Open research questions in Neurology and Historical Studies
73 gap statements mined from Neurology and Historical Studies papers in our 4.5M-paper local library, which holds 853 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.
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What the literature leaves open
The paper mentions the need for further research in artificial general intelligence.
De la neurona de Cajal a la superinteligencia artificial: paralelismo cerebral-artificial · 2026 · DOIThe need for a better understanding of the human brain. The lack of effective treatments for neurological disorders. The need for collaborative efforts in neuroscience.
International initiatives for the study of the human brain: EBRAINS and its Spanish node · 2026 · DOIThe lack of understanding of the role of trophic factors in neuronal growth and survival. The need to elucidate the mechanisms of neural plasticity, regeneration, and brain aging. The potential for NGF to be used in the development of therapies for mental illnesses, neurodegenerative diseases, and cancer.
From the Scientific Underground to the Height of Recognition: The 40th Anniversary of Rita Levi-Montalcini’s Nobel Prize and the Promising Horizon in Psychiatry · 2026 · DOIAlthough hip bracing can prevent hip displacement in cerebral palsy, its effectiveness in FCMD remains unexplored. However, whether inhibiting GSK3β will produce similar benefits when D2 mdx mice are housed at thermoneutrality remains unknown.
Abstracts of the 19th International Congress on Neuromuscular Diseases 7th – 11th July 2026 · 2026 · DOIDelayed cerebellar haemorrhage following migration of cervical spine fixation rods and penetration of the occipital bone represents a unique complication in patients without predisposing metabolic bone disease, and, to our knowledge, has not been previously reported.
Second international Vilnius neuroscience conference for young researchers, 2026. Abstract book · 2026 · DOIThere is a lack of measures to improve patient safety and staff well-being in neurological training. There is a need for clinics to prioritize the well-being of their staff.
Umgang mit belastenden Ereignissen in der neurologischen Weiterbildung: ein Weißbuch der Jungen Neurologie · 2026 · DOIThe paper does not explicitly identify a research gap, but rather highlights the challenges facing the field of psychiatry, including the risk of clinicians becoming the weak link between healthcare systems, industry, and patients. The importance of clinical judgment and individualized care in psychiatry.
Corticospinal inhibition and slower motor unit firing rates following anterior cruciate ligament reconstruction (ACLR) suggest supraspinal mechanisms underly persistent quadriceps weakness, yet the relationship between each has not been explored.
Injury History, Not Corticospinal Excitability, Explains Slower Quadriceps Motor Unit Firing After Acl Reconstruction · 2024 · DOITracing an underexplored social history of Penfield's patients through more than sixty clinical records, it suggests that making knowledge about the brain was a multidirectional process in which patients meaningfully participated, and in which their experiences of epilepsy and motivations for surgery were significant.
Speaking Secrets: Epilepsy, Neurosurgery, and Patient Testimony in the Age of the Explorable Brain, 1934–1960 · 2015 · DOIFuture research could focus on developing new information networks that address the limitations of the Neurological Information Network. The importance of funding and user charges could be further explored.
The brain drain is a complex issue that involves political and economic factors. Developing countries face challenges in preventing the brain drain. Industrialized countries face challenges in balancing their immigration policies with the needs of developing countries.
The brain drain is a complex issue that involves political and economic factors. There is a need to analyze the causes and effects of the brain drain. There is a need to examine the policies that influence the brain drain.
Future research should focus on determining the three-dimensional structures of nucleic acids. Future research should focus on understanding evolutionary change at the molecular level.
The gap in understanding the evolution of macromolecules is addressed through comparative biochemical studies. The gap in understanding the three-dimensional structures of nucleic acids is a challenging one.
One challenge is the small sample size of the study. Another challenge is the lack of a control group of individuals without dyslexia for direct comparison.
Future research should investigate the relationship between cerebral asymmetries and dyslexia in larger samples. Future research should also explore the developmental origins of cerebral asymmetries in individuals with dyslexia.
Further research can be done to explore the role of the mother in the evolution of artists and geniuses. The study's findings can be applied to other fields such as psychology and education.
