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Open research questions in Sarcoma Diagnosis and Treatment

183 unresolved questions extracted from the limitations and future-work sections of 480 Sarcoma Diagnosis and Treatment papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • However, limited research has focused on identifying prognostic factors (PFs) for pediatric osteosarcoma with pulmonary metastasis (POPM).

    Prognostic nomogram for overall survival in pediatric osteosarcoma with pulmonary metastases: a SEER database analysis · 2025 · DOI

  • Due to the rarity of these tumors, few studies have examined their molecular composition and gene expression.

    Molecular Characterization of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma · 2025 · DOI

  • RESULTS: Diagnostic delay in soft tissue sarcomas is a frequent event that is poorly characterized and has important consequences, including prognostic, medico-legal and psycho-social effects.

    Diagnostic Delay in Soft Tissue Sarcomas: A Review · 2025 · DOI

  • Median overall survival (mOS) varied widely, ranging from 234 months in chondrosarcoma to 16–20 months in rhabdomyosarcoma and SBRC sarcoma.

    Clinical Differences Among Histological Categories of Sarcoma: Insights from 97,062 Patients · 2025 · DOI

  • BACKGROUND: Soft tissue tumors (STTs) in adolescents are relatively rare, and their characteristics and behavior have not been well studied in this age group.

    Epidemiology and clinicopathological features of soft tissue tumors in adolescents: a cross-sectional study · 2025 · DOI

  • However, little is known about the molecular mechanisms underlying ESPN-mediated migration and invasion in OS cells.

    ESPN activates ZEB1-mediated EMT through the PI3K/AKT/mTOR axis to promote osteosarcoma metastasis · 2025 · DOI

  • Targeted therapies for DSRCT have not been developed, and standard multimodal therapy is insufficient, leading to a 5-year survival rate of only 15% to 25%.

    Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors · 2024 · DOI

  • While the reason for this male predominance remains unknown, one hypothesis is that the androgen receptor (AR) plays a critical role in DSRCT and elevated testosterone levels in males help drive tumor growth.

    Enzalutamide induces cytotoxicity in desmoplastic small round cell tumor independent of the androgen receptor · 2024 · DOI

  • However, the biological significance of morphological sarcomatous transformation in ASCPLT remains uncertain.

    Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update · 2024 · DOI

  • However, the chromatin remodeling events induced by CIC-DUX4 are not well understood, limiting our ability to identify new mechanism-based therapeutic strategies for these patients.

    CIC-DUX4 Chromatin Profiling Reveals New Epigenetic Dependencies and Actionable Therapeutic Targets in CIC-Rearranged Sarcomas · 2024 · DOI

  • The rarity and nonspecific nature of clinical presentation of soft tissue sarcomas. The need for early and accurate detection of soft tissue sarcomas. The complexity of analyzing MRI sequences for soft tissue sarcoma detection.

    Automated detection of primary soft tissue sarcomas of the extremities using artificial intelligence and ChatGPT · 2026 · DOI

  • The detection of primary soft tissue sarcomas in the extremities presents significant challenges in the field of oncology. There is a need for more effective methods for detecting soft tissue sarcomas. The use of ChatGPT in adapting CNNs for medical image analysis is a novel approach.

    Automated detection of primary soft tissue sarcomas of the extremities using artificial intelligence and ChatGPT · 2026 · DOI

  • An algorithm to distinguish between DSRCT (where WART is standard) and other sarcoma subtypes for individualized WART consideration is proposed but not fully validated.

    Whole Abdominal Radiotherapy in Bone and Soft Tissue Sarcomas: Indications, Techniques, Clinical Outcomes, and Future Directions · 2026 · DOI

  • WART use in sarcoma subtypes other than DSRCT (rhabdomyosarcoma, Ewing sarcoma, myxoid liposarcoma) should be individualized based on peritoneal involvement and prior treatment response, but evidence remains emerging rather than definitive.

