Open research questions in Muscle activation and electromyography studies
115 unresolved questions extracted from the limitations and future-work sections of 505 Muscle activation and electromyography studies papers in our library. Each links back to the study that raised it.
What the literature leaves open
Sample sizes were limited due to requirements for medical supervision, cost, and logistics. No prior effect size was available for a formal sample size estimation for PIC-related estimates. Bed rest studies are constrained by requirements for medical supervision, cost, and logistics.
Bed rest and endurance retraining alter persistent inward current estimates in young and older males · 2026 · DOIInvestigate the mechanisms underlying deconditioning in both young and older adults. Examine the effects of different types of exercise-based recovery on motoneuron excitability. Study the long-term effects of bed rest and retraining on neural and functional adaptations.
Bed rest and endurance retraining alter persistent inward current estimates in young and older males · 2026 · DOIThe joint range of motion showed lower reliability, especially at higher speeds. Systematic biases remained small and clinically acceptable. The study identified challenges in interpreting joint kinematics and speed at different walking speeds.
Effect of Walking Speed on the Reliability of a Smartphone-Based Markerless Gait Analysis System · 2025 · DOIfurther studies on larger and more diverse populations, - investigation of OpenCap's reliability in clinical settings, - comparison of OpenCap with other markerless systems
Effect of Walking Speed on the Reliability of a Smartphone-Based Markerless Gait Analysis System · 2025 · DOIAlthough A-mode ultrasound can outperform sEMG at fixed positions, it is more sensitive to positional changes, an issue that has rarely been examined.
However, previous studies have primarily considered changes in individual muscle state variables, whereas the hysteresis behavior associated with simultaneous changes in muscle length and force, remains insufficiently understood.
A “thermodynamic” model of synergistic interaction of human elbow flexor muscles during simultaneous change in their length and force · 2026 · DOIWe further discuss a unified interpretation that might explain the conflicting evidence previously encountered in the physical fatigue literature.
Modulation of beta oscillatory dynamics in motor and frontal areas during physical fatigue · 2025 · DOIData augmentation can help address these limitations, but its use in biomechanical time-series data remains insufficiently evaluated.
CONCLUSION: This review highlights the importance of data augmentation in addressing limited data availability and improving model generalization in biomechanics.
Conclusions Overall, the Modified Hodges, Gaussian and Laplacian Approximate Generalized Likelihood Ratio, and the Fuzzy Entropy detectors were identified as the potential candidates that warrant further investigation with real surface EMG data since they had consistent detection performance on low SNR EMG data.
Although numerous algorithms for EMG detection exist, the detector with the highest accuracy and lowest latency for low signal-to-noise ratio (SNR) remains unknown.
The proposed framework is limited by the availability of high-quality EMG data, and further research is needed to develop more effective and efficient data collection and processing methods. The framework is also limited by the complexity of the digital twin model, and further research is needed to develop more simplified and interpretable models.
There is a need for more effective and efficient solutions for EMG monitoring and decision support. There is a need for further research and development in the use of digital twin technology for healthcare applications. There is a need for more simplified and interpretable digital twin models for EMG monitoring and decision support.
To investigate the robustness of the LSTAM model to noise and interference. To evaluate the performance of the model on a diverse range of subjects and environments. To develop more advanced models that can integrate multiple modalities of biosignals and achieve better performance in joint moment prediction.
Long short-term attention memory (LSTAM): a global-feature-integrated model for joint moment prediction in human rehabilitation · 2026 · DOIExisting methods for joint moment prediction have limitations in capturing global features and temporal complexity. There is a need for a model that can integrate global features from biosignals and achieve state-of-the-art performance in joint moment prediction.
Long short-term attention memory (LSTAM): a global-feature-integrated model for joint moment prediction in human rehabilitation · 2026 · DOINonconformal device/skin interfaces. Poor wearability. Anatomical variability among users. Limited signal fidelity and stimulation precision.
Drawn-on-skin electronic tattoo as a closed-loop sensing-stimulation system for the muscles · 2026 · DOICurrent systems for electromyography sensing and electrical stimulation often suffer from nonconformal device/skin interfaces and poor wearability. Traditional ES approaches often use generalized treatment protocols, which may not account for individual variability in anatomy, physiology, or pathology.
Drawn-on-skin electronic tattoo as a closed-loop sensing-stimulation system for the muscles · 2026 · DOICrosstalk between signals of multiple muscles. Insufficient accuracy for simultaneous movements of multiple degrees of freedom (DoFs). Limited sparsity and interpretability of the factorized results.
