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Open research questions in Mosquito-borne diseases and control

314 unresolved questions extracted from the limitations and future-work sections of 896 Mosquito-borne diseases and control papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Contamination of samples - False positives in sequencing data - Limited availability of reference genomes for certain viruses - Difficulty in assembling contigs from sequencing reads

    Evidence of dengue transmission and a diverse Aedes mosquito virome on the Congo’s Angola border · 2026 · DOI

  • Tailoring mosquito xenosurveillance approaches to specific use cases, - Further study of arboviral disease outbreaks in the DRC

    Evidence of dengue transmission and a diverse Aedes mosquito virome on the Congo’s Angola border · 2026 · DOI

  • The study faces challenges in terms of data quality and availability, particularly with regards to death certificates and climate data. The analysis is limited by the lack of individual-level data and the use of aggregated data. The study must also account for the complex interplay of factors influencing dengue transmission, including climate, vector ecology, and human behavior.

    Dengue-Associated Mortality, Climate Anomalies, and Geographic Emergence in Peru, 2017–2024: A Spatiotemporal Study Triangulating Death Records and Epidemiological Surveillance · 2026 · DOI

  • Comparative studies across Latin American settings, - Evaluation of the effectiveness of surveillance, vector-control, clinical, or hospital-capacity interventions, - Investigation of delayed diagnosis, weaker referral systems, lower prior experience, or facility saturation in emergent provinces

    Dengue-Associated Mortality, Climate Anomalies, and Geographic Emergence in Peru, 2017–2024: A Spatiotemporal Study Triangulating Death Records and Epidemiological Surveillance · 2026 · DOI

  • Investigate the role of Ae. albopictus in CHIKV transmission dynamics - Study the genetic adaptations of CHIKV to Ae. albopictus

    Spatial–temporal distribution of chikungunya virus in Brazil: a review on the circulating viral genotypes and Aedes (Stegomyia) albopictus as a potential vector · 2024 · DOI

  • Conclusion: Together, these results identify key genetic differences between cryptic lineages of this international disease vector that warrant further investigation given potential differences in vector competence.

    Reproductive isolation and structural variation among sympatric lineages of an international mosquito pest · 2026 · DOI

  • Madariaga virus (MADV) is an understudied member of the eastern equine encephalitis virus (EEEV) complex that circulates widely in Latin America and may be geographically expanding.

    Eastern equine encephalitis virus-vaccinated mice are protected against Madariaga virus despite negligible neutralizing antibody titers · 2026 · DOI

  • However, previous studies have shown weak or undetectable MADV-neutralizing antibody responses in equids and humans immunized with inactivated NA EEEV vaccines, and whether protection can occur despite these limited neutralizing antibody responses remains unknown.

    Eastern equine encephalitis virus-vaccinated mice are protected against Madariaga virus despite negligible neutralizing antibody titers · 2026 · DOI

  • Very limited data on cross reactivity after Zabdeno/Mvabea vaccination suggests a higher drop in recognition of BDBV (39.

    Evidence for cross-reactivity and protection against Bundibugyo virus disease after heterologous vaccination: a systematic review and meta-analysis · 2026 · DOI

  • However, little is known about the specificity, phenotype, and repertoire of the enduring B cell response due to limitations in high-throughput methods.

    Signatures of the neutralizing dengue virus-reactive memory B cell repertoire identified by multiplexed envelope dimer probes · 2026 · DOI

  • Evidence for rotations is more limited and context dependent, while support for other strategies remains sparse or largely theoretical in mosquito systems.

    Insecticide Resistance Management for Mosquito Control: Mechanisms, Evidence, and Future Challenges · 2026 · DOI

  • However, the development of drugs is limited by the need for Biosafety Level 3 (BSL-3) containment and the lack of tools for real-time infection monitoring.

    A nanoluciferase-expressing attenuated CHIKV vaccine strain enables rapid and visual drug screening in vitro and in vivo · 2026 · DOI

  • IMPORTANCE Dengue virus infection during pregnancy is linked to adverse fetal outcomes, but the underlying mechanisms remain unclear.

    Trophoblast metabolic reprogramming triggers adverse pregnancy outcomes during DENV-2 infection in mice · 2026 · DOI

  • This highlights the need for further studies into noncanonical pathways of neuroinvasion.

    Interactions between Tick-Borne Encephalitis Virus Nonstructural Protein 1 and Blood–Brain Barrier Tight Junction Proteins: Potential Clues to Strain-Specific Neuropathogenicity · 2026 · DOI

  • Abstract Tick-borne encephalitis virus (TBEV) invades the central nervous system (CNS) through strain-specific mechanisms that remain poorly understood.

    Interactions between Tick-Borne Encephalitis Virus Nonstructural Protein 1 and Blood–Brain Barrier Tight Junction Proteins: Potential Clues to Strain-Specific Neuropathogenicity · 2026 · DOI

  • Public recreational areas represent under-recognized environments for Aedes breeding, with infestation patterns driven more by localized ecological conditions than by container abundance or broad geographic classification.

    Public recreational areas as potential environments for Aedes breeding in Malaysia: an entomological survey · 2026 · DOI

  • While surveillance efforts have traditionally focused on residential environments, public recreational areas may serve as under-recognized habitats for vector breeding.

    Public recreational areas as potential environments for Aedes breeding in Malaysia: an entomological survey · 2026 · DOI

  • Introduction: Systemic manifestations of dengue fever are well characterised, however ocular involvement has historically been considered a rare and under-recognised complication.

    Retinal Vascular Complications of Dengue Fever, an Unexplored Entity: · 2026 · DOI

  • Introduction/objectives Intrauterine exposure to the Zika virus (ZIKV) has been primarily associated with neurological outcomes, while its potential metabolic and nutritional consequences remain poorly understood.

    Interaction of intrauterine Zika virus exposure on the relationship between body adiposity and dyslipidemia in school-aged children · 2026 · DOI

  • Whether the recently introduced MAL causes comparably severe disease in China remains unknown.

    Clinical epidemiology and viral genomics insights from a Chikungunya fever outbreak in South China, 2025 · 2026 · DOI

  • However, the underlying host response products and interfering metabolic pathways and mechanisms of DENV infection remain unclear.

    The disturbance of ABC transporters in patients with dengue fever: integration of metabolomics and transcriptomics · 2026 · DOI

  • Despite dramatic recent increases in dengue that many anecdotally connect with climate change, the effect of anthropogenic climate change on dengue remains poorly quantified.

    Climate warming is expanding dengue burden in the Americas and Asia · 2025 · DOI

  • However, it remains unclear whether and how ZIKV regulates these receptors during infection.

    Autophagy-mediated downregulation of AXL and TIM-1 promotes sustained Zika virus infection · 2025 · DOI

  • Studies involving skin immunopathogenesis during CHIKV infection are still scarce; therefore, the findings presented here can contribute to a better understanding of the disease immunopathogenesis.

    Chikungunya virus infection in the skin: histopathology and cutaneous immunological response · 2025 · DOI

  • While trained immunity has been observed in invertebrates like shrimp after exposure to pathogens, the underlying molecular mechanisms remain elusive.

    Histone H3K27 acetylation mediated by KAT8 maintains antiviral trained immunity in shrimp induced by inactivated white spot syndrome virus · 2025 · DOI

Most-cited papers in Mosquito-borne diseases and control

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314 open questions have been extracted from the limitations and future-work passages of 896 Mosquito-borne diseases and control papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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