Open research questions in Drug-Induced Adverse Reactions
65 unresolved questions extracted from the limitations and future-work sections of 321 Drug-Induced Adverse Reactions papers in our library. Each links back to the study that raised it.
What the literature leaves open
The patient's advanced age and poor vascular access conditions posed significant challenges to nursing care. The patient's bedridden status due to fracture resulted in impaired local blood circulation and further damage to the skin barrier function.
There is a lack of specific guidelines for the nursing care of elderly patients with toxic epidermal necrolysis. The disease poses significant challenges to nursing care, particularly in patients with compromised immunity and multiple comorbidities.
The current diagnostic methods for sulfonamide allergy are limited and often disappointing. There is a lack of standardized methods to measure the N4 and N1 positions, which are important in some hypersensitivity reactions. The PGx evidence for DIHRs for sulfonamides has not been extensively studied.
The Role of In Vivo, In Vitro and Pharmacogenomic Diagnostic Approaches to Sulfonamide Allergy · 2026 · DOIThere is limited knowledge of hypersensitivity reactions induced by biological drugs. There is a need for further research on the management of hypersensitivity reactions to evolocumab.
Evolocumab-induced delayed skin hypersensitivity reaction in a patient with familial hypercholesterolaemia · 2024 · DOIFurther studies are needed to develop more effective diagnostic methods for sulfonamide allergy. The paper's findings highlight the importance of considering pharmacogenomic associations in the diagnosis and treatment of sulfonamide allergy. Additional research is needed to fully understand the mechanisms of hypersensitivity reactions to sulfonamide antibiotics.
The Role of In Vivo, In Vitro and Pharmacogenomic Diagnostic Approaches to Sulfonamide Allergy · 2026 · DOIThe lack of understanding of the risks of allopurinol treatment for asymptomatic hyperuricaemia. The need for alternative treatments for asymptomatic hyperuricaemia.
The mechanisms of cutaneous reactions to captopril are not fully understood. The incidence and characteristics of severe cutaneous reactions to captopril are not well described.
There is a lack of controlled studies comparing the effectiveness of erythromycin and isoniazid in treating BCG reactions. The natural resolution of the lesions is not well understood.
Comparison of erythromycin and isoniazid in treatment of adverse reactions to BCG vaccination. · 1985 · DOIThere is a lack of awareness of zinc deficiency in patients treated with anticonvulsants. The diagnosis of zinc deficiency is difficult and usually rests on the clinical picture and response to zinc treatment.
There is a lack of evidence on the nature and magnitude of the effects of prolonged use of OTC hydrocortisone. There is a need for studies to assess the safety and efficacy of OTC hydrocortisone.
Further study of the mechanisms involved in Wegener's granulomatosis. Investigation of the use of antiplatelet agents and prostacyclin analogues in preventing thrombotic complications.
The assumption that development of a rash is a contraindication to further use of sulphasalazine has not been challenged. There is a lack of methods for desensitising patients who have had a rash or fever after taking sulphasalazine.
There is a lack of reporting on allergic reactions to Disulfiram implants. The authors identify a need for a pre-operative regime to avoid such reactions.
The lack of knowledge about the side effects of high-dose twice-weekly rifampicin. The need to identify the association between antibodies to rifampicin and side effects.
There is a need to identify predisposing factors for adverse reactions in hospital patients. Previous studies have found conflicting results on the relationship between age, sex, and adverse reactions.
The paper identifies a gap in the understanding of the risks associated with the use of noradrenaline in patients with severe peripheral circulatory failure.
Small sample size. Limited information on the patients' medical histories and concomitant medications.
The rarity of gastrointestinal complications in Wegener's granulomatosis. The lack of understanding of the mechanisms involved in the disease.
Investigating the long-term effects of desensitisation. Studying the mechanism of desensitisation to sulphasalazine.
The study only reports on one patient. The pathogenesis of the patient's skin reaction is unknown.
The pathogenesis of levamisole-induced cutaneous necrotising vasculitis is unknown. The toxicity of levamisole has not been well-studied.
The mechanism of acute hypersensitivity reactions to paracetamol is not clear. The role of excipients in the reactions is not well understood. The incidence of photosensitivity reactions to azapropazone is not well established.
The high incidence of ulceration induced by piroxicam is not well understood. Clinical trials may have underestimated the incidence of serious gastrointestinal side effects.
The incidence of photosensitivity reactions to azapropazone is not well established. The proportion of photosensitivity reactions to azapropazone is not well understood.
The mechanism by which the tissue damage occurs remains unknown. The long-term prognosis of patients with oculomucocutaneous syndrome is not well understood.
Untoward effects associated with practolol administration: oculomucocutaneous syndrome. · 1975 · DOI
Most-cited papers in Drug-Induced Adverse Reactions
- Diagnosis, classification, and management of erythema multiforme and Stevens-Johnson syndrome · Archives of Disease in Childhood · 2000 · 189 citations
- Spatial proteomics identifies JAKi as treatment for a lethal skin disease · Nature · 2024 · 129 citations
- A review of causes of Stevens–Johnson syndrome and toxic epidermal necrolysis in children · Archives of Disease in Childhood · 2013 · 106 citations
- Eptinezumab: First Approval · Drugs · 2020 · 56 citations
- Mechanisms, Management and Prevention of Pemetrexed-Related Toxicity · Drug Safety · 2021 · 34 citations
- Hydroxychloroquine- A New Treatment Option for Erosive Oral Lichen Planus · Indian Journal of Dental Research · 2021 · 19 citations
- Clinical Evaluation of Efficacy of Triamcinolone Acetonide with Tacrolimus in the Management of Oral Lichen Planus · Contemporary Clinical Dentistry · 2022 · 10 citations
- Drug-induced Stevens–Johnson syndrome in Indian population: A multicentric retrospective analysis · Nigerian Journal of Clinical Practice · 2017 · 9 citations
- Infusion reactions to rituximab administration: algorithm of management · KIDNEYS · 2022 · 4 citations
- An overview of penicillin allergies for nurses · Nursing · 2023 · 3 citations
Most recent work
- Nursing care of an elderly patient with toxic epidermal necrolysis: a case report · Frontiers in Medicine · 2026
- A case of bullous fixed drug eruption induced by tenofovir disoproxil fumarate/ emtricitabine · Annales de Dermatologie et de Vénéréologie · 2026
- The Role of In Vivo, In Vitro and Pharmacogenomic Diagnostic Approaches to Sulfonamide Allergy · The Journal of Allergy and Clinical Immunology In Practice · 2026
- Toxic epidermal necrolysis following a furosemide injection: a case report · Journal of Medical Case Reports · 2026
- Drug-associated cytokine release syndrome: a FAERS pharmacovigilance study with complementary transcriptomic analysis · Naunyn-Schmiedeberg's Archives of Pharmacology · 2026
- Antibiotic Allergy Labels in Hospitalized Patients: Results of a Multicenter Cross-Sectional Study · Journal of Investigational Allergology and Clinical Immunology · 2026
- Systemic Therapy for Paediatric Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review of Current Evidence and Limitations · Journal of Paediatrics and Child Health · 2026
- Rapid progression to toxic epidermal necrolysis following switch of PD-1 inhibitors: a case report · Frontiers in Medicine · 2026
- Cutaneous adverse reactions to dupliumab in children: four case reports · Chinese Journal of Dermatology · 2026
- A Curious Gingival Erosion: A Rare Oral Manifestation of Fixed Drug Eruption · Cureus · 2026
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