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Open research questions in Advancements in Transdermal Drug Delivery

744 gap statements mined from Advancements in Transdermal Drug Delivery papers in our 7.9M-paper local library, which holds 2,909 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Future research should focus on. Formulation of preservative-free herbal jelly masks (for example, silymarin-based formulations) with enhanced healing potential. Application of nanotechnology to more effectively deliver phytochemicals. Clinical assessment of safety and effectiveness in human subjects. Quality control and standardization of herbal extracts.

    A REVIEW ON HERBAL PEEL-OFF (JELLY) MASKS FORMULATED USING SELECTED HERBAL PLANTS · 2026 · DOI

  • Second, chronic rather than acute dermal biosafety data for MAS and MSN carriers, ideally generated under conditions that mirror realistic patchwear regimens rather than single-dose exposure, would directly address the principal safety evidence gap identified in Section 10.

    NANOPARTICLE-ENABLED TRANSDERMAL DELIVERY OF CANNABIDIOL AND RELATED CANNABINOIDS: CARRIER CHEMISTRY, QUALITY-BY-DESIGN FORMULATION, AND THERAPEUTIC TRANSLATION · 2026 · DOI

  • Although preliminary and conducted without a comparator arm, these findings support the rationale for further investigation of engineered synthetic lipid vesicles as active adjuncts in minimally invasive aesthetic strategies focused on skin-quality enhancement.

    Safety and Preliminary Clinical Outcomes of Integrating Engineered Synthetic Lipid Vesicles (Biosomes) in a Skin Booster Protocol: A Prospective Observational Study · 2026 · DOI

  • The current coverage of action scenarios is insufficient; future studies need to include actions such as bending over and sit–stand transitions to thoroughly validate the anti-interference capability of the MNA electrodes.

    Development of a Flexible Microneedle Array Electrode with a High Signal-to-Noise Ratio for Surface Bioelectrical Signal Recording · 2026 · DOI

  • With the rapid advancement in microneedle research, the need for a reliable, scalable characterization platform has become increasingly evident. From penetration to application (e.g., therapy or sensing), microneedle functionality must be rigorously evaluated with respect to insertion mechanics, drug delivery efficiency, and biosensing capabilities.

    Artificial Tissue Models for Microneedle Testing and Analysis · 2026 · DOI

  • However, the safety of NFs remains poorly studied, especially in atopic skin, hindering the development of marketable products. These characteristics supported further investigation of such NFs, particularly their intrinsic capacity to reinforce the skin barrier via their lipid composition, and to evaluate their safety and efficacy in both healthy and atopic volunteers, as detailed herein.

    Assessing the Impact on Barrier Function of Black Soldier Fly Larvae Lipids-Based Nanoparticles · 2026 · DOI

  • A primary limitation of this study is the structural divergence between the two intervention tracks—specifically, weekly clinic-based Synerjet treatments versus twice-daily at-home topical applications—which introduces potential confounding variables such as application frequency, setting, and professional administration.

    Beyond Nano-Delivery: Synerjet-Assisted Transdermal Delivery of Nano-Formulated Nicotinamide Mononucleotide (Nano-NMN) for Comprehensive Skin Rejuvenation · 2026 · DOI

  • Even though oleofoams have been mainly investigated for food applications, their potential use in cosmetics and pharmaceuticals remains unexplored and requires further research to be substantiated.

    Oleogel-Based Formulations for Cosmetics and Pharmaceutical Applications: Current Landscape and Future Directions · 2026 · DOI

  • To bridge the gap between experimental formulations and commercial implementation, a set of requirements must be addressed. Ensuring effective skin dermal or transdermal permeation of the actives and long-term physicochemical stability by improving oleogel’s structural stability, mitigating syneresis and instability risks stemming from impurities is critical.

    Oleogel-Based Formulations for Cosmetics and Pharmaceutical Applications: Current Landscape and Future Directions · 2026 · DOI

  • Because LP-PTE was not included in the ECM or gene-expression experiments, the separate contributions of HA modification and liposomal encapsulation to the ECM-related effects remain unclear. Longer-term safety, irritation potential, persistence of pharmacodynamic effects, and anti-photoaging activity therefore remain to be examined in vivo.

    Multifunctional Hyaluronic Acid-Modified Pterostilbene Nanoliposomes for Enhanced Dermal Delivery and Extracellular Matrix Protection · 2026 · DOI

  • This discrepancy reflects a fundamental challenge: the majority of microneedle designs are optimized for technical feasibility rather than for functional and clinical performance. A central conclusion emerging from this analysis is that microneedle systems cannot be effectively developed through material- or technology-driven approaches alone.

    Beyond Material Selection: Function-Driven Design of Polymer-Based Microneedles for Transdermal Drug Delivery · 2026 · DOI

  • Further research is needed to explore the full potential of 3D printing for topical drug delivery, including the development of new polymers, the optimization of printing parameters, and the integration of smart technologies that can provide real-time feedback on drug release and efficacy.

    Review on 3D Printing Filaments Used in Fused Deposition Modeling Method for Dermatological Preparations · 2025 · DOI

  • Although the TFR of the synthesized NLPUS process exceeded 80 mL/min, it still remains insufficient as compared to the requirements of actual industrial production processes.

