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Open research questions in Research on Leishmaniasis Studies

130 gap statements mined from Research on Leishmaniasis Studies papers in our 4.5M-paper local library, which holds 777 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The need for a better understanding of the genetic factors associated with visceralization in L. tropica.

    Investigation of viscerotropism-associated genes in Leishmania tropica strains causing visceral leishmaniasis · 2026 · DOI

  • The study faces challenges due to the lack of data on sociodemographic and environmental characteristics. The high proportion of missing laboratory data is a challenge. The study must consider the complex transmission dynamics of CL in Brazil.

    Epidemiological, Clinical, and Socioenvironmental Characteristics of Cutaneous Leishmaniasis Cases in the Xakriabá Indigenous Population, Brazil · 2026 · DOI

  • The current therapeutic interventions for Leishmania infantum infection have limitations. There is a need for new targets and regulators to develop more effective treatments. The study aims to address this gap by identifying host immune regulatory targets and their modulators.

    Identification of host immune regulatory targets and their modulators in Leishmania infantum infection through integrated transcriptomic and molecular modeling approaches · 2026 · DOI

  • The need to identify potential host targets to combat parasitic infections. The limited understanding of the role of p38-MAPK in L. donovani and P. falciparum infections.

    Chemical degradation of Human p38-MAPK reveals it as a potential host target to combat parasitic infections by Leishmania donovani and Plasmodium falciparum · 2026 · DOI

  • The treatment requires multiple cryosurgery sessions and prolonged imiquimod application, which may compromise compliance. The study is a single case report, and further evaluation is needed to confirm the efficacy of immunocryosurgery for cutaneous leishmaniasis.

    Successful Treatment of Cutaneous Leishmania infantum Infection with Immunocryosurgery after Failure of the Respective Monotherapies · 2026 · DOI

  • Treatment failure and clinical relapse are major challenges in leishmaniasis. The current understanding of drug responses is limited to classical resistance. Emerging technologies require careful experimental design to capture the complexity of drug responses.

    Beyond resistance: Emerging methods to dissect drug responses in Leishmania · 2026 · DOI

  • The current understanding of drug responses in Leishmania is limited to classical resistance. Emerging technologies offer new opportunities for understanding a broader range of responses. There is a need to move beyond resistance-centric models to capture the complexity of drug responses.

    Beyond resistance: Emerging methods to dissect drug responses in Leishmania · 2026 · DOI

  • The diagnosis of hemophagocytic syndrome is challenging due to its nonspecific manifestations. The patient presented with a rare association of hemophagocytic syndrome secondary to visceral leishmaniasis. The diagnosis was delayed due to the lack of specific symptoms.

    Síndrome Hemofagocítico Secundario a Infección por Leishmania visceral en paciente pediátrico. Una relación excepcional que representa un reto diagnóstico · 2026 · DOI

  • Further studies are needed to investigate the long-term effects of anti-PD-1 immunotherapy in chronic L. mexicana infection. Research should focus on understanding the mechanisms underlying the therapeutic response to PD-1 blockade. The development of new treatments for DCL may benefit from a better understanding of the Tex landscape.

    Immunotherapeutic potential of PD-1 blockade in chronic Leishmania mexicana infection through the enhancement of progenitor-like CXCR5+ and intermediate CXCR5+TIM-3+ exhausted T cells · 2026 · DOI

  • The paper identifies the need for sustained and targeted interventions to eliminate kala-azar. The lack of effective diagnostics and treatment options has been a significant challenge in controlling the disease.

    The historical fight against visceral leishmaniasis (kala-azar) in India: From epidemic to elimination · 2026 · DOI

  • The co-occurrence of high parasite burden and TLS in P1 raises the possibility of a relationship between parasite persistence and lymphoid neogenesis, though whether this is causal or reflects lesion duration, severity, or anatomical location remains to be tested in larger cohorts.

    Spatial mapping of Ethiopian cutaneous leishmaniasis lesions reveals distinct tissue level immune programs · 2026 · DOI

  • When a negative result is not consistent with the overall clinical picture, particularly in dogs with strong clinical suspicion, previous or ongoing treatment, or when low-level parasite DNA is expected, confirmation by a more sensitive reference laboratory qPCR is warranted.

    Evaluation of an Automated Cartridge-Based PCR Assay for the Detection of Leishmania spp. DNA in Canine Lymph Node Samples · 2026 · DOI

  • It highlights the need for proper management and treatment to prevent complications.

    Mucosal leishmaniasis of the nasal septum: diagnostic pitfalls and management considerations · 2026 · DOI

  • Developing a monoclonal antibody that can recognize native LACK antigen. Optimizing the immunohistochemistry technique to achieve high sensitivity and specificity. Validating the diagnostic technique using a large number of clinical samples.

