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Open research questions in Traditional and Medicinal Uses of Annonaceae

53 gap statements mined from Traditional and Medicinal Uses of Annonaceae papers in our 4.5M-paper local library, which holds 203 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Comprehensive toxicological data supporting the safety of Annona senegalensis remain limited. The study aims to fill this gap by evaluating the sub-acute oral toxicity of the leaf extract of Annona senegalensis.

    SUB-ACUTE ORAL TOXICITY EVALUATION OF AQUEOUS LEAF EXTRACT OF Annona senegalensis IN WISTAR ALBINO RATS · 2026 · DOI

  • There is a lack of studies investigating the potential of P. heptaphyllum essential oil in controlling plant diseases, especially pathogens of cacao. The chemical composition and bioactivity of P. heptaphyllum essential oil are not fully understood in the context of plant disease control.

    Protium heptaphyllum, a tree native to the Atlantic Forest, is a potential source of compounds against important cocoa phytopathogen · 2026 · DOI

  • Future research on Annona muricata should prioritize systematic translation from ethnomedicinal observations and preclinical findings to clinically meaningful hematological outcomes. While existing studies provide biological plausibility, advancing this field will require coordinated efforts that integrate phytochemistry, hematology, pharmacology, and clinical research.

    Annona muricata (Soursop) and Hematopoiesis: Ethnomedicinal Insights, Immunomodulatory Mechanisms, and Translational Challenges · 2026 · DOI

  • Further preclinical and clinical studies are needed to confirm the efficacy and clarify the mechanisms of action of Taraxacum officinale. The development of new anticancer drugs based on the plant's bioactive compounds. The evaluation of the plant's potential as a complementary or adjuvant option in cancer therapy.

    THERAPEUTIC AND ANTICANCER INSIGHTS INTO TARAXACUM OFFICINALE BIOACTIVE COMPOUNDS · 2026 · DOI

  • Further studies are needed to elucidate the molecular mechanisms underlying the effect of NO on ajmalicine production. The potential of exogenous nitric oxide as an elicitor for other valuable secondary metabolites should be explored. Optimization of the SNP treatment protocol for large-scale ajmalicine production is necessary.

    Exogenous Nitric Oxide (NO) Functions as a Potent Abiotic Elicitor, Triggering a Concentration-Dependent Enhancement of Ajmalicine Accumulation in Undifferentiated Rauwolfia Serpentina Tissues · 2026 · DOI

  • Traditional extraction methods for ajmalicine are limited by slow plant growth and sustainability issues. There is a need for alternative strategies for controlled and efficient alkaloid production. The regulatory role of nitric oxide in plant secondary metabolite production is not fully understood.

    Exogenous Nitric Oxide (NO) Functions as a Potent Abiotic Elicitor, Triggering a Concentration-Dependent Enhancement of Ajmalicine Accumulation in Undifferentiated Rauwolfia Serpentina Tissues · 2026 · DOI

  • The study aims to investigate the effects of Aronia melanocarpa fruit extract on breast cancer cells and healthy endothelial cells, which is a gap in current research.

    Comparative Evaluation of the Anti-Proliferative, Apoptotic, and Migratory Effects of Aronia melanocarpa Fruit Extract on Breast Cancer Cells and Healthy Endothelial Cells · 2026 · DOI

  • The potential anticancer mechanisms of J. regia on human cell lines remain to be fully elucidated. The effective concentration of J. regia leaf extract for anticancer effects is not well established.

    Apoptosis-related gene modulation by Juglans regia leaf extract in breast and colon cancer cells · 2026 · DOI

  • There is a need to develop new strategies to prevent resistance mechanisms. There is a lack of studies on the biological activities of the Gundelia tournefortii L. plant.

    Phytocomponent Profile, Antimicrobial, Antibiofilm, Antioxidant and Cytotoxic Activities of Gum Acanthus Obtained From Gundelia Tournefortii L. (Kenger) Plant · 2026 · DOI

  • The study aims to address this gap by investigating the triphytochemistry, free radical scavenging activity, and cytotoxicity of T. catappa bark.

    Triphytochemistry, free radical scavenging activity and in vitro cytotoxicity of Terminalia <span style="font-size: 1rem;">catappa L. bark during neuroinflammation</span> · 2026 · DOI

  • The study mentions the need for further investigation into the contribution of individual compounds to the biological effects. The study does not explicitly state other technical or domain challenges.

    Maclura tinctoria as a Modulator of Oxidative Stress and Inflammatory Responses · 2026 · DOI

  • There is a need for alternative treatments for snakebite envenomation. Local medicinal plants have not been fully explored for their antivenom potentials.

    Antivenom Potentials of Local Medicinal Plants Against Echis ocellatus Envenomation in Aliero, Kebbi State, Nigeria · 2026 · DOI

  • Research fractions across therapeutic models remain to be elucidated through detailed phytochemical characterization and mode-of-action studies. Second, the n-hexane fraction's preferential curative activity warrants investigation as a potential source of compounds effective against established, drug-resistant infections.

    ANTIMALARIAL AND ANTIPLASMODIAL ACTIVITIES OF EXTRACTS AND FRACTIONS OF ANACARDIUM OCCIDENTALE L. IN MICE EXPERIMENTALLY INFECTED WITH PLASMODIUM BERGHEI · 2026 · DOI

  • Further in vivo studies are required to confirm efficacy and safety. Isolation of bioactive constituents is necessary to develop new antimalarial medicines.

