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Pharmacology, Toxicology and Pharmaceutics · Research topic

Open research questions in Advancements in Transdermal Drug Delivery

199 unresolved questions extracted from the limitations and future-work sections of 403 Advancements in Transdermal Drug Delivery papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Overcoming the highly organized structure of the stratum corneum for transdermal drug delivery. Achieving sufficient needle length and tip sharpness for insertion. Providing adequate structural support for the microneedles.

    Fabrication and Characterization of Benzhydroxamic Acid-Loaded Dissolving Microneedles Using a 3D-Printing-Assisted Mold Fabrication Approach · 2026 · DOI

  • investigating the long-term stability of the microneedles, - conducting in vivo studies to evaluate the efficacy and safety of the microneedles, - exploring the use of different polymeric materials for the microneedles

    Fabrication and Characterization of Benzhydroxamic Acid-Loaded Dissolving Microneedles Using a 3D-Printing-Assisted Mold Fabrication Approach · 2026 · DOI

  • The study used in vitro and ex vivo models, which may not fully reflect in vivo conditions, - The study tested a limited number of antiseptic formulations and concentrations, - The study did not investigate the effects of antiseptic formulations on wound healing in vivo

    Cytotoxicity of antimicrobial wound irrigation solutions and antiseptics: an in vitro and ex vivo study · 2026 · DOI

  • Investigate the effects of antiseptic formulations on wound healing in vivo, - Test a wider range of antiseptic formulations and concentrations, - Examine the mechanisms of cytotoxicity and cell death induced by antiseptic formulations

    Cytotoxicity of antimicrobial wound irrigation solutions and antiseptics: an in vitro and ex vivo study · 2026 · DOI

  • However, their physicochemical compatibility and emulsion stability upon continuous infusion remain unclear.

    Physicochemical compatibility and stability of urapidil-propofol admixtures during simulated Y-site Administration · 2026 · DOI

  • Future research should focus on developing intelligent DDSs with multi-stimuli responsiveness, leveraging omics for mechanistic insights, and creating patient-specific delivery strategies to enhance clinical application.

    Research progress in treatment of rheumatoid arthritis with Sinomenine and related formulations based on different administration routes · 2025 · DOI

  • By addressing gaps in the literature regarding their integrated diagnostic and treatment capabilities, this review underscores the pivotal role of microneedles in personalizing medicine.

    Microneedles at the Forefront of Next Generation Theranostics · 2025 · DOI

  • Although these advancements are favorable in terms of biocompatibility and production costs, they are insufficient for the therapeutic use of MNs.

    Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles · 2024 · DOI

  • However, conventional microneedles are limited by the low drug loading capacity, making it challenging to be applied on human skin at a reasonable size for a lasting glucose-controlling effect, thus hindering their clinical translation.

    Glucose-Responsive Microneedle Patch with High Insulin Loading Capacity for Prolonged Glycemic Control in Mice and Minipigs · 2024 · DOI

  • However, studies documenting LPS-pre-Exos as a therapeutic intervention for oral mucosal-like diseases are lacking.

    Silk Fibroin Microneedles Loaded with Lipopolysaccharide-Pretreated Bone Marrow Mesenchymal Stem Cell-Derived Exosomes for Oral Ulcer Treatment · 2024 · DOI

  • The study does not mention any specific limitations. However, it can be inferred that the study may have limitations such as small sample size or limited scope.

    Topical Emulgels: A Hybrid System for Improved Dermal and Transdermal Drug Delivery · 2026 · DOI

  • The study identifies a gap in the development of drug delivery systems for medications with poor water solubility. It also identifies a need for more effective topical treatments.

    Topical Emulgels: A Hybrid System for Improved Dermal and Transdermal Drug Delivery · 2026 · DOI

  • There is a need for more effective and safer treatments for psoriasis. Traditional drugs have many limitations, including large dosages and potential toxicity. Nano-based drug delivery systems have the potential to fill this gap.