    High-Throughput Microfluidic Production of Ultrasmall Lecithin Nanoliposomes for High-Efficacy Transdermal Delivery and Skin-Aging Treatment · 2025 · DOI

  • Despite these advantages, several technical and translational challenges remain, such as vesicle aggregation, fusion, leakage of encapsulated agents, and difficulties in large-scale production, stabilization, and distribution.

    Niosomes as Vesicular Carriers: From Formulation Strategies to Stimuli-Responsive Innovative Modulations for Targeted Drug Delivery · 2025 · DOI

  • Although a comparison of active and inactive ingredients was performed for the three gels (Table 4), the precise formulations, specifically, the percentages of weight and volume of each ingredient, remain unknown, as this information is proprietary and not publicly available.

    A Mechanistic Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach Informed by In Vitro and Clinical Studies for Topical Administration of Adapalene Gels · 2025 · DOI

  • While encouraging, the results are limited to a single tumor model and short-term exposure; more study involving pharmacokinetics, toxicity profiles, HER2-specific breast cancer models, and biodistribution studies is required before any translational consideration.

    Harnessing Dual Power: Genistein-Loaded Pumpkisomes in Pullulan Microneedles for Potent Antioxidant and Anticancer Therapy Against Ehrlich Ascites Carcinoma and Breast Cancer Cells · 2025 · DOI

  • Based on the dosage of Rhein used in various studies concerning tumour treatment, specifically 50 mg/kg body-weight, we propose that a dose of 20 mg/kg bodyweight of Rhein encapsulated in liposomes could be considered an optimal starting point for further investigation into its antitumour efficacy.

    Fluorescent Rhein-Loaded Liposomes for In Vivo Biodistribution Study · 2025 · DOI

  • Natural cosmetics today are no longer confined to traditional herbal remedies; they represent a dynamic and multidisciplinary field encompassing molecular biology, pharmacognosy, cosmetic technology, and environmental science.

    Botanical and Upcycled Bioactives for Advanced Topical Formulations: Mechanistic Pathways, Cutaneous Delivery, and Sustainability-by-Design · 2026 · DOI

  • In addition, maintaining a constant drug concentration at the injection region represents sustained drug supply and does not account for depletion of a finite dose. EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood.

    In Silico Investigation of Electrically Guided Drug Transport Toward Morphology-Specific Brain Tumor Treatment · 2026 · DOI

  • The maximal reduction of the tip diameter is often limited by the manufacturing method of the master array as well as the properties of the materials used for the DMNA.

    What Is the Optimal Geometry of Dissolving Microneedle Arrays? A Literature Review · 2025 · DOI

  • The main limitation of the present study is that the validation is confined to the materials level and to ex vivo tests: in vivo RF energy delivery, mapping of the resulting thermal zones, histological assessment of the thermal damage, the durability of the silver layer over repeated insertions and the release of silver ions over a clinically relevant period remain to be evaluated, and these aspects are the subject…

    Low-Shrinkage 3D-Printed Polymeric Microneedle Arrays with Electroless Silver Coating for Enhanced Thermal and Mechanical Performance in Dermatological Applications · 2026 · DOI

  • Beyond functional form, the accuracy achievable from public data is limited at least as much by standardisation of the underlying experiments as by model sophistication; the two information sources could not be ranked against each other on these data…

    Human Skin Permeability Prediction by Machine Learning for Transdermal Drug Delivery · 2026 · DOI

  • The liposomal encapsulation effectively enhanced the solubility, stability, and skin penetration of both KA and LE, overcoming a key limitation of conventional brightening formulations.

    Dissolvable Face Mask with Liposomal Licorice Extract and Kojic Acid: An Innovative Approach for Skin Brightening · 2026 · DOI

  • We conducted a comprehensive search in the Scopus database using keywords such as “androgenetic alopecia” and “transdermal delivery”, with the annual publication output over the past six decades illustrated in Figure 9.

    Advances in Transdermal Delivery Systems for Treating Androgenetic Alopecia · 2025 · DOI

  • As a revolutionary breakthrough in transdermal drug delivery, MN technology demonstrates unique application value in dermatological treatment. Addressing the inherent issues of low bioavailability caused by gastrointestinal digestion and hepatic first-pass metabolism in oral administration, MNs enable drug delivery through skin or mucosal membranes with minimal systemic exposure.

    Microneedle-Mediated Transdermal Drug Delivery for the Treatment of Multiple Skin Diseases · 2025 · DOI

Most-cited papers in Advancements in Transdermal Drug Delivery

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Open questions raised by papers listed on this page include: (1) The current coverage of action scenarios is insufficient; future studies need to include actions such as bending over and sit–stand transitions to thoroughly validate the anti-interference capability of the MNA electrodes (“Development of a Flexible Microneedle Array Electrode with a High…”, 2026); (2) Even though oleofoams have been mainly investigated for food applications, their potential use in cosmetics and pharmaceuticals remains unexplored and requires further research to be substantiated (“Oleogel-Based Formulations for Cosmetics and Pharmaceutical Applications:…”, 2026); (3) Because LP-PTE was not included in the ECM or gene-expression experiments, the separate contributions of HA modification and liposomal encapsulation to the ECM-related effects remain unclear (“Multifunctional Hyaluronic Acid-Modified Pterostilbene Nanoliposomes for…”, 2026). 744 gap statements have been mined from Advancements in Transdermal Drug Delivery papers in our 7.9M-paper local library, which holds 2,909 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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