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Open research questions in Venous Thromboembolism Diagnosis and Management

96 unresolved questions extracted from the limitations and future-work sections of 637 Venous Thromboembolism Diagnosis and Management papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Several laboratory-derived composite indices reflecting metabolic, inflammatory, thrombotic, and nutritional status have been proposed as prognostic markers in cardiovascular diseases; however, their relationship with imaging-defined RVD in acute PE remains insufficiently investigated.

    Association of Composite Metabolic, Inflammatory, and Nutritional Indices with Right Ventricular Dysfunction in Acute Pulmonary Embolism: A Retrospective Cohort Study · 2026 · DOI

  • Importance Although the YEARS algorithm is a safe and efficient way to rule out acute pulmonary embolism (PE), robust evidence on its accuracy in patients with cancer is lacking, and current guidelines suggest proceeding directly to computed tomographic pulmonary angiography (CTPA).

    YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism in Patients With Cancer · 2026 · DOI

  • Nevertheless, given the predominance of sin- gle-arm and non-randomized studies, further pro- spective randomized controlled trials are warranted to compare mechanical thrombectomy with alterna- tive treatment strategies, including catheter-directed thrombolysis and systemic thrombolysis, particular- ly with respect to long-term morbidity and mortality.

    FlowTriever-based mechanical thrombectomy for non-traumatic pulmonary embolism: a systematic review and meta-analysis · 2026 · DOI

  • Although arthroscopic procedures generally carry low postoperative VTE risk, it remains unclear whether OCP use differentially influences thromboembolic complications following upper- and lowerextremity arthroscopic procedures.

    Oral Contraceptive Use Is Associated With an Increased Risk of Venous Thromboembolism After Lower-Extremity but Not Upper-Extremity Arthroscopic Sports Procedures · 2026 · DOI

  • If the patient deteriorates hemodynamically despite the suggested intervention, or wile applying it, the use of extracorporal membrane oxygenation (ECMO) as a rescue tool is warranted, as outlined in the algorithm by Baran et al.

    Detected residual venous thrombi and catheter-directed management of intermediate-risk pulmonary thromboembolism · 2026 · DOI

  • Unfractionated heparin infusions are commonly used, sometimes with lower activated partial thromboplastin time targets, but the safety and effectiveness of lower-intensity UFH nomograms remain poorly defined.

    Comparison of safety and efficacy of lower-intensity versus standard unfractionated heparin infusion nomograms for extracranial venous thromboembolism in the neurological intensive care unit · 2026 · DOI

  • Importance: Pharmacologic thromboprophylaxis is widely used for medical inpatients, but its contemporary benefits remain uncertain for clinically relevant venous thromboembolism (VTE).

    Pharmacologic Thromboprophylaxis in Medical Inpatients · 2026 · DOI

  • Conclusion Long-term ECS may modestly reduce mild-to-moderate PTS after DVT, but their effect on severe PTS, recurrent DVT, and mortality remains uncertain.

    Effectiveness of long-term graduated compression stockings after deep vein thrombosis: a GRADE-based meta-analysis of randomized controlled trials · 2026 · DOI

  • Elastic compression stockings (ECS) are widely used for PTS prevention; however, their effectiveness remains controversial, particularly across different severities of PTS.

    Effectiveness of long-term graduated compression stockings after deep vein thrombosis: a GRADE-based meta-analysis of randomized controlled trials · 2026 · DOI

  • VTE rehabilitation despite obvious demand faces a lack of standardized protocols, a scarcity of high-quality research, and unequal access to specialized care.

    The silent legacy of venous thromboembolism: why rehabilitation is the missing link · 2026 · DOI

  • Venous thromboembolism (VTE) remains a clinically relevant and impactful complication in patients with adult-type diffuse gliomas, and its overall frequency and determinants remain poorly defined.

    Assessment of venous thromboembolism in adult-type diffuse gliomas at a quaternary neuro-oncology center: a retrospective cross-sectional study and systematic review · 2026 · DOI

  • No population-based studies directly quantify VTE incidence or outcomes in crSCI, and existing cancer or SCI risk models lack validation in this population.

    Venous Thromboembolism in Cancer-related Spinal Cord Injury: Evidence Gaps and a Roadmap for Future Research · 2026 · DOI

  • Limitations: • Retrospective design • The limited number of cancers detected after VTE diag- nosis • Lack of data regarding the duration of symptoms before VTE diagnosis, as this could also influence DD levels at VTE diagnosis.

