Open research questions in Electronic Health Records Systems
223 unresolved questions extracted from the limitations and future-work sections of 1,375 Electronic Health Records Systems papers in our library. Each links back to the study that raised it.
What the literature leaves open
evaluation on a limited set of one hundred answerable and one hundred unanswerable questions, - potential limitations due to the complexity of the MIMIC-IV database, - need for further evaluation of the system's performance on larger and more diverse datasets
M3: Conversational LLMs simplify secure clinical data access, understanding, and analysis · 2026 · DOIfocus on ambiguity detection and resolution, - development of multi-turn conversations to iteratively refine query specification, - formal security evaluation (e.g., adversarial SQL-injection testing, penetration testing, and authentication audits)
M3: Conversational LLMs simplify secure clinical data access, understanding, and analysis · 2026 · DOIThe existence of 100% custom terminology in the legacy electronic medical record system - The need for manual mapping of over 1,894 fields - The presence of data quality issues, such as non-standard free-text fields
From fragmentation to federation: multi-partner OMOP implementation in Uganda enabling global real-world evidence generation · 2026 · DOI5% of source records were not transformed due to data quality issues or being out of scope, - no HCV cases were documented throughout the study period, - data fragmentation remains a major barrier to multi-site research collaboration across Africa
From fragmentation to federation: multi-partner OMOP implementation in Uganda enabling global real-world evidence generation · 2026 · DOIThe number and management of documents, as multiple clinical use systems can be reported without going into detail. The complexity of synthesizing available information on clinical research data capture, collection, and storage systems. The need to ensure the quality and relevance of the included studies.
Data capture, collection, management, and storage systems for clinical research: A scoping review protocol · 2026 · DOIThe increasing volume of data and the need to strengthen data governance and organizational independence in clinical research. The lack of a comprehensive overview of existing literature on data capture, collection, management, and storage systems for clinical research.
Data capture, collection, management, and storage systems for clinical research: A scoping review protocol · 2026 · DOIProcedure-centric documentation in dentistry, which limits patient comprehension. The use of specialized terminology and technical indices in dental notes, which can be a barrier to patient engagement. The need for documentation standardization, clinician training, and technology integration to enable OpenNotes implementation in dentistry.
OpenNotes in dentistry as a strategy for patient engagement: opportunities, barriers, and a framework for implementation · 2026 · DOINo studies directly addressing OpenNotes implementation in dental practice were identified, - The anticipated benefits for dentistry are derived by analogy with medical evidence and should be regarded as hypotheses requiring empirical testing, - Important barriers remain, including procedure-centric documentation, specialized terminology, fragmented electronic health record adoption, and privacy regulations
OpenNotes in dentistry as a strategy for patient engagement: opportunities, barriers, and a framework for implementation · 2026 · DOIfurther studies on AI scribe implementation, - investigation of AI transparency and limitations
Clinician and simulated patient perspectives on ambient AI scribes in psychiatric consultations: a qualitative study · 2026 · DOIThe experiential perspectives of clinicians and standardized patients on ambient AI scribes in psychiatric consultations remain unexplored. The study aims to address this gap by exploring clinician and standardized patient perspectives on ambient AI scribes.
Clinician and simulated patient perspectives on ambient AI scribes in psychiatric consultations: a qualitative study · 2026 · DOIThe study identifies the digital divide as a critical challenge in addressing healthcare disparities. The study highlights the impact of socioeconomic status on technology access and healthcare disparities. The study notes the need to address the root causes of healthcare disparities, including systemic racism and historical exclusion.
Technology access, use, socioeconomic status, and healthcare disparities among African Americans in the US · 2025 · DOIAbstract Background Prospective studies examining electronic health record (EHR) implementation in multi-professional healthcare provider samples remain scarce, particularly with respect to impacts on providers’ workflows and outcomes in real-world clinical settings.
Effects of electronic health records implementation on workflow and health care provider outcomes: a prospective, multi-professional cohort study · 2026 · DOIThe impact of social influence appears more nuanced in the context of a longstanding EHR, and warrants further research.
Healthcare professionals’ perceptions of a maternal and newborn electronic health record and the role of design in their experiences: a qualitative study · 2026 · DOIEarly implementation phases are particularly critical for shaping long-term adoption patterns but remain insufficiently studied, especially in large-scale, policy-driven rollouts.
Early Implementation of a Nationwide Opt-Out Electronic Health Record for Outpatient Care in Germany: Qualitative Semistructured Interview Study · 2026 · DOIHowever, use remains limited to administrative functions, while advanced technologies such as telemedicine or electronic health records are poorly adopted.
