Science AI Journal
Medicine · Research topic

Open research questions in Spondyloarthritis Studies and Treatments

318 gap statements mined from Spondyloarthritis Studies and Treatments papers in our 7.9M-paper local library, which holds 1,601 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Spondyloarthritis Studies and Treatments? See the ranked Medicine journals.

What the literature leaves open

  • The need to balance sagittal correction with the risk of neurological complications. The challenge of achieving sufficient sagittal correction while minimizing morbidity.

    Combined anterior-posterior osteotomy technique for correction of chin-on-chest deformity in ankylosing spondylitis: illustrative case · 2026 · DOI

  • The association between DISH and postoperative outcomes after surgery for degenerative lumbar spine disease is not well understood. There is a need to analyze retrospective data from Japanese studies to determine the risk of reoperation with DISH/L-DISH.

    Association of diffuse idiopathic skeletal hyperostosis with postoperative outcomes following surgery for degenerative lumbar spine disease · 2026 · DOI

  • The mechanisms underpinning ongoing pain in chronic whiplash-associated disorder are not well understood. The reasons for reduced intra-epidermal nerve fibre density in people with chronic whiplash-associated disorder are unclear. There is a need to investigate skin inflammatory cytokine gene expression in people with chronic WAD II.

    Skin inflammatory cytokine gene expression in chronic whiplash-associated disorder: a cross-sectional study · 2026 · DOI

  • The study identifies challenges in recruiting patients with psoriatic arthritis who fulfill established classification criteria and have an indication for ixekizumab therapy. It highlights the need for a sensitive assessment of myocardial deformation using speckle-tracking echocardiography.

    Changes in biventricular myocardial function after six months of ixekizumab therapy in patients with psoriatic arthritis: a prospective speckle-tracking echocardiographic study · 2026 · DOI

  • The gap in the current research is the lack of understanding of whether predefined structural abnormalities already visible on abdominal CT are documented in an established SpA cohort. Prior studies have mainly focused on incidental SIJ abnormalities in inflammatory bowel disease cohorts or the diagnostic performance of abdominal CT.

    Underreporting of sacroiliac joint structural abnormalities on routine abdominal CT in axial spondyloarthritis: a longitudinal workflow analysis · 2026 · DOI

  • There is a lack of understanding of the environmental and genetic determinants of ankylosing spondylitis. The current research aims to fill this gap by providing valuable information and encouraging further research. The paper identifies the need for more research on the connections between inflammatory disorders and selected environmental and genetic factors.

    Environmental and Genetic Determinants of Ankylosing Spondylitis · 2024 · DOI

  • The circulating immune-cell programs associated with inflammatory heterogeneity in ankylosing spondylitis remain incompletely understood. The relationship between phthalate ester exposure and ankylosing spondylitis is not well understood.

    A Database-Derived Phthalate Ester–Ankylosing Spondylitis Signature Identifies an AP-1/CXCL8 Inflammatory Classical-Monocyte Program · 2026 · DOI

  • It remains unknown whether this also applies to patients with axial spondyloarthritis (axSpA).

    Site-specific articular response to TNF inhibitor in axial spondyloarthritis: A European cohort study · 2026 · DOI

  • While studies have suggested that tumour necrosis factor inhibitors (TNFis) may alleviate depressive symptoms, their effect on the incidence of depression remains unclear.

    Effect of tumour necrosis factor inhibitors on risk of depression in patients with AS: a nationwide propensity score-matched cohort study · 2026 · DOI

  • The clinical and immunologic significance of rheumatoid factors (RF) in psoriatic arthritis (PsA) remains unclear.

    Clinical outcomes in psoriatic arthritis patients with rheumatoid factor positivity · 2026 · DOI

  • Data regarding progression from oligoarticular to polyarticular psoriatic arthritis (PsA) are sparse.

    Progression from oligoarticular to polyarticular psoriatic arthritis and apremilast as a disease modifier: Novel insights from FOREMOST · 2026 · DOI

  • T1-weighted MRI alone is insufficient for reliably evaluating structural lesions of SIJs due to sacroiliitis in patients with axial spondyloarthritis.

    Diagnostic performance of pelvic CT, T1-weighted MRI and mineralized-tissue MRI for the assessment of structural lesions in sacroiliitis in patients with axial spondyloarthritis · 2025 · DOI

  • Immunosuppressive/immunomodulatory therapies, including biologic/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARD), are common effective treatments for PsA; however, discontinuation is reported and contributing factors remain unclear.

    Real-world use of biologic and targeted synthetic disease-modifying antirheumatic drugs in US patients with psoriatic arthritis: Persistence, patient characteristics associated with discontinuation, and dosing patterns · 2025 · DOI

  • Conflicting data exist on TNF inhibitors' (TNFi) role in preventing PsA in psoriasis.

    TNF-alpha inhibitors reduce the incidence of PsA in patients with psoriasis: a propensity score-matched cohort study · 2025 · DOI

  • Biologic therapies for skin psoriasis (PsO) have been linked to a lower risk of developing psoriatic arthritis (PsA), but their efficacy across different mechanisms of action remains to be fully explored.