    THE ASSESSMENT OF INDIVIDUAL AND COMBINED ANTIMALARIAL POTENTIAL OF FAGONIA CRETICA AND TAMARIX APHYLLA PLANTS AGAINST PLASMODIUM VIVAX · 2026 · DOI

  • The lack of safe and effective anti-oomycete agents for sustainable control of P. capsici. The need to develop new strategies to manage the resistance of P. capsici to chemical fungicides.

    In Vitro And in Silico Evaluation of Piceatannol Against Phytophthora Capsici (Phytopathogen) Targeting The Nadph-Dependent Quinone Oxidoreductase · 2026 · DOI

  • Further studies involving phytochemical isolation and characterization of active compounds are recommended. In vivo antioxidant investigations are suggested to validate the therapeutic potential of Digera muricata leaf extract. Studies to elucidate the underlying mechanisms of action are needed.

    Exploring the Antioxidant Properties of Digera muricata (L.) Mart. Leaves Through In Vitro Assays · 2026 · DOI

  • The antioxidant potential of Digera muricata leaves has not been fully explored. There is a need to evaluate the antioxidant activity of the plant using in vitro assays. The study aims to fill this gap by assessing the antioxidant potential of Digera muricata leaves.

    Exploring the Antioxidant Properties of Digera muricata (L.) Mart. Leaves Through In Vitro Assays · 2026 · DOI

  • Limited access to modern healthcare services. Cultural influences on traditional medicine use. The need to preserve traditional knowledge and promote the use of medicinal plants in healthcare.

    CYTOTOXIC, ANTIOXIDANT, AND ANTIBACTERIAL POTENTIALS OF SELECTED ETHIOPIAN MEDICINAL PLANTS: A PHYTOCHEMICAL REVIEW · 2026 · DOI

  • There is a need to preserve traditional knowledge and promote the use of medicinal plants in healthcare.

    CYTOTOXIC, ANTIOXIDANT, AND ANTIBACTERIAL POTENTIALS OF SELECTED ETHIOPIAN MEDICINAL PLANTS: A PHYTOCHEMICAL REVIEW · 2026 · DOI

  • Even though Acacia Nilotica has shown a great deal of pharmacological potential, more research is needed to properly determine its therapeutic uses. Future studies should concentrate on standardizing extracts, identifying and characterizing new bioactive components, and clarifying their molecular mechanisms of action.

    A REVIEW ARTICLE ON ISOLATION, CHARACTERIZATION, PHYTOCHEMICAL PROFILE AND INVITRO ANTIOXIDANT ACTIVITY OF ACACIA NILOTICA SEEDS · 2026 · DOI

  • Further investigation of the contribution of individual compounds to the biological effects observed, - Investigation of the effects of the extract on human subjects, - Elucidation of the mechanisms underlying the antioxidant and anti-inflammatory activities of M.

    Maclura tinctoria as a Modulator of Oxidative Stress and Inflammatory Responses · 2026 · DOI

  • Further evaluation of the efficacy and safety of the ynone-tethered 2-pyrone derivative. Investigation of the mode of action of the derivative. Development of novel antifungal agents with distinct modes of action.

    Synthesis and Antifungal Evaluation of a Ynone-Tethered 2‑Pyrone Derivative against Phytopathogenic Fungi · 2026 · DOI

  • Further studies on the anticancer potential of Benalu batu extracts in vivo. Investigation of the mechanisms of action of the bioactive compounds. Development of new anticancer drugs based on the identified bioactive compounds.

    In Vitro and In Silico Study of the Anticancer Activity of Benalu batu (Begonia medicinalis Ardi & D.C. Thomas) an Endemic Plant of Sulawesi Against A549 Lung Cancer Cells · 2026 · DOI

  • Identifying the plant's potential antimicrobial and antioxidant properties. Developing effective methods for extraction and analysis. Understanding the plant's potential applications in future healthcare.

    PHYTOCHEMICAL, ANTIMICROBIAL ANALYSIS AND ANTIOXIDANT ACTIVITY OF CLITORIA TERNATEA LEAVES (APRAJITA) · 2026 · DOI

  • The study identifies a gap in the understanding of Clitoria ternatea's antimicrobial and antioxidant properties. The study aims to fill this gap through phytochemical analysis and antimicrobial assays.

    PHYTOCHEMICAL, ANTIMICROBIAL ANALYSIS AND ANTIOXIDANT ACTIVITY OF CLITORIA TERNATEA LEAVES (APRAJITA) · 2026 · DOI

Most-cited papers in Traditional and Medicinal Uses of Annonaceae

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Open questions raised by papers listed on this page include: (1) Comprehensive toxicological data supporting the safety of Annona senegalensis remain limited (“SUB-ACUTE ORAL TOXICITY EVALUATION OF AQUEOUS LEAF EXTRACT OF Annona…”, 2026); (2) There is a lack of studies investigating the potential of P. heptaphyllum essential oil in controlling plant diseases, especially pathogens of cacao (“Protium heptaphyllum, a tree native to the Atlantic Forest, is a potential…”, 2026); (3) Further preclinical and clinical studies are needed to confirm the efficacy and clarify the mechanisms of action of Taraxacum officinale (“THERAPEUTIC AND ANTICANCER INSIGHTS INTO TARAXACUM OFFICINALE BIOACTIVE…”, 2026); (4) Further studies are needed to elucidate the molecular mechanisms underlying the effect of NO on ajmalicine production (“Exogenous Nitric Oxide (NO) Functions as a Potent Abiotic Elicitor, Triggering…”, 2026); (5) The potential anticancer mechanisms of J. regia on human cell lines remain to be fully elucidated (“Apoptosis-related gene modulation by Juglans regia leaf extract in breast and…”, 2026). 53 gap statements have been mined from Traditional and Medicinal Uses of Annonaceae papers in our 4.5M-paper local library, which holds 203 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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