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Open research questions in Natural Products and Applications

51 gap statements mined from Natural Products and Applications papers in our 4.5M-paper local library, which holds 564 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The lack of documentation on the botanical wealth of Indonesia. The need for evaluation of the physicochemical properties and antioxidant activity of isotonic drinks formulated with yellow rope stem extract.

    Physicochemical and Antioxidant Activity Evaluation of Yellow Rope (Anamirta cocculus (L.) Wight & Arn.) Stem Extract Isotonic Drink · 2026 · DOI

  • The lack of research on the use of herbal ingredients in creating deodorant sprays. The need for more research on the potential of herbal ingredients in creating deodorants.

    Sosialisasi dan Pelatihan Pembuatan Deodoran Spray Untuk Mendorong Kewirausahaan Kosmetik Skala Rumah Tangga · 2026 · DOI

  • The study has a limited sample size. The study only evaluates the physical properties and SPF of the gel in vitro. The study does not compare the results with other sunscreen products.

    Formulasi Gel Tabir Surya Ekstrak Daun Ketapang (Terminalia Catappa L.) Terpurifikasi Dan Penentuan Nilai SPF · 2026 · DOI

  • The study identifies the need for regular water quality monitoring in Karaman, Turkey. The study highlights the importance of irrigation water quality for sustainable agriculture.

    Karaman İlinin Sulama Suyu Kalitesinin Belirlenmesi · 2026 · DOI

  • Future research should focus on the development of new green extraction techniques. The use of PLE should be explored for extracting other biologically active compounds from plant materials.

    Ubrzana ekstrakcija otapalom · 2026 · DOI

  • There is a need for the development of green extraction processes that reduce the negative impact on the environment. The paper identifies a gap in the literature regarding the evaluation of PLE in extracting phenolic compounds from berries.

    Ubrzana ekstrakcija otapalom · 2026 · DOI

  • The study has a limited sample size (n = 130). The paper relies on self-reported data from the questionnaire. The study does not provide a comprehensive analysis of the curriculum and practice gap.

    Keeleteadus ja kooligrammatika: Kas räägime samast keelest? · 2026 · DOI

  • Future research should investigate the impact of curriculum and instructional materials on student learning outcomes. The study suggests the need for ongoing professional development and support for teachers. Future research should explore the role of grammatical concepts in first language education in different contexts and languages.

    Keeleteadus ja kooligrammatika: Kas räägime samast keelest? · 2026 · DOI

  • There is a need to improve the functional properties of tapioca starch. The current modification methods have limitations and there is a need for new approaches.

    STUDI AWAL SINTESIS PRODUK PATI TAPIOKA YANG MENGEMBANG DALAM AIR DINGIN (GRANULAR COLD WATER SWELLING STARCH): PENGARUH KOMPOSISI ETHANOL DAN KONSENTRASI AWAL PATI · 2026 · DOI

  • There is a need to investigate the effect of Sesbania grandiflora leaf-based organic tablets on semen quality. The limited feed supply during the dry season can impair semen quality, and alternative strategies are needed.

    The Effect of Organic Tablet Supplementation Based on Sesbania Grandiflora Leaves on The Quality of Post-Thaw Kacang Buck Semen · 2026 · DOI

  • The lack of studies on the use of kalsium karbonat and sorbitol as additives in bioplastik production. The need for a novel method for producing bioplastik from bengkoang starch with the addition of CaCO3 as a strengthening material.

    PEMBUATAN PLASTIK DEGRADABLE BERBAHAN DASAR PATI BENGKOANG DENGAN PENAMBAHAN CaCO3 SEBAGAI BAHAN PENGUAT · 2026 · DOI

  • There is limited research on the effects of kinesiotaping and vitamin B complex on lumbar disc herniation in third-trimester pregnant women. There is a need for further studies to evaluate the effectiveness of kinesiotaping and vitamin B complex in reducing discomfort and disability.

    PEMBERIAN TERAPI KINESIOTAPPING VERSUS VITAMIN B KOMPLEKS TERHADAP LUMBAR DISC HERNIATION PADA IBU HAMIL TRIMESTER III · 2026 · DOI

  • The production and purification of biologically active peptides are crucial for their application in the pharmaceutical industry. The development of new methods for producing and purifying biologically active peptides is necessary.

    BIOLOGIK FAOL PEPTIDLARNING OLINISHI, TOZALASH USULLARI VA FARMATSEVTIKADA QO'LLANILISHI · 2026 · DOI

  • The study only analyzed the effect of organic materials on the chemical and biological properties of Vertisol soil and did not consider other factors that may affect soil fertility. The study used a limited number of treatments and did not include a control group with no organic materials.

    Peningkatan Sifat Kimia dan Biologi Tanah Vertisol pada Budidaya Tebu Melalui Aplikasi Berbagai Jenis Bahan Organik · 2026 · DOI

  • There is limited research on the effect of different types and combinations of organic materials on the chemical and biological properties of Vertisol soil. The study aims to fill this gap by analyzing the effect of various organic materials on soil properties.

