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Open research questions in Traditional and Medicinal Uses of Annonaceae

50 unresolved questions extracted from the limitations and future-work sections of 156 Traditional and Medicinal Uses of Annonaceae papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The lack of access to clean water in developing countries contributes to the prevalence of diarrhea. The development of novel therapeutic compounds is a complex process. The study's findings must be validated through further research.

    Pongamia pinnata (L.) Pierre leaf extract: in vitro, in vivo, and in silico approaches to combat the waterborne bacterial pathogens associated with diarrheal conditions · 2026 · DOI

  • Limited access to modern healthcare services. Cultural influences on traditional medicine use. The need to preserve traditional knowledge and promote the use of medicinal plants in healthcare.

    CYTOTOXIC, ANTIOXIDANT, AND ANTIBACTERIAL POTENTIALS OF SELECTED ETHIOPIAN MEDICINAL PLANTS: A PHYTOCHEMICAL REVIEW · 2026 · DOI

  • Identifying the plant's potential antimicrobial and antioxidant properties. Developing effective methods for extraction and analysis. Understanding the plant's potential applications in future healthcare.

    PHYTOCHEMICAL, ANTIMICROBIAL ANALYSIS AND ANTIOXIDANT ACTIVITY OF CLITORIA TERNATEA LEAVES (APRAJITA) · 2026 · DOI

  • Antimicrobial resistance is a growing problem worldwide. Oxidative stress is a major contributor to various diseases. The development of novel antimicrobial therapies is hindered by the lack of effective lead compounds.

    Sequential soxhlet fractionation of Cistus ladanifer L. reveals a polarity–activity gradient: GC-MS profiling, multimechanistic bioactivity, and in silico identification of antifungal and antibacterial lead compounds · 2026 · DOI

  • Drug resistance and side effects of current antimalarial treatments. Limited availability of effective antimalarial medicines.

    THE ASSESSMENT OF INDIVIDUAL AND COMBINED ANTIMALARIAL POTENTIAL OF FAGONIA CRETICA AND TAMARIX APHYLLA PLANTS AGAINST PLASMODIUM VIVAX · 2026 · DOI

  • sibthorpiana and support the further investigation of its constituents as safe antioxidant and chemopreventive agents with potential nutraceutical applications.

    Phytochemical Analysis and Bioevaluation of Echinophora sibthorpiana Guss. (Apiaceae): Antioxidant Capacity, DNA Protection and In Vivo Genotoxic Safety · 2026 · DOI

  • (Apiaceae) is an aromatic plant of considerable ethnobotanical significance, traditionally employed as a flavouring and preservative agent in food and valued for its medicinal properties across the Eastern Mediterranean region, yet its non-volatile phytochemistry and biosafety profile remain insufficiently characterized.

    Phytochemical Analysis and Bioevaluation of Echinophora sibthorpiana Guss. (Apiaceae): Antioxidant Capacity, DNA Protection and In Vivo Genotoxic Safety · 2026 · DOI

  • Further preclinical and clinical studies are needed to confirm the efficacy and clarify the mechanisms of action of Taraxacum officinale. The development of new anticancer drugs based on the plant's bioactive compounds. The evaluation of the plant's potential as a complementary or adjuvant option in cancer therapy.

    THERAPEUTIC AND ANTICANCER INSIGHTS INTO TARAXACUM OFFICINALE BIOACTIVE COMPOUNDS · 2026 · DOI

  • Further studies are needed to elucidate the molecular mechanisms underlying the effect of NO on ajmalicine production. The potential of exogenous nitric oxide as an elicitor for other valuable secondary metabolites should be explored. Optimization of the SNP treatment protocol for large-scale ajmalicine production is necessary.

    Exogenous Nitric Oxide (NO) Functions as a Potent Abiotic Elicitor, Triggering a Concentration-Dependent Enhancement of Ajmalicine Accumulation in Undifferentiated Rauwolfia Serpentina Tissues · 2026 · DOI

  • Traditional extraction methods for ajmalicine are limited by slow plant growth and sustainability issues. There is a need for alternative strategies for controlled and efficient alkaloid production. The regulatory role of nitric oxide in plant secondary metabolite production is not fully understood.

    Exogenous Nitric Oxide (NO) Functions as a Potent Abiotic Elicitor, Triggering a Concentration-Dependent Enhancement of Ajmalicine Accumulation in Undifferentiated Rauwolfia Serpentina Tissues · 2026 · DOI

  • The study aims to investigate the effects of Aronia melanocarpa fruit extract on breast cancer cells and healthy endothelial cells, which is a gap in current research.

    Comparative Evaluation of the Anti-Proliferative, Apoptotic, and Migratory Effects of Aronia melanocarpa Fruit Extract on Breast Cancer Cells and Healthy Endothelial Cells · 2026 · DOI

  • The potential anticancer mechanisms of J. regia on human cell lines remain to be fully elucidated. The effective concentration of J. regia leaf extract for anticancer effects is not well established.

    Apoptosis-related gene modulation by Juglans regia leaf extract in breast and colon cancer cells · 2026 · DOI

  • There is a need to develop new strategies to prevent resistance mechanisms. There is a lack of studies on the biological activities of the Gundelia tournefortii L. plant.

