Science AI Journal
Medicine · Research topic

Open research questions in Wound Healing and Treatments

214 unresolved questions extracted from the limitations and future-work sections of 729 Wound Healing and Treatments papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Further development of purpose-designed lactic acid-optimized hydrogel systems is suggested, - Refinement of pH stabilization precision, lactate diffusion control, mucoadhesive retention, and targeted release kinetics may be explored, - Continued development of hydrogel-based platforms specifically engineered for postpartum perineal repair is supported

    Lactic Acid-Loaded Hydrogels for Post-Episiotomy Wound Healing: Microenvironment Engineering and Regenerative Strategies—A Narrative Review · 2026 · DOI

  • Investigate the effects of scutellarein on primary dermal fibroblasts, - Examine the chronic hyperglycemic milieu of diabetic wounds, - Study the role of scutellarein in other types of wounds or diseases

    Scutellarein promotes diabetic wound repair and preserves fibroblast calcium-mitochondrial homeostasis · 2026 · DOI

  • The lack of understanding of the mechanisms underlying diabetic wound repair. The need for therapeutic agents that can promote wound healing and preserve fibroblast function. The gap in current research on the effects of scutellarein on diabetic wound repair and fibroblast calcium-mitochondrial homeostasis.

    Scutellarein promotes diabetic wound repair and preserves fibroblast calcium-mitochondrial homeostasis · 2026 · DOI

  • Investigate the effects of crude LSE on wound healing in vivo. Compare the effects of crude LSE with other wound healing agents. Evaluate the long-term effects of crude LSE on wound healing.

    In vitro assessment of cell proliferation and migration induced by crude lychee seed extract in human gingival fibroblast cells (HGF-1) · 2026 · DOI

  • The lack of understanding of the effect of crude lychee seed extract on human gingival fibroblast cells. The need to characterize the phenolic and flavonoid composition of crude lychee seed extract. The need to evaluate the cytotoxicity and efficacy of crude lychee seed extract on human gingival fibroblast cells.

    In vitro assessment of cell proliferation and migration induced by crude lychee seed extract in human gingival fibroblast cells (HGF-1) · 2026 · DOI

  • further studies are needed to confirm the efficacy of BTM, - studies should investigate the cost-effectiveness of BTM, - research should focus on optimizing BTM treatment protocols

    Accelerated Wound Healing with a Bilayer Biodegradable Synthetic Matrix in Post-Surgical Diabetes-Related Foot Wounds: A Randomised Controlled Trial · 2026 · DOI

  • There is a lack of clinical trials concerning the treatment of severe acute post-surgical diabetes-related foot wounds. Most published clinical trials concern the treatment of chronic diabetes-related foot wounds.

    Accelerated Wound Healing with a Bilayer Biodegradable Synthetic Matrix in Post-Surgical Diabetes-Related Foot Wounds: A Randomised Controlled Trial · 2026 · DOI

  • The heterogeneity in reporting and definition of complications makes it difficult to perform a meta-analysis. The lack of standardized reporting on complications and mortality associated with CEAs is a challenge. The availability of data on treatment-related complications is limited.

    Forty Years Later—Complications and Mortality Associated with Cultured Epithelial Autografts in Burn Patients: A Systematic Review · 2026 · DOI

  • There is a lack of standardized reporting on the complications and mortality associated with CEAs. There is a need for prospective long-term follow-up to better define the safety and effectiveness of CEAs. The available evidence is largely derived from retrospective case series and heterogeneous study populations.

    Forty Years Later—Complications and Mortality Associated with Cultured Epithelial Autografts in Burn Patients: A Systematic Review · 2026 · DOI

  • The need for consistent quality and scale in the production of green-synthesized silver nanoparticle hydrogels. The requirement for rigorous clinical trials to evaluate the efficacy and safety of AgNP hydrogels. The challenge of translating laboratory performance into reliable clinical outcomes.

    Green-synthesized silver nanoparticle hydrogels for biofilm-infected wounds: Bridging sustainability and clinical translation · 2025 · DOI

  • Substantial heterogeneity across trials indicates the need for more rigorous, head-to-head comparisons with current best practices - The limitations of comparator choice and sample size highlight the necessity of larger RCTs across diverse chronic wounds complicated by biofilm - Consistency across batches, validated Ag + release kinetics, and transparent manufacturing protocols will determine whether these formulations can move beyond research

    Green-synthesized silver nanoparticle hydrogels for biofilm-infected wounds: Bridging sustainability and clinical translation · 2025 · DOI

  • exploring therapeutic strategies employed in the reduction and prevention of scarring conditions, - investigating the role of TGF-β3 in scar treatment

    Scarring Skin: Mechanisms and Therapies · 2024 · DOI

  • The underlying mechanisms of skin scarring are not well understood. The current treatments for scarring are limited, and more effective therapies are needed. The role of fibroblast heterogeneity in scar formation is not fully elucidated.

