Open research questions in Cancer-related cognitive impairment studies
144 gap statements mined from Cancer-related cognitive impairment studies papers in our 4.5M-paper local library, which holds 534 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.
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What the literature leaves open
The study highlights the need for comprehensive symptom management to improve cognitive outcomes. The study notes the challenge of quantifying cumulative symptom burden and its impact on cognitive impairment.
Association between cumulative symptom burden and cognitive impairment among breast cancer survivors: a cross-sectional study · 2026 · DOILess is known about the cumulative impact of comorbid symptoms on cognitive outcomes in breast cancer survivors. Prior work has focused on individual symptoms rather than cumulative symptom burden.
Association between cumulative symptom burden and cognitive impairment among breast cancer survivors: a cross-sectional study · 2026 · DOIFew studies have explored the combined effect of Pilates and lymphatic massage on cognition in breast cancer survivors. There is a need to investigate the effects of Pilates and Massage-Pilates interventions on memory, attention, and sustained attention in breast cancer survivors.
The effect of 12 sessions of lymphatic massage and Pilates exercise on the executive functions of breast cancer survivors · 2026 · DOIA significant gap exists in understanding the nuances of the relationship between CRCI and work, impacting the ability to develop tailored interventions. Most CRCI research interfaced with occupational functioning focuses on both subjectively and objectively measured CRCI determination and/or severity and its relation to return-to-work, performance, and functioning at work.
Work challenges and cancer-related cognitive impairment: level of education accounts for unmet needs beyond cognitive impairment severity · 2026 · DOICognitive impairment is common among older breast cancer survivors, yet factors that promote healthy cognitive function remain poorly understood.
Abstract B103: Cognitively supportive neighborhood environments and cognitive function after breast cancer · 2026 · DOICognability, an emerging measure of positive neighborhood environments that support cognitive health, has not been examined in cancer survivorship.
Abstract B103: Cognitively supportive neighborhood environments and cognitive function after breast cancer · 2026 · DOINeural substrates of cancer-related cognitive impairment (CRCI) remain poorly understood, especially in older adults facing aging-related cognitive decline and comorbid chronic conditions.
Longitudinal effects of comorbidities on brain structure and cognition in older breast cancer survivors · 2026 · DOIHowever, it remains unclear which cognitive domains are most relevant for global HRQoL, how fatigue relates to these associations, and whether this differs across disease stages.
Contribution of cognitive function and fatigue to health-related quality of life in patients with IDH -mutant gliomas from diagnosis to long-term follow-up · 2026 · DOIComputerized tools might be advantageous, but there is a lack of standardized, sensitive, and clinically feasible methods.
Developing a screening tool for cognitive deficits in routine neuro-oncology clinical practice: Clinical feasibility and cognitive insight · 2026 · DOIChemotherapy-induced cognitive impairment (CICI) is a frequently reported complication in lung cancer patients, yet the underlying cerebral metabolic changes remain poorly characterized.
Longitudinal voxel-based FDG PET assessment of chemotherapy effects on brain metabolism in lung cancer · 2026 · DOIHowever, because ALL chemotherapy involves multiple agents, the independent contribution of MTX to the previously observed metabolic changes remains unclear.
Methotrexate induces alterations in one-carbon metabolism and in plasmalogen and phosphatidylcholine levels in CSF of juvenile rats · 2026 · DOIDietary interventions could be highly disseminable and acceptable, but have not been evaluated for CRCI.
Rationale and study protocol for a randomized controlled MIND diet feeding trial for breast cancer-related cognitive impairment · 2026 · DOIAngiotensin receptor–neprilysin inhibitors and angiotensin II type-1 receptor blockers, such as sacubitril/valsartan (VS), have demonstrated neuroprotective potential; however, their effects in cisplatin (CIS)-induced neurotoxicity models remain poorly characterized.
Long‐term neurocognitive outcomes in paediatric cancer survivors treated with chemotherapy remain incompletely characterized, particularly in relation to cortical structure.
Temporal lobe cortical thickness and cognition in paediatric cancer survivors previously treated with chemotherapy · 2026 · DOIChemotherapy-related cognitive impairment (CRCI), is a well-recognized phenomenon in cancer patients who have undergone chemotherapy but the exact molecular mechanisms underpinning CRCI remain elusive.
Gene co-expression patterns shared between chemobrain and neurodegenerative disease models in rodents · 2025 · DOIThe effectiveness of traditional Chinese medicine (TCM)-based interventions in improving subjective and objective cognitive functions has not yet been investigated in previous network meta-analyses.
Comparative effectiveness of various nonpharmacological interventions, including traditional Chinese medicine-based interventions for cancer-related cognitive impairment: a comprehensive network meta-analysis · 2025 · DOIExisting whole-region analyses show inconsistent findings, while subregional changes and their interactions remain unclear.
Hippocampal-amygdala subregional characteristic changes predict heterogeneous post-chemotherapy neuropsychological outcomes · 2025 · DOIData from preclinical studies suggest that exercise during chemotherapy may prevent or diminish cognitive problems; however, clinical data are scarce.