Conventional methods only allow discrete control of a single degree of freedom (DoF). Pattern recognition-based approaches still operate in a discrete manner and struggle to achieve synchronous, proportional, and continuous control across multiple DoFs.
Prior work has focused on complex and larger motions of wrist, hand, and arm. There is a need for more accurate and natural human-computer interaction systems.
Further research could explore the application of TransTCNet in various real-time applications such as adaptive user interfaces, virtual and augmented reality, prosthetic control, and communication systems
TransTCNet: Transformer-Based Temporal-Contextual Network for Low-Latency Typing Interfaces on Edge Devices · 2026 · DOICharacter-level typing recognition poses greater challenges than coarse gesture recognition due to subtle temporal variations and overlapping muscle dynamics. Prior work has focused on coarse gesture recognition, but character-level recognition requires more precise models.
TransTCNet: Transformer-Based Temporal-Contextual Network for Low-Latency Typing Interfaces on Edge Devices · 2026 · DOIThe non-stationarity and stochastic noise in raw sEMG signals. The need for a distributed computational pipeline to transition from biological movements to mechanical actions. The requirement for advanced AI-based teleoperation in a portable design.
Portable Holonomic Educational Robot Platform for Home Laboratory—Study Case: AI-Based Electromyography Control · 2026 · DOIThe lack of portable, low-cost robotic platforms that can bridge the gap between theoretical modeling and physical experimentation outside the laboratory. The need for a scalable framework for the next generation of laboratory-at-home educational tools and research regardless of physical location. The requirement for advanced AI-based teleoperation in a portable design.
Portable Holonomic Educational Robot Platform for Home Laboratory—Study Case: AI-Based Electromyography Control · 2026 · DOIThe paper identifies the challenge posed by noise and variability in sEMG signals as a research gap. It also mentions that the fixed forearm posture during data collection limited model generalizability.
Most-cited papers in Muscle activation and electromyography studies
- Guidelines for Human Electromyographic Research · Psychophysiology · 1986 · 1,325 citations
- Targeted Muscle Reinnervation for Real-time Myoelectric Control of Multifunction Artificial Arms · JAMA · 2009 · 941 citations
- The Effects of Adding Mass to the Legs on the Energetics and Biomechanics of Walking · Medicine & Science in Sports & Exercise · 2007 · 537 citations
- Strategies for the control of voluntary movements with one mechanical degree of freedom · Behavioral and Brain Sciences · 1989 · 388 citations
- ActiGraph and Actical Physical Activity Monitors · Medicine & Science in Sports & Exercise · 2011 · 291 citations
- Electromagnetic midsagittal articulometer systems for transducing speech articulatory movements · The Journal of the Acoustical Society of America · 1992 · 259 citations
- Variation in Neuromuscular Responses during Acute Whole-Body Vibration Exercise · Medicine & Science in Sports & Exercise · 2007 · 239 citations
- An electromyographic investigation of masticatory muscles symmetry in normo‐occlusion subjects · Journal of Oral Rehabilitation · 2000 · 220 citations
- Optimal signal bandwidth for the recording of surface EMG activity of facial, jaw, oral, and neck muscles · Psychophysiology · 2001 · 218 citations
- Electromyographic changes during strength training and detraining · Medicine & Science in Sports & Exercise · 1983 · 215 citations
Most recent work
- Synergy-based Feedforward with Minimal Feedback Control Predicts Walking Over Multiple Cycles · bioRxiv · 2026
- Long short-term attention memory (LSTAM): a global-feature-integrated model for joint moment prediction in human rehabilitation · Scientific Reports · 2026
- Ultra-wideband radar to measure in vivo muscle forces · Science Robotics · 2026
- AI-Driven EMG Monitoring and Decision Support Framework · IEEE Sensors Journal · 2026
- Machine learning outperforms anthropometric scaling in predicting muscle parameters and spinal loading: a subject-specific musculoskeletal modeling study · European Spine Journal · 2026
- Drawn-on-skin electronic tattoo as a closed-loop sensing-stimulation system for the muscles · Science Advances · 2026
- The biarticularity of the gastrocnemii muscles provides relevant mechanisms for managing drop-like gait perturbations in humans · Journal of Experimental Biology · 2026
- Musculoskeletal modeling based on deep-nsNMF for multi-DoF motion decoding · Medical & Biological Engineering & Computing · 2026
- Quantification of thigh-calf contact forces during high knee-flexion tasks · Journal of Mechanics in Medicine and Biology · 2026
- HAND GESTURE RECOGNITION FOR EMG SIGNAL BASED ON DIFFERENT MACHINE LEARNING METHODS · Journal of Digital Security and Forensics · 2026
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