    Anti-Leishmania activated C-kinase monoclonal antibody immunohistochemical technique for cutaneous leishmaniasis diagnosis · 2026 · DOI

  • There is a need for effective diagnostic techniques for cutaneous leishmaniasis. Current diagnostic methods have limitations in terms of sensitivity and specificity.

    Anti-Leishmania activated C-kinase monoclonal antibody immunohistochemical technique for cutaneous leishmaniasis diagnosis · 2026 · DOI

  • The involvement of mucosal-associated invariant T cells in protozoal diseases, particularly visceral leishmaniasis and HIV co-infection, is poorly understood. There is a need to evaluate the immunophenotypic profile of circulating MAIT cells in visceral leishmaniasis patients, VL-HIV co-infection patients, and reference groups.

    Phenotypic characterization of mucosal-associated invariant T cells in visceral leishmaniasis and HIV co-infection · 2026 · DOI

  • Despite their recognized role in bacterial and viral infections, their involvement in protozoal diseases, particularly visceral leishmaniasis (VL) and HIV co-infection, remains poorly understood.

    Phenotypic characterization of mucosal-associated invariant T cells in visceral leishmaniasis and HIV co-infection · 2026 · DOI

  • To investigate the long-term effects of the vaccine. To explore the use of DNA constructs as a potential vaccine platform. To develop a more effective vaccine against Leishmaniasis.

    Bulky pcDNA plasmid encoding Leishmania- and Sandfly-derived antigens resulted in transient Th1 response post Leishmania major infection in BALB/c mice · 2026 · DOI

  • Limited efficacy and significant toxicity of current treatments. Disfiguring and refractory lesions are challenging to treat. Immunocryosurgery requires multiple cryosurgery sessions and prolonged imiquimod application, which may compromise compliance.

    Successful Treatment of Cutaneous Leishmania infantum Infection with Immunocryosurgery after Failure of the Respective Monotherapies · 2026 · DOI

  • Therapeutic failure to antimonials is a growing problem. The pathology in LC by L. braziliensis appears to be mediated by an exacerbated inflammatory response. The heterogeneity of laboratory methodologies and outcome definitions limited the ability to perform a quantitative meta-analysis.

    Correlación entre la respuesta inmune local y la evolución clínica en la leishmaniasis cutánea por L. braziliensis: Una revisión sistemática · 2026 · DOI

  • The heterogeneity of laboratory methodologies and outcome definitions limited the ability to perform a quantitative meta-analysis. The study only included studies published in the last 10 years.

    Correlación entre la respuesta inmune local y la evolución clínica en la leishmaniasis cutánea por L. braziliensis: Una revisión sistemática · 2026 · DOI

  • Further study of the ecology and behavior of the new species. Investigation of the role of the new species in the transmission of leishmaniasis and other diseases. Comparison of the new species with other sand fly species in the region.

    Sergentomyia (Neophlebotomus) chattiensis n. sp.: morphological and molecular description of a new sand fly species from Himachal Pradesh, India · 2026 · DOI

  • Investigation of the therapeutic potential of p38-MAPK inhibitors in parasitic infections. Study of the role of p38-MAPK in other diseases, such as cancer and inflammatory diseases.

    Chemical degradation of Human p38-MAPK reveals it as a potential host target to combat parasitic infections by Leishmania donovani and Plasmodium falciparum · 2026 · DOI

  • Further investigations into the molecular mechanisms underlying the patho-physiology of VL, - Study of gene expression patterns associated with L.

    Comparative RNA-Seq Analysis Reveals Macrophage Polarization and T Cell Exhaustion Signatures in Visceral Leishmaniasis · 2026 · DOI

  • This study highlights the broad, underexplored potential of fungal SMs for antiparasitic drug 17 ARTICLE…

    Profiling fungal secondary metabolites with anti-leishmanial activity: an integrated in silico and in vitro study · 2026 · DOI

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Open questions raised by papers listed on this page include: (1) The study faces challenges due to the lack of data on sociodemographic and environmental characteristics (“Epidemiological, Clinical, and Socioenvironmental Characteristics of Cutaneous…”, 2026); (2) There is a need for new targets and regulators to develop more effective treatments (“Identification of host immune regulatory targets and their modulators in…”, 2026); (3) There is a need to move beyond resistance-centric models to capture the complexity of drug responses (“Beyond resistance: Emerging methods to dissect drug responses in Leishmania”, 2026); (4) The diagnosis was delayed due to the lack of specific symptoms (“Síndrome Hemofagocítico Secundario a Infección por Leishmania visceral en…”, 2026); (5) Further studies are needed to investigate the long-term effects of anti-PD-1 immunotherapy in chronic L. mexicana infection (“Immunotherapeutic potential of PD-1 blockade in chronic Leishmania mexicana…”, 2026). 130 gap statements have been mined from Research on Leishmaniasis Studies papers in our 4.5M-paper local library, which holds 777 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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