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Pharmacology, Toxicology and Pharmaceutics · Research topic

Open research questions in Drug Solubulity and Delivery Systems

188 unresolved questions extracted from the limitations and future-work sections of 488 Drug Solubulity and Delivery Systems papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • investigation of the in-vivo performance of the pellets, - optimization of the formulation using other statistical designs, - development of oral disintegrating pellets for other drugs

    Development, Optimization, and Evaluation of a Taste-Masked Oral Disintegrating Pellet Dosage Form Using Full Factorial Design · 2026 · DOI

  • The need for a patient-friendly oral drug delivery system for patient populations with difficulty swallowing traditional oral solid dose forms. The lack of a optimized taste-masked oral disintegrating pellet dosage form for BCS class III antihistaminic drugs.

    Development, Optimization, and Evaluation of a Taste-Masked Oral Disintegrating Pellet Dosage Form Using Full Factorial Design · 2026 · DOI

  • Further studies are needed to evaluate the bioavailability of the active compounds in RYR-containing FSs. Studies should be conducted to assess the long-term effects of consuming RYR-containing FSs. Research should be done to develop standardized methods for evaluating the pharmaceutical-technological quality of RYR-containing FSs.

    Pharmaceutical technological evaluation of red yeast rice food supplements: Quality characteristics of tablets and capsules · 2026 · DOI

  • Variability in the pharmaceutical-technological quality of red yeast rice-containing food supplements. Lack of systematic evaluation of these supplements.

    Pharmaceutical technological evaluation of red yeast rice food supplements: Quality characteristics of tablets and capsules · 2026 · DOI

  • Further research is needed to develop innovative ODT formulations and manufacturing strategies that address specific patient needs. The development of standardized high-speed quality control methods for personalized 'printlets' is necessary for widespread industrial adoption. Emerging technologies such as 3D printing and nanotechnology should be explored further for ODT formulation and manufacturing.

    Advances in Orally Disintegrating Tablets (ODTs): Formulation Strategies and Future Prospects · 2026 · DOI

  • Conventional ODT approaches have limitations, particularly for poorly soluble and high-dose drug substances. Emerging technologies such as 3D printing and nanotechnology have high capital equipment costs and low production throughput. The lack of standardized high-speed quality control methods for personalized 'printlets' remains a primary bottleneck for widespread industrial adoption.

    Advances in Orally Disintegrating Tablets (ODTs): Formulation Strategies and Future Prospects · 2026 · DOI

  • Uniform absorption is not exhibited by all medications across the entire gut or gastrointestinal tract. Conventional controlled oral dose formulations exhibit two key challenges: erratic emptying time from gut and brief time of gastric retention.

    Preparation and Evaluation of Oil Entrapped Gastro-Retentive Floating Gel Beads of Metoprolol Succinate as Antihypertensive · 2026 · DOI

  • Stability studies are mentioned as evaluating long-term stability and shelf life under varied storage conditions, but specific protocols, acceptable criteria, and comparative data across different FDT formulations are not detailed.

    A Comprehensive Review on Fast Dissolving Tablets · 2026 · DOI

  • Poor drug solubility is a significant challenge in pharmaceutical development. Existing solubility enhancement strategies have limitations and drawbacks.

    Solubility Enhancement Strategies for Poorly Soluble Drugs: Recent Trends · 2026 · DOI

  • AI/ML models (LASSO, MLP, SVR) correlate solubility with density but require validation across broader drug libraries and diverse physicochemical properties.

    Solubility Enhancement Strategies for Poorly Soluble Drugs: Recent Trends · 2026 · DOI

  • Sự cần thiết của các công nghệ hiện đại để đảm bảo sự phát triển và ứng dụng của thuốc FDC. Sự cần thiết của việc nghiên cứu và phát triển các dạng bào chế mới cho thuốc FDC.

    Fixed-dose Combination Medicinal Products: the Role of Modern Pharmaceutics · 2026 · DOI

  • Systematic and scientific approaches to research and formulation of FDC drugs are necessary to guide pharmaceutical research and development activities and promote rational, safe drug use in clinical practice.

    Fixed-dose Combination Medicinal Products: the Role of Modern Pharmaceutics · 2026 · DOI

  • There is a need for fixed-dose combinations of statin and other hypolipidemic drugs to overcome the challenges of high-intensity statin use. There is a lack of lipid-polymer hybrid nanoparticles for dual delivery of rosuvastatin and ezetimibe.

