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Open research questions in Temporomandibular Joint Disorders

474 unresolved questions extracted from the limitations and future-work sections of 3,995 Temporomandibular Joint Disorders papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • small sample size, - limited to patients with RA and healthy controls, - no long-term follow-up, - limited to a specific population (aged between 18 and 65)

    Examination of the Temporomandibular Joint with a Holistic Approach in Individuals with Rheumatoid Arthritis · 2026 · DOI

  • further studies are needed to investigate the relationship between RA and TMJ involvement, - investigation of the effects of RA on TMJ in different populations, - longitudinal studies to examine the progression of TMJ involvement in RA patients

    Examination of the Temporomandibular Joint with a Holistic Approach in Individuals with Rheumatoid Arthritis · 2026 · DOI

  • Investigate the long-term effects of prolotherapy with autologous blood or 10 % dextrose - Compare the efficacy of prolotherapy with other treatments for TMJ subluxation - Study the effects of prolotherapy on other temporomandibular joint disorders

    Proloterapia combinada con artrocentesis en el tratamiento de la subluxación crónica de la articulación temporomandibular · 2026 · DOI

  • The need for specialized equipment, including ultra-small diameter optical fibers and dedicated laser systems. The limitation of ultra-small diameter optical fibers, which provide lower image resolution and reduced optical clarity. The need for further clinical studies to evaluate safety, clinical outcomes, and long-term effectiveness.

    Needle-based level II temporomandibular joint arthroscopy under local anesthesia · 2026 · DOI

  • the implementation still involves specialized equipment, - ultra-small diameter optical bers provide lower image resolution and reduced optical clarity, - the technique may have limited accessibility due to the need for specialized instrumentation and training

    Needle-based level II temporomandibular joint arthroscopy under local anesthesia · 2026 · DOI

  • A formal measure of inter-reviewer agreement was not calculated, - The search was limited to articles in English with full text available, - The certainty of the body of evidence for each outcome was assessed using the GRADE approach

    Effects of Botulinum Toxin Injection on Masticatory Muscle Activity in Sleep Bruxism: A Systematic Review and Meta-Analysis · 2026 · DOI

  • There is a need to evaluate the efficacy of BoNT-A injections in reducing masticatory muscle activity in sleep bruxism. The current literature lacks a comprehensive review of the effects of BoNT-A on bruxism-related muscle activity. The review aims to fill this gap by providing a systematic review and meta-analysis of the existing literature.

    Effects of Botulinum Toxin Injection on Masticatory Muscle Activity in Sleep Bruxism: A Systematic Review and Meta-Analysis · 2026 · DOI

  • The technical challenge of combining orthognathic surgery, temporomandibular joint surgery, and distraction osteogenesis in a single operation. The challenge of achieving significant improvement in mandibular retrusion and facial symmetry. The need to balance the goals of improving airway dimensions, occlusion, and facial esthetics.

    Case Report: Orthognathic surgery combined with distraction osteogenesis for severe obstructive sleep apnea secondary to unilateral temporomandibular joint ankylosis · 2026 · DOI

  • The need for clearly defined treatment objectives and appropriately sequenced surgical interventions for severe obstructive sleep apnea secondary to temporomandibular joint ankylosis. The lack of a standardized protocol for combining orthognathic surgery, temporomandibular joint surgery, and distraction osteogenesis.

    Case Report: Orthognathic surgery combined with distraction osteogenesis for severe obstructive sleep apnea secondary to unilateral temporomandibular joint ankylosis · 2026 · DOI

  • Most existing dental registries remain treatment-or diagnosis-centered, - They rarely incorporate objective physiological measurements or standardized behavioral data, - The ability to elucidate measurement device variability and phenotypic diversity is limited

    Multicenter Sleep Bruxism Clinical Registry in Japan: Development of the registry and exploratory analysis of data-driven clinical subgroups · 2026 · DOI

  • Longitudinal tracking of disease dynamics at the individual level, - Incorporation of objective physiological measurements and standardized behavioral data, - Elucidation of measurement device variability and phenotypic diversity

    Multicenter Sleep Bruxism Clinical Registry in Japan: Development of the registry and exploratory analysis of data-driven clinical subgroups · 2026 · DOI

  • The effects of increased habitual chewing on cortical activity remain unclear. There is a lack of studies on the effects of habitual chewing on cortical activity in young adults. The study aims to fill this gap by evaluating the effects of habitual chewing on cortical activity in young adults.

