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Open research questions in Magnesium in Health and Disease

49 unresolved questions extracted from the limitations and future-work sections of 218 Magnesium in Health and Disease papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Systemic biochemical alterations associated with endometrial and ovarian cancers remain incompletely characterized. There is a need for simple, reliable, blood-based biomarkers for early detection, therapeutic decisions, or disease progression monitoring.

    Systemic dysregulation of essential and toxic elements and redox homeostasis in gynecologic malignancies · 2026 · DOI

  • The study faced challenges in terms of confounding variables and the exclusion of patients with stage 4-5 chronic kidney disease or end-stage renal disease. The study's findings may be limited by the observational design and the potential for bias. The study's results may not be generalizable to all populations.

    Association between low magnesium status and new-onset dementia in the general population: a propensity score-matched cohort study · 2026 · DOI

  • The complex pathophysiology of RA and ILD. The lack of studies specifically examining magnesium in RA-ILD. The need to identify independent predictors of ILD in patients with RA.

    Serum Levels of Magnesium in Patients with Rheumatoid Arthritis and Its Association with Interstitial Lung Disease · 2026 · DOI

  • The study faced challenges in controlling for confounding variables due to the retrospective nature of the data collection. The lack of repeated value analysis limited the ability to account for dynamic changes in magnesium levels.

    Relationship Between Magnesium Levels and Mortality in Intensive Care Patients · 2026 · DOI

  • Increased metabolic demands during pregnancy. Heightened vulnerability to environmental factors during pregnancy. The need for adequate micronutrient status during pregnancy.

    Pattern of magnesium, selenium and chromium in pregnant women attending antenatal clinics at Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria · 2026 · DOI

  • Background/objectives Dietary magnesium, primarily derived from plant foods, has been inconsistently associated with sarcopenia, and the underlying mechanisms have rarely been explored.

    Associations of magnesium intake and a magnesium-rich diet score with sarcopenia in middle-aged and older Korean adults: potential mediation by C-reactive protein · 2026 · DOI

  • Background: Magnesium may play a protective role against the progression of vascular calcification in CKD, however the evidence remains scarce.

    Serum Magnesium and Progression of Coronary Artery Calcification: A Report from the Chronic Renal Insufficiency Cohort (CRIC) Study · 2026 · DOI

  • The effect of magnesium supplementation on blood pressure in patients receiving long-term diuretic treatment is not well understood. The mechanisms by which magnesium influences blood pressure are not fully understood.

    Effect of magnesium on blood pressure. · 1983 · DOI

  • The need for further workup to identify underlying causes of familial hypomagnesemia with secondary hypocalcemia - The importance of monitoring urine calcium/creatinine ratio and urinary magnesium excretion

    Familial Hypomagnesemia with Secondary Hypocalcemia Presenting As Infantile Cyanotic Spells · 2026 · DOI

  • The study had a limited sample size. Advanced inflammatory markers were not measured due to resource limitations. Multivariate regression analyses were not performed due to the risk of model overfitting.

    Micronutrient–immune interactions in mood and psychotic disorders: a case–control study of vitamin C, iron, zinc, magnesium, and peripheral blood cell indices · 2026 · DOI

  • The lack of understanding of the relationship between serum magnesium and insulin resistance in PCOS. The need for further investigation into the metabolic abnormalities in PCOS patients.

    Association of Serum Magnesium Level with Insulin Resistance in Women with PCOS · 2026 · DOI

  • The study identifies a research gap in the understanding of the effects of magnesium foliar fertilization on hybrid rice grown in lowland soils of Tarlac. The study notes that the deposition of volcanic materials has altered soil composition and reduced essential nutrient levels, resulting in poor crop growth.

    Effect of Magnesium Foliar Fertilization on Hybrid Rice Grown in Lowland Soils of Tarlac · 2026 · DOI

  • Farmers growing hybrid rice in lahar-laden soils of Tarlac and similar volcanic ash-affected lowland areas are strongly advised to adopt foliar application of Magnesium Sulfate (MgSO₄) at 75 g/L as their standard Mg fertilization practice. Among all treatments evaluated, MgSO₄ at 75 g/L (T8) produced the highest grain yield of 8.81 t/ha, representing a gain of 2.53 t/ha over the unfertilized control, and delivered the greatest economic returns, with a net income of PhP83,874 and a Return on Investment of 406%. These figures represent a 129-percentage- point advantage in ROI over the control treatment and a 75-percentage-point advantage over the best-performing MgCO₃ treatment at the same concentration. The superiority of MgSO₄ is attributed to the additional availability of Sulfur, a nutrient that is frequently deficient in flooded lowland soils and critical for protein synthesis and chlorophyll function. Applied three times at 25, 40, and 60 days after transplanting, this treatment is practical, cost-effective, and scalable for smallholder rice farmers. Future studies should evaluate this recommendation across multiple cropping seasons and in other lahar-affected municipalities to confirm its robustness and further optimize application timing.