Effects of physical exercise during adjuvant chemotherapy for breast cancer on long-term tested and perceived cognition: results of a pragmatic follow-up study · 2024 · DOIFuture research should explore the potential of DNM1 in CRCI pathogenesis and therapeutics development.
Despite the presumed association between these two factors, evidence remains sparse.
Understanding the association between fatigue and neurocognitive functioning in patients with glioma: A cross-sectional multinational study · 2024 · DOIFew studies have examined cognitive function in long-term survivors with brain metastases (BM).
Cognitive function in long-term survivors after treatment for brain metastases compared with normative samples · 2025 · DOISmall sample size of people with newly diagnosed aggressive lymphoma (n = 30), - Limited generalizability to other types of cancer or populations, - Exclusion of participants with lymphomatous CNS involvement or those who had undergone cranial radiation…
Cognitive impairment is associated with altered blood cell profiles in aggressive lymphoma · 2026 · DOIInvestigate the underlying biological mechanisms linking blood cell parameters to cognitive impairments, - Examine the relationships between blood cell parameters and cognitive outcomes in other types of cancer, - Develop personalised treatment plans based on blood cell…
Cognitive impairment is associated with altered blood cell profiles in aggressive lymphoma · 2026 · DOIInvestigate the effects of Pilates and lymphatic massage on other cognitive functions, - Explore the effects of Pilates and lymphatic massage on breast cancer survivors of different ages, - Examine the long-term effects of Pilates and lymphatic massage on cognitive…
The effect of 12 sessions of lymphatic massage and Pilates exercise on the executive functions of breast cancer survivors · 2026 · DOIDevelopment of more universally applicable intervention strategies, - Exploration of the common pathophysiological pathways across cancer types, - Investigation of the relationship between cognitive impairment and symptoms including anxiety and depression across distinct tumor…
Analysis of the current status and influencing factors of cognitive impairment in patients with different cancer types: a cross-sectional study · 2026 · DOI
Most-cited papers in Cancer-related cognitive impairment studies
- Validation of the Mindful Attention Awareness Scale in a cancer population · Journal of Psychosomatic Research · 2005 · 423 citations
- Mechanisms of Chemotherapy-Induced Neurotoxicity · Frontiers in Pharmacology · 2022 · 276 citations
- A multicenter, randomized clinical trial of a cognitive remediation program for childhood survivors of a pediatric malignancy. · Journal of Consulting and Clinical Psychology · 2008 · 249 citations
- Cognitive Function of Older Patients Receiving Adjuvant Chemotherapy for Breast Cancer: A Pilot Prospective Longitudinal Study · Journal of the American Geriatrics Society · 2006 · 220 citations
- Neurocognitive Outcomes in Survivors of Childhood Cancer · Journal of Pediatric Psychology · 2004 · 217 citations
- Long-Term Cognitive Dysfunction in Cancer Survivors · Frontiers in Molecular Biosciences · 2021 · 182 citations
- Background Noise · Nursing Research · 2007 · 174 citations
- Neurocognitive Interventions for Children and Adolescents Surviving Cancer · Journal of Pediatric Psychology · 2004 · 163 citations
- Efficacy of cognitive-behavioral therapy for insomnia in women treated for nonmetastic breast cancer. · Journal of Consulting and Clinical Psychology · 2003 · 153 citations
- Oxidative Stress and Redox Imbalance: Common Mechanisms in Cancer Stem Cells and Neurodegenerative Diseases · Cells · 2025 · 144 citations
Most recent work
- Mechanistic insights and therapeutic interventions of mitochondrial quality control in chemotherapy-related cognitive impairment · Neoplasia · 2026
- Chemotherapy-induced chemobrain and cognitive decline: A pharmacological perspective on neurovascular injury as a therapeutic target · Advances in Translational Research · 2026
- Urolithin A counteracts cyclophosphamide-induced chemobrain in rats through modulation of mitochondrial signaling pathways · Journal of Ethnopharmacology · 2026
- Cancer treatment–related cognitive impairment · Neuro-Oncology Advances · 2026
- Advances in neuroimaging in cancer-related cognitive impairment · Frontiers in Human Neuroscience · 2026
- Microvascular and microstructural brain abnormalities in paediatric haematological cancer survivors are related to cognitive deficits: An IVIM ‐ FWI MRI study · British Journal of Haematology · 2026
- Dose‐dependent impairment of brain functional and microstructural connectivity during leukaemia chemotherapy · British Journal of Haematology · 2026
- Effects of Exercise on Cognitive Impairment in Patients Receiving Chemotherapy: A Multicenter Phase III Randomized Controlled Trial · Journal of the National Comprehensive Cancer Network · 2026
- A Novel NAD+ Supporting Supplement Increased NAD+ Levels, Improved Well-Being, and Alleviated Aging Symptoms: A Double-Blind, Placebo-Controlled Study · medRxiv · 2026
- Repurposing Imeglimin for Chemotherapy-Induced Cognitive Impairment: Targeting Mitochondrial Dysfunction and Neuroinflammation · Cellular and Molecular Neurobiology · 2026
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