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Open research questions in Viral gastroenteritis research and epidemiology

142 gap statements mined from Viral gastroenteritis research and epidemiology papers in our 4.5M-paper local library, which holds 605 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

What the literature leaves open

  • the sample was limited to teachers and students from a specific class, - the sample quantity was relatively small, - there were no control samples from other classes in the same school, other schools, or the community

    Epidemiological and genetic characteristics of a sapovirus GI.6 acute gastroenteritis outbreak in Jiangxi, China · 2026 · DOI

  • The study identifies a gap in the understanding of the molecular characteristics of sapovirus and its transmission routes. There is a need for further research on the genetic evolutionary characteristics of sapovirus. The study highlights the importance of molecular typing and whole-genome sequencing in identifying the cause of outbreaks.

    Epidemiological and genetic characteristics of a sapovirus GI.6 acute gastroenteritis outbreak in Jiangxi, China · 2026 · DOI

  • the study only analyzed serum samples from pet cats and dogs, - the sample size was limited to 296 serum samples, - the study only detected GyVg1 in cats and dogs from Henan, Shaanxi, and Gansu provinces

    Genetic and recombination analysis of GyVg1 varients from companion animals in central and northwest China · 2025 · DOI

  • further studies are needed to understand the pathogenic mechanisms of GyVg1, - research on the genetic characteristics of GyVg1 is still needed, - studies on the detection of GyVg1 in other hosts are required

    Genetic and recombination analysis of GyVg1 varients from companion animals in central and northwest China · 2025 · DOI

  • The study only collected samples from Yunnan Province, China, - The sample size for some species was limited, - The study did not investigate the transmission pathways of RVA

    Diversity and Potential Cross-Species Transmission of Rotavirus A in Wild Animals in Yunnan, China · 2025 · DOI

  • Social network analysis has been applied to simple transmission systems, but empirical applications to wild, multi-species systems are scarce.

    Co-occurrence networks from wetland bird surveys predict H5N1 genetic similarity between wild birds with strong effects of time, space and viral clustering. · 2026 · DOI

  • This study was conducted to expand the limited knowledge regarding the detection, molecular characterization, and epidemiology of feline calicivirus (FCV) in Türkiye by examining viral pathogens associated with ulcerative stomatitis in cats.

    Sustained circulation of genotype I and the first whole-genome sequencing of feline calicivirus in Turkish cats · 2026 · DOI

  • However, the mechanism underlying its induction of spleen injury remains to be elucidated.

    GoAstV Induced Mitophagy and Ferroptosis in the Spleen of Goslings · 2026 · DOI

  • ABSTRACT Human norovirus (HuNoV) is a leading cause of acute viral gastroenteritis, but despite high impact on public health and healthcare, the mechanisms of viral attachment to and entry into target cells are not yet fully understood.

    Bile acids accumulate norovirus-like particles and enhance binding to and entry into human enteric epithelial cells · 2026 · DOI

  • Human bile acids indirectly promote norovirus entry into and infection of human enteroids, but the direct effect of bile acids on attachment and uptake, along with the impact of other gastrointestinal fluids, remains unknown.

    Bile acids accumulate norovirus-like particles and enhance binding to and entry into human enteric epithelial cells · 2026 · DOI

  • IMPORTANCEHuman noroviruses are the leading cause of acute viral gastroenteritis worldwide, yet individuals experience repeated infections throughout life, indicating that protective immunity is incomplete and remains poorly understood.

    Norovirus-specific monoclonal antibodies that block histo-blood group antigen binding isolated from healthy donors · 2026 · DOI

  • However, whether the same HuNoV-positive stool specimens replicate similarly in both systems has not been examined.

    Comparison of human intestinal enteroid and zebrafish larva models for replication of human norovirus · 2026 · DOI

  • The results also provide scientific evidence to improve treatment and disinfection processes and to support further research on the infectivity of detected viruses.

    Investigation of the presence of human adenovirus, norovirus, and rotavirus in tap water in Marrakech, Morocco · 2026 · DOI

  • As the first investigation of its kind in Marrakech, it provides essential baseline data in a context where such information is scarce in Morocco.

    Investigation of the presence of human adenovirus, norovirus, and rotavirus in tap water in Marrakech, Morocco · 2026 · DOI

  • So far, no standard cultivation tool is available for detecting viable hNoV, resulting in the challenges of evaluating inactivation effectiveness of various disinfection technologies, including UV 222 treatments.

    Evaluation of ultraviolet irradiation at 254 nm and 222 nm in inactivating human noroviruses on surfaces · 2026 · DOI

  • However, the molecular basis of norovirus-bacteria interactions remains poorly understood.

    A single amino acid in the viral capsid makes a major contribution to the interaction between human norovirus GII.6 and the bacterial Psl exopolysaccharide · 2026 · DOI

  • However, limited information is available regarding AGE in Yunnan, Southwest China.

    Prevalence and genetic characterization of viral gastroenteritis in hospitalized children aged <5 years in Yunnan Province, China, 2020–2022 · 2025 · DOI

  • However, few studies have focused on how the interaction between intestinal bacteriophages and bacterial LPS affects the development and progression of NAFLD.

    Butyrate Regulates Intestinal DNA Virome and Lipopolysaccharide Levels to Prevent High-Fat Diet-Related Liver Damage in Rats · 2025 · DOI

  • However, the regulatory function of Paneth cells under pathological conditions, such as RV infection, remains unclear.

    Paneth cells inhibit intestinal stem cell proliferation through the bone morphogenic protein 7 pathway under rotavirus-mediated intestinal injury · 2025 · DOI

  • These findings will be useful for the development of diagnostic kits for GoAstV-2 and will aid further research on the structure and function of the capsid protein.

    Identification of a novel linear B-cell epitope recognized by a monoclonal antibody against the capsid protein of goose astrovirus genotypes 2 · 2025 · DOI

  • This study provides valuable insights into the molecular epidemiology, genetic diversity and evolutionary dynamics of BKV, offering an important reference for developing diagnostics, vaccines and further studies on its pathogenesis.

    Genomic sequencing and evolutionary analysis of bovine kobuvirus in Yunnan Province, China · 2025 · DOI

  • Future research should focus on broader sampling and molecular characterization to understand genetic diversity and devise effective control measures.

    Detection and characterization of bovine coronavirus and rotavirus in calves in Ethiopia · 2025 · DOI

  • Despite its global prevalence and five genotypes, the virus’s pathogenic mechanism is not well understood due to difficulties in isolating and culturing it in vitro.

    Isolation and identification of a new porcine astrovirus 5 demonstrated that oxidative stress enhances porcine astrovirus replication · 2025 · DOI

  • Antibody responses appear to play an important role in protection from HAstV infection; however, knowledge about the neutralizing epitope landscape is lacking, as only three neutralizing antibody epitopes have previously been determined.

    Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization · 2025 · DOI

  • Despite the prevalence of human astroviruses, little is known about how antibodies block virus infection.

    Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization · 2025 · DOI

Most-cited papers in Viral gastroenteritis research and epidemiology

Most recent work

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142 gap statements have been mined from Viral gastroenteritis research and epidemiology papers in our 4.5M-paper local library, which holds 605 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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