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Open research questions in Vibrio bacteria research studies

119 gap statements mined from Vibrio bacteria research studies papers in our 4.5M-paper local library, which holds 395 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

What the literature leaves open

  • Investigate the molecular mechanisms underlying the effects of vscW deletion on Vibrio parahaemolyticus, - Examine the role of vscW in other Vibrio parahaemolyticus strains

    T3SS1 accessory protein gene vscW alters motility, biofilm formation, outer membrane homeostasis, and virulence in Vibrio parahaemolyticus · 2026 · DOI

  • Vibrio parahaemolyticus must pass through the gastric acid barrier to cause disease. Gastric acid can kill most bacteria that enter the stomach with food. The survival strategies of Vibrio parahaemolyticus under gastric acid stress are unclear.

    Transcriptome Sequencing Reveals Survival Strategies and Pathogenic Potential of Vibrio parahaemolyticus Under Gastric Acid Stress · 2025 · DOI

  • investigation of the molecular mechanisms of V. parahaemolyticus tolerance to gastric acid, - study of the effects of different food matrices on V. parahaemolyticus survival, - examination of the role of virulence genes in V. parahaemolyticus pathogenicity

    Transcriptome Sequencing Reveals Survival Strategies and Pathogenic Potential of Vibrio parahaemolyticus Under Gastric Acid Stress · 2025 · DOI

  • More studies should focus on Ría de Vigo to acquire novel or pathogenic microbes, - Further investigations on this bacterial community in previously unexplored areas should be conducted, - Studies on the ecological distribution of Vibrio in other sea areas should be carried out

    A Diverse Vibrio Community in Ría de Vigo (Northwestern Spain) · 2024 · DOI

  • One of the challenges is the complexity of the regulatory networks involved in the pathogenesis of non-O1 and non-O139 Vibrio cholerae. Another challenge is the lack of understanding of the role of climate change in altering the habitats and distribution patterns of aquatic bacteria. The paper also highlights the challenge of developing effective prevention and treatment strategies for non-O1 and non-O139 Vibrio cholerae infections.

    Non-O1/Non-O139 Vibrio cholerae—An Underestimated Foodborne Pathogen? An Overview of Its Virulence Genes and Regulatory Systems Involved in Pathogenesis · 2024 · DOI

  • There is a lack of understanding of the infection pathway and virulence factors of non-O1 and non-O139 Vibrio cholerae. The regulatory systems involved in the pathogenesis of the disease are not fully explored. There is a need for more research on the role of climate change in altering the habitats and distribution patterns of aquatic bacteria and potentially leading to more infections.

    Non-O1/Non-O139 Vibrio cholerae—An Underestimated Foodborne Pathogen? An Overview of Its Virulence Genes and Regulatory Systems Involved in Pathogenesis · 2024 · DOI

  • The relationship between macroalgae and pathogenic Vibrio spp. is not well understood. The study aims to fill this gap by investigating the presence and abundance of pathogenic Vibrio spp. across seven genera of macroalgae in a temperate estuary. The study also examines potential environmental factors influencing pathogenic Vibrio prevalence.

    Macroalgae host pathogenic Vibrio spp. in a temperate estuary · 2025 · DOI

  • Optimal allocation of a limited global OCV stock across countries with different transmission dynamics is a central operational question, yet quantitative, surveillance-based guidance is scarce.

    Time-series characterisation of cholera outbreaks and optimisation of oral cholera vaccine resource allocation in Africa, 2010–2023 · 2026 · DOI

  • However, the pH findings were mixed: neither strain showed measurable migration at pH 3, the limited migration observed for the adapted strain at pH 12 was highly variable, and both strains showed reduced growth at extreme pH.

    Prolonged CBD Exposure Is Associated with Higher Expression of flgA in Salmonella Typhimurium · 2026 · DOI

  • Because the repeated measurements were technical replicates rather than independent biological replicates, the findings are descriptive and limited to the two strains examined.

    Prolonged CBD Exposure Is Associated with Higher Expression of flgA in Salmonella Typhimurium · 2026 · DOI

  • ), relatively little is known about the distribution of multiple pathogenic Vibrio species in Lake Pontchartrain in Louisiana, the second largest estuary in the U.

