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Open research questions in Salmonella and Campylobacter epidemiology

546 gap statements mined from Salmonella and Campylobacter epidemiology papers in our 7.9M-paper local library, which holds 2,059 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Salmonella and Campylobacter epidemiology? See the ranked Biology journals.

What the literature leaves open

  • The diagnosis of C. fetus infection can be challenging due to the lack of awareness and the rarity of the disease. The treatment of C. fetus infection can be challenging due to the lack of established optimal antimicrobial regimens. The patient's advanced age and underlying medical conditions posed challenges for treatment.

    Campylobacter fetus Bacteremia Presenting with Bilateral Lower Leg Cellulitis in an Immunocompetent Adult · 2026 · DOI

  • The study highlights the need for further research on the transmission of S. Typhimurium from animals to humans.

    Outbreak of Salmonella Typhimurium ST19 linked to passerine birds and cats in Norway, March to July 2024 · 2026 · DOI

  • Comprehensive analyses of research trends on Campylobacter spp. in human health remain limited. There is a need to map and quantify the scientific literature on Campylobacter spp. in the context of human health and medical research. The study aims to fill the gap by conducting a bibliometric analysis of the scientific literature on Campylobacter spp. in human health.

    Global Research Trends on Campylobacter spp. and Human Health: A bibliometric analysis (2017–2025) · 2026 · DOI

  • The growing accessibility of genomic technologies suggests that future studies can increasingly adopt these approaches, thus improve pathogen surveillance and advance our understanding of bacterial ecology in reptile hosts.

    Global prevalence of Salmonella spp. and Escherichia coli in reptile taxa: a systematic review and meta-analysis · 2026 · DOI

  • The study highlights the need for molecular typing of Salmonella serovars to understand the epidemiology of Salmonella in bushmeat.

    Prevalence and Molecular Epidemiology of Nontyphoidal Salmonella enterica Serovars Enteritidis and Typhimurium in Bushmeat Carcasses Sold in the Centre Region Markets, Cameroon · 2026 · DOI

  • There is a need for effective interventions to mitigate antimicrobial resistance in Campylobacter! Current strategies to control Campylobacter in poultry are not sufficient!

    The Global Challenge of Campylobacter: Antimicrobial Resistance and Emerging Intervention Strategies · 2025 · DOI

  • The study highlights the need for improved hygiene and sanitation infrastructure in areas with high rates of homelessness. The paper emphasizes the importance of addressing the crisis of homelessness in Canada to prevent similar outbreaks.

    An Outbreak of Multidrug-Resistant Shigella flexneri Serotype 2a Among People Experiencing Homelessness in Vancouver · 2025 · DOI

  • There is a need to study the development of antibiotic resistance in C. jejuni. The paper highlights the importance of monitoring antibiotic resistance in C. jejuni.

    Emergence of Multidrug-Resistant Campylobacter jejuni in a Common Variable Immunodeficiency Patient: Evolution of Resistance Under the Selective Antibiotic Pressure · 2025 · DOI

  • There are knowledge gaps regarding foodborne zoonotic diseases in migrant populations. The study aims to fill this gap by assessing the seroprevalence of various pathogens in populations with and without migration backgrounds. The gap is related to the lack of understanding of the risk factors and exposure routes for these diseases in migrant populations.

    Risk Factors for Foodborne Zoonoses Among Populations With and Without a Migration Background in Berlin, Germany · 2025 · DOI

  • There is a lack of studies on typhoidal Salmonella antimicrobial susceptibility trends in British Columbia, Canada. Most published studies are from the Ontario province, and there is a need for more research in other regions of Canada.

    Current Antimicrobial Susceptibility Trends and Clinical Outcomes of Typhoidal Salmonella in a Large Health Authority in British Columbia, Canada · 2025 · DOI

  • Emerging antimicrobial resistance is a significant challenge in treating typhoid disease. The presence of a chronic carrier state also poses a challenge in controlling the spread of typhoid disease.

    Environmental surveillance for Salmonella Typhi to detect the typhoid burden in Yogyakarta, Indonesia · 2025 · DOI

  • The development of effective therapeutic strategies is limited by a poor understanding of how C. jejuni expands during infection. The role of inflammation in C. jejuni infection is not well understood.

    Microbiota-derived indole limits Campylobacter jejuni colonization by inhibiting respiration and metabolism · 2026 · DOI

  • The Salmonella protein tyrosine phosphatase (sptP), a type III secretion system effector and critical SE virulence factor, contributes to pathogenesis, but its precise role in SE -induced intestinal injury remains unclear.

    Salmonella virulence factor sptP activates the NLRP3/Caspase-1 pathway to induce pyroptosis and exacerbate intestinal injury in chicks · 2026 · DOI

  • These findings were inconsistent with several characteristic biochemical reactions of Salmonella sp.