    Psoriatic arthritis risk in psoriasis patients receiving anti-IL-23 vs anti-IL-17: comparison of drug classes and individual agents · 2025 · DOI

  • Early diagnosis and treatment could offer significant benefits to the patient and potentially reduce productivity losses; however, future research is needed to evaluate the long-term health economic impact.

    What is the economic burden of delayed axial spondyloarthritis diagnosis in the UK? · 2025 · DOI

  • Investigate the direct effects of PAEs on AS pathogenesis. Examine the role of PAEs in other immune-mediated inflammatory diseases. Explore the potential therapeutic applications of targeting the AP-1/CXCL8 pathway in AS.

    A Database-Derived Phthalate Ester–Ankylosing Spondylitis Signature Identifies an AP-1/CXCL8 Inflammatory Classical-Monocyte Program · 2026 · DOI

  • Prior studies have reported varying rates of skin flares after glucocorticoid tapering.

    Cutaneous Deterioration Following Glucocorticoid Discontinuation in Psoriatic Arthritis: A Real-World Cohort Study · 2026 · DOI

  • Tuft resorption is an important radiographic feature of psoriatic arthritis (PsA), yet its clinical significance remains inadequately characterized.

    Tuft resorption in patients with psoriatic arthritis · 2025 · DOI

  • Evidence for the association between MTX use and liver fibrosis in PsA remains inconclusive.

    The lack of association between cumulative MTX dose and liver fibrosis in PsA: a cohort study · 2025 · DOI

  • Further studies are needed to determine the association between DISH/L-DISH and postoperative outcomes, - Prospective studies with larger sample sizes and diverse populations are required, - Studies should investigate the effect of DISH/L-DISH on different surgical procedures…

    Association of diffuse idiopathic skeletal hyperostosis with postoperative outcomes following surgery for degenerative lumbar spine disease · 2026 · DOI

  • Investigate the mechanisms underpinning the association between reduced IENFD and chronic WAD II, - Examine a broader range of inflammatory cytokines, - Conduct longitudinal studies to examine changes in cytokine gene expression over…

    Skin inflammatory cytokine gene expression in chronic whiplash-associated disorder: a cross-sectional study · 2026 · DOI

  • Further study on the diagnostic performance of abdominal CT, - Examination of treatment effects on reporting behavior, - Investigation of reporting behavior in other clinical…

    Underreporting of sacroiliac joint structural abnormalities on routine abdominal CT in axial spondyloarthritis: a longitudinal workflow analysis · 2026 · DOI

  • Research in the area of connections between inflammatory disorders leading to the pathogenesis of AS and selected environmental and genetic factors, - Investigation of the link between infections and the risk…

    Environmental and Genetic Determinants of Ankylosing Spondylitis · 2024 · DOI

  • This insufficient awareness correlated with lower activity and worse disease status.

    From awareness to action: poor knowledge of physical activity correlates with lower activity and worse disease in axial spondyloarthritis · 2025 · DOI

Most-cited papers in Spondyloarthritis Studies and Treatments

Most recent work

Find a gap in your own Spondyloarthritis Studies and Treatments sub-topic

This page shows what the Spondyloarthritis Studies and Treatments literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 7.9M-paper local library and writes the gaps from its rows.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
4,200 open questions
Dementia and Cognitive Impairment Research
2,789 open questions
Substance Abuse Treatment and Outcomes
2,285 open questions
Cancer Immunotherapy and Biomarkers
2,273 open questions
Liver Disease Diagnosis and Treatment
2,102 open questions
Sports Performance and Training
1,952 open questions
Parkinson's Disease Mechanisms and Treatments
1,915 open questions
Mosquito-borne diseases and control
1,849 open questions
Open questions raised by papers listed on this page include: (1) The association between DISH and postoperative outcomes after surgery for degenerative lumbar spine disease is not well understood (“Association of diffuse idiopathic skeletal hyperostosis with postoperative…”, 2026); (2) The mechanisms underpinning ongoing pain in chronic whiplash-associated disorder are not well understood (“Skin inflammatory cytokine gene expression in chronic whiplash-associated…”, 2026); (3) The circulating immune-cell programs associated with inflammatory heterogeneity in ankylosing spondylitis remain incompletely understood (“A Database-Derived Phthalate Ester–Ankylosing Spondylitis Signature Identifies…”, 2026); (4) It remains unknown whether this also applies to patients with axial spondyloarthritis (axSpA) (“Site-specific articular response to TNF inhibitor in axial spondyloarthritis: A…”, 2026); (5) While studies have suggested that tumour necrosis factor inhibitors (TNFis) may alleviate depressive symptoms, their effect on the incidence of depression remains unclear (“Effect of tumour necrosis factor inhibitors on risk of depression in patients…”, 2026). 318 gap statements have been mined from Spondyloarthritis Studies and Treatments papers in our 7.9M-paper local library, which holds 1,601 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 1,100,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? Acceptance odds for top, mid and open/emerging journals, in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck for prior publication across 7 sources and our local library.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

How Pre-Check worksHow AI Review works

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.