Digital Transformation of Medical Services in Romania: Does the Healthcare System Meet the Current Needs of Patients? · 2025 · DOIHome blood pressure monitoring (HBPM) offers promise for improving care, but its integration into workflows is poorly understood.
Using RE-AIM to inform the adaptation of a clinical decision support application for hypertension disorders of pregnancy: a qualitative study of provider perspectives · 2025 · DOIFuture research should explore the integration of care maps into electronic medical records and care pathways and evaluate the impact on clinical outcomes.
Importance: Timely evaluation of ambient scribing technology is warranted to assess whether this technology can lessen the burden of clinical documentation on clinicians.
Clinician Experiences With Ambient Scribe Technology to Assist With Documentation Burden and Efficiency · 2025 · DOIHowever, HI curricula found for healthcare professions were insufficient for a distinguishable benchmark for HI education in academic disciplines of the healthcare professions.
Improving Health Informatics Competencies: A Scoping Review of the Components of Health Informatics Academic Programs · 2024 · DOIHowever, research on assessing and improving nursing students’ informatics competencies remains scarce.
Evaluation and improvement of nursing undergraduates’ informatics competencies using a hybrid multi-criteria decision-making model · 2024 · DOIBACKGROUND: The impact of the Plan-Do-Check-Act (PDCA) cycle in improving the timeliness of electronic medical record documentation (EMRd) remains uncertain.
Enhancing the timeliness of EMR documentation in resident doctors: the role of PDCA cycle management · 2024 · DOIHowever, little is known about patient portal activation rates in FQHC settings and the factors associated with activation.
Factors Associated with Uptake of Patient Portals at a Federally Qualified Health Care Center · 2024 · DOIHowever, its specific impact on data quality, availability, and performance in Primary Health Unit (PHU) facilities in Ethiopia remains underexplored.
Unveiling the role of DHIS2 in enhancing data quality and accessibility in primary healthcare facilities: Evidence from Ethiopia · 2024 · DOIHowever, the specific causes of data quality issues within aged care and disability services and solutions for optimisation are not well understood.
Factors impacting clinical data and documentation quality in Australian aged care and disability services: a user-centred perspective · 2024 · DOILimited research has evaluated disparities in portal use during and after the COVID-19 pandemic.
Most-cited papers in Electronic Health Records Systems
- MIMIC-IV, a freely accessible electronic health record dataset · Scientific Data · 2023 · 3,030 citations
- Assessing, Controlling, and Assuring the Quality of Medical Information on the Internet · JAMA · 1997 · 2,358 citations
- The “Meaningful Use” Regulation for Electronic Health Records · New England Journal of Medicine · 2010 · 1,575 citations
- Digital Transformation in Healthcare: Technology Acceptance and Its Applications · International Journal of Environmental Research and Public Health · 2023 · 843 citations
- A global federated real-world data and analytics platform for research · JAMIA Open · 2023 · 801 citations
- Digital transformation in healthcare: Analyzing the current state-of-research · Journal of Business Research · 2020 · 737 citations
- Defining knowledge translation · Canadian Medical Association Journal · 2009 · 728 citations
- Enterprise resource planning: cultural fits and misfits · Communications of the ACM · 2000 · 554 citations
- How do patients evaluate and make use of online health information? · Social Science & Medicine · 2007 · 546 citations
- Using Electronic Health Records for Population Health Research: A Review of Methods and Applications · Annual Review of Public Health · 2015 · 537 citations
Most recent work
- Changes in Clinician Time Expenditure and Visit Quantity With Adoption of Artificial Intelligence–Powered Scribes · JAMA · 2026
- Barriers and opportunities of scaling ambient AI scribes for clinical documentation across diverse healthcare settings · npj Digital Medicine · 2026
- When better data meets better design: How EHR data usability and system usability shape physicians’ cognitive load · npj Digital Medicine · 2026
- Electronic Health Record Intervention and Deprescribing for Older Adults · JAMA · 2026
- Performance, acceptability, and impact of ambient listening scribe technology in an outpatient context: a mixed methods trial evaluation · BMC Health Services Research · 2026
- Ambient scribe in general practice: a multi-perspective before-after longitudinal mixed-methods study · npj Digital Medicine · 2026
- Software Application Profile: T-Rx: A toolbox for reproducible processing of prescriptions (Rx) stored in electronic health record databases · medRxiv · 2026
- Clinician and simulated patient perspectives on ambient AI scribes in psychiatric consultations: a qualitative study · Frontiers in Psychiatry · 2026
- Hospital information systems evaluation criteria: a scoping review · BMC Health Services Research · 2026
- Rule-based natural language processing to extract clinical trial and research study enrollment history from unstructured notes · Health Informatics Journal · 2026
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