    Peningkatan Sifat Kimia dan Biologi Tanah Vertisol pada Budidaya Tebu Melalui Aplikasi Berbagai Jenis Bahan Organik · 2026 · DOI

  • There is a need to compare the effectiveness of different fixatives for preserving tissue morphology. The choice of fixative can affect the quality of tissue preservation and diagnosis.

    Perbandingan Efektivitas Cairan Fiksatif Ethanol 70% Komersial vs Neutral Buffered Formalin (NBF) 10% terhadap Morfologi Jaringan Hati dan Ginjal · 2026 · DOI

  • Further studies can be done to optimize the device performance and antibacterial activity. The device can be integrated with other optoelectronic devices to create more complex systems.

    Au/Jelatin:Ag NP/p-Si/Al Hibrit Biyo-Nanokompozit Fotodiyotun Geliştirilmiş Foto tepkisi ve Antibakteriyel Performansı · 2026 · DOI

  • The study only investigated the adsorption of enrofloxacin, and not other antibiotics. The study did not investigate the potential toxicity of the hydrochar. The study only used a limited number of samples.

    Efektivitas Hydrochar Serbuk Kayu Sengon sebagai Adsorben dalam Menurunkan Kadar Antibiotik Enrofloxacin pada Limbah Cair · 2026 · DOI

  • There is a lack of effective methods for removing antibiotics from wastewater. The current methods for removing antibiotics from wastewater are not efficient and can be costly.

    Efektivitas Hydrochar Serbuk Kayu Sengon sebagai Adsorben dalam Menurunkan Kadar Antibiotik Enrofloxacin pada Limbah Cair · 2026 · DOI

  • To investigate the effect of varying the concentration of CaCO3 on the biodegradability and mechanical properties of the bioplastik. To compare the bioplastik with conventional plastic in terms of biodegradability and mechanical properties.

    PEMBUATAN PLASTIK DEGRADABLE BERBAHAN DASAR PATI BENGKOANG DENGAN PENAMBAHAN CaCO3 SEBAGAI BAHAN PENGUAT · 2026 · DOI

  • The study only compared two fixatives and did not evaluate other fixatives. The study was limited to liver and kidney tissues and did not evaluate other tissue types.

    Perbandingan Efektivitas Cairan Fiksatif Ethanol 70% Komersial vs Neutral Buffered Formalin (NBF) 10% terhadap Morfologi Jaringan Hati dan Ginjal · 2026 · DOI

  • Masalah produksi ASI yang tidak cukup masih menjadi masalah yang sering dialami oleh ibu nifas di Indonesia. Kurangnya intervensi non-farmakologis yang efektif untuk meningkatkan produksi ASI.

    Pengaruh Aromatherapy Lavender dan Pijat Oksitosin terhadap Peningkatan ASI Pada Ibu Nifas · 2026 · DOI

  • An'anaviy ftoridli birikmalar faqat yuzaki florapatit qatlamini hosil qiladi va chuqur mineral yo'qotishlarni tiklay olmaydi. Tish kariesi boshlang'ich bosqichida invaziv aralashuvlarsiz kimyoviy-terapevtik yo'l bilan qayta tiklash muammosi mavjud.

    KARIES PROFILAKTIKASIDA REMINERALIZATSIYALOVCHI NANO-FAZA KIMYOVIY BIRIKMALARNING SAMARADORLIGI · 2026 · DOI

  • Lipsa unei teorii care să derive toate constantele fizice fundamentale dintr-o axioma centrală. Necesitatea unei abordări noi pentru înțelegerea constantelor fizice fundamentale.

    MRU-v24 · 2026 · DOI

  • Further studies on the toxicity of the mouthwash preparation. Evaluation of the mouthwash preparation against other bacteria. Development of other natural mouthwash preparations.

    Formulasi Sediaan Mouthwash Ekstrak Daun Sirsak (Annona muricata L.) dengan Penambahan Variasi Konsentrasi Ekstrak Daun Kelor (Moringa oleifera L.) sebagai Antibakteri · 2026 · DOI

Most-cited papers in Natural Products and Applications

Most recent work

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Open questions raised by papers listed on this page include: (1) The lack of documentation on the botanical wealth of Indonesia (“Physicochemical and Antioxidant Activity Evaluation of Yellow Rope (Anamirta…”, 2026); (2) The lack of research on the use of herbal ingredients in creating deodorant sprays (“Sosialisasi dan Pelatihan Pembuatan Deodoran Spray Untuk Mendorong…”, 2026); (3) Future research should focus on the development of new green extraction techniques (“Ubrzana ekstrakcija otapalom”, 2026); (4) Future research should investigate the impact of curriculum and instructional materials on student learning outcomes (“Keeleteadus ja kooligrammatika: Kas räägime samast keelest?”, 2026); (5) There is a need to improve the functional properties of tapioca starch (“STUDI AWAL SINTESIS PRODUK PATI TAPIOKA YANG MENGEMBANG DALAM AIR DINGIN…”, 2026). 51 gap statements have been mined from Natural Products and Applications papers in our 4.5M-paper local library, which holds 564 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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