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Open research questions in Veterinary Orthopedics and Neurology

164 gap statements mined from Veterinary Orthopedics and Neurology papers in our 4.5M-paper local library, which holds 908 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • One challenge is the variability in radiographic positioning and landmark visualization, which can affect the reliability of tibial plateau angle measurements. Another challenge is the potential for implant/plate superimposition to prevent reliable assessment of radiographic osteotomy healing.

    Association Between Body Condition Score and Early Radiographic Osteotomy Healing Following Tibial Plateau Leveling Osteotomy in Dogs: A Retrospective Study · 2026 · DOI

  • The effectiveness of peri- and postoperative antimicrobial administration in preventing surgical site infections remains controversial. There is a need to determine whether perioperative antibiotic treatment alone is sufficient to maintain surgical site infections within acceptable limits.

    Comparison of Surgical Site Infection (SSI) Rates in Dogs Undergoing Tibial Plateau Leveling Osteotomy (TPLO) Using Perioperative Versus Peri- and Postoperative Antimicrobial Prophylaxis · 2025 · DOI

  • One challenge is the variability in radiography's diagnostic accuracy for medial coronoid disease (MCD). Another challenge is the need to consider the sensitivity, specificity, and predictive values of radiography, especially at low disease prevalences. The study also highlights the challenge of avoiding superimposition in radiography, which can obscure early lesions.

    Cross-Modality Diagnostic Agreement in Canine Medial Coronoid Disease in a Screening Population: Radiographs vs. CT in 424 Elbow Joints · 2025 · DOI

  • There is a need to evaluate the diagnostic accuracy of radiography in a screening population. The study identifies a gap in the understanding of the limitations of radiography in diagnosing MCD.

    Cross-Modality Diagnostic Agreement in Canine Medial Coronoid Disease in a Screening Population: Radiographs vs. CT in 424 Elbow Joints · 2025 · DOI

  • There is a need for effective fixation methods for humeral condylar fractures in dogs. Traditional stabilization methods may have limitations, and self-compressing screws can offer simpler procedures and additional advantages.

    Biomechanical Comparison of Self-Compressing Screws and Cortical Screw Inserted with Lag Fashion in Canine Cadaveric Humeral Condylar Fracture Model · 2025 · DOI

  • The complexity of intervertebral disc disease is not yet fully understood. The precise etiology of compressive and contusive intervertebral disc disease remains elusive.

    A Comparative Analysis of Clinical Presentation, Prognosis and Outcomes in Paralytic Dogs with a Compressive and a Contusive Intervertebral Disc Disease · 2025 · DOI

  • The limited understanding of the stifle joint in Puma concolor. The need for a comprehensive study of the stifle joint in Puma concolor using different imaging methods.

    Imaging Studies of the Stifle Joint in Puma concolor (Linnaeus, 1771) · 2025 · DOI

  • Further studies are needed to evaluate the clinical effectiveness of self-compressing screws in humeral condylar fractures. Research should be conducted to compare the outcomes of self-compressing screws with traditional stabilization methods. The study of self-compressing screws in other types of fractures could provide additional insights.

    Biomechanical Comparison of Self-Compressing Screws and Cortical Screw Inserted with Lag Fashion in Canine Cadaveric Humeral Condylar Fracture Model · 2025 · DOI

  • Further studies are needed to compare the stifle joint anatomy of Puma concolor with other feline species. Future research should investigate the clinical significance of the findings. More studies are required to understand the variations in the stifle joint anatomy among different subspecies of Puma concolor. Research on the development and growth of the stifle joint in Puma concolor is needed.

    Imaging Studies of the Stifle Joint in Puma concolor (Linnaeus, 1771) · 2025 · DOI

  • Future investigations and development of this technique in vivo are warranted before implementation in clinical cases.

    Cervical articular process joint versus ventral cervical stabilization in horses: A biomechanical study · 2026 · DOI

  • Neuropathy of the L7 spinal nerve is common in dogs with degenerative lumbosacral disease, yet description of targeted perineural injection therapy in this region is scarce.

    Ventral approach for ultrasound-guided perineural injection of the canine L7 spinal nerve: a cadaveric feasibility study · 2026 · DOI

  • This report highlights the diagnostic role of DWI/ADC mapping and the novel use of patient repositioning to assess intraventricular material dynamics, underscoring the need for further research into advanced imaging and treatment strategies.

    MRI Features of Ventricular Empyema Caused by Escherichia coli in a Dog · 2026 · DOI

  • Ultrasonographic studies of canine carpal disorders are scarce and typically limited to case reports or evaluations of single structures.

    Ultrasonography in Canine Carpal Disorders · 2026 · DOI

  • The prevalence of incongruity as a primary cause of elbow dysplasia is not well understood. The correlation between incongruity and other primary causes of elbow dysplasia is not well established.

