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Pharmacology, Toxicology and Pharmaceutics · Research topic

Open research questions in Advanced Drug Delivery Systems

135 gap statements mined from Advanced Drug Delivery Systems papers in our 4.5M-paper local library, which holds 825 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The need for more intelligent and responsive release technologies. The lack of understanding of the features and performance of plant-based and mucoadhesive polymers.

    THIS ARTICLE PRESENTS ON: OVERVIEW OF VARIOUS POLYMERS UTILIZED IN PHARMACEUTICAL DRUG DELIVERY SYSTEMS · 2026 · DOI

  • Glipizide exhibits poor solubility and limited oral bioavailability. There is a need to improve the bioavailability and therapeutic efficacy of Glipizide.

    DEVELOPMENT, OPTIMIZATION AND CHARACTERIZATION OF MOUTH DISSOLVING FILM OF GLIPIZIDE FOR THE TREATMENT OF DIABETES MELLITUS · 2026 · DOI

  • Current advancements and clinical translation prospects are discussed. Future directions in this field are discussed to provide insights into the development of effective oral peptide formulations.

    Enhancing Oral Bioavailability of Therapeutic Peptides Using Permeation Enhancer and Nanocarrier Hybrid Systems · 2026 · DOI

  • The lack of effective treatments for neurological disorders. The need for innovative therapeutic strategies for the delivery of therapeutics to the CNS. The limited understanding of the mechanisms of intranasal drug delivery to the CNS.

    A rationally designed polypeptide-based hybrid platform for targeted intranasal brain drug delivery · 2026 · DOI

  • The drug dissolution process in the colon is still not fully understood due to the complexities of this environment. Limited intraluminal fluid is the key feature that reduces the disintegration and dissolution of the dosage forms in the colon.

    Exploration of Colonic Mucus as A Dissolution Compartment for Orally Administered Drugs · 2026 · DOI

  • Together, our results suggest that the integration and diffusion of venom-inhibiting drugs in WPI hydrogels is possible and that the development of such drug-integrated hydrogels into snakebite wound dressings warrants further research.

    Heparin-incorporated whey protein isolate-derived hydrogels with an intended dual function as snakebite wound dressings and drug delivery systems inhibit spitting cobra venom-induced cytotoxicity · 2026

  • Moisture sensitivity is a challenge that restricts commercialization of sublabial strips. Limited drug loading capacity is another limitation of sublabial strips. Scale-up difficulties and packaging instability are also challenges associated with sublabial strips.

    SUBLABIAL STRIPS: AN EMERGING APPROACH FOR TRANSMUCOSAL DRUG DELIVERY · 2026 · DOI

  • Conventional oral dosage forms have limitations such as hepatic first-pass metabolism and gastrointestinal degradation. There is a need for alternative transmucosal drug delivery systems for improved therapeutic effectiveness.

    SUBLABIAL STRIPS: AN EMERGING APPROACH FOR TRANSMUCOSAL DRUG DELIVERY · 2026 · DOI

  • Further considerations such as large-scale manufacturability, physicochemical stability, and batch reproducibility remain to be systematically addressed prior to clinical application. Although microbiome compatibility was evaluated using representative Lactobacillus species, comprehensive assessment of the vaginal microbial ecosystem is required.

    Thermoresponsive carbohydrate polymer mucoadhesive gel for synergistic delivery of acarbose and fluconazole against Candida biofilms · 2026 · DOI

  • There is a lack of comprehensive and integrated analysis of chitosan-based vaccine delivery systems. Existing reviews have not systematically compared the performance of CS-NPs across all three major antigen modalities.

    Chitosan nanoparticles for mucosal and needle-free vaccination · 2026 · DOI

  • Continued research and regulatory evaluation are essential to ensure safety, scalability, and cost-effectiveness of novel drug delivery systems. Further investigation of the integration of nanotechnology and biodegradable polymers for controlled and site-specific drug release.

    Pharmacokinetic and Pharmacodynamic Evaluation of Novel Drug Delivery Systems in Chronic Disease Management · 2026 · DOI

  • Batch-to-batch variability, microbiological contamination, inadequate mechanical strength, stability concerns, and lack of standardization are limitations of natural polymers. Additional standardization and regulatory control are needed to address these difficulties.

    Present Developments and Prospects for Natural Polymer-Based Drug Delivery Systems and Patient-Friendly Formulations · 2026 · DOI

  • Future research should focus on biopolymer engineering, customized medicine, and green pharmaceutical technologies. The use of natural polymers in combination with intelligent drug delivery systems, green pharmaceutical technology, and personalized treatment should be explored.

    Present Developments and Prospects for Natural Polymer-Based Drug Delivery Systems and Patient-Friendly Formulations · 2026 · DOI

  • Across this set, cytosine deaminase has not been evaluated in any cancer cell line or animal tumor model.

