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Pharmacology, Toxicology and Pharmaceutics · Research topic

Open research questions in Drug-Induced Hepatotoxicity and Protection

145 unresolved questions extracted from the limitations and future-work sections of 729 Drug-Induced Hepatotoxicity and Protection papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • prospective validation of combining an available genotype with the patient's age, comorbidities, concomitant medications, expected antibiotic exposure, and the strength of the pharmacovigilance signal - further study on the use of NAT2 genotype to guide isoniazid dosing

    A pharmacist-led framework for antibiotic-associated liver injury: from pharmacovigilance signals to bedside surveillance with the updated RUCAM and susceptibility markers · 2026 · DOI

  • There is a lack of a confirmatory test for liver injury. The clinical manifestations, biochemical patterns, and time intervals from exposure to injury vary significantly among patients. Prior studies have not provided a comprehensive approach to diagnosing and managing liver injury.

    A pharmacist-led framework for antibiotic-associated liver injury: from pharmacovigilance signals to bedside surveillance with the updated RUCAM and susceptibility markers · 2026 · DOI

  • Further studies are needed to investigate the long-term effects of HT on liver injury, - Research on the potential therapeutic applications of HT in human liver diseases is necessary, - Studies on the mechanisms of HT in reducing inflammation and improving liver function are required

    Hydroxytyrosol Alleviates Acute Liver Injury by Inhibiting the TNF-α/PI3K/AKT Signaling Pathway via Targeting TNF-α Signaling · 2024 · DOI

  • The lack of understanding of the mechanisms of Hydroxytyrosol in acute liver injury. The need for effective treatments for acute liver injury. The limited knowledge of the underlying mechanisms of LPS and D-GalN-induced liver injury.

    Hydroxytyrosol Alleviates Acute Liver Injury by Inhibiting the TNF-α/PI3K/AKT Signaling Pathway via Targeting TNF-α Signaling · 2024 · DOI

  • Together, these data identify LSECs as a drug-responsive hepatic cell type for fenofibrate, suggesting that LSECs could represent an underrecognised contributor to the complex, multifactorial processes underlying DILI.

    Fenofibrate, but not fenofibric acid, reduces fenestrations and impairs endocytic function in liver sinusoidal endothelial cells · 2026 · DOI

  • Understanding the effects of fenofibrate on LSEC ultrastructure may therefore provide insights into previously underexplored endothelial contributions to hepatic drug responses.

    Fenofibrate, but not fenofibric acid, reduces fenestrations and impairs endocytic function in liver sinusoidal endothelial cells · 2026 · DOI

  • The precise mechanisms that give rise to sepsis-induced liver injury, however, remain incompletely understood.

    Mechanisms of sepsis-induced acute liver injury: a comprehensive review · 2025 · DOI

  • However, understanding specific risk factors remains challenging due to limited data.

    Hepatotoxicity of antipsychotics: an exploratory pharmacoepidemiologic and pharmacodynamic study integrating FAERS data and in vitro receptor-binding affinities · 2024 · DOI

  • The need for effective therapeutic agents to prevent or treat acetaminophen-induced liver damage. The potential of curcumin to mitigate oxidative stress and preserve mitochondrial function.

    Hepatoprotectıve Property Of Turmeric (Curcumin) Administration On Chronic Acetaminophen Induced Liver Damage In Albino Wistar Rats · 2026 · DOI

  • The study does not compare curcumin's hepatoprotective efficacy directly with the conventional antidote N-acetylcysteine (NAC) in the same experimental design.

    Hepatoprotectıve Property Of Turmeric (Curcumin) Administration On Chronic Acetaminophen Induced Liver Damage In Albino Wistar Rats · 2026 · DOI

  • The effect of the hydroalcoholic extract of Pterocarpus marsupium heartwood on L-thyroxine induced liver injury has not been previously studied. There is a need for alternative therapeutic agents for the management of liver injury.

    Hepatoprotective Activity of Vijaysar Heartwood Extract Against Drug-Induced Liver Injury in Wistar Rats · 2026 · DOI

  • The study does not identify the intracellular pathways leading to injury. The system uses a limited number of cell lines. The study does not provide a comprehensive understanding of the mechanisms of drug-induced liver injury.

    A new in vitro rat liver platform capturing biological diversity for drug-induced liver injury assessment and reduction of animal use in drug discovery and development · 2026 · DOI

  • Current preclinical models have limitations in translatability to human responses. There is a need for a new in vitro rat liver platform for drug-induced liver injury assessment.

