Science AI Journal
Medicine · Research topic

Open research questions in Drug-Induced Adverse Reactions

115 gap statements mined from Drug-Induced Adverse Reactions papers in our 4.5M-paper local library, which holds 854 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Drug-Induced Adverse Reactions? See the ranked Medicine journals.

What the literature leaves open

  • The study notes that prior literature has reported on the characteristics of FDE, but a more detailed analysis is needed.

    Adult fixed drug eruptions in hospitalized patients: a retrospective review · 2026 · DOI

  • The incidence and characteristics of hypersensitivity reactions to iodinated contrast media are not well understood. There is a need to characterize patients with a history of iodinated contrast media allergy. The potential cross-reactivity between different iodinated contrast media agents is not well studied.

    Characterization of Hypersensitivity to Iodinated Contrast Media: Insights from a Six-Year Cohort of 26,465 Procedures · 2025 · DOI

  • While structured delabeling interventions are safe and effective, their translation into routine care across different healthcare settings remains unclear.

    Penicillin allergy delabeling in a German University Hospital—implementation in inpatient settings: the PenGuin Pilot Study · 2026 · DOI

  • Postoperative morbidity after suspected grade III POH when surgery is completed remains uncertain.

    Postoperative morbidity after suspected grade III perioperative immediate hypersensitivity reactions with completed surgery: a matched case–control study · 2026 · DOI

  • Although the pathomechanisms have not yet been fully elucidated, it has been reported that some cases were triggered by viral infections, vaccines, or drugs.

    Drug‐Induced Blaschkitis Associated With Dipeptidyl Peptidase‐4 Inhibitor: A Case Report and Review of the Literature · 2026 · DOI

  • There is no consensus regarding the treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

    Stevens‐Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Current Management and Innovative Therapies · 2025 · DOI

  • The Janus kinase (JAK) pathway has been implicated in its pathogenesis, albeit evidence supporting the therapeutic potential of JAK inhibitors in treating LPP remains scarce.

    Treatment of Lichen Planopilaris With Abrocitinib · 2025 · DOI

  • The pathogenesis of LPP is not fully understood but is considered an autoimmune disease in which the IFNγ-induced bulge immune privilege (IP) collapse plays a significant role.

    Treatment of Lichen Planopilaris With Abrocitinib · 2025 · DOI

  • The specific characteristics of severe adverse reactions caused by ICIs remain unclear.

    Clinical characteristics of Stevens-Johnson syndrome/toxic epidermal necrolysis-like reactions induced by immune checkpoint inhibitors · 2025 · DOI

  • A key limitation of the penicillin de-labelling service was the strict inclusion criteria, which restricted the number of patients eligible for the DPT.

    (ID: 270) Implementation and evaluation of a penicillin de-labelling service at King’s College Hospital · 2025 · DOI

  • Research on physical symptoms experienced during acute hospitalization is well documented, but limited studies have been completed on the long-term biopsychosocial effects of SJS/TEN, particularly from the patient's perspective.

    Recovering From Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis · 2025 · DOI

  • The underlying immunopathogenesis remains unclear, potentially involving mast cell activation or superantigen-like effects.

    Minocycline‐Induced Delayed Dermographism With Tolerance to Doxycycline · 2025 · DOI

  • Despite the frequent need for antipyretic and analgesic therapy, the impact of nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen on clinical outcomes in patients with SJS/TEN remains unclear.

    Comparative Impact of NSAIDs Versus Acetaminophen on Mortality in Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Retrospective Cohort Study of 2484 Patients From a Nationwide Inpatient Database · 2025 · DOI

  • However, their role in predicting severity and mortality in Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) remains unclear.

    The Predictive Value of Inflammatory Markers in the Severity and Mortality Risk of Stevens‐Johnson Syndrome/Toxic Epidermal Necrolysis · 2025 · DOI

  • Despite its link to suboptimal adherence and uncontrolled blood pressure, MDIS in the context of hypertension remains insufficiently explored.

    Multiple drug intolerance in antihypertensive patients: what is known and what is missing · 2024 · DOI

  • Lack of standardization in the prevention, management, and reporting of IRRs across cancer-treating institutions represents not only a quality and safety gap but also a disparity in cancer care.

    Management of infusion-related reactions in cancer therapy: strategies and challenges · 2024 · DOI

  • Future studies are needed to construct models to estimate long-term outcomes and sequelae in patients with EN.

