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Medicine · Research topic

Open research questions in Nonmelanoma Skin Cancer Studies

165 gap statements mined from Nonmelanoma Skin Cancer Studies papers in our 4.5M-paper local library, which holds 989 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

It also highlights the need for dedicated laboratory infrastructure, trained support staff, and a surgeon with subspecialty expertise. The paper mentions the challenge of intraoperative frozen-section processing, which is subject to artifact and tissue distortion that may occasionally compromise histologic interpretation.
Current and Future Perspectives in Mohs Micrographic Surgery for Non-Melanoma Skin Cancers: A Narrative Review · 2026 · DOI
The paper identifies the gap in the treatment of non-melanoma skin cancers, particularly in high-risk tumors, where conventional excision may not provide complete margin control. It also highlights the need for adjunctive tools for preoperative tumor delineation and margin control to further refine patient selection and surgical accuracy.
Current and Future Perspectives in Mohs Micrographic Surgery for Non-Melanoma Skin Cancers: A Narrative Review · 2026 · DOI
The study is limited by the inherent challenges of using coding data from the TriNetX US Collaborative Network database. The study is retrospective in design, which may introduce biases. The study is limited by the potential for detection bias, as those with a diagnosis of hypertension without taking antihypertensive medications may have less access or interaction with the healthcare system.
76849 Stratified Temporal Risk of Skin Cancer by Age Associated with Hydrochlorothiazide: A Retrospective Cohort Study Using the TriNetX Database · 2026 · DOI
The clinical utility of AI-assisted MMS is still evolving. Significant challenges must be addressed before widespread adoption, including validation across diverse tumor subtypes and staining protocols.
Artificial intelligence-assisted margin assessment in Mohs micrographic surgery: a step toward real-time precision · 2026 · DOI
The diagnosis of base-involving SCCis is not a standardized diagnostic category. Prior literature notes a 3% to 5% rate of progression to SCC, but it is unclear if this applies to all SCCis or only non-base-involving cases. The study aims to address the gap in knowledge regarding the diagnosis and treatment of base-involving SCCis.
Clinical characteristics and outcome of base-involving cutaneous squamous cell carcinoma in situ · 2026 · DOI
The need for a practical solution to process conservative thickness layers. The limitations of prior devices and methods in improving slide quality and margin visualization. The lack of a widely employed technique to address the challenges of processing thin specimens.
The bubble technique as a method for processing conservative thickness layers in Mohs micrographic surgery · 2026 · DOI
There is a need to understand current practice patterns amongst members of the American College of Mohs Surgery. The existing guidelines, such as the 2012 appropriate use criteria, may not be all-encompassing of clinical presentations. Emerging evidence highlights the effectiveness of non-surgical methods, but there is a lack of understanding of their integration into current practice.
Squamous cell carcinoma in situ treatment practices amongst the American College of Mohs Surgery · 2026 · DOI
The identification of factors that increase the risk of recurrence is crucial for informing closer follow-up strategies and individualized management approaches. The study highlights the need for careful surgical margin assessment and individualized management approaches for patients with head and neck BCCs.
The role of histopathologic subtype and comorbidities in recurrence of head and neck basal cell carcinoma · 2026 · DOI
There is a lack of specific dermoscopic features that can definitively identify basal cell carcinoma subtypes. Current dermoscopic findings are correlated with tumor thickness rather than subtype.
Dermoscopy of Basal Cell Carcinoma Part 2: Dermoscopic Findings by Lesion Subtype, Location, Age of Onset, Size and Patient Phototype · 2025 · DOI
Limited resource availability for specialized high-risk transplant clinics. Barriers to patient access to care. Need for coordination between local dermatologists and high-risk transplant clinics.
Dermatology Scheduling Triage of Transplant Patients and Transplant Candidates to Improve Early Diagnosis and Prevention of Skin Cancer: International Immunosuppression and Transplant Skin Cancer Collaborative Expert Consensus Recommendations · 2025 · DOI
The potential impact of tobacco/nicotine use on postoperative complications after Mohs micrographic surgery is not well understood. There is a need to investigate the association between tobacco/nicotine use and post-Mohs complications using a large retrospective cohort.
Association of tobacco/nicotine use with postoperative complications following Mohs micrographic surgery: a retrospective cohort analysis · 2026 · DOI
Further studies evaluating international variations in CSCC treatment and outcomes in larger, more diverse cohorts are warranted.
International Variability in Cutaneous Squamous Cell Carcinoma Management and Outcomes: An Exploratory Analysis From the United States, Spain, and Brazil · 2026 · DOI
Limitations of this study include that the centers included may not be fully reflective of their countries, academic centers were overrepresented (10/12 sites), and the Brazil cohort was limited to head and neck tumors.
International Variability in Cutaneous Squamous Cell Carcinoma Management and Outcomes: An Exploratory Analysis From the United States, Spain, and Brazil · 2026 · DOI
Patient-specific 3D-printed applicators could improve conformity, yet geriatric BCC data are limited.
Patient-specific 3D-printed HDR surface brachytherapy for basal cell carcinoma in older patients: prospective feasibility and imaging response · 2026 · DOI
The perioperative role of systemic therapy remains poorly defined in borderline resectable or unresectable non-head-and-neck locally advanced cutaneous squamous cell carcinoma (cSCC).
Conversion-intent PD-1-based chemoimmunotherapy restores surgical feasibility in borderline resectable or unresectable non–head-and-neck cutaneous squamous cell carcinoma · 2026 · DOI
Programmed death receptor 1 (PD-1) blockade produces high response rates in resectable and locally advanced cutaneous squamous cell carcinoma (CSCC), but how many doses are needed and whether surgery or radiation after immunotherapy (consolidation) adds benefit in deep responders (patients with substantial clinical responses) remain unclear.
Frontline immunotherapy with response-guided subsequent treatment (FIRST) in cutaneous squamous cell carcinoma: a Bayesian causal analysis of dose intensity, early benefit, and treatment de-escalation · 2026 · DOI
Anti-programmed-death-1 receptor immune check point inhibitor (anti PD-1 ICI) therapy has shown benefit in advanced cSCC, however imaging response of PNS to immunotherapy remain incompletely characterized.
Response of Perineurial Tumor Spread from Cutaneous Squamous Cell Carcinoma Treated with Immunotherapy · 2026 · DOI
Investigate the potential effects of other photosensitizing drugs in combination with HCTZ usage, - Examine sun exposure, sunscreen use, family history, and medication adherence or dosing to gauge cumulative…
76849 Stratified Temporal Risk of Skin Cancer by Age Associated with Hydrochlorothiazide: A Retrospective Cohort Study Using the TriNetX Database · 2026 · DOI
Power is limited as data were available for under 60% of cases - The data generated and analyzed in this study are not publicly available due to patient privacy and institutional…
Clinical characteristics and outcome of base-involving cutaneous squamous cell carcinoma in situ · 2026 · DOI
Targeted studies and updated guidelines are needed to refine the treatment of SCCIS, - Further research is needed to better understand the effectiveness of non-surgical methods, - International studies could be conducted to compare the treatment preferences of Mohs surgeons in different…
Squamous cell carcinoma in situ treatment practices amongst the American College of Mohs Surgery · 2026 · DOI
Mohs micrographic surgery or Mohs-equivalent complete margin assessment techniques are not currently performed at the institution, - standard clinical excision margins were generally 3-4 mm for low-risk basal cell carcinomas and 4-6 mm for higher-risk tumors, - margins were occasionally limited to preserve tissue in cosmetically sensitive head and neck…
The role of histopathologic subtype and comorbidities in recurrence of head and neck basal cell carcinoma · 2026 · DOI
Overlapping characteristics with other skin conditions cause challenges in differential diagnosis, - Rare lesions can remain dermoscopically indistinguishable from BCC, - No unique dermoscopic features identified for linear…
Dermoscopy of Basal Cell Carcinoma Part 3: Differential Diagnosis, Treatment Monitoring and Novel Technologies · 2025 · DOI
Further studies on novel diagnostic technologies, - Investigation of dermoscopic features in rare skin lesions, - Research on the role of UVFD and OSHMD in BCC…
Dermoscopy of Basal Cell Carcinoma Part 3: Differential Diagnosis, Treatment Monitoring and Novel Technologies · 2025 · DOI
Data on chemotherapy regimens are derived primarily from small case series and retrospective studies, - Limited efficacy of platinum-based chemotherapy, - Resistance and intolerance to HHIs…
Basal Cell Carcinoma: An Old Friend with Multiple Faces · 2025 · DOI
Future studies are needed to evaluate whether this technique affects recurrence rates compared to standard processing…
The bubble technique as a method for processing conservative thickness layers in Mohs micrographic surgery · 2026 · DOI