    Nano-Based Drug Delivery System for Psoriasis Management: A Comprehensive Review · 2026 · DOI

  • The paper references nanotechnology-driven innovations for psoriasis management but does not specify whether nano-based drug delivery systems have been optimized for different clinical psoriasis subtypes (plaque psoriasis, pustular psoriasis, erythrodermic psoriasis) with varying pathophysiological characteristics.

    Nano-Based Drug Delivery System for Psoriasis Management: A Comprehensive Review · 2026 · DOI

  • The poor water solubility of itraconazole limits its therapeutic efficacy. There is a need to develop a formulation that can enhance the solubility of itraconazole.

    Comparative Development and Characterization of Itraconazole-Loaded Solid Lipid Nanoparticles Incorporating Myristic Acid and Pluronic F127 for Oral Delivery · 2026 · DOI

  • Long-term stability of SLN9 formulation is problematic, with particle size increasing dramatically to 2741-2856 nm and PDI reaching 1 after one month of storage, indicating severe aggregation that requires investigation into stabilization strategies.

    Comparative Development and Characterization of Itraconazole-Loaded Solid Lipid Nanoparticles Incorporating Myristic Acid and Pluronic F127 for Oral Delivery · 2026 · DOI

  • Conventional methods of drug delivery often face limitations such as poor bioavailability and rapid drug clearance. There is a need for a new hybrid vesicular system that combines the advantages of Ufasome and Niosome.

    Novasome: A Novel Hybrid Vesicular Drug Delivery System Combining Ufasome And Niosome · 2026 · DOI

  • It remains to be elucidated whether the same would be observed for other cytokines relevant in skin research, as IL-8 measured on the MSD assay was found to have improved extraction in the PBS-T + CAA buffer instead.

    Optimization of protein extraction from skin tape strips for biomarker assessment · 2026 · DOI

  • There is a lack of understanding of the ingredients and mechanisms of moisturizers. The paper aims to fill this gap by clarifying the operational mechanism of moisturizers on the skin.

    Research on the Working Mechanism of Skin Moisturizers · 2026 · DOI

  • Scaleup complexities are a challenge to the widespread application of proniosomes. Cost considerations are another limitation. Limited clinical data are available for proniosomes.

    PRONIOSOMAL DRUG DELIVERY SYSTEMS: FABRICATION APPROACHES, MECHANISTIC INSIGHTS, AND MULTIFUNCTIONAL THERAPEUTIC APPLICATIONS · 2026 · DOI

  • There is a need for more research on the clinical applications of proniosomes. The scalability and cost-effectiveness of proniosome production are challenges that need to be addressed.

    PRONIOSOMAL DRUG DELIVERY SYSTEMS: FABRICATION APPROACHES, MECHANISTIC INSIGHTS, AND MULTIFUNCTIONAL THERAPEUTIC APPLICATIONS · 2026 · DOI

  • Conventional drug delivery systems have limitations that can be overcome by nanoparticles. The delivery of poorly water-soluble drugs is a challenge that can be addressed by nanoparticles.

    Nanoparticles novel approach in dosage form designing · 2026 · DOI

  • The paper identifies the need for improved penetration of drugs through the skin. The study highlights the importance of understanding the anatomy of human skin for effective drug delivery.

    Comparative Analysis of In Vitro and In Vivo Models for Evaluating Transdermal Drug Delivery Systems · 2026 · DOI

  • Limited understanding of the molecular mechanisms underlying the biological effects of RFMN. Limited applicability of previous studies using in vivo human or animal skin.

    Deciphering molecular responses to radiofrequency microneedling in a 3D human skin model: new insights and modulation by aftercare treatment · 2026 · DOI

  • The molecular mechanisms underlying the biological effects of RFMN are poorly understood. There is a need for standardized in vitro models to investigate the effects of RFMN.

    Deciphering molecular responses to radiofrequency microneedling in a 3D human skin model: new insights and modulation by aftercare treatment · 2026 · DOI

Most-cited papers in Advancements in Transdermal Drug Delivery

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199 open questions have been extracted from the limitations and future-work passages of 403 Advancements in Transdermal Drug Delivery papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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