    ANALISIS MIKROBIOLOGI Salmonella sp. PADA UDANG WINDU (Penaeus monodon) · 2026 · DOI

  • Poultry antibiotic residues arise mainly from improper administration or non-compliance with withdrawal periods, and their contribution to resistance selection remains debated.

    A Simulation-based framework for integrating poultry antibiotic residue data with Salmonella resistance profiles: a methodological proof-of-concept · 2026 · DOI

  • There is a lack of global consensus on the prevalence of Salmonella spp. and Escherichia coli in reptiles. The variation in prevalence according to reptile taxon, geographical region, sample type, and diagnostic method is not well understood.

    Global prevalence of Salmonella spp. and Escherichia coli in reptile taxa: a systematic review and meta-analysis · 2026 · DOI

  • Zoonotic Salmonella remains a major target of control programmes in European poultry production, yet its economic burden at the animal production level is not well quantified across countries.

    Quantifying the economic burden of zoonotic Salmonella in poultry using a stochastic modelling approach for the Netherlands, Belgium, and Denmark · 2026 · DOI

  • Multidrug-resistant (MDR) Salmonella enterica serotype Enteritidis (SE) carrying bla CTX-M-15 has emerged in South Korea; however, the genetic characteristics and evolutionary dynamics of the plasmids remain understudied.

    Genomic evidence for interserovar transfer and evolution of blaCTX-M-15 carrying plasmid in multidrug-resistant Salmonella Enteritidis and Salmonella Virchow isolated in South Korea · 2025 · DOI

  • Regions and age groups with the greatest AMR rates were identified, which warrants further studies to identify individual and area-level risk factors.

    Temporal, regional, and demographic differences among antimicrobial-resistant domestic Campylobacter jejuni human infections across the United States, 2013–2019 · 2025 · DOI

  • The development of a simple and cost-effective format for the molecular detection of pathogens at the point of need. The integration of molecular detection and lateral flow detection in a single vial. The miniaturization of the lateral flow test without compromising its sensitivity.

    CampyTube: Seamless Integration of a Molecular Test and Lateral Flow Detection of Campylobacter in a Single Vial · 2025 · DOI

  • No underlying immunodeficiency or exposure history, - Limited access to MALDI-TOF MS for definitive identification, - No comparative studies have established an optimal antimicrobial…

    Campylobacter fetus Bacteremia Presenting with Bilateral Lower Leg Cellulitis in an Immunocompetent Adult · 2026 · DOI

  • Methodological and technological approaches must also be strengthened - The goal is to improve the understanding, surveillance, and control of Campylobacter…

    Global Research Trends on Campylobacter spp. and Human Health: A bibliometric analysis (2017–2025) · 2026 · DOI

  • The impact of sample preparation on CampyTube performance, - The need for further options for test optimization, - The study primarily developed and evaluated CampyTube for the detection of Campylobacter in chicken neck skin…

    CampyTube: Seamless Integration of a Molecular Test and Lateral Flow Detection of Campylobacter in a Single Vial · 2025 · DOI

  • Convenience sampling approach may not be representative of the entire population, - Limited sample size of 1180 participants, - Study only included adults with Russian, Turkish, or Vietnamese background or Germans residing in Berlin…

    Risk Factors for Foodborne Zoonoses Among Populations With and Without a Migration Background in Berlin, Germany · 2025 · DOI

  • Further research on the use of WES in different settings, - Investigation into the epidemiology of typhoid disease…

    Environmental surveillance for Salmonella Typhi to detect the typhoid burden in Yogyakarta, Indonesia · 2025 · DOI

Most-cited papers in Salmonella and Campylobacter epidemiology

Most recent work

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Open questions raised by papers listed on this page include: (1) The diagnosis of C. fetus infection can be challenging due to the lack of awareness and the rarity of the disease (“Campylobacter fetus Bacteremia Presenting with Bilateral Lower Leg Cellulitis…”, 2026); (2) Comprehensive analyses of research trends on Campylobacter spp. in human health remain limited (“Global Research Trends on Campylobacter spp. and Human Health: A bibliometric…”, 2026); (3) The role of inflammation in C. jejuni infection is not well understood (“Microbiota-derived indole limits Campylobacter jejuni colonization by…”, 2026); (4) The Salmonella protein tyrosine phosphatase (sptP), a type III secretion system effector and critical SE virulence factor, contributes to pathogenesis, but its precise role in SE -induced intestinal injury remains unclear (“Salmonella virulence factor sptP activates the NLRP3/Caspase-1 pathway to…”, 2026); (5) There is a lack of global consensus on the prevalence of Salmonella spp. and Escherichia coli in reptiles (“Global prevalence of Salmonella spp. and Escherichia coli in reptile taxa: a…”, 2026). 546 gap statements have been mined from Salmonella and Campylobacter epidemiology papers in our 7.9M-paper local library, which holds 2,059 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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