    Response0 surface guided design of lipid-polymer hybrid nanoparticles for dual delivery of rosuvastatin and ezetimibe · 2026 · DOI

  • The study demonstrates that EZE exhibits more variable release governed by mixed diffusion-matrix relaxation mechanisms compared to ROS (dominantly diffusion-driven), but the specific molecular interactions or localization differences within the PLGA core versus lipid shell that govern these distinct release mechanisms in the lipid-polymer hybrid nanoparticles remain mechanistically unclear.

    Response0 surface guided design of lipid-polymer hybrid nanoparticles for dual delivery of rosuvastatin and ezetimibe · 2026 · DOI

  • The complexity of the rheological behavior of cellulose ethers. The need for a comprehensive understanding of polymer structure property relationships. The challenge of selecting the optimal excipient for a given pharmaceutical formulation.

    A REVIEW ON PHARMACEUTICAL GRADE CELLULOSE ETHER BASED RHEOLOGICAL BEHAVIOUR EXCIPIENT SELECTION IN DRUG FORMULATION · 2026 · DOI

  • The study relies solely on rheological measurements and does not consider other factors that may influence excipient selection. The study only examines a limited range of polymer types and grades.

    A REVIEW ON PHARMACEUTICAL GRADE CELLULOSE ETHER BASED RHEOLOGICAL BEHAVIOUR EXCIPIENT SELECTION IN DRUG FORMULATION · 2026 · DOI

  • Investigation of the long-term stability of the amorphous solid dispersion. Evaluation of the formulation in human subjects. Application of the formulation strategy to other compounds with similar properties.

    Formulation Design of a Hot-melt Extrusion-Based Amorphous Solid Dispersion to Optimize Palatability of Berberine Hydrochloride with In Vitro and In Vivo Evaluation · 2026 · DOI

  • Conventional taste-masking polymers may not be effective for berberine hydrochloride. There is a need for a novel formulation strategy to improve palatability and bioavailability.

    Formulation Design of a Hot-melt Extrusion-Based Amorphous Solid Dispersion to Optimize Palatability of Berberine Hydrochloride with In Vitro and In Vivo Evaluation · 2026 · DOI

  • Conventional oral drug delivery methods have limitations, including short and inconsistent gastric residence duration. There is a need for a promising approach for site-specific and controlled drug delivery.

    Gastroretentive Floating Microspheres: A Promising Approach for Site-Specific and Controlled Drug Delivery. · 2026 · DOI

  • Section 10.2 asserts that floating microspheres are particularly effective for drugs acting locally in the stomach (gastritis, gastric ulcers, acid-related diseases) by maintaining prolonged gastric retention, but does not provide comparative efficacy data or head-to-head clinical trials comparing floating microsphere formulations to existing gastroretentive therapies (e.g., sucralfate suspension, bismuth compounds) in these disease states.

    Gastroretentive Floating Microspheres: A Promising Approach for Site-Specific and Controlled Drug Delivery. · 2026 · DOI

  • The low solubility of lovastatin results in dissolution-limited absorption, leading to low and variable oral bioavailability and reduced therapeutic efficiency. There is a need to develop effective formulation strategies to enhance the solubility and dissolution of lovastatin.

    Design and Optimization of PEG 6000-Based Lovastatin Solid Dispersion and Development of Orodispersible Tablets for Enhanced Dissolution · 2026 · DOI

  • There is a need for novel approaches to improve the bioavailability of poorly soluble drugs like Aceclofenac. The liquisolid compact technique has not been extensively studied for its application to specific drugs like Aceclofenac.

    DESIGN AND EVALUATION OF GASTROPROTECTIVE LIQUISOLID COMPACT OF ACECLOFENAC WITH ENHANCED INTESTINAL DISSOLUTION · 2026 · DOI

  • The aqueous solubility and bioavailability of famotidine need to be improved. There is a need for a stable and efficient method to prepare the inclusion complex of famotidine with Captisol.

    Comprehensive Investigation of a Famotidine/Captisol Inclusion Complex: Formulation, Characterization, and Enhanced Bioactivity · 2026 · DOI

  • The poor aqueous solubility and low oral bioavailability of artemether. The need for a more effective drug delivery system to enhance the therapeutic performance of artemether.

    In Vitro and Ex Vivo Studies of a Self-Emulsifying Drug Delivery System (Smedds) for Improved Oral Absorption of a Lipophilic Anti-Malarial Drug (Artemether) · 2026 · DOI

  • Overcoming the limited bioavailability of famotidine. Developing a formulation that provides sustained drug release and prolonged gastric residence time. Ensuring the stability of the formulation under accelerated stability conditions.

    Formulation and optimization of gastroretentive tablets containing famotidine in combination with antacids: In vitro evaluations and stability studies · 2026 · DOI

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188 open questions have been extracted from the limitations and future-work passages of 488 Drug Solubulity and Delivery Systems papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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