    Effect of Magnesium Foliar Fertilization on Hybrid Rice Grown in Lowland Soils of Tarlac · 2026 · DOI

  • The relatively small number of ILD cases may have limited the ability to identify more subtle effects. The study did not investigate the mechanisms underlying the relationship between magnesium and ILD.

    Serum Levels of Magnesium in Patients with Rheumatoid Arthritis and Its Association with Interstitial Lung Disease · 2026 · DOI

  • Further research is needed to determine the optimal treatment strategy for COPD patients with hypomagnesemia. Studies should investigate the mechanisms by which magnesium affects COPD exacerbation. Research should explore the potential benefits of magnesium supplementation in COPD patients.

    Exploring the connection between serum magnesium and exacerbation of chronic obstructive pulmonary disease · 2026 · DOI

  • There is a lack of understanding of the relationship between serum magnesium and COPD exacerbation. Previous studies have found that hypomagnesemia is associated with increased risk of exacerbation, but the mechanisms are not well understood.

    Exploring the connection between serum magnesium and exacerbation of chronic obstructive pulmonary disease · 2026 · DOI

  • The study identifies a gap in the current understanding of the relationship between serum magnesium levels and mortality in intensive care patients. The study highlights the need for further research into the prognostic value of magnesium levels in critically ill patients.

    Relationship Between Magnesium Levels and Mortality in Intensive Care Patients · 2026 · DOI

  • Larger, multicenter studies to confirm the findings. Evaluation of Mg's efficacy in different patient populations. Investigation of Mg's mechanisms of action in reducing AF incidence.

    Pharmacokinetic-guided magnesium prophylaxis in cardiac surgery: A randomized trial demonstrating guideline-level reductions in atrial fibrillation, accelerated recovery, and systemic cost savings · 2026 · DOI

  • There is a need for further research on the use of magnesium sulfate in healthcare settings with structural limitations. There is a need for further research on the efficacy and safety of abbreviated maintenance regimens.

    Uso do sulfato de magnésio na prevenção e tratamento da pré-eclâmpsia grave: revisão de literatura · 2026 · DOI

  • There is a need to evaluate the serum concentrations of essential minerals among pregnant women. The study aims to address this gap by comparing the serum concentrations of magnesium, selenium, and chromium among pregnant and non-pregnant women.

    Pattern of magnesium, selenium and chromium in pregnant women attending antenatal clinics at Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria · 2026 · DOI

  • However, due to conflicting results among studies investigating the relationship between magnesium, glycemic control and insulin sensitivity with increasing interest, more comprehensive, prospective studies with longer follow-up periods are needed.

    Relationship between serum magnesium levels and glycemic control and insulin resistance · 2025 · DOI

  • Future studies should investigate the underlying mechanisms of the relationship between micronutrient levels and immune function in patients with mood and psychotic disorders. Future studies should explore the potential of nutritional interventions as a therapeutic strategy for psychiatric disorders.

    Micronutrient–immune interactions in mood and psychotic disorders: a case–control study of vitamin C, iron, zinc, magnesium, and peripheral blood cell indices · 2026 · DOI

  • There is a lack of evidence for the benefit of intravenous magnesium in acute pediatric asthma. Previous studies have methodologic limitations.

    Magnesium in acute pediatric asthma in the emergency department (MAGICIAN)—A multicentre randomized controlled clinical trial protocol · 2026 · DOI

  • Further studies are needed to examine the mechanisms underlying the association between low magnesium status and dementia. The development of preventive strategies for cognitive decline may be informed by the study's findings. Additional research is needed to examine the relationship between magnesium status and dementia risk in different populations.

    Association between low magnesium status and new-onset dementia in the general population: a propensity score-matched cohort study · 2026 · DOI

  • Further studies are needed to confirm the study's findings and to investigate the potential benefits of magnesium supplements for acne treatment. Studies with larger sample sizes and longer follow-up periods are needed to fully understand the relationship between serum magnesium levels and acne severity.

    Exploring the Link Between Serum Magnesium Levels and Acne Vulgaris Severity · 2026 · DOI

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49 open questions have been extracted from the limitations and future-work passages of 218 Magnesium in Health and Disease papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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