Accordingly, the findings may be most directly applicable

The gap

Evidence profile

Stated in the limitations and inline gaps sections of the source papers, classified as general, spanning 3 journals. Those papers have been cited 1 times in total.

Supporting evidence — 4 representative gaps

• Osteoporotic fractures prediction in Chinese postmenopausal women: a machine learning-based multi-dimensional approach (2026) · Frontiers in Endocrinology · cited 1× · doi

  Several limitations should be considered. First, as this study focused on biomarker exploration, the model was not directly ®, leaving compared with the clinical gold standard FRAX its incremental value within existing frameworks to be clarified. Second, the cohort mainly comprised Han Chinese postmenopausal women from Northwestern China, limiting generalizability to other ethnic or regional populations. Third, the retrospective design relying on electronic medical records did not capture dynamic lifestyle factors such as falls, diet, or physical activity, potentially omitting relevant predictors. Finally, model validation was restricted to internal and local external datasets, lacking multicentric prospective confirmation. Future studies should incorporate perform multi-population prospective validations, in realdynamic variables, and evaluate integration with FRAX world clinical settings.

  generalstated in limitationsevidence 5/5
  Keywords: model clinical frax dynamic prospective several limitations considered first focused biomarker exploration directly leaving compared
• A serum exosomal four-miRNA signature for the diagnosis of central precocious puberty: a discovery and validation study (2026) · Frontiers in Pediatrics · doi

  study has should be acknowledged. First, the sample size, while sufficient for a requires discovery and validation expansion to confirm large-scale, multi-center cohorts in generalizability across different ethnicities. Second, regarding the mechanistic insights, we acknowledge that this study primarily focused on biomarker discovery and diagnostic model construction.

  generalstated in limitationsevidence 5/5
  Keywords: discovery acknowledged first sample size cient requires validation expansion large scale multi center cohorts generalizability
• Analysis of risk factors for heart failure in patients with type 2 diabetes mellitus and acute ST-segment elevation myocardial infarction after percutaneous coronary intervention (2026) · Frontiers in Medicine · doi

  Future prospective, multi-center, large-scale cohort studies that incor- porate serial dynamic biomarkers and detailed procedural and treat- ment data are warranted to validate, refine, and enhance the clinical applicability of this prediction model. Future prospective, multi- center, large-scale cohort studies that incorporate serial dynamic biomarkers, detailed procedural and treatment data, and independent external validation are warranted to validate, refine, and enhance the clinical applicability of this prediction model.

  generalstated in inline gapsevidence 5/5
  Keywords: future prospective multi center large scale cohort serial dynamic biomarkers detailed procedural warranted validate refine
• Metabolic, inflammatory, and lipoprotein(a)-related risk profiling for incident ASCVD: a multi-biomarker study (2026) · Frontiers in Endocrinology · doi

  Accordingly, the findings may be most directly applicable to individuals with available measurements of these biomarkers, and validation in cohorts with systematic biomarker assessment is warranted. External validation in multi-ethnic and multicentre cohorts is warranted before these biomarker profiles are incorpo- rated into routine clinical risk assessment.

  generalstated in limitationsevidence 5/5
  Keywords: validation cohorts biomarker assessment warranted accordingly ndings directly applicable individuals available measurements biomarkers systematic external

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