    Spatiotemporal distribution and diversity of pathogenic Vibrio species in estuarine recreational waters of southeast Louisiana · 2026 · DOI

  • Functional annotation revealed enrichment of genes associated with chemotaxis, flagellar motility, regulation, metabolism, and poorly characterized functions.

    Phenotypic characterization of signature-tagged mutants identifies physiological determinants of Vibrio vulnificus fitness · 2026 · DOI

  • IMPORTANCE Vibrio vulnificus causes rapidly progressive wound infections and septicemia, yet the bacterial functions that support fitness within host environments remain incompletely defined.

    Phenotypic characterization of signature-tagged mutants identifies physiological determinants of Vibrio vulnificus fitness · 2026 · DOI

  • Both the aquatic and market environments offer conditions that support bacterial survival, colonization, and transmission, especially where hygiene control is lacking.

    Antimicrobial susceptibility of common foodborne bacteria isolated from freshwater fish · 2026 · DOI

  • The government's primary role in leading and financing preparedness and response interventions has been limited by the conflict, urging investment in community-led interventions, while moving to more strategic outbreak preparedness and response financing mechanisms remains a priority, with partner support being essential in conflict settings.

    Cholera in conflict: outbreak analysis and response lessons from Gadaref state, Sudan (2023–2024) · 2025 · DOI

  • While bile salts are known to modulate virulence gene expression, their effects on biofilm formation and motility remain unclear.

    Sodium taurocholate induces a colonization-adapted state in Vibrio parahaemolyticus by repressing acute virulence and promoting adhesion · 2025 · DOI

  • Despite a partial identification of the gut microbiota of melon-headed whales (Peponocephala electra), comparative analyses across anatomical systems are lacking.

    Vibrio spp.: a potential critical pathogen for mammals with implications beyond marine aquaculture · 2025 · DOI

  • However, no studies have carried out in-depth analyses of the O and K antigen-related gene clusters of V.

    Integrated analysis of O/K-antigen biosynthesis diversity and molecular serotyping scheme development of Vibrio alginolyticus · 2025 · DOI

  • phenotypes and genotypes in sea otters is warranted to observe biologically relevant changes in antimicrobial resistance.

    Antimicrobial resistance of Vibrio spp. from the coastal California system: discordance between genotypic and phenotypic patterns · 2025 · DOI

  • Unexpectedly, genomic classification identified an understudied species, Vibrio diabolicus , in sea otter and environmental isolates that were previously identified as Vibrio alginolyticus .

    Antimicrobial resistance of Vibrio spp. from the coastal California system: discordance between genotypic and phenotypic patterns · 2025 · DOI

  • Zooplankton play a critical role in natural systems and are known to inactivate bacteria, but their interaction with viruses is not well understood.

    Zooplankton protect viruses from sunlight disinfection · 2025 · DOI

  • berryi light organ, including its microbial constituency and specificity for microbial partners, has not been examined.

    Euprymna berryi as a comparative model host for Vibrio fischeri light organ symbiosis · 2025 · DOI

  • Despite recent discoveries regarding Class 2 and 4 OLD family nucleases and how phages overcome them, Class 1 OLD family nucleases remain underexplored, with only one antiphage Class 1 OLD family nuclease described to date.

    A DNA nicking Class 1 OLD family nuclease mediates phage defense in Vibrio cholerae and is countered by a phage-encoded inhibitor · 2025 · DOI

  • Despite their co-occurrence during infection, the interaction between these two species remains poorly understood.

    Impact of intestinal bacteria on biofilm formation, motility, virulence, and gene expression in Vibrio parahaemolyticus · 2025 · DOI

  • IMPORTANCE Although reports of non-O1/non-O139 Vibrio cholerae (NOVC) infections are rare, their actual incidence remains uncertain.

    Genomic insights into clinical non-O1/non-O139 Vibrio cholera e isolates in Japan · 2025 · DOI

Most-cited papers in Vibrio bacteria research studies

Most recent work

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This page shows what the Vibrio bacteria research studies literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 4.5M-paper local library and writes the gaps from its rows.

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119 gap statements have been mined from Vibrio bacteria research studies papers in our 4.5M-paper local library, which holds 395 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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