    Whole Abdominal Radiotherapy in Bone and Soft Tissue Sarcomas: Indications, Techniques, Clinical Outcomes, and Future Directions · 2026 · DOI

  • The lack of reports on the outcomes of radical resection with multiorgan resection and resection of main arteries and veins in patients with retroperitoneal nonorgan liposarcomas. The limited understanding of the feasibility and effectiveness of this technique.

    POSSIBILITIES AND RESULTS OF SURGICAL TREATMENT OF PATIENTS WITH RETROPERITONEAL NONORGAN LIPOSARCOMAS WITH INVASION OF THE MAIN VESSELS · 2026 · DOI

  • Delayed MTX clearance. Toxicity risks. Prolonged hospital stays. The need for early prediction and personalized treatment.

    Development of a web-based machine learning model for early prediction of delayed high-dose methotrexate clearance in pediatric osteosarcoma · 2026 · DOI

  • The development of prospective studies to validate the model. The exploration of other machine learning approaches. The investigation of the model's generalizability to other populations.

    Development of a web-based machine learning model for early prediction of delayed high-dose methotrexate clearance in pediatric osteosarcoma · 2026 · DOI

  • The study is limited to a retrospective analysis of 150 patients. The algorithm may not perform well in other datasets due to differences in gene panels and sequencing depths. The study does not investigate the underlying mechanisms of DDLPS.

    RNA-based next-generation sequencing strategy for screening MDM2-amplified sarcomas · 2026 · DOI

  • Investigating the underlying mechanisms of DDLPS. Developing targeted therapies for DDLPS. Validating the algorithm in larger and more diverse datasets.

    RNA-based next-generation sequencing strategy for screening MDM2-amplified sarcomas · 2026 · DOI

  • The disease has a broad anatomical distribution, making diagnosis and treatment challenging. The diverse histological patterns of synovial sarcoma also pose a challenge for diagnosis and therapy. The lack of convincing evidence on the origin and differentiation of synovial sarcoma makes it difficult to develop effective treatment strategies.

    Synovial Sarcoma: Molecular Biology, Pathology, and Therapeutic Strategies · 2026 · DOI

  • further study of epigenetic therapies for SS, - investigation of EZH2 inhibition as a treatment approach, - exploration of histone acetylation as a therapeutic target

    Synovial Sarcoma: Molecular Biology, Pathology, and Therapeutic Strategies · 2026 · DOI

  • The rarity of OS in the jaw bones. The difficulty in diagnosing COS due to its non-specific symptoms. The need for a multidisciplinary approach for the diagnosis and treatment of COS.

    Unmasking a rare maxillary tumor: Chondroblastic osteosarcoma – A case report · 2026 · DOI

  • The rarity of OS in the jaw bones. The lack of awareness among dental professionals about the possibility of COS in the maxillary region.

    Unmasking a rare maxillary tumor: Chondroblastic osteosarcoma – A case report · 2026 · DOI

  • The diagnosis of lipoblastoma can be challenging due to histomorphologic overlaps with other tumors. There is a need for molecular diagnostics to confirm the diagnosis of lipoblastoma. The paper identifies a gap in the use of target RNA sequencing in diagnosing lipoblastoma.

    Myxoid Lipoblastoma with New Fusion Transcript CHCHD7::PLAG1 in an 18-Month-Old Girl Diagnosed by Target RNA Sequencing: A Case Report · 2026 · DOI

  • The difficulties associated with sarcoma resection and limb-sparing surgery. The need for extensive excisions that result in significant defects. The risk of microvascular thrombosis and greater physiological demand for the patient.

    Appendicular Soft Tissue Sarcoma Surgery in the Era of Orthoplastics · 2026 · DOI

Most-cited papers in Sarcoma Diagnosis and Treatment

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183 open questions have been extracted from the limitations and future-work passages of 480 Sarcoma Diagnosis and Treatment papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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