    D-dimer levels in patients with acute venous thromboembolism and occult cancer: the DD-Neo study · 2026 · DOI

  • Clinicians require reinforced expert laboratory oversight and guided application of D-dimer testing by validated clinical decision rules to ensure accurate, timely, and safe diagnosis of VTE and PE in various patient populations.

    Hemostasis assessment in patients suspected of venous thrombosis and pulmonary embolism in the emergency setting: challenges for clinicians · 2026 · DOI

  • The adoption of age-adjusted thresholds and probability-adapted algorithms such as YEARS and PEGeD improves specificity, reduces unnecessary imaging, and optimizes resource utilization without compromising patient safety, but further implementation and validation across diverse patient populations is needed.

    Hemostasis assessment in patients suspected of venous thrombosis and pulmonary embolism in the emergency setting: challenges for clinicians · 2026 · DOI

  • Analytical differences among analytical platforms, antibody specificity, and sources of interference underscore the need for assay-specific validation, context-aware cutoffs, and standardized reporting in FEU.

    Hemostasis assessment in patients suspected of venous thrombosis and pulmonary embolism in the emergency setting: challenges for clinicians · 2026 · DOI

  • Interpretation of the current findings should take potential limitations into account. Firstly, the study population is rather small to show a statistical effect on mortality. Secondly, two different time periods were analyzed for both groups. Therefore, a historical trend cannot be ruled out. It must be noted that the effect of the evolution of anticoagulation therapy is unknown. in in (PERT) (42% each). Moreover, the conservative group, while improvement of efficiency and simplicity of However, the anticoagulation therapy by using NOACs over the past years could have positively influenced the conservative treatment of PE (21).

    Mortality in patients undergoing catheter-based therapy vs. anticoagulation alone for intermediate-high risk pulmonary embolism · 2026 · DOI

  • Evidence-based clinical guidelines are needed to maintain heightened suspicion for pulmonary embolism in the differential diagnosis of post-COVID conditions, particularly when accompanied by signs of deep vein thrombosis or disproportionate oxygen desaturation.

    Pulmonary embolism in a post-COVID-19 patient: a critical diagnostic challenge · 2025 · DOI

  • The diagnostic challenge posed by symptom overlap between long COVID (fatigue, dyspnea, chest discomfort) and pulmonary embolism needs to be addressed to reduce the likelihood of missed or postponed treatment.

    Pulmonary embolism in a post-COVID-19 patient: a critical diagnostic challenge · 2025 · DOI

  • Although certain mechanisms of thrombosis in obesity have been elucidated, the frequent fatal thrombotic consequences of severe COVID-19 remain unclear, mainly in the category of patients with obesity, carbohydrate metabolism disorders, and diabetes.

    Management of a patient with cardiac arrest: a clinical case of massive pulmonary embolism in an obese young man · 2022 · DOI

  • Accumulating studies on COVID-19 patients report high incidences of thrombotic complications, but guidance on the best diagnostic approach for suspected pulmonary embolism (PE) in COVID-19 patients is lacking.

    Challenges in the diagnostic approach of suspected pulmonary embolism in COVID-19 patients · 2021 · DOI

  • There is no consensus on the use of inferior vena cava filters; they are not recommended as a routine thromboprophylactic measure, but their placement could be considered in patients with pulmonary embolism or lower limb proximal deep vein thrombosis (especially during the first 2–4 weeks), if anticoagulants are contraindicated.

    Thromboembolism in cancer patients. What should anaesthesiologists know · 2021 · DOI

  • To clarify the contradictory results of the recent meta-analysis related to the comparison between the stated factor X inhibitors and various comparator enoxaparin regimens as well as related to the risk for symptomatic PTE and total bleeding events following major orthopedic surgery, new research will be required.

    Prevention of venous thromboembolism with rivaroxaban and apixaban in orthopedic surgery · 2020 · DOI

  • INTRODUCTION: As far as we know, left atrium (LA) imaging findings of pre-treatment and post-treatment nonmassive, submassive and massive acute pulmonary embolism (APE) have not been reported in literature.

    Assessment of the association between pre-treatment and post-treatment left atrium size and severity of disease in patients with acute pulmonary embolism by using computed tomography pulmonary angiography · 2019 · DOI

  • There is incomplete data reporting with missing percentages in key statistics (e.g., 'thrombolytic treatment was given during cardiopulmonary resuscitation in 13 (%) of these patients').

    The Results of Thrombolytic Treatment In Patients with Massive Pulmonary Embolism · 2019 · DOI

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96 open questions have been extracted from the limitations and future-work passages of 637 Venous Thromboembolism Diagnosis and Management papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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