    Incidence, In-Hospital and Long-Term Mortality, and Sequelae of Epidermal Necrolysis in Adults · 2024 · DOI

  • While in-hospital mortality rates range from 15% to 20%, contributors to long-term mortality have been rarely evaluated and remain unknown.

    Incidence, In-Hospital and Long-Term Mortality, and Sequelae of Epidermal Necrolysis in Adults · 2024 · DOI

  • AKI is associated with a high incidence in TEN cases, but the full manifestation remains unclear.

    A Case of Allopurinol-Induced Toxic Epidermal Necrolysis Complicated by Kidney Failure · 2024 · DOI

  • The study aims to investigate the association between HLA class I and II alleles, CYP2C9 polymorphisms, and NSAID-induced SJS/TEN in a Thai population.

    Genetic Variants Associated with Non-Steroidal Anti-Inflammatory Drug-Induced Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis · 2026 · DOI

  • Severe cutaneous adverse reactions (SCARs) encompassing Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS) and acute generalized exanthematous pustulosis (AGEP) are increasingly reported among patients treated with novel antiandrogens, but the signals of disproportionate reporting and clinical features remain inadequately defined.

    Severe cutaneous adverse reactions associated with novel antiandrogens: A disproportionality analysis of three databases · 2025 · DOI

  • DIHS is often challenging to diagnose in its early stages, and its clinical course varies widely, ranging from relatively mild to life-threatening cases.

    Guidelines for the management of drug‐induced hypersensitivity syndrome 2023 · 2025 · DOI

  • While increased short-term mortality in this group is well documented, few studies have quantified this risk over extended follow-up.

    Toxic Epidermal Necrolysis and Mortality: A Danish Cohort Study With 30 Years of Follow‐Up · 2025 · DOI

  • Future studies should investigate the associations between NSAID-induced SJS/TEN and genetic polymorphisms in other populations - Future studies should evaluate the role of HLA-DP in NSAID-induced SJS/TEN - Future studies should investigate the mechanisms underlying the associations between HLA alleles and NSAID-induced…

    Genetic Variants Associated with Non-Steroidal Anti-Inflammatory Drug-Induced Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis · 2026 · DOI

  • In the Asia-Pacific region, screening practices vary widely due to infrastructure gaps, cost concerns, and differing health policies.

    HLA-B*58:01 screening in Asia-Pacific is an ethical imperative – not just a cost question · 2025 · DOI

Most-cited papers in Drug-Induced Adverse Reactions

Most recent work

Find a gap in your own Drug-Induced Adverse Reactions sub-topic

This page shows what the Drug-Induced Adverse Reactions literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 4.5M-paper local library and writes the gaps from its rows.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
2,876 open questions
Substance Abuse Treatment and Outcomes
2,034 open questions
Dementia and Cognitive Impairment Research
1,793 open questions
Cancer Immunotherapy and Biomarkers
1,619 open questions
Sports Performance and Training
1,473 open questions
Liver Disease Diagnosis and Treatment
1,423 open questions
Ferroptosis and cancer prognosis
1,343 open questions
Physical Activity and Health
1,253 open questions
Open questions raised by papers listed on this page include: (1) The study notes that prior literature has reported on the characteristics of FDE, but a more detailed analysis is needed (“Adult fixed drug eruptions in hospitalized patients: a retrospective review”, 2026); (2) While structured delabeling interventions are safe and effective, their translation into routine care across different healthcare settings remains unclear (“Penicillin allergy delabeling in a German University Hospital—implementation in…”, 2026); (3) Although the pathomechanisms have not yet been fully elucidated, it has been reported that some cases were triggered by viral infections, vaccines, or drugs (“Drug‐Induced Blaschkitis Associated With Dipeptidyl Peptidase‐4 Inhibitor: A…”, 2026); (4) The incidence and characteristics of hypersensitivity reactions to iodinated contrast media are not well understood (“Characterization of Hypersensitivity to Iodinated Contrast Media: Insights from…”, 2025); (5) There is no consensus regarding the treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) (“Stevens‐Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Current…”, 2025). 115 gap statements have been mined from Drug-Induced Adverse Reactions papers in our 4.5M-paper local library, which holds 854 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? Acceptance odds for top, mid and open/emerging journals, in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck for prior publication across 7 sources and our local library.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

How Pre-Check worksHow AI Review works

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.