    Formulation, characterization and evaluation of cytotoxic potential for febuxostat loaded chitosomes against cervical cancer cells (Hela cells) · 2026 · DOI

  • The biocompatibility of PDMS as a vitreous humour substitute has not been evaluated. The relationship between physicochemical properties and biocompatibility of PDMS is not well understood. There is a need to assess the storage stability, emulsification resistance, and cytotoxicity of PDMS.

    Biocompatibility Assessment of Polydimethylsiloxane for Vitreous Substitution Application in Relation to Physicochemical Properties · 2026 · DOI

  • Limited oral bioavailability of Glipizide. Physicochemical and pharmacokinetic problems associated with pharmaceuticals.

    DEVELOPMENT, OPTIMIZATION AND CHARACTERIZATION OF MOUTH DISSOLVING FILM OF GLIPIZIDE FOR THE TREATMENT OF DIABETES MELLITUS · 2026 · DOI

  • The solid state of studied compounds was not further confirmed after the solubility measurements. The study did not investigate the effect of the polymer on solubility for all compounds.

    Exploration of Colonic Mucus as A Dissolution Compartment for Orally Administered Drugs · 2026 · DOI

  • Limited oral bioavailability of Efavirenz due to low solubility and high protein binding. Inadequate penetration of Efavirenz into the central nervous system.

    Intranasal Solid Lipid Nanoparticles of Efavirenz in Thermosensitive Gel for Enhanced Brain Targeting: Formulation, Optimization, and Evaluation · 2026 · DOI

  • To effectively manage the escalating global threat of fungal infections and successfully accelerate the clinical translation of advanced nanocarriers, the field must establish harmonized regulatory standards, implement robust quality-controlled manufacturing protocols, and prioritize early engagement with regulatory agencies.

    Lipid-based nanocarriers for antifungal drug delivery · 2026 · DOI

  • Further evaluation of the potential toxicity of the nanocarrier system. Detailed analysis of the pharmacokinetics and pharmacodynamics of the delivered therapeutics. Exploration of the use of the platform for the delivery of a wide range of therapeutics.

    A rationally designed polypeptide-based hybrid platform for targeted intranasal brain drug delivery · 2026 · DOI

  • Additional studies including impurity profiling, full release curve evaluation, and post-storage characterization of nanoparticle attributes such as particle size, 1 3BioNanoScience (2026)…

    Folic Acid–Conjugated Chitosan Nanoparticles for Colon-Targeted Delivery of Imatinib Mesylate · 2026 · DOI

  • Poor brain delivery of melatonin due to first-pass effects and the blood-brain barrier. Rapid mucociliary clearance and poor water solubility of intranasal administration. Uneven distribution of traditional in situ gels.

    Ion-Triggered In Situ Gel Combined with Melatonin Liposomes: Breaking Through the Dual Barriers of Nasal and Brain Delivery to Treat Insomnia · 2026 · DOI

  • The study identifies a gap in the development of effective drug delivery systems for Dasatinib. The poor water solubility of Dasatinib poses a challenge to its pharmacokinetics.

    FORMULATION, CHARACTERIZATION, AND CYTOTOXICITY EVALUATION OF DASATINIB-LOADED NANOSPONGES ON A498 AND MCF-7 CELL LINES · 2026 · DOI

  • No study in this set evaluates cytosine deaminase activity or expression in cancer cells or tumor models.

    Formulation, characterization and evaluation of cytotoxic potential for febuxostat loaded chitosomes against cervical cancer cells (Hela cells) · 2026 · DOI

  • Further development of Microbiome-Active Drug Delivery Systems (MADDS). Investigation of AI-driven design for personalized medicine. Exploration of emerging techniques for mucopenetrating vaginal drug delivery.

    Chitosan nanoparticle based mucoadhesive and mucopenetrating vaginal drug delivery systems · 2026 · DOI

Most-cited papers in Advanced Drug Delivery Systems

Most recent work

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Open questions raised by papers listed on this page include: (1) The lack of understanding of the features and performance of plant-based and mucoadhesive polymers (“THIS ARTICLE PRESENTS ON: OVERVIEW OF VARIOUS POLYMERS UTILIZED IN…”, 2026); (2) There is a need to improve the bioavailability and therapeutic efficacy of Glipizide (“DEVELOPMENT, OPTIMIZATION AND CHARACTERIZATION OF MOUTH DISSOLVING FILM OF…”, 2026); (3) The lack of effective treatments for neurological disorders (“A rationally designed polypeptide-based hybrid platform for targeted intranasal…”, 2026); (4) The drug dissolution process in the colon is still not fully understood due to the complexities of this environment (“Exploration of Colonic Mucus as A Dissolution Compartment for Orally…”, 2026); (5) There is a need for alternative transmucosal drug delivery systems for improved therapeutic effectiveness (“SUBLABIAL STRIPS: AN EMERGING APPROACH FOR TRANSMUCOSAL DRUG DELIVERY”, 2026). 135 gap statements have been mined from Advanced Drug Delivery Systems papers in our 4.5M-paper local library, which holds 825 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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