Open research questions in Polysaccharides Composition and Applications
138 gap statements mined from Polysaccharides Composition and Applications papers in our 4.5M-paper local library, which holds 904 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.
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What the literature leaves open
There is a lack of knowledge about the physicochemical characteristics of exopolysaccharides produced by Janibacter limosus. The study aims to fill this gap by characterizing the novel exopolysaccharide.
Physicochemical and Functional Characterization of a Novel Extremophilic Exopolysaccharide Produced by Janibacter limosus · 2026 · DOIIt highlights the need for improved methods to protect and deliver bioactives effectively.
The evidence supporting digestive effects is substantially less extensive than that supporting rheology and food structuring. Most studies use formulation-specific in vitro digestion or fermentation models. Direct human evidence is limited to the randomized crossover study of low-acyl gellan gum-structured rice.
Gellan Gum Modification and Structural Regulation for Food Applications: Delivery Systems and Digestive Behavior · 2026 · DOIThe need to develop efficient management of water resources in agriculture. The challenge of reducing hydrogen peroxide and protecting cellular components under water deficit stress.
Applying Exogenous Methyl Jasmonate and Chitosan Enhances the Antioxidant Enzyme Activity and Photosynthesis of Guar Varieties Under Water Deficit Stress · 2026 · DOIThe need to develop novel anti-inflammatory agents with enhanced safety and efficacy profiles. The challenge of simulating the assembly process of molecules using molecular dynamics simulations.
Carrier-Free Supramolecular Hydrogel Self-Assembled from Triterpenoid Saponins from Traditional Chinese Medicine: Preparation, Characterization, and Evaluation of Anti-Inflammatory Activity · 2026 · DOIThe need to balance the amount of ethanol to avoid excessive intermolecular interactions among the KGM chains.
Regulation of Microstructure and Properties of Konjac Glucomannan Gels via Ethanol Under Low-Alkali Conditions · 2026 · DOIThe lack of eco-friendly synthesis methods for alkali-treated konjac glucomannan gels. The need for more durable alternatives to alkali-treated konjac glucomannan gels. The limited understanding of the effect of ethanol on the microstructure and properties of KGM gels.
Regulation of Microstructure and Properties of Konjac Glucomannan Gels via Ethanol Under Low-Alkali Conditions · 2026 · DOITraditional manufacturing processes are energy-intensive and may compromise emulsion stability. There is a need to investigate the impact of sustainable manufacturing procedures on biopolymer-stabilized emulsions. The study identifies a gap in the applicability of sustainable methods beyond traditional stabilizers.
Impact of Sustainable Manufacturing Processes on the Rheological and Microstructural Stability of Biopolymer-Stabilized Oil-in-Water Emulsions · 2026 · DOIThe limited stability and susceptibility to gastrointestinal environmental stresses of jujube polysaccharides and cyclic adenosine monophosphate. The need for a delivery system that can protect these compounds during gastrointestinal digestion. The lack of a pH-responsive composite hydrogel bead system for co-delivery of these compounds.
pH-Responsive Chitosan–Alginate Hydrogel Beads Co-Encapsulating Jujube Polysaccharides and cAMP: Enhanced Antioxidant Activity and Gastrointestinal Controlled Release · 2026 · DOIThe production of extracellular polymeric substances by Rhodococcus has not been deeply studied. There is a lack of understanding of the genes and mechanisms involved in the synthesis of extracellular polymeric substances by Rhodococcus.
Limited understanding of the microstructural evolution during disintegration. Need for optimization of the formulation and preparation process to achieve rapid disintegration.
Development of HPMC-Based Hard Capsules with Rapid Disintegration Across Simulated Gastrointestinal pH Conditions: Formulation Design, Process Optimization, and Disintegration Mechanism of the HPMC/GG/ι-C Ternary System · 2026 · DOILimited efficacy of chemical antivirals against TMV. Potential environmental hazards of chemical antivirals. Need for sustainable and eco-friendly alternatives for plant protection.
Discovery of a Marine Beauveria bassiana Polysaccharide with Antiviral Activity Against Tobacco Mosaic Virus · 2026 · DOIIt highlights the need for environmentally friendly and simple extraction methods. The paper notes the challenge of measuring ketoses like fructose in monosaccharide detection.
Preparation, Structure, Function, and Application of Dietary Polysaccharides from Polygonatum sibiricum in the Food Industry: A Review · 2025 · DOIThere is a need to expand the deep processing of and feasibility research on Polygonatum sibiricum polysaccharides. Further efforts are needed to explore their bioactive molecular mechanisms in depth.
Preparation, Structure, Function, and Application of Dietary Polysaccharides from Polygonatum sibiricum in the Food Industry: A Review · 2025 · DOIThe structure-function relationships of PYPS have not been fully elucidated. The effects of concentration, temperature, pH, and calcium ion addition on the rheological properties of PYPS have not been systematically investigated.
Rheological Behavior, Textural Properties, and Antioxidant Activity of Porphyra yezoensis Polysaccharide · 2025 · DOIThere is a lack of understanding of the viscoelastic properties of edible gels, such as cherry Jell-O, under different amplitude oscillatory shear experiments. The behavior of hydrocolloid gels under high deformations is not well understood.
Probing the Small, Medium and Large Amplitude Rheological Properties of Cherry Jell-O® as a Model System for Edible Gels · 2026 · DOIThe genetic basis of galactomannan biosynthesis is unclear. The evolutionary history of galactomannan biosynthesis in the Fabaceae family is not well understood. The paper aims to fill this gap by studying the genome of guar and its phylogenetic placement within the Fabaceae family.