    Assessment of Elbow Joint Incongruity as a Primary Cause of Canine Elbow Dysplasia: Comparative Imaging Analysis Using CT and Radiography in 108 Dogs—A Retrospective Study · 2025 · DOI

  • Further MRI signal changes including contrast enhancement are not fully understood; however, incomplete red-to-yellow conversion and serous atrophy of the bone marrow are suspected (Fig 1).

    Magnetic resonance manifestation of diffuse osteopenia in a cat with presumed nutritional secondary hyperparathyroidism, hypocobalaminaemia and thiamine deficiency · 2025 · DOI

  • Although significant progress has been made in recent years regarding jumping biomechanics of agility dogs, there is still a lack of data on the specific biomechanical pattern of the jump.

    Assessment of the inter and intra-individual variability in the jump of agility dogs · 2025 · DOI

  • Despite widespread use of tibial plateau leveling osteotomy (TPLO), the influence of partial medial collateral ligament transection (pMCLX) and physiologic loading on rotational stability remains unclear.

    Femorotibial joint rotation in intact joints and following partial medial collateral ligament transection, tibial plateau leveling osteotomy, and cranial cruciate ligament transection – A limb press study · 2025 · DOI

  • A high proportion of agility injuries associated with an obstacle are due to the A-frame, however, there is limited research into the kinetics and kinematics of dogs traversing this type of equipment.

    The effects of altered distances between A-frame and the preceding jump on front limb dynamics in agility dogs · 2025 · DOI

  • Although the potential influence of morphometric variables on biomechanics of jumping dogs has been acknowledged, few studies have examined their actual relationships.

    Influence of height, body weight and body weight-to-height ratio on jump kinematics in agility dogs · 2026 · DOI

  • Assessment of the clinical relevance of the association between BCS and early radiographic osteotomy healing alongside functional outcomes, - Investigation of the relationship between BCS and long-term TPA…

    Association Between Body Condition Score and Early Radiographic Osteotomy Healing Following Tibial Plateau Leveling Osteotomy in Dogs: A Retrospective Study · 2026 · DOI

  • The study was conducted in a limited number of breeds, - The study was retrospective, - The sample size was 108…

    Assessment of Elbow Joint Incongruity as a Primary Cause of Canine Elbow Dysplasia: Comparative Imaging Analysis Using CT and Radiography in 108 Dogs—A Retrospective Study · 2025 · DOI

  • Retrospective study, - Limited to dogs undergoing TPLO procedures, - Excluded dogs with potentially contaminated skin lesions or other…

    Comparison of Surgical Site Infection (SSI) Rates in Dogs Undergoing Tibial Plateau Leveling Osteotomy (TPLO) Using Perioperative Versus Peri- and Postoperative Antimicrobial Prophylaxis · 2025 · DOI

  • No pathological examination was performed due to the owner's denial, - The study was retrospective, - The sample size was limited to 95…

    A Comparative Analysis of Clinical Presentation, Prognosis and Outcomes in Paralytic Dogs with a Compressive and a Contusive Intervertebral Disc Disease · 2025 · DOI

  • Small sample size of 10 dogs, - Limited to normal dogs, - No evaluation of kinesiology taping in dogs with neurologic or orthopedic…

    Kinesiology Taping Does Not Affect Tarsal Joint Motion During Selected Exercises in Dogs · 2025 · DOI

  • Assess kinesiology taping in other joints, - Evaluate kinesiology taping in dogs with neurologic or orthopedic conditions, - Investigate the effect of kinesiology taping on other gait…

    Kinesiology Taping Does Not Affect Tarsal Joint Motion During Selected Exercises in Dogs · 2025 · DOI

Most-cited papers in Veterinary Orthopedics and Neurology

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Open questions raised by papers listed on this page include: (1) Future investigations and development of this technique in vivo are warranted before implementation in clinical cases (“Cervical articular process joint versus ventral cervical stabilization in…”, 2026); (2) Neuropathy of the L7 spinal nerve is common in dogs with degenerative lumbosacral disease, yet description of targeted perineural injection therapy in this region is scarce (“Ventral approach for ultrasound-guided perineural injection of the canine L7…”, 2026); (3) The effectiveness of peri- and postoperative antimicrobial administration in preventing surgical site infections remains controversial (“Comparison of Surgical Site Infection (SSI) Rates in Dogs Undergoing Tibial…”, 2025); (4) There is a need to evaluate the diagnostic accuracy of radiography in a screening population (“Cross-Modality Diagnostic Agreement in Canine Medial Coronoid Disease in a…”, 2025); (5) There is a need for effective fixation methods for humeral condylar fractures in dogs (“Biomechanical Comparison of Self-Compressing Screws and Cortical Screw Inserted…”, 2025). 164 gap statements have been mined from Veterinary Orthopedics and Neurology papers in our 4.5M-paper local library, which holds 908 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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