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Open research questions in Veterinary Oncology Research

534 gap statements mined from Veterinary Oncology Research papers in our 7.9M-paper local library, which holds 1,622 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Substantial work is needed before proteomics can be routinely applied in clinical veterinary practice. Future work might focus on the development of biomarker panels using multiple proteins rather than using individual proteins, as single proteins often have multiple biological roles and interact in a complex manner with multiple pathways.

    Proteomics in Gastrointestinal Diseases of Companion Animals: Current State and Knowledge Gaps · 2026 · DOI

  • These platforms improve drug targeting and reduce systemic toxicity while also providing insights into formulation challenges, such as palatability, treatment compliance, and dose scheduling, which are critical for therapeutic success in both animals and humans.

    Comparative Cancer Genetics and Veterinary Therapeutics in Dogs and Cats: A Species-Aware Framework for Comparative Oncology · 2026 · DOI

  • The use of RT for microscopic residual disease following incomplete surgical excision has been investigated in a limited number of studies, with conflicting results regarding its impact on local recurrence and survival.

    Outcomes and prognostic factors in dogs with subcutaneous and intramuscular hemangiosarcoma treated with hypofractionated radiation therapy and chemotherapy · 2026 · DOI

  • In addition, some indicators, particularly those related to active case ascertainment, could not be assessed because the Abruzzo ACR currently relies exclusively on passive reporting. First, the framework was applied to a single animal cancer registry, and therefore its performance has not been evaluated under different organizational and epidemiological situations.

    A framework for assessing quality indicators in animal cancer registries: a case study · 2026 · DOI

  • However, most available data on MLO are based on tumors arising from the skull, and little is known about the clinical behavior and prognosis of rib-origin MLO.

    Surgical Management of Recurrent Rib-Origin Multilobular Osteochondrosarcoma with Pulmonary Metastasis in a Dog: A Case Report · 2026 · DOI

  • Vincristine is the standard treatment for canine transmissible venereal tumor (CTVT), and its combination with ivermectin has yielded inconsistent results.

    A clinical-cytological scoring system predicts response to vincristine with or without ivermectin in canine transmissible venereal tumor · 2026 · DOI

  • 0 mg/m2 in small dogs with malignant tumors resulted in gastrointestinal toxicity within clinically acceptable limits, but close monitoring for neutropenia is warranted.

    Adverse events in small dogs treated with a single dose of vinblastine · 2026 · DOI

  • Clinical trials are needed to determine whether these vitamin supplements are useful for improving the prognosis of dogs with CE and PLE.

    Chronic Enteropathy and Vitamins in Dogs · 2025 · DOI

  • In light of the increasing development costs of novel immunotherapeutics and challenges in thoroughly evaluating their effects before approval, streamlining preclinical drug screening and development is critical. Here, we revealed key similarities in canine and human immune checkpoint expression patterns in cancer, thereby reinforcing the argument for comparative oncology.

    Barking up the right tree: Immune checkpoint signatures of human and dog cancers · 2025 · DOI

  • Over the past decades, this field has advanced significantly, and it is poised to evolve further with the development of new tools that expand the available arsenal for investigating unresolved scientific questions.

    Canine, Feline, and Murine Mammary Tumors as a Model for Translational Research in Breast Cancer · 2025 · DOI

  • Large-scale, prospective, randomized clinical trials specifically in both human and veterinary medicine are lacking for many repurposed drugs, leading to variable evidence. There is an insufficient understanding of optimal dosages and long-term safety profiles for repurposed drugs when used for oncologic indications in non-primary species or indications.

    Drug Repurposing in Veterinary Oncology: Myth or Reality? · 2025 · DOI

  • Leukocytes have a key role in the inflammatory response seen in CE, with alterations in circulating leukocyte populations commonly observed, although limited data exist on their specific numbers in published research.

    Blood Leukocyte Ratios as Predictive Markers of Chronic Enteropathy Phenotypes in Cats · 2025 · DOI

  • Future research should focus on randomized clinical trials to validate these findings and further assess the comparative efficacy of THOP- and CHOP-based protocols.

    Pilot Study of a Novel First-Line Protocol (THOP) for Intermediate–Large B-Cell Lymphoma in Dogs · 2025 · DOI

  • Hepatic dearterialization should be further investigated as a palliative management option for multinodular and diffuse liver tumors because it may provide a minimally invasive, safe, and palliative option based on the observation that all patients survived