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Open research questions in Hidradenitis Suppurativa and Treatments

131 gap statements mined from Hidradenitis Suppurativa and Treatments papers in our 4.5M-paper local library, which holds 777 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • One challenge is the complexity of the relationship between genetic susceptibility and environmental exposures in HS. Another challenge is the lack of research studies establishing causal relationships between environmental factors and HS. The paper also notes the challenge of determining the complete pathogenesis of HS due to the multifactorial nature of the disease.

    Exposome Versus Genome in HS: How Do We Currently Explain Where Disease Arises from? · 2026 · DOI

  • It highlights the need for further research on the potential of dietary modulation as a nutritional strategy. The paper notes that the current evidence is largely based on preclinical studies and that clinical validation is needed.

    Dietary Modulation of microRNAs as a Potential Nutritional Strategy in Inflammatory and Autoimmune Skin Diseases: A Narrative Review · 2026 · DOI

  • The lack of a clear diagnosis for Charles Darwin's recurrent boils. The limited understanding of the impact of chronic skin disease on historical figures. The need for a systematic review of Darwin's correspondence and diaries to determine whether his symptoms satisfy modern criteria for hidradenitis suppurativa.

    Under Darwin’s skin: a retrospective diagnosis of hidradenitis suppurativa · 2026 · DOI

  • Limited understanding of EIMs in patients with co-existing IBD and HS. Need for further research on the risk of EIMs in patients with HS alone versus those with co-existing IBD and HS.

    Characterizing extra-intestinal manifestations in patients with inflammatory bowel disease and hidradenitis suppurativa: a retrospective cohort study · 2026 · DOI

  • However, the relationship between HS and irritable bowel syndrome (IBS), a functional gastrointestinal disorder without underlying structural or inflammatory pathology, remains unclear.

    Modestly Increased Incidence of Irritable Bowel Syndrome in Hidradenitis Suppurativa: A Retrospective Cohort Study Using TriNetX · 2026 · DOI

  • Complete regional excision (CRE) is highly effective; however, no consensus exists regarding closure approaches, including primary suture-closure (PSC), split-thickness skin grafting (STSG), flaps, or healing by secondary intention (CRE/SIH).

    Surgical Management of Hidradenitis Suppurativa: Postoperative Outcomes Following Complete Regional Excision With Secondary Intent Healing Versus Suture‐Closure Techniques · 2026 · DOI

  • Although T helper (Th) 17-mediated inflammation is well-described in advanced HS (Hurley II-III), the immune mechanisms driving early disease remain unclear.

    Cellular and molecular landscape of early hidradenitis suppurativa lesions reveals early immune microenvironment · 2026 · DOI

  • Despite growing use of patient-reported outcome measures (PROMs) in HS trials, variance in quality and validation of existing instruments remains to be studied.

    Hidradenitis Suppurativa Patient-Reported Outcome Measures · 2026 · DOI

  • It is known that there is an increased risk of IBD in HS populations, but it remains unclear whether IL-17 inhibition increases the IBD risk or unmasks underlying disease.

    Inflammatory Bowel Disease and Interleukin-17 Inhibitors in Hidradenitis Suppurativa · 2026 · DOI

  • Hidradenitis suppurativa (HS) is a highly comorbid condition understudied in pediatric populations.

    Clinical Characteristics and Management of Pediatric Hidradenitis Suppurativa: A Canadian Single-Centre Multidisciplinary Experience · 2026 · DOI

  • Current evidence indicates a significant association between hidradenitis suppurativa (HS) and Down syndrome (DS), though the underlying mechanisms remain unclear.

    Clinical Features of Hidradenitis Suppurativa in Down Syndrome Patients: A Multicenter Spanish Study · 2026 · DOI

  • Neutrophils are scarce in healthy skin but infiltrate lesions of hidradenitis suppurativa (HS) patients.

    Neutrophil Extracellular Traps Are Widely Distributed Across Lesional and Perilesional Hidradenitis Suppurativa Skin, and Elevated Serum NET Markers Associate With Moderate to Severe HS Disease · 2025 · DOI

  • The relationship between hidradenitis suppurativa (HS) and arthritis is well-established; however, the impact of their combined disease burden and the associated treatment pattern has not been determined yet.

    Disease Burden and Treatment Patterns in Patients With Hidradenitis Suppurativa and Concomitant Arthritis: A Multicenter Case–Control Study · 2025 · DOI

  • Global reviews have compiled just over 250 cases across age groups and sites, while Indian data are limited to sporadic case reports.

