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Open research questions in Venous Thromboembolism Diagnosis and Management

303 unresolved questions extracted from the limitations and future-work sections of 1,026 Venous Thromboembolism Diagnosis and Management papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • One challenge is the risk of bleeding associated with catheter-directed thrombolysis. Another challenge is the need for close monitoring of patients with intermediate-high-risk acute pulmonary embolism to identify those who may require reperfusion therapy. The paper also mentions the challenge of diagnosing and treating saddle pulmonary embolism, which can cause significant morbidity and mortality.

    Echocardiographic follow-up of a patient with saddle pulmonary embolism successfully treated with catheter-directed thrombolysis · 2026 · DOI

  • There is a need for effective treatment options for patients with intermediate-high-risk acute pulmonary embolism. Catheter-directed thrombolysis is not a first-line treatment for patients with acute pulmonary embolism, but it can be considered in patients with high-risk PE when systemic thrombolysis is contraindicated or ineffective.

    Echocardiographic follow-up of a patient with saddle pulmonary embolism successfully treated with catheter-directed thrombolysis · 2026 · DOI

  • Managing postoperative bleeding during VA-ECMO support. Balancing the need for anticoagulation with the risk of bleeding. Managing the patient's condition complicated by residual left popliteal deep vein thrombosis, postoperative inguinal hematoma, and surgical-site infection.

    Case Report: Postoperative pulmonary embolism causing obstructive shock and circulatory collapse after gynecologic surgery: successful rescue with VA-ECMO · 2026 · DOI

  • further study is needed to determine the optimal management of patients with postoperative pulmonary embolism, - research is needed to develop strategies to balance anticoagulation and bleeding risk in these patients, - investigation of the role of VA-ECMO in the treatment of very-high-risk pulmonary embolism

    Case Report: Postoperative pulmonary embolism causing obstructive shock and circulatory collapse after gynecologic surgery: successful rescue with VA-ECMO · 2026 · DOI

  • The association between IDA and VTE remains inadequately characterized. Prior studies have limitations, such as rudimentary demographic matching procedures and inability to establish a temporal sequence between IDA onset and subsequent thrombotic events. The potential mechanistic role of reactive thrombocytosis in mediating the relationship between IDA and VTE is not well understood.

    Association between iron deficiency anemia and risk of venous thromboembolism: a multi-institutional retrospective study · 2025 · DOI

  • Investigation of the long-term associations of dyspnea with health-related quality of life, - Examination of the risk factors of developing persisting dyspnea after acute PE

    Dyspnea after a first episode of pulmonary embolism: prevalence, predictors and long-term associations with health-related quality of life · 2025 · DOI

  • 52), whereas three radiologists showed no agreement when rating the same measurement as favorable or incorrect (Fleiss kappa, -0.

    PERADS.net: Automated PE-RADS Grading with Named Anatomic Localization and Right-to-Left Ventricular Ratio Measurement on CT Pulmonary Angiography · 2026 · DOI

  • Radiologists showed no agreement rating RV/LV plausibility as favorable or incorrect (Fleiss kappa, -0.

    PERADS.net: Automated PE-RADS Grading with Named Anatomic Localization and Right-to-Left Ventricular Ratio Measurement on CT Pulmonary Angiography · 2026 · DOI

  • In part, SPECT adoption is limited by the differences in clinical interpretation.

    Artificial count enhancement in lung scintigraphy for acquisition acceleration and pseudo-planar generation · 2026 · DOI

  • Conclusions CAC-related stroke is a distinct and underrecognized entity characterized by specific biological and radiological features and poor outcomes.

    Stroke secondary to cancer-associated coagulopathy: a systematic review · 2026 · DOI

  • Its key components are known to exert anti-inflammatory and antiplatelet effects; however, the potential association between adherence to the EAT‑Lancet diet and incident venous thromboembolism (VTE), as well as the underlying biological mechanisms, remains unclear.

