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Open research questions in Magnesium in Health and Disease

80 gap statements mined from Magnesium in Health and Disease papers in our 4.5M-paper local library, which holds 412 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The study had a limited sample size. Advanced inflammatory markers were not measured due to resource limitations. Multivariate regression analyses were not performed due to the risk of model overfitting.

    Micronutrient–immune interactions in mood and psychotic disorders: a case–control study of vitamin C, iron, zinc, magnesium, and peripheral blood cell indices · 2026 · DOI

  • Future studies should evaluate this recommendation across multiple cropping seasons and in other lahar-affected municipalities to confirm its robustness and further optimize application timing.

    Effect of Magnesium Foliar Fertilization on Hybrid Rice Grown in Lowland Soils of Tarlac · 2026 · DOI

  • The lack of studies specifically examining magnesium in RA-ILD. The need to identify independent predictors of ILD in patients with RA.

    Serum Levels of Magnesium in Patients with Rheumatoid Arthritis and Its Association with Interstitial Lung Disease · 2026 · DOI

  • Further research is needed to determine the optimal treatment strategy for COPD patients with hypomagnesemia. Studies should investigate the mechanisms by which magnesium affects COPD exacerbation. Research should explore the potential benefits of magnesium supplementation in COPD patients.

    Exploring the connection between serum magnesium and exacerbation of chronic obstructive pulmonary disease · 2026 · DOI

  • There is a lack of understanding of the relationship between serum magnesium and COPD exacerbation. Previous studies have found that hypomagnesemia is associated with increased risk of exacerbation, but the mechanisms are not well understood.

    Exploring the connection between serum magnesium and exacerbation of chronic obstructive pulmonary disease · 2026 · DOI

  • Since the aim of the study was to examine the relationship between serum total magnesium levels and mortality upon admission to the intensive care unit, the lack of repeated value analysis is a significant limitation.

    Relationship Between Magnesium Levels and Mortality in Intensive Care Patients · 2026 · DOI

  • There is a need for further research on the use of magnesium sulfate in healthcare settings with structural limitations. There is a need for further research on the efficacy and safety of abbreviated maintenance regimens.

    Uso do sulfato de magnésio na prevenção e tratamento da pré-eclâmpsia grave: revisão de literatura · 2026 · DOI

  • Routine monitoring of serum magnesium, selenium, and chromium during antenatal care is recommended to facilitate early detection of micronutrient imbalances. Nutritional counselling and appropriate supplementation, where indicated, should be incorporated into antenatal care to optimize maternal and fetal outcomes.

    Pattern of magnesium, selenium and chromium in pregnant women attending antenatal clinics at Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria · 2026 · DOI

  • Magnesium may play a protective role against the progression of vascular calcification in CKD, however the evidence remains scarce.

    Serum Magnesium and Progression of Coronary Artery Calcification: A Report from the Chronic Renal Insufficiency Cohort (CRIC) Study · 2026 · DOI

  • Hypomagnesemia was associated with increased risks of HA-SBP and sepsis in patients with cirrhosis, and these findings should be further validated in prospective studies.

    Association of serum magnesium levels with the risk of spontaneous bacterial peritonitis and sepsis in hospitalized patients with cirrhosis: a retrospective cohort study · 2026 · DOI

  • Future research should focus on large-scale, long-term randomized controlled trials with standardized mineral compositions and well-characterized populations, together with formal assessments of methodological quality and risk of bias, in order to clarify dose–response relationships and further elucidate the mechanisms underlying the observed metabolic effects.

    Dyslipidemia and the Consumption of Mineral Waters: A Narrative Review · 2026 · DOI

  • The study requires large-scale data to investigate the association between MDS and HUA. The study needs to control for various covariates, such as demographic and chronic disease factors, to assess the association between MDS and HUA.

    Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018 · 2025 · DOI

  • Future research should continue to investigate the complex relationship between diet, gender, and magnesium metabolism, with the aim of developing more precise and individualized dietary guidelines. Addressing these gender-specific needs in nutrition and public health policies will be essential for optimizing magnesium intake and supporting overall well-being.

    Magnesium: Exploring Gender Differences in Its Health Impact and Dietary Intake · 2025 · DOI

  • The study had to exclude some patients due to incomplete medical records or lack of timely blood gas analysis. The small sample size of cats limited the analysis of the relationship between ionized calcium and magnesium disturbances and clinical outcomes. The study had to control for potential confounding variables, such as the administration of diuretics or blood products.

