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Open research questions in Dysphagia Assessment and Management

194 unresolved questions extracted from the limitations and future-work sections of 869 Dysphagia Assessment and Management papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • There are no specific methods available that can dynamically reveal pulmonary excess secretions, diaphragm weakness, mucosal injury or edema in critically ill patients. The clinical utility of ultrasound in decannulation remains underexplored. There is a need for a diagnostic method and treatment guidance tool that can demonstrate anatomical and physiological effects of long-term artificial-airway in critically-ill-patients.

    Ultrasound-guided assessment for decannulation with critically ill patients: a prospective cohort study · 2026 · DOI

  • Laryngeal ultrasound has previously been applied to characterize vocal fold nodules and phonation disorders28,29; however, the relationship between DV and inspiratory muscle strength or airway resistance has not yet been established. Never- theless, the clinical utility of ultrasound in decannulation remains underexplored.

    Ultrasound-guided assessment for decannulation with critically ill patients: a prospective cohort study · 2026 · DOI

  • The strategies and outcomes of swallowing improvement surgery for dysphagia associated with Wallenberg syndrome remain unclear. There is a lack of comprehensive synthesis of the evidence on swallowing improvement surgery for Wallenberg syndrome. The evidence cannot distinguish surgical effects from spontaneous recovery, rehabilitation, or patient selection.

    Swallowing Improvement Surgery for Dysphagia in Wallenberg Syndrome: A Scoping Review of the English and Japanese Literature · 2026 · DOI

  • Further studies are needed to confirm the prognostic utility of the CALLY index in other populations. Research on the pathophysiological mechanisms underlying the association between the CALLY index and overall survival is needed.

    C-reactive protein-albumin-lymphocyte (CALLY) index predicts overall survival in elderly Japanese patients with dysphagia: a retrospective cohort study · 2025 · DOI

  • There is a lack of research on the use of the CALLY index in patients with dysphagia. The relationship between the CALLY index and overall survival in elderly Japanese patients with dysphagia is not well understood.

    C-reactive protein-albumin-lymphocyte (CALLY) index predicts overall survival in elderly Japanese patients with dysphagia: a retrospective cohort study · 2025 · DOI

  • These findings suggest that prescribed biofeedback manipulation may improve estimates of maximal voluntary effort in the muscles involved in swallowing and warrant further investigation in clinical populations.

    A Proof‐of‐Concept Study Investigating Biofeedback Manipulations During a Common Dysphagia Assessment in Healthy Adults · 2026 · DOI

  • However, the characteristics of tongue position and motor performance, which are crucial for DFD assessment and treatment, remain poorly understood.

    Tongue myofunctional performance, strength and functionality index in Class II and Class III dentofacial deformities · 2025 · DOI

  • However, the relationship among tongue pressure, occlusal status, and prosthetic treatment in older individuals requiring care remains unclear.

    Relationship between tooth loss and tongue pressure and the effectiveness of removable denture for older people requiring long-term care · 2025 · DOI

  • There are recent reports of a possible association between changes in oral function and cognitive impairment, but the details of this association remain unclear.

    Association Between Cognitive Impairment and Poor Oral Function in Community-Dwelling Older People: A Cross-Sectional Study · 2025 · DOI

  • However, few studies have evaluated the association between quality of life (QOL) and oral function, including tongue and lip movements.

    Association Between Oral Function and Oral-Related Quality of Life in Independent Community-Dwelling Elderly People in Taiwan · 2025 · DOI

  • Despite its clinical impact, the mechanisms underlying aspiration-related lung injury remain unclear.

    Microbial alterations in the lungs of children with chronic pulmonary aspiration · 2025 · DOI

  • The impact of pre-hospital living setting on oral intake at discharge remains unclear.

    Effect of pre-hospital living setting on nutritional intake route upon discharge in older adults with aspiration pneumonia: a prospective cohort study · 2025 · DOI

  • The effectiveness of intermittent theta burst stimulation (iTBS) targeting the right dorsal lateral prefrontal cortex (rDLPFC) remains unclear.

    Effects of intermittent theta burst stimulation on cognitive and swallowing function in patients with MCI and dysphagia risk: a randomized controlled trial · 2025 · DOI

  • However, the longitudinal relationship between the DSF and frailty status remains unclear.

    Effect of deterioration of swallowing functions on the frailty status in older adults: a longitudinal cohort study · 2025 · DOI

  • BACKGROUND: Sarcopenic Dysphagia (SD) is a relatively new concept, the prevalence of which has been reported abroad fluctuates greatly, and the risk factors need to be further explored.

    Prevalence and risk factors of sarcopenic dysphagia in elderly hospitalized patients: a retrospective cohort study based on data from a comprehensive geriatric assessment system · 2025 · DOI

  • However, few studies have investigated the association between CRP/ALB and mortality in Japan older people with dysphagia patients.

    Association between the C-reactive protein/albumin ratio and mortality in older Japanese patients with dysphagia · 2024 · DOI

  • BACKGROUND: Dysphagia is common, but there is limited information about its prevalence and patient preferences regarding dosage forms (oral solids, liquids, topical, etc.

    Dysphagia Prevalence in Brazil, UK, China, and Indonesia and Dysphagic Patient Preferences · 2024 · DOI

  • Background: The mechanism by which high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) improves swallowing function by regulating intestinal flora remains unexplored.

    Comprehensive assessment of HF-rTMS treatment mechanism for post-stroke dysphagia in rats by integration of fecal metabolomics and 16S rRNA sequencing · 2024 · DOI

  • BACKGROUND: Relationship between dysphagia and dehydration has not been studied widely.

    The relationship between oropharyngeal dysphagia and dehydration in older adults · 2024 · DOI

  • However, whether intramuscular adipose tissue of the quadriceps in older patients with aspiration pneumonia is related to ADL recovery remains unclear.

    Increased intramuscular adipose tissue of the quadriceps at admission is more strongly related to activities of daily living recovery at discharge compared to muscle mass loss in older patients with aspiration pneumonia · 2024 · DOI

  • The lack of a practical and efficient method for quantifying muscle mass in oral cancer patients. The need for an objective prognostic biomarker in oral cancer.

    Deep learning-based automated masseter muscle area on routine CT stratifies survival in oral cancer · 2026 · DOI

  • There is a lack of understanding of the relationship between swallowing dysfunction and disease severity in patients with acute respiratory events. The clinical and anatomical predictors of airway invasion in this population are not well established.

    Swallowing impairment and aspiration risk in clinically stabilized patients hospitalized for acute respiratory events: a cohort-wide machine-learning analysis with COPD-specific insights · 2026 · DOI

  • Funding identify COPD as a clinically The present findings support systematic dysphagia screening following acute respiratory hospitalization, particularly in patients with recent respiratory infections or neuromuscular disease, important group with and a substantial and often underrecognized aspiration burden.

    Swallowing impairment and aspiration risk in clinically stabilized patients hospitalized for acute respiratory events: a cohort-wide machine-learning analysis with COPD-specific insights · 2026 · DOI

  • Oral care is under-researched in stroke services, - Limited evidence to underpin clinical guidelines, particularly from the perspective of patients and carers

    Improving Oral Care in Stroke Patients: Patients' and Carers' Experiences of Oral Care in a Hospital Environment Following Acute Stroke · 2026 · DOI

  • The lack of uniformity in FEES protocols. The need for standardized FEES protocols.

    Fiberoptic endoscopic evaluation of swallowing in neurogenic oropharyngeal dysphagia in adults: Part 1 of a scoping review · 2026 · DOI

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194 open questions have been extracted from the limitations and future-work passages of 869 Dysphagia Assessment and Management papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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