    Adherence to the EAT-Lancet Diet, plasma proteomics, and risk of venous thromboembolism: a large-scale prospective cohort study · 2026 · DOI

  • While causal treatment removes the thrombus, supportive organ management keeps patients alive until it takes effect, yet clear algorithms are lacking.

    Supportive organ management in acute right ventricular failure secondary to pulmonary embolism: a narrative review · 2026 · DOI

  • Stent design might impact the patency rates, but data comparing the performance of open-cell versus closed-cell IVC stents are lacking.

    Long-term clinical outcomes of self-expandable closed-cell and open-cell stents for endovascular reconstruction of the inferior vena cava · 2026 · DOI

  • However, no studies have specifically evaluated the association between DVT and periodontitis.

    Risk of deep vein thrombosis in patients with periodontitis: A nationwide population-based cohort study in Taiwan · 2025 · DOI

  • Despite its widespread occurrence, the association between IDA and venous thromboembolism (VTE) remains inadequately characterized.

    Association between iron deficiency anemia and risk of venous thromboembolism: a multi-institutional retrospective study · 2025 · DOI

  • Introduction The predictors and consequences of dyspnea after pulmonary embolism (PE) are only rarely investigated.

    Dyspnea after a first episode of pulmonary embolism: prevalence, predictors and long-term associations with health-related quality of life · 2025 · DOI

  • No mortality rate reduction or secondary outcome benefits were observed, highlighting the need for consistent management protocols and further research on therapeutic approaches for intermediate high-risk PE.

    Management of intermediate high-risk pulmonary embolism: a single-center retrospective study · 2025 · DOI

  • Recognition of such patterns may inform further research into thromboprophylaxis and treatment of PE as a complication of cancer and cancer-directed therapy.

    Pulmonary Embolism–Related Mortality in Patients With Cancer · 2025 · DOI

  • With the increasing utility of the single-port (SP) robotic platform, there remains limited evidence surrounding the perioperative morbidity associated with the novel techniques.

    Low incidence of venous thromboembolic complications following single-port robotic surgeries for upper and lower tract urological malignancies: a report from the Single-Port Advanced Research Consortium (SPARC) · 2025 · DOI

  • This scientific statement summarizes disparities in diagnosis, treatment strategies, and outcomes related to pulmonary embolism, and reviews approaches to create equitable pulmonary embolism care and address the knowledge gaps in the literature.

    Disparities in Current Pulmonary Embolism Management and Outcomes: A Scientific Statement From the American Heart Association · 2025 · DOI

  • Inflammatory and cardiac biomarkers may predict these complications, but their role remains unclear.

    Venous thromboembolism and bleeding in cancer patients: role of inflammatory and cardiac biomarkers · 2025 · DOI

  • Known nongenetic factors alone cannot fully explain this variability, and the impact of genetic polymorphisms remains debated.

    Association of Genetic Variants With Rivaroxaban Pharmacokinetics and Pharmacodynamics and Hemorrhage Risk Factors in Patients With Venous Thromboembolism · 2025 · DOI

  • Introduction Studies on the use of direct oral anticoagulants (DOACs) for preventing venous thromboembolism (VTE) in hospitalized cancer patients are lacking.

    Efficacy and safety of direct oral anticoagulants for preventing venous thromboembolism in hospitalized cancer patients: a national multicenter retrospective cohort study · 2024 · DOI

  • Nevertheless, there have been few reports on the application of the Guidezilla GEC as a novel option for patients with massive PE when dedicated catheters and surgical thrombectomy are not available.

    Case Report: Thrombus aspiration and in situ thrombolysis via a Guidezilla guide extension catheter in a patient with high-risk pulmonary embolism · 2024 · DOI

  • Data regarding the effectiveness and safety of invasive therapies such as venoarterial extracorporeal membrane oxygenation (VA-ECMO) in this patient population remains controversial.

    Successful pharmaco-invasive approach using a lower alteplase dose and VA-ECMO support in high-risk pulmonary embolism: case report · 2024 · DOI

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303 open questions have been extracted from the limitations and future-work passages of 1,026 Venous Thromboembolism Diagnosis and Management papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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