    Ionized calcium and ionized magnesium disturbances in dogs and cats with septic peritonitis · 2025 · DOI

  • There is a lack of knowledge about the associations between ionized calcium and magnesium disturbances and clinical outcomes in dogs and cats with septic peritonitis. Previous studies have reported varying prevalence of ionized hypocalcemia in critically ill dogs and cats.

    Ionized calcium and ionized magnesium disturbances in dogs and cats with septic peritonitis · 2025 · DOI

  • The exact mechanisms of some medications causing hypomagnesemia are not fully understood. The prevalence of hypomagnesemia in different settings is not well-defined. The effectiveness of compensatory mechanisms in mitigating hypomagnesemia varies among individuals.

    The Clinical Spectrum of Acquired Hypomagnesemia: From Etiology to Therapeutic Approaches · 2025 · DOI

  • The relationship between pre-treatment serum electrolyte levels and treatment outcomes in patients with locally advanced gastric cancer (LAGC) after NICT remains unclear.

    Preoperative serum magnesium level as a prognostic and predictive biomarker in locally advanced gastric cancer patients receiving neoadjuvant immunochemotherapy · 2025 · DOI

  • Epithelial sodium channel (ENaC)‐mediated Na + entry provides the driving force for K + secretion via ROMK, but how hypomagnesaemia affects ENaC activity remains unknown.

    Hypomagnesaemia‐associated hypokalaemia requires activation of both ENaC and ROMK · 2025 · DOI

  • While the critical role of TRPM7 in the cellular balance of Mg2+, Zn2+, and Ca2+ is well-documented, its contribution to the cellular uptake of trace metal cations, frequent respiratory pollutants, remains unclear.

    TRPM7 underlies cadmium cytotoxicity in pulmonary cells · 2025 · DOI

  • Acknowledgments: Due to the scope and limitations of this study, we apologize for not being able to include all the important work in the field. Interestingly, two major clinical studies have produced contradictory findings, creating a state of equipoise that underscores the need for further investigation.

    Magnesium and Vascular Calcification in Chronic Kidney Disease: Current Insights · 2024 · DOI

  • The study's findings may be limited by the observational design and the potential for bias. The study's results may not be generalizable to all populations.

    Association between low magnesium status and new-onset dementia in the general population: a propensity score-matched cohort study · 2026 · DOI

  • The relatively small number of ILD cases may have limited the ability to identify more subtle effects. The study did not investigate the mechanisms underlying the relationship between magnesium and ILD.

    Serum Levels of Magnesium in Patients with Rheumatoid Arthritis and Its Association with Interstitial Lung Disease · 2026 · DOI

  • While generally regarded as safe, long-term PPI use has been increasingly associated with adverse metabolic effects, among which hypomagnesemia remains one of the most underrecognized complications.

    Hypomagnesemia as an Underrecognized Adverse Effect of Long-Term Proton Pump Inhibitor Therapy: Literature review · 2026 · DOI

  • The frequency and prognostic significance of abnormalities in serum magnesium concentrations have not been described in a contemporary heart failure (HF) population.

    Serum magnesium and outcomes in heart failure with reduced ejection fraction: the GALACTIC-HF trial · 2025 · DOI

  • Functional validation of SiMGT2 is needed, - Further research on the genetic basis of grain fat content in foxtail millet…

    QTL-Guided Prioritization of SiMGT2 as a Candidate Gene Associated with Grain Fat Content in Foxtail Millet · 2026 · DOI

Most-cited papers in Magnesium in Health and Disease

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Open questions raised by papers listed on this page include: (1) Future studies should evaluate this recommendation across multiple cropping seasons and in other lahar-affected municipalities to confirm its robustness and further optimize application timing (“Effect of Magnesium Foliar Fertilization on Hybrid Rice Grown in Lowland Soils…”, 2026); (2) The lack of studies specifically examining magnesium in RA-ILD (“Serum Levels of Magnesium in Patients with Rheumatoid Arthritis and Its…”, 2026); (3) Further research is needed to determine the optimal treatment strategy for COPD patients with hypomagnesemia (“Exploring the connection between serum magnesium and exacerbation of chronic…”, 2026); (4) Since the aim of the study was to examine the relationship between serum total magnesium levels and mortality upon admission to the intensive care unit, the lack of repeated value analysis is a significant limitation (“Relationship Between Magnesium Levels and Mortality in Intensive Care Patients”, 2026); (5) There is a need for further research on the use of magnesium sulfate in healthcare settings with structural limitations (“Uso do sulfato de magnésio na prevenção e tratamento da pré-eclâmpsia grave:…”, 2026). 80 gap statements have been mined from Magnesium in Health and Disease papers in our 4.5M-paper local library, which holds 412 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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