    A new in vitro rat liver platform capturing biological diversity for drug-induced liver injury assessment and reduction of animal use in drug discovery and development · 2026 · DOI

  • Further studies are needed to investigate the therapeutic potential of targeting p38γ or microRNA-125 for APAP-induced liver injury. Additional research is needed to understand the molecular mechanisms of p38γ in liver injury. Studies are needed to develop new biomarkers for APAP-induced liver injury.

    Hepatic p38γ exacerbates acetaminophen‑induced acute liver injury via PI3K/Akt‑dependent mechanisms · 2026 · DOI

  • The molecular mechanisms of p38γ in liver injury are not well understood. There is a need for effective treatments for APAP-induced liver injury. The current standard clinical antidote for APAP poisoning has limited clinical use.

    Hepatic p38γ exacerbates acetaminophen‑induced acute liver injury via PI3K/Akt‑dependent mechanisms · 2026 · DOI

  • There is a need to discover new drugs with no adverse effects. The treatment of liver diseases with presently available medications poses severe adverse effects. The study aims to investigate the phytoconstituents of Tabernaemontana divaricata against hepatotoxicity using an in silico approach of molecular docking and molecular dynamic simulation studies.

    Network Pharmacology, Molecular Docking And Molecular Dynamic Studies Of Phytoconstituents Of Tabernaemontana Divaricata For The Hepatoprotective Activity · 2026 · DOI

  • The study identifies a research gap in the investigation of the protective effects of total flavonoids from Puerariae Lobatae Radix on exercise-induced liver injury. The study highlights the need for further research on the health impacts of high-intensity or excessive exercise.

    Protective effects of a commercial total flavonoid preparation from Puerariae Lobatae Radix on exhaustive exercise–induced liver injury in mice · 2026 · DOI

  • To investigate the therapeutic potential of targeting SNHG9 in DILI. To study the role of SNHG9 in other liver diseases. To further elucidate the molecular mechanisms of SNHG9 in the liver.

    Hepatic SNHG9 links gut microbiota to liver protection in drug-induced liver injury · 2026 · DOI

  • The lack of understanding of the molecular mechanisms of SNHG9 in the liver. The need to investigate the role of hepatic SNHG9 in mediating gut-liver crosstalk in DILI.

    Hepatic SNHG9 links gut microbiota to liver protection in drug-induced liver injury · 2026 · DOI

  • The study has a limited sample size. The study only included pediatric patients diagnosed with tuberculosis at Changsha Central Hospital. Further validation in larger, independent cohorts is warranted.

    NAT2 rs1495741 and anti-tuberculosis drug-induced liver injury in children: genetic association and risk prediction · 2026 · DOI

  • Pediatric pharmacogenetic evidence remains limited. There is a need for further research on the genetic factors associated with ATB-DILI in children.

    NAT2 rs1495741 and anti-tuberculosis drug-induced liver injury in children: genetic association and risk prediction · 2026 · DOI

  • There is a lack of evidence for the efficacy of botanical drugs in treating liver diseases. There are concerns about the quality of studies testing herbal remedies.

    HERBAL PLANTS TARGETING OXIDATIVE STRESS IN HEPATOTOXICITY · 2026 · DOI

  • Liver damage caused by toxins, drugs, and oxidative stress is a major health problem worldwide. There is a need for safer herbal medicines for treating liver disorders.

    Phytochemical and Hepatoprotective Potential of Randia dumetorum: A Comprehensive Review · 2026 · DOI

  • There is a need for safer herbal medicines for treating liver disorders. Additional clinical and pharmacological studies are necessary to establish the therapeutic potential of Randia dumetorum in modern medicine.

    Phytochemical and Hepatoprotective Potential of Randia dumetorum: A Comprehensive Review · 2026 · DOI

  • There is a lack of scientific evidence for the hepatoprotective potential of Murvadi Agada. The study aims to fill this gap by evaluating the hepatoprotective effect of Murvadi Agada.

    Evaluation of hepatoprotective activity of Murvadi Agada - A polyherbal formulation in Methotrexate induced hepatotoxicity in Wistar albino rats. · 2026 · DOI

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145 open questions have been extracted from the limitations and future-work passages of 729 Drug-Induced Hepatotoxicity and Protection papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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