. Critical peer reviews of published papers are designed to remove business interests from the IVF literature. Enhanced post-marketing surveillance should provide much more transparent communications with patients about evidence quality and costs. Reimbursement policies should reward demonstrated value.

    Paying more for no better outcome: The add-on crisis in modern medicine – using infertility treatment as the primary example · 2026 · DOI

  • Further study on the long-term reproductive health risks associated with unintended pregnancies - Research on the impact of access to safe abortion services on maternal health…

    Fertility protection needs, experiences, and decision-making of women with unintended pregnancies: a qualitative study · 2026 · DOI

Most-cited papers in Reproductive Health and Technologies

Most recent work

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Open questions raised by papers listed on this page include: (1) Addressing the potential limitations of the study, including the lack of clinical relationship between researchers and participants (“Fertility protection needs, experiences, and decision-making of women with…”, 2026); (2) Currently, little is known about reproductive decision-making (RDM) for those affected by or at-risk of genodermatoses (“Patient Perspectives, Unmet Needs and Dilemmas in Repro ductive Decision-making…”, 2026); (3) Little is known about male partners’ emotional experience during MAR with their partner (“A Longitudinal Investigation of the Emotional Experience of Men Using Medically…”, 2026); (4) The impact of changes in estradiol (E2) levels prior to human chorionic gonadotropin (hCG) administration during controlled ovarian hyperstimulation (COH) on pregnancy and live birth outcomes remains poorly understood (“Non-Linear Association Between Serum Estradiol Decline and Clinical Outcomes in…”, 2026); (5) Emotional, relational and socio‐cognitive factors are known to influence decisions; however, these factors have not been examined within a comprehensive framework (“Parents' Disclosure Intentions in Donor‐Conceived Families: Integrating…”, 2026). 697 gap statements have been mined from Reproductive Health and Technologies papers in our 7.9M-paper local library, which holds 5,327 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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