    Phytocomponent Profile, Antimicrobial, Antibiofilm, Antioxidant and Cytotoxic Activities of Gum Acanthus Obtained From Gundelia Tournefortii L. (Kenger) Plant · 2026 · DOI

  • The study identifies a gap in the understanding of the potential of Terminalia catappa L. bark as a therapeutic candidate against neuroinflammation. The study aims to address this gap by investigating the triphytochemistry, free radical scavenging activity, and cytotoxicity of T. catappa bark.

    Triphytochemistry, free radical scavenging activity and in vitro cytotoxicity of Terminalia <span style="font-size: 1rem;">catappa L. bark during neuroinflammation</span> · 2026 · DOI

  • Further evaluation of the efficacy and safety of the ynone-tethered 2-pyrone derivative. Investigation of the mode of action of the derivative. Development of novel antifungal agents with distinct modes of action.

    Synthesis and Antifungal Evaluation of a Ynone-Tethered 2‑Pyrone Derivative against Phytopathogenic Fungi · 2026 · DOI

  • There is a need for alternative treatments for snakebite envenomation. Local medicinal plants have not been fully explored for their antivenom potentials.

    Antivenom Potentials of Local Medicinal Plants Against Echis ocellatus Envenomation in Aliero, Kebbi State, Nigeria · 2026 · DOI

  • The increasing resistance of Plasmodium parasites to existing antimalarial drugs necessitates the search for new therapeutic agents. There is a need for scientific support for the traditional use of A. occidentale in the management of malaria.

    ANTIMALARIAL AND ANTIPLASMODIAL ACTIVITIES OF EXTRACTS AND FRACTIONS OF ANACARDIUM OCCIDENTALE L. IN MICE EXPERIMENTALLY INFECTED WITH PLASMODIUM BERGHEI · 2026 · DOI

  • World Journal of Pharmaceutical Research fractions across therapeutic models remain to be elucidated through detailed phytochemical characterization and mode-of-action studies. Second, the n-hexane fraction's preferential curative activity warrants investigation as a potential source of compounds effective against established, drug-resistant infections.

    ANTIMALARIAL AND ANTIPLASMODIAL ACTIVITIES OF EXTRACTS AND FRACTIONS OF ANACARDIUM OCCIDENTALE L. IN MICE EXPERIMENTALLY INFECTED WITH PLASMODIUM BERGHEI · 2026 · DOI

  • Further studies on the anticancer potential of Benalu batu extracts in vivo. Investigation of the mechanisms of action of the bioactive compounds. Development of new anticancer drugs based on the identified bioactive compounds.

    In Vitro and In Silico Study of the Anticancer Activity of Benalu batu (Begonia medicinalis Ardi & D.C. Thomas) an Endemic Plant of Sulawesi Against A549 Lung Cancer Cells · 2026 · DOI

  • Further in vivo studies are required to confirm efficacy and safety. Isolation of bioactive constituents is necessary to develop new antimalarial medicines.

    THE ASSESSMENT OF INDIVIDUAL AND COMBINED ANTIMALARIAL POTENTIAL OF FAGONIA CRETICA AND TAMARIX APHYLLA PLANTS AGAINST PLASMODIUM VIVAX · 2026 · DOI

  • Further mechanistic studies are warranted to identify the active phytoconstituents responsible for cytokine regulation. Studies should focus on isolating active phytoconstituents and elucidating the molecular mechanisms underlying the synergism.

    EVALUATION OF ORAL ADMINISTRATION OF POLYHERBAL LEAF EXTRACT OF ANNUNA SQUAMOSA AND OCIMUM SANCTUM ON THE ANTI-INFLAMMATORY ACTIVITIES INDUCED IN RATS · 2026 · DOI

  • There is a need for safer alternatives to conventional anti-inflammatory drugs. The mechanisms underlying the anti-inflammatory effects of herbal and polyherbal formulations are not fully understood.

    EVALUATION OF ORAL ADMINISTRATION OF POLYHERBAL LEAF EXTRACT OF ANNUNA SQUAMOSA AND OCIMUM SANCTUM ON THE ANTI-INFLAMMATORY ACTIVITIES INDUCED IN RATS · 2026 · DOI

  • The lack of safe and effective anti-oomycete agents for sustainable control of P. capsici. The need to develop new strategies to manage the resistance of P. capsici to chemical fungicides.

    In Vitro And in Silico Evaluation of Piceatannol Against Phytophthora Capsici (Phytopathogen) Targeting The Nadph-Dependent Quinone Oxidoreductase · 2026 · DOI

  • There is a lack of understanding of the phytochemicals present in Raphia vinifera fruit mesocarp aqueous extract. There is a need to investigate the effects of the extract on haematological parameters in Wistar rats. There is a gap in the knowledge of the potential therapeutic applications of Raphia vinifera fruit mesocarp aqueous extract.

    Raphia vinifera Fruit Mesocarp Aqueous Extract: Phytochemicals and Effects on Some Haematological Parameters in Male Wistar Rats · 2026 · DOI

  • The lack of access to clean water in developing countries contributes to the prevalence of diarrhea. There is a need for cost-effective approaches to combating waterborne bacterial pathogens. The study aims to address this gap by investigating the traditional use of plants in medicine.

    Pongamia pinnata (L.) Pierre leaf extract: in vitro, in vivo, and in silico approaches to combat the waterborne bacterial pathogens associated with diarrheal conditions · 2026 · DOI

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50 open questions have been extracted from the limitations and future-work passages of 156 Traditional and Medicinal Uses of Annonaceae papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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