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Open research questions in Oral and gingival health research

29 unresolved questions extracted from the limitations and future-work sections of 665 Oral and gingival health research papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The text is incomplete and cuts off mid-sentence regarding treatment with recombinant growth hormone (rGH), suggesting missing discussion of how such treatments may affect periodontal outcomes in TS patients.

    Histopathological and immunohistochemical changes of the marginal periodontium in patients with Turner syndrome · 2021 · DOI

  • This paper reports the first two cases of VPS45-associated SCN5 in Saudi Arabia and describes the treatment approaches for periodontal disease as a manifestation of that disorder since the existing dental literature is lacking sufficient information on the management of those kinds of patients.

    Periodontal Disease in Two Siblings with VPS45-associated Severe Congenital Neutropenia Type V: A Case Report · 2020 · DOI

  • Although autologous mesenchymal stromal cell therapy is a potential treatment, the effects of medication‐related osteonecrosis of the jaw microenvironment on mesenchymal stromal cells remain unclear.

    Transcriptomic Profiling of Mesenchymal Stromal Cells Derived From Medication‐Related Osteonecrosis of the Jaw · 2026 · DOI

  • For adjunc- tive therapies, different adjunctive products have been tested: • For systemic antimicrobials, very limited evidence is available (mainly case series) and the one randomised control trial identified did not demonstrate additional benefit (doxycycline).

    Gingival and periodontal diseases and conditions in children and adolescents: consensus report · 2026 · DOI

  • Abstract Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a poorly understood entity and is probably a misnomer too.

    Localized juvenile spongiotic gingival hyperplasia · 2023 · DOI

  • CLINICAL SIGNIFICANCE: Port-wine stains should not be considered as just birthmarks and should be further investigated for its systemic involvement to arrive at a confirmatory diagnosis and treated accordingly with special precautions.

    Sturge–Weber Syndrome: Roots to a Cure a Nightmare in Pediatric Dentistry · 2021 · DOI

  • LJSGH pathogenesis remains to be elucidated, while a possible origin from the gingival sulcus epithelium is nowadays proposed.

    Localized Juvenile Spongiotic Gingival Hyperplasia: Report of Two Cases · 2017 · DOI

  • CONCLUSION: Stillman's cleft remains to be investigated as for the possible causes of such lesion of the gingival margin, although an inflammatory response seems to be evident and active from a strictly histopathological standpoint.

    The gingival Stillman�s clefts: histopathology and cellular characteristics · 2015 · DOI

  • OBJECTIVES: Only few studies on gingival lesions considered large enough populations and contemporary literature does not provide a valid report regarding the epidemiology of gingival lesions within the Italian population.

    Clinical and histological features of gingival lesions: A 17-year retrospective analysis in a northern Italian population · 2012 · DOI

  • The present case reports on an adult periodontitis patient with a diffuse and atypic actinomycotic lesion which was limited to the gingiva and had an abscess formation, a large desquamation and subsequent exposure of the alveolar bone in the involved region.

    Rare lesions of the oral cavity: case report of an actinomycotic lesion limited to the gingiva · 2003 · DOI

  • The introduction of an alternative immunosuppressive agent (Tacrolimus) offers potential as it does not appear to cause overgrowth, although research to date is limited by the small sample size of many of the studies.

    Mechanisms and management of gingival overgrowth in paediatric transplant recipients: a review · 2003 · DOI

  • On the cellular and molecular levels, particularly, the oral cavity and associated structures comprise a somewhat under-investigated area in diabetes mellitus research and, thus, hold great promise for increasing our knowledge of this complex disease.

    Diabetes mellitus and associated oral manifestations: a review · 1985 · DOI

Most-cited papers in Oral and gingival health research

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29 open questions have been extracted from the limitations and future-work passages of 665 Oral and gingival health research papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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