Investigate the effect of vitamin D supplementation

The gap

Evidence profile

Stated in the limitations and inline gaps and cells future research sections of the source papers, classified as general, spanning 5 journals.

Supporting evidence — 6 representative gaps

• Functional and Symptomatic Effects of Vitamin D Supplementation Following Carpal Tunnel Release: A Randomized Controlled Trial (2026) · Journal of Southeast Asian Orthopaedics · doi

  This study had several limitations. First, serum vitamin D levels were not measured before or after treatment, which precludes analysis of whether baseline deficiency or achieved serum concentrations influenced the outcomes. However, epidemiological studies in Thailand and other Asian populations have shown that vitamin D insufficiency common, particularly among urban residents and women, thus providing a clinical context for evaluating vitamin D supplementation. However, the absence of biochemical assessments remains an important limitation. relatively remains Second, the 12-week follow-up period may not have been sufficient to capture longer-term motor recovery or the potential delayed benefits of supplementation. Third, the relatively small sample size may have limited the statistical power to detect subtle intergroup differences.

  generalstated in limitationsevidence 5/5
  Keywords: vitamin serum supplementation remains relatively several limitations first levels measured treatment precludes whether baseline deficiency
• Prevalence of Hypovitaminosis D Among Patients With Type 2 Diabetes Mellitus: Evidence From a Diabetes Clinic in Durgapur, West Bengal (2026) · Cureus · doi

  The use of multivariable logistic regression enabled adjustment for potential confounders and the identification of independent predictors of hypovitaminosis D. However, because this was a hospital-based cross-sectional study, the findings may not be fully generalizable to the broader community. The relatively high absolute error (10%) used in sample size calculation resulted in a modest sample size. Berksonian bias may also have influenced the findings. Additionally, the cross-sectional design precludes causal inference regarding the relationship between vitamin D status and microvascular complications. Biochemical markers such as parathyroid hormone, serum calcium, phosphate, and inflammatory markers were not assessed, which limits mechanistic interpretation. Further multicentric studies with larger sample sizes are recommended to improve external validity and confirm these findings.

  generalstated in limitationsevidence 5/5
  Keywords: sample cross sectional size markers multivariable logistic regression enabled adjustment potential confounders identification independent predictors
• Relationship Between Serum Vitamin D Levels and Clinical Findings: What We Know and Unknown in Pediatric Cases (2026) · Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi · doi

  The main limitation of this study is its retrospective design. Additionally, by checking the hospital information system or pharmacy information system, the possibility of RRIs in the patient should be investigated. Furthermore, due to the observational nature of the study, causal relationships between vitamin D levels and the evaluated symptoms and clinical findings could not be established.

  generalstated in inline gapsevidence 5/5
  Keywords: information system main limitation retrospective design additionally checking hospital pharmacy possibility rris patient investigated observational
• Intervention methods and influencing factors of vitamin D deficiency in Northeast China: a self-controlled trial and randomized controlled trial study (2026) · Frontiers in Nutrition · doi

  From a precise nutrition perspective, children with different SNP genotypes and different dietary vitamin D intakes differ in their sensitivity to vitamin D supplementation, warranting further research on genotype-specific vitamin D requirements. a for Third, are only although these genetic-related differences foundation for preliminary further research on precise nutrition for children living in high-latitude regions.

  generalstated in inline gapsevidence 5/5
  Keywords: vitamin precise nutrition children erent further perspective genotypes dietary intakes sensitivity supplementation warranting genotype speci
• Prevalence, predictors, and clinical impact of vitamin D deficiency on 12-month outcomes in hip fracture patients (2026) · Journal of Endocrinological Investigation · doi

  Further studies are needed to investigate the effect of vitamin D supplementation on outcomes in hip fracture patients. - Studies are needed to develop and validate practical tools for identifying patients at highest risk of vitamin D deficiency. - Research is needed to investigate the relationship between vitamin D deficiency and skeletal fragility in other populations.

  generalstated in cells future researchevidence 4/5
  Keywords: further studies needed investigate effect vitamin supplementation outcomes
• Functional and Symptomatic Effects of Vitamin D Supplementation Following Carpal Tunnel Release: A Randomized Controlled Trial (2026) · Journal of Southeast Asian Orthopaedics · doi

  Further research is needed to investigate the effects of different doses and durations of vitamin D supplementation on musculoskeletal and neurological health. - Studies with larger sample sizes and longer follow-up periods are needed to capture long-term effects. - Research into the mechanisms by which vitamin D supplementation affects musculoskeletal and neurological health is needed.

  generalstated in cells future researchevidence 4/5
  Keywords: further research needed investigate effects different doses durations

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