Most-cited papers in Nonmelanoma Skin Cancer Studies

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells · Nature · 1984 · 2,006 citations
Prevalence and Costs of Skin Cancer Treatment in the U.S., 2002−2006 and 2007−2011 · American Journal of Preventive Medicine · 2014 · 697 citations
The global burden of skin cancer: A longitudinal analysis from the Global Burden of Disease Study, 1990–2017 · JAAD International · 2021 · 330 citations
United States burden of melanoma and non-melanoma skin cancer from 1990 to 2019 · Journal of the American Academy of Dermatology · 2021 · 273 citations
Cutaneous Squamous Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches · Biomedicines · 2021 · 228 citations
The incidence and clinical analysis of non-melanoma skin cancer · Scientific Reports · 2021 · 200 citations
Pembrolizumab for locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 study): an open-label, nonrandomized, multicenter, phase II trial · Annals of Oncology · 2021 · 198 citations
Skin Cancer in a Subtropical Australian Population: Incidence and Lack of Association with Occupation · American Journal of Epidemiology · 1996 · 194 citations
Cutaneous head and neck SCCs and risk of nodal metastasis – UK experience · Journal of Cranio-Maxillofacial Surgery · 2009 · 146 citations
Nevoid basal cell carcinoma syndrome: a review of the literature · International Journal of Oral and Maxillofacial Surgery · 2004 · 141 citations

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Most-cited papers in Nonmelanoma Skin Cancer Studies

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