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Open research questions in Salmonella and Campylobacter epidemiology

153 unresolved questions extracted from the limitations and future-work sections of 522 Salmonella and Campylobacter epidemiology papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Investigate the molecular responses associated with ArtAB-induced epithelial barrier disruption, - Examine the effects of ArtAB and ArtB on other cell types or in vivo models, - Elucidate the role of TGF-β signaling in ArtAB-induced transcriptional remodeling

    Multi-Omics and Functional Analysis of Salmonella ArtAB Toxin Activity Reveals Transcriptomic Remodeling and Epithelial Barrier Dysfunction · 2026 · DOI

  • The effects of AB5 toxins, such as ArtAB, on host cell signaling and epithelial barrier function remain poorly understood. There is a need to characterize the molecular and functional effects of ArtAB toxin and its binding subunit, ArtB.

    Multi-Omics and Functional Analysis of Salmonella ArtAB Toxin Activity Reveals Transcriptomic Remodeling and Epithelial Barrier Dysfunction · 2026 · DOI

  • The growing global emergence of multidrug-resistant S. Infantis strains carrying plasmid-mediated resistance determinants. The lack of routine serotyping in many diagnostic laboratories in India. The need for strengthened surveillance systems to monitor the spread of resistant strains.

    A rare case of gastroenteritis due to salmonella enterica serovar Infantis in South India · 2026 · DOI

  • Strengthening surveillance systems, - Adopting a One Health approach, integrating human, animal, and environmental health, - Monitoring the spread of resistant strains

    A rare case of gastroenteritis due to salmonella enterica serovar Infantis in South India · 2026 · DOI

  • in laboratory mice are extremely limited, and molecular screening studies are scarce.

    Presence of Salmonella spp. in Laboratory Mice from Licensed Experimental Animal Facilities in the Aegean Region of Türkiye · 2026 · DOI

  • However, it is perplexing that very few studies have been conducted on the economics in the developing and resource-limited areas (Aqeel et al.

    The rise of non-typhoidal Salmonella: an emerging global public health concern · 2025 · DOI

  • Salmonellosis is one of the main foodborne diseases in Eastern and Southern Africa, however its different forms are not fully understood.

    Virulence gene landscapes of Salmonella in Eastern and Southern Africa · 2025 · DOI

  • These findings underscore the need for further research on the role of virulence genes in shaping the pathogenicity of Campylobacter, which is essential for developing effective intervention and control strategies in the GCC region.

    The role of virulence genes in Campylobacter pathogenicity: a perspective from the Gulf Cooperation Council countries · 2025 · DOI

  • Molecular analyses of resistant strains are warranted to characterize the genomic drive of antibiotic resistance.

    High prevalence of antibiotic resistant Campylobacter among patients attending clinical settings in Kigali, Rwanda · 2025 · DOI

  • In Rwanda, data is limited on the prevalence and AMR carriage rate of Campylobacter strains.

    High prevalence of antibiotic resistant Campylobacter among patients attending clinical settings in Kigali, Rwanda · 2025 · DOI

  • How the microaerobic pathogen Campylobacter jejuni establishes its niche and expands in the gut lumen during infection is poorly understood.

    Gut metabolite L-lactate supports Campylobacter jejuni population expansion during acute infection · 2024 · DOI

  • Despite the clinical importance of RE-CmeABC, the molecular mechanisms for its functional gain and its evolutionary trajectory remain unknown.

    Mutation-based mechanism and evolution of the potent multidrug efflux pump RE-CmeABC in Campylobacter · 2024 · DOI

  • Despite this, few data exist surrounding the presence of these bacteria in RMD in the United Kingdom.

    An investigation of the presence and antimicrobial susceptibility of Enterobacteriaceae in raw and cooked kibble diets for dogs in the United Kingdom · 2024 · DOI

  • Data were collected from the Web of Science Core Collection and limited to articles and reviews published between 1999 and 2024 in English.

    Trends in horizontal gene transfer research in Salmonella antimicrobial resistance: a bibliometric analysis · 2024 · DOI

  • The gap in evidence across regions should be mitigated when studies undertaken in African countries are published.

    The cost of typhoid illness in low- and middle-income countries, a scoping review of the literature · 2024 · DOI

  • There remains a lack of evidence on the cost to treat typhoid in the context of increasing antimicrobial resistance.

    The cost of typhoid illness in low- and middle-income countries, a scoping review of the literature · 2024 · DOI

  • The importance of these O-Antigen decorations for the induced immunogenicity and cross-reactivity has been poorly characterized.

    O-Antigen decorations in Salmonella enterica play a key role in eliciting functional immune responses against heterologous serovars in animal models · 2024 · DOI

  • The genetic mechanisms involved in establishing the carrier state are poorly understood, but S.

    Salmonella Typhi Haplotype 58 biofilm formation and genetic variation in isolates from typhoid fever patients with gallstones in an endemic setting in Kenya · 2024 · DOI

  • There is a lack of information on the biochemical profile and antibiotic resistance of Salmonella in N'Djamena, Chad. The study aims to fill this knowledge gap.

    Biochemical and antibiotic resistance profile of Salmonella isolated from stool in N'Djamena, Chad: associated risk factors · 2026 · DOI

  • Controlling these infections requires a concerted effort between different actors (governments, the Ministry of Public Health and Prevention of Chad, basic humanitarian services and the population), suggesting the need for future implementation and evaluation of coordinated public health interventions.

    Biochemical and antibiotic resistance profile of Salmonella isolated from stool in N'Djamena, Chad: associated risk factors · 2026 · DOI

  • The lack of data from large parts of the world represents a critical blind spot in global health security. Significant barriers to implementing whole-genome sequencing persist in low-resource settings, including infrastructure, reagent costs, and bioinformatics expertise.

    Epidemiology, antimicrobial resistance transmission, and One Health–based prevention of non-typhoidal Salmonella and Campylobacter infections: an updated literature review · 2026 · DOI

  • There is a need for a comprehensive understanding of the epidemiology, antimicrobial resistance, and transmission of non-typhoidal Salmonella and Campylobacter infections. The lack of data from large parts of the world represents a critical blind spot in global health security.

    Epidemiology, antimicrobial resistance transmission, and One Health–based prevention of non-typhoidal Salmonella and Campylobacter infections: an updated literature review · 2026 · DOI

  • The study faced challenges in identifying the exact production step where Salmonella contamination occurred. The study had to overcome the challenge of limited information on the kinds of chocolate products the milk powder was used for.

    Large outbreak of Salmonella Muenchen linked to dried coconut pieces, September 2020 to July 2021, Germany · 2026 · DOI

  • There was a lack of understanding of the vehicle of infection for the Salmonella Muenchen outbreak. The study aimed to address this gap by using genome sequencing and case-control studies.

    Large outbreak of Salmonella Muenchen linked to dried coconut pieces, September 2020 to July 2021, Germany · 2026 · DOI

  • Future research should investigate the prevalence of plasmid-mediated AmpC β-lactamases in non-typhoidal Salmonella infections. Studies should explore the potential for zoonotic transmission of antimicrobial-resistant Salmonella. Research should focus on developing effective treatment strategies for non-typhoidal Salmonella infections with cephalosporin resistance.

    Disseminated multidrug-resistant Salmonella enterica serovar Dublin infection associated with plasmid-borne CMY-2 gene in a patient with travel to a farm in Mexico · 2026 · DOI

Most-cited papers in Salmonella and Campylobacter epidemiology

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153 open questions have been extracted from the limitations and future-work passages of 522 Salmonella and Campylobacter epidemiology papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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