    Isolated Cutaneous Crohn's Disease of the Vulva and Gluteal Region With Coexisting Hidradenitis Suppurativa · 2025 · DOI

  • Importance: Patients with hidradenitis suppurativa (HS) have an increased risk of new-onset depression and anxiety, but whether disease severity is a potential independent risk factor remains unknown.

    Risk of New-Onset and Recurrent Depression and Anxiety Among Patients With Hidradenitis Suppurativa · 2025 · DOI

  • However, the association of neighborhood-level socioeconomic status (nSES) and HS has not been adequately assessed.

    Neighborhood Socioeconomic Status and New Hidradenitis Suppurativa Diagnoses in a Single Health System · 2025 · DOI

  • While tertiary care data show that 22% of patients progress to severe disease within 2 years, estimates of disease development outside the hospital setting remain unknown.

    Hidradenitis Suppurativa Remission and Progression in a Community Setting · 2025 · DOI

  • The association between hidradenitis suppurativa and low socioeconomic status may impact patients' access to medication. The introduction of biosimilars may lead to cost-effective alternatives for patients.

    Dermatologists’ use of Humira biosimilars for hidradenitis · 2026 · DOI

  • Vulvar Crohn's disease remains difficult to manage, with no standardized guidelines and often suboptimal responses.

    Cutaneous Crohn of the Genital Area Mimicking Hidradenitis Suppurativa in a Patient With Quiescent Intestinal Disease · 2026 · DOI

  • Vulvar involvement is uncommon and often under-recognized, presenting with edema, ulcerations, fissures, nodules, and fistulas.

    Cutaneous Crohn of the Genital Area Mimicking Hidradenitis Suppurativa in a Patient With Quiescent Intestinal Disease · 2026 · DOI

  • Limitations include the lack of research studies establishing causal relationships between environmental factors and HS, - The strength of evidence supporting these factors varies, - There is a lack of mechanistic insight from environmental risk…

    Exposome Versus Genome in HS: How Do We Currently Explain Where Disease Arises from? · 2026 · DOI

  • Further studies are needed to assess the long-term efficacy and safety of adalimumab biosimilars, - Research on strategies to mitigate the Nocebo effect, - Investigations into the impact of biosimilar adoption on patient outcomes and healthcare costs, - Studies on the perspectives of patients with HS on biosimilar…

    Dermatologists’ use of Humira biosimilars for hidradenitis · 2026 · DOI

  • The study was performed in a specific region (north-west Spain), - The study had a limited sample size (211 primary care nurses), - The study used a non-probability sampling method…

    Nursing Knowledge and Skills in Hidradenitis Suppurativa: A Multi-Centre Exploratory Study · 2025 · DOI

  • Conducting studies that show the gaps in knowledge and skills to propose specific measures to improve the quality of care, - Continuing to conduct research on the competences of primary care nurses in HS, - Investigating the impact of further training on patients and the health…

    Nursing Knowledge and Skills in Hidradenitis Suppurativa: A Multi-Centre Exploratory Study · 2025 · DOI

  • FSTH serves as an effective model for uniting stakeholders, bridging gaps in knowledge and trust, and accelerating translational research to improve HS care.

    Full spectrum town halls for hidradenitis suppurativa: A model for advancing clinician–patient–researcher engagement in clinical and translational research · 2025 · DOI

Most-cited papers in Hidradenitis Suppurativa and Treatments

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Open questions raised by papers listed on this page include: (1) Another challenge is the lack of research studies establishing causal relationships between environmental factors and HS (“Exposome Versus Genome in HS: How Do We Currently Explain Where Disease Arises…”, 2026); (2) The paper notes that the current evidence is largely based on preclinical studies and that clinical validation is needed (“Dietary Modulation of microRNAs as a Potential Nutritional Strategy in…”, 2026); (3) The lack of a clear diagnosis for Charles Darwin's recurrent boils (“Under Darwin’s skin: a retrospective diagnosis of hidradenitis suppurativa”, 2026); (4) The relationship between HS and irritable bowel syndrome (IBS), a functional gastrointestinal disorder without underlying structural or inflammatory pathology, remains unclear (“Modestly Increased Incidence of Irritable Bowel Syndrome in Hidradenitis…”, 2026); (5) Although T helper (Th) 17-mediated inflammation is well-described in advanced HS (Hurley II-III), the immune mechanisms driving early disease remain unclear (“Cellular and molecular landscape of early hidradenitis suppurativa lesions…”, 2026). 131 gap statements have been mined from Hidradenitis Suppurativa and Treatments papers in our 4.5M-paper local library, which holds 777 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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