High-quality genome of guar (Cyamopsis tetragonoloba) provides the new insights into the biosynthesis and origination of galactomannans in Fabaceae family · 2026 · DOIIt also provides an overview of their taxonomic distribution within the genus, their composition, structures, yield, and the underexplored genes and possible mechanisms involved in the synthesis of extracellular polymeric substances.
Investigate the impact of different hydrocolloids on gel formation and stability. Explore the use of emerging technologies for enhancing bioactive compound delivery.
Investigating the effects of MeJA and CHT on other crop varieties, - Examining the molecular mechanisms underlying the observed effects, - Studying the potential applications of MeJA and CHT in agricultural…
Applying Exogenous Methyl Jasmonate and Chitosan Enhances the Antioxidant Enzyme Activity and Photosynthesis of Guar Varieties Under Water Deficit Stress · 2026 · DOIExtending simulation time scales to the microsecond level, - Investigating the assembly of other natural small molecules, - Evaluating the in vivo efficacy and safety…
Carrier-Free Supramolecular Hydrogel Self-Assembled from Triterpenoid Saponins from Traditional Chinese Medicine: Preparation, Characterization, and Evaluation of Anti-Inflammatory Activity · 2026 · DOIConfirmation of the results in conditions closer to industrial production, - Investigation of the transferability of the findings to food emulgel…
Impact of Sustainable Manufacturing Processes on the Rheological and Microstructural Stability of Biopolymer-Stabilized Oil-in-Water Emulsions · 2026 · DOIThe study focused on the release profiles of highly soluble compounds, - Class II and IV drugs were excluded from this study, - The study used a limited number of model…
Development of HPMC-Based Hard Capsules with Rapid Disintegration Across Simulated Gastrointestinal pH Conditions: Formulation Design, Process Optimization, and Disintegration Mechanism of the HPMC/GG/ι-C Ternary System · 2026 · DOIInvestigate the effects of high-pressure treatments on other types of polysaccharides, - Optimize the conditions for HP-s treatment, - Explore the application of high-pressure pretreatment in large-scale production…
Preparation of Alginate Oligosaccharides by Autoclaving Pretreatment Combined with Enzymatic Method · 2026 · DOIFurther purification and fractionation analyses to resolve the relative contributions of polysaccharidic and proteinaceous…
Physicochemical and Functional Characterization of a Novel Extremophilic Exopolysaccharide Produced by Janibacter limosus · 2026 · DOI
Most-cited papers in Polysaccharides Composition and Applications
- Applications of infrared spectroscopy in polysaccharide structural analysis: Progress, challenge and perspective · Food Chemistry X · 2021 · 691 citations
- A Review of Natural Polysaccharides: Sources, Characteristics, Properties, Food, and Pharmaceutical Applications · International Journal of Molecular Sciences · 2024 · 470 citations
- Polysaccharide degradation by the Bacteroidetes: mechanisms and nomenclature · Environmental Microbiology Reports · 2021 · 367 citations
- Advances in xanthan gum production, modifications and its applications · Biocatalysis and Agricultural Biotechnology · 2022 · 176 citations
- Ultrasound-assisted extraction and properties of polysaccharide from Ginkgo biloba leaves · Ultrasonics Sonochemistry · 2023 · 170 citations
- Comparative FTIR Characterization of Various Natural Gums: A Criterion for Their Identification · Journal of Polymers and the Environment · 2023 · 154 citations
- Carrageenan: structure, properties and applications with special emphasis on food science · RSC Advances · 2025 · 136 citations
- Effects of different plant polysaccharides as fat substitutes on the gel properties, microstructure and digestion characteristics of myofibrillar protein · Food Hydrocolloids · 2024 · 120 citations
- Application of guar (Cyamopsis tetragonoloba L.) gum in food technologies: A review of properties and mechanisms of action · Food Science & Nutrition · 2023 · 115 citations
- Chia (Salvia hispanica L) Gel Can Be Used as Egg or Oil Replacer in Cake Formulations · Journal of the American Dietetic Association · 2010 · 112 citations
Most recent work
- Dual-frequency ultrasonic-assisted extraction of pumpkin polysaccharides: Process optimization, structural characterization, and antioxidant activity · LWT · 2026
- Efficient extraction of Cercis chinensis seeds polysaccharides by ultrasound-assisted deep eutectic solvent: Process optimization, identification, kinetics and bioactivity · Ultrasonics Sonochemistry · 2026
- A Comprehensive Review of Carbohydrate Polymer Hydrocolloids: Structure, Function, and Applications in Food Systems · Food Reviews International · 2026
- Effect of type and concentration of hydrocolloids on the rheology, water mobility, and 3D printing properties of pitaya fruit-based ink · Frontiers in Nutrition · 2026
- Small Oscillatory Rheology: Evaluating Microstructure and Component Interactions in Different Food Systems · Comprehensive Reviews in Food Science and Food Safety · 2026
- Extraction, characteristics and activities of polysaccharides from Lycium barbarum · Journal of Functional Foods · 2026
- Ultrasound-assisted deep eutectic solvent extraction of ginseng folium polysaccharides: Extraction mechanism, process optimization, structural characterization, and in vitro biological activity · Ultrasonics Sonochemistry · 2026
- Transcriptomic Insights into Metabolic Reprogramming and Exopolysaccharide Synthesis in Porphyridium purpureum Under Gradual Nitrogen Deprivation · Marine Drugs · 2026
- Functional roles and applications of polysaccharides in biomedical and food systems · Frontiers in Bioengineering and Biotechnology · 2026
- Hydrocolloid–small-molecule interactomics in food systems: Linking binding, phase behavior, rheology, flavor release, and bioaccessibility · Food Hydrocolloids · 2026
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