The study of commissurotomy subjects is challenging due to the complexity of the neural systems involved. The interpretation of the findings is also challenging due to the need to infer the subjective experience of the minor hemisphere. The study requires the development of new methods for testing the separate hemispheres.
The concept of an Information Analysis Center was not fully developed.
The development of new neurotechnologies for the diagnosis and treatment of neurological disorders. The advancement of data science and engineering in neuroscience. The expansion of the Spanish node of EBRAINS.
International initiatives for the study of the human brain: EBRAINS and its Spanish node · 2026 · DOIFuture research can focus on the application of Hebb's theory to the development of new treatments for brain-related disorders, - Future research can also focus on the development of artificial intelligence based on Hebb's…
The paper identifies a gap in the understanding of the influence of Cajal and Lorente de Nó on Hebb's theory, - The paper also identifies a gap in the understanding of how Hebb developed his…
The paper does not explicitly state a research gap, but it implies that the study of the bridged central sulcus is an area that has not been fully explored with modern neuroimaging…
When historical anatomy meets modern neuroimaging: reflections on the bridged central sulcus · 2026 · DOIThe book identifies a gap in the coverage of DNA replication, with less attention paid to the elongation step and no mention of the termination of DNA synthesis.
The paper identifies a gap in the understanding of the relationship between diegophrenia and genius. The study aims to fill this gap by exploring the role of the mother in the evolution of artists and geniuses.
Most-cited papers in Neurology and Historical Studies
- The functional anatomy of a hysterical paralysis · Cognition · 1997 · 277 citations
- The concept of the stimulus in psychology. · American Psychologist · 1960 · 265 citations
- The Cerebral Subject and the Challenge of Neurodiversity · BioSocieties · 2009 · 259 citations
- THE SYSTEMATIC DESENSITIZATION TREATMENT OF NEUROSES · The Journal of Nervous and Mental Disease · 1961 · 247 citations
- THE NATURE OF APRAXIA · The Journal of Nervous and Mental Disease · 1958 · 229 citations
- Contemporary neuroscience in the media · Social Science & Medicine · 2010 · 188 citations
- Diagnosis of brain death. Statement issued by the honorary secretary of the Conference of Medical Royal Colleges and their Faculties in the United Kingdom on 11 October 1976. · BMJ · 1976 · 179 citations
- Brain acidosis · Annals of Emergency Medicine · 1985 · 178 citations
- A Manual of Diseases of the Nervous System · The American Journal of Psychology · 1888 · 164 citations
- Neuroanatomy—An Atlas of Structures, Sections, and Systems · Military Medicine · 1983 · 156 citations
Most recent work
- How to view the autonomic nervous system as physiologist, anatomist and pharmacologist? · The Journal of Physiology · 2026
- Death by neurologic criteria: a nuclear medicine approach based on the 2023 AAN/AAP/CNS/SCCM Guideline and 2025 SNMMI Procedure Standard · Pediatric Radiology · 2026
- The origins of neuroimaging and Johann Puluj: Early X‐rays and the foundations of radiographic neuroanatomy · Anatomical Sciences Education · 2026
- Improving access to care for neurological disorders in Sub-Saharan Africa: leading the change after a twenty years lesson from primary care - DREAM · Neurological Sciences · 2026
- De la neurona de Cajal a la superinteligencia artificial: paralelismo cerebral-artificial · Revista Kranion · 2026
- International initiatives for the study of the human brain: EBRAINS and its Spanish node · Revista Kranion · 2026
- Contemporary neurology: controversies, economic impact, and innovation · Revista Mexicana de Neurociencia · 2026
- THE ROLE OF A NEUROLOGY INTERNSHIP IN PSYCHIATRY RESIDENCY TRAINING: A SURVEY FROM BRAZIL · ARACÊ · 2026
- From guillotine to EEG: Revisiting the neurological controversies of decapitation through modern neurophysiology · Neuroscience & Biobehavioral Reviews · 2026
- From the Scientific Underground to the Height of Recognition: The 40th Anniversary of Rita Levi-Montalcini’s Nobel Prize and the Promising Horizon in Psychiatry · Neurochemical Research · 2026
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