    Habitual attentional mastication boosts prefrontal activity during chewing: A randomized trial · 2026 · DOI

  • There is a lack of clear standards regarding which types of data are necessary for prosthesis design. The paper identifies a gap in understanding the relationships and differences between mandibular movement and complementary mandibular movement.

    Relationship and spatial differences between mandibular movement and complementary mandibular movement · 2026 · DOI

  • One challenge is the difficulty in simulating the effects of molar loss on masticatory function. Another challenge is the need to develop effective methods for assessing masticatory function. The study also faced the challenge of recruiting participants with intact dentition.

    Effects of occlusal contact loss on the preferred chewing side on masticatory function: An experimental randomized crossover trial · 2026 · DOI

  • Further studies are needed to investigate the long-term effects of molar loss on masticatory function. Research should be conducted to develop more effective prosthetic interventions for restoring masticatory function after molar loss. Studies should be done to determine the optimal location of the MOA for minimizing the impact of molar loss on masticatory function.

    Effects of occlusal contact loss on the preferred chewing side on masticatory function: An experimental randomized crossover trial · 2026 · DOI

  • Future studies could investigate the effect of new denture fabrication on CF-ST in different populations, - such as patients with different types of dental restorations or occlusal conditions, - Future studies could also examine the relationship between CF-ST and other oral functions, - such as swallowing or speech, - Future research could explore the development of new denture designs or materials that can further improve CF-ST

    Improvement in food comminution at swallowing threshold with newly fabricated removable dentures · 2025 · DOI

  • The study involves measuring occlusal force, which can be challenging. The study requires patients to bite down on an occlusal force measuring sheet, which can be uncomfortable. The study needs to account for various factors that can affect occlusal force, such as periodontal condition and temporomandibular disorder.

    Effects of denture use on occlusal force on abutment teeth in molar distal-extension edentulism · 2024 · DOI

  • Few studies have examined the occlusal forces on the abutment teeth of distal extension RPDs. The study aims to fill this gap by investigating the load exerted on abutment teeth in patients with distal extension edentulism.

    Effects of denture use on occlusal force on abutment teeth in molar distal-extension edentulism · 2024 · DOI

  • There is a need for more effective treatments for chronic temporomandibular joint subluxation. The current treatment options have limitations.

    Proloterapia combinada con artrocentesis en el tratamiento de la subluxación crónica de la articulación temporomandibular · 2026 · DOI

  • Future studies should investigate the effects of increased habitual chewing strokes on cognitive function in older adults - Future studies should examine the neural mechanisms underlying the effects of chewing on cognitive function - Future studies should develop more effective interventions to increase habitual chewing strokes in individuals with impaired chewing function

    Habitual attentional mastication boosts prefrontal activity during chewing: A randomized trial · 2026 · DOI

  • While acute dental trauma often receives greater clinical attention, chronic occlusal trauma may remain underrecognised in routine practice, despite its potential to influence mandibular movement patterns, modify joint loading and contribute to patient-reported functional complaints.

    Chronic Traumatic Dental Occlusion: Its Impact on Temporomandibular Joint and Systemic Health, and Clinical Management Strategies · 2026 · DOI

  • Yet how oral somatosensation shapes motor cortical output to drive individual tongue muscles remains unknown.

    Oral somatosensation shapes lingual muscle maps in macaque orofacial primary motor cortex · 2026 · DOI

  • Further longitudinal and interventional studies are warranted to validate these findings and establish clinical guidelines.

    Occlusal Overload and Periodontitis: Integrating Mechanisms, Clinical Evidence, and Emerging Perspectives—A Scoping Review · 2026 · DOI

  • Background The relationship between head–neck posture and temporomandibular joint dysfunction (TMJD) remains a topic of controversy, with existing studies reporting inconsistent findings.

    Postural Analysis in Temporomandibular Joint Dysfunction (TMJD) Patients: Correlation With Head and Neck Positioning · 2026 · DOI

  • Background: The effects of simultaneous bilateral chewing are not well understood.

    Comparison of Jaw Muscle Activity, Masticatory Performance, and Salivation Across Three Chewing Patterns: A Within‐Subjects Experimental Study · 2026 · DOI

Most-cited papers in Temporomandibular Joint Disorders

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474 open questions have been extracted from the limitations and future-work passages of 3,995 Temporomandibular Joint Disorders papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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