    Scarring Skin: Mechanisms and Therapies · 2024 · DOI

  • further clinical trials are needed, - the absence of a basement membrane in synthetic substitutes is a notable drawback, - the study is based on existing research and does not present new experimental data

    Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges · 2024 · DOI

  • further clinical trials to allow the use of skin substitutes in the personalized treatment of chronic wounds, - development of new skin substitutes with improved properties, - investigation of the immune reaction to skin substitutes, - exploration of the use of 3D bio-printing and electrospinning in skin substitute production

    Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges · 2024 · DOI

  • The lack of studies on the effects of tomato-derived nanovesicles on wound healing. The need for sustainable and natural products for wound healing applications.

    Solanum lycopersicum (Tomato)-Derived Nanovesicles Accelerate Wound Healing by Eliciting the Migration of Keratinocytes and Fibroblasts · 2024 · DOI

  • Whilst the function of these distinct factors has previously been studied individually, how they operate together, synergistically or not, is not fully characterized.

    Distinct regulation of collagen biosynthesis by hypoxia and vitamin C uncovers an essential role for CXCL12-CXCR4 signaling · 2026 · DOI

  • Evidence on bromelain-based enzymatic debridement involving treatment areas greater than 15% total body surface area (TBSA) remains scarce.

    Sequential Bromelain-Based Enzymatic Debridement in a Near-Total (97%) TBSA Burn: A Case Report · 2026 · DOI

  • However, approaches for delivering mitochondria to achieve optimized wound repair remain lacking.

    Inhibition and Rescue of Hyperglycemia‐Induced Cellular Senescence by Mitochondrial Transfer from Enucleated Mesenchymal Stem Cell‐Derived Microvesicles for Chronic Wound Healing · 2025 · DOI

  • The development of reactive oxygen species (ROS)-based antibacterial strategies that overcome ROS's ultrashort diffusion distance and disrupt bacterial electron transfer represents a promising yet underexplored avenue for nonantibiotic therapies.

    Bimetallic Metal–Organic Framework Microneedle Array for Wound Healing through Targeted Reactive Oxygen Species Generation and Electron Transfer Disruption · 2025 · DOI

  • For example, the composition and function of skin microbiota are affected by many factors, and there are relatively few studies on other microorganisms such as fungi and viruses.

    Skin microbiota and diabetic foot ulcers · 2025 · DOI

  • The main components of topical radiation protection preparations currently available on the market are antioxidants, such as SOD, which are limited by their unstable activity and short duration of action, making it difficult to achieve the effects of radiation protection and skin radiation damage treatment.

    X-ray Responsive Antioxidant Drug-Free Hydrogel for Treatment of Radiation Skin Injury · 2025 · DOI

  • Oncostatin M (OSM) has various biological activities through OSM receptor β (OSMRβ) in many conditions such as inflammation and tissue regeneration, but it remains elusive on its precise roles in skin wound healing.

    OSMRβ-mediated signals on resident fibroblasts restore healing in diabetic skin wounds through promoting angiogenesis and granulation tissue formation · 2025 · DOI

  • The small GTPase RhoA is key for cell migration, but the molecular mechanisms controlling Rho proteins in keratinocytes remain incompletely characterized.

    Keratinocyte-derived VEGF-A is an essential pro-migratory autocrine mediator, acting through the KDR/GEF-H1/RhoA pathway · 2025 · DOI

  • We have shown that the expression of the antimicrobial protein, perforin-2 (P-2) in skin GDTs is decreased in DFUs, but the specific roles of GDTs in the DFU microenvironment remain unclear.

    A distinctive skin gamma delta T cell repertoire in diabetic wound repair 2121 · 2025 · DOI

Most-cited papers in Wound Healing and Treatments

Most recent work

Find a gap in your own Wound Healing and Treatments sub-topic

This page shows what the Wound Healing and Treatments literature already flags as unresolved. To narrow it to your specific question, run the guided finder — it searches the gap library on demand and checks candidates against 250M+ OpenAlex works.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
2,044 open questions
Substance Abuse Treatment and Outcomes
1,964 open questions
Smoking Behavior and Cessation
990 open questions
Dementia and Cognitive Impairment Research
974 open questions
Innovations in Medical Education
960 open questions
Physical Activity and Health
923 open questions
Attention Deficit Hyperactivity Disorder
839 open questions
Schizophrenia research and treatment
709 open questions
214 open questions have been extracted from the limitations and future-work passages of 729 Wound Healing and Treatments papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? A Tier 1–5 acceptance probability in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck prior-publication & salami-slicing risk across 8 sources.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.