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Open research questions in Listeria monocytogenes in Food Safety

147 gap statements mined from Listeria monocytogenes in Food Safety papers in our 4.5M-paper local library, which holds 930 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The research also acknowledges the challenge of differentiating the observed effects in detail, which requires further analyses and investigations. Another challenge is the potential methodological limitation due to the difference in handling of the treatment and control samples.

    Plasma-Treated Water (PTW) Delaying the Lag Phase of Food-Related Pathogens · 2026 · DOI

  • There is a need for eco-friendly antimicrobial approaches to improve food safety. The current methods for mitigating or killing foodborne pathogens have limitations. The study aims to fill this gap by investigating plasma-treated water as a novel antimicrobial approach.

    Plasma-Treated Water (PTW) Delaying the Lag Phase of Food-Related Pathogens · 2026 · DOI

  • Conventional microbial growth prediction models have limitations in accounting for prior-parameter errors. Traditional predictive microbiology models cannot adequately reflect the effects of initial state errors and environmental fluctuations. The need for a method that can accurately quantify fungal growth risk and select optimal environmental control schemes.

    Fungal Growth Risk Prediction and Optimal Regulation Method for Food Storage Based on the Forward Reachable Set · 2026 · DOI

  • There is a need to investigate the molecular epidemiology of L. monocytogenes in raw yak meat. The study aims to fill the gap in knowledge on the genomic characteristics of L. monocytogenes isolates from raw yak meat.

    Molecular Characterization of Listeria monocytogenes Isolated from Retail Yak Meat in Nyingchi, Xizang, China · 2026 · DOI

  • The model needs to account for the simultaneous influence of multiple factors, including temperature, pH, NaCl, and nitrite. The study also faces the challenge of integrating outputs from different simulation tools, FSSP and PMP.

    A Machine Learning Approach to Predict Listeria monocytogenes Growth by Integrating FSSP and PMP Simulations: A Focus on t100 as a Possible Endpoint Parameters for Predictive Models · 2026 · DOI

  • Further research could focus on integrating AI and genomic data in predictive microbiology. The model could be validated with experimental data.

    A Machine Learning Approach to Predict Listeria monocytogenes Growth by Integrating FSSP and PMP Simulations: A Focus on t100 as a Possible Endpoint Parameters for Predictive Models · 2026 · DOI

  • The need for a comprehensive overview of the current knowledge on L. monocytogenes and its implications for public health. The lack of understanding of the bacterium's transmission routes and antibiotic resistance mechanisms. The need for improved methods to prevent and control the dissemination of L. monocytogenes through ready-to-eat foods.

    Listeria monocytogenes and Listeriosis: The Global Enigma · 2025 · DOI

  • Traditional decontamination methods have limitations and may not be effective against all pathogens. There is a need for novel technologies for pathogen inactivation. The current methods may raise health and environmental concerns.

    Emerging and Innovative Technologies for the Sanitization of Fresh Produce: Advances, Mechanisms, and Applications for Enhancing Food Safety and Quality · 2025 · DOI

  • The need to balance food safety with clean-label demands. The challenge of controlling microbial growth in products with high water activity and near-neutral pH.

    Pathogen and Spoilage Microorganisms in Meat and Dairy Analogues: Occurrence and Control Strategies · 2025 · DOI

  • The paper identifies the need for a better understanding of L. monocytogenes and its implications for One Health. It highlights the challenge of controlling L. monocytogenes due to its bacterial perpetuation characteristics.

    Listeria monocytogenes: A Foodborne Pathogen with Implications for One Health and the Brazilian Context · 2025 · DOI

  • There is a lack of understanding of the virulence of L. monocytogenes strains isolated from different sources. The differences in virulence among strains are not well characterized. There is a need to investigate the correlation between virulence genes and virulence.

    Comparative Analysis of In Vivo and In Vitro Virulence Among Foodborne and Clinical Listeria monocytogenes Strains · 2025 · DOI

  • The need to develop novel anti-microbial targets and host-targeted metabolic interventions.

    Listeria monocytogenes requires phosphotransferase systems to facilitate intracellular growth and virulence · 2025 · DOI

  • The mechanisms of L. monocytogenes survival and replication in the gallbladder are not well understood. The roles of L. monocytogenes genes in the intracellular lifecycle and systemic disease are not fully characterized.

    A genome-wide screen in ex vivo gallbladders identifies Listeria monocytogenes factors required for virulence in vivo · 2025 · DOI

  • The study had a limited dataset, which did not support robust prevalence estimates. The isolation of species other than L. monocytogenes was not pursued for all samples. The study was unable to adequately identify Listeria species for six of 27 isolates.

    Isolation, Identification, and Characterization of Listeria from Municipal and Dairy Farm Wastewater · 2026 · DOI

  • The proliferation of Shigella colonies was extremely limited. The study required simulating the infection of a post-harvest tomato stored in different conditions (fridge, room temperature, and hot temperature).

    The Tomato Variety Affects the Survival of Shigella flexneri 2a in Fruit Pericarp · 2024 · DOI

  • The study only collected samples from four markets, 79 retail stalls, two farms, and two water sources in Nyingchi, Xizang, China, - The sample size was limited to 231 yak-associated meat and environmental samples, - No pooled samples were used…

    Molecular Characterization of Listeria monocytogenes Isolated from Retail Yak Meat in Nyingchi, Xizang, China · 2026 · DOI

  • Investigation of ecological drivers for persistence, - Study of biofilm formation on farm surfaces, - Examination of survival kinetics in silage vs. feed vs. water, - Analysis of competition or synergy between L. innocua and L.

    Isolation, Identification, and Characterization of Listeria from Municipal and Dairy Farm Wastewater · 2026 · DOI

  • Explore the combined use of high-pressure processing with other methods for enhancing microbial inactivation in fresh and fresh-cut fruits…

    Emerging and Innovative Technologies for the Sanitization of Fresh Produce: Advances, Mechanisms, and Applications for Enhancing Food Safety and Quality · 2025 · DOI

  • Limited penetration capability of pulse light, - Higher fluences may lead to change in sensory quality, - Ultrasound parameters should be optimized for each product type, - The efficacy of interventions varies with both product and process…

    Listeria monocytogenes: A Continuous Global Threat in Ready-to-Eat (RTE) Foods · 2025 · DOI

  • Expand the application of QMRA in managing recall risks throughout the RTE food supply chain, - Investigate the effectiveness of emerging multi-hurdle technology, - Optimize ultrasound parameters for each product…

    Listeria monocytogenes: A Continuous Global Threat in Ready-to-Eat (RTE) Foods · 2025 · DOI

  • Integration of non-thermal technologies and biocontrol methods - Development of clean and low-environmental-impact strategies to enhance food safety - Exploration of bacteriophages as biocontrol agents in food…

    Pathogen and Spoilage Microorganisms in Meat and Dairy Analogues: Occurrence and Control Strategies · 2025 · DOI

  • Regulatory heterogeneity has direct consequences for technology adoption, - Higher doses of gamma irradiation led to reductions in phenolic content and antioxidant activity, - Ozone treatment efficiency increased with exposure dose and time but had limited effect on ground…

    Processing and Real-Time Monitoring Strategies of Aflatoxin Reduction in Pistachios: Innovative Nonthermal Methods, Advanced Biosensing Platforms, and AI-Based Predictive Approaches · 2025 · DOI

  • Exploring the potential of cold plasma treatment for AF reduction in nuts, - Investigating the effects of combined treatments on AF contamination and pistachio quality, - Developing more sustainable and effective methods for AF…

    Processing and Real-Time Monitoring Strategies of Aflatoxin Reduction in Pistachios: Innovative Nonthermal Methods, Advanced Biosensing Platforms, and AI-Based Predictive Approaches · 2025 · DOI

  • Investigating the survival of Shigella in other types of produce, - Studying the role of the SRL PAI in the survival and fitness of Shigella in different environments, - Examining the impact of various factors on Shigella survival…

    The Tomato Variety Affects the Survival of Shigella flexneri 2a in Fruit Pericarp · 2024 · DOI

  • The proposed framework could potentially be extended to other classes…

    Fungal Growth Risk Prediction and Optimal Regulation Method for Food Storage Based on the Forward Reachable Set · 2026 · DOI

Most-cited papers in Listeria monocytogenes in Food Safety

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Open questions raised by papers listed on this page include: (1) There is a need for eco-friendly antimicrobial approaches to improve food safety (“Plasma-Treated Water (PTW) Delaying the Lag Phase of Food-Related Pathogens”, 2026); (2) There is a need to investigate the molecular epidemiology of L. monocytogenes in raw yak meat (“Molecular Characterization of Listeria monocytogenes Isolated from Retail Yak…”, 2026); (3) Further research could focus on integrating AI and genomic data in predictive microbiology (“A Machine Learning Approach to Predict Listeria monocytogenes Growth by…”, 2026); (4) The lack of understanding of the bacterium's transmission routes and antibiotic resistance mechanisms (“Listeria monocytogenes and Listeriosis: The Global Enigma”, 2025); (5) There is a need for novel technologies for pathogen inactivation (“Emerging and Innovative Technologies for the Sanitization of Fresh Produce:…”, 2025). 147 gap statements have been mined from Listeria monocytogenes in Food Safety papers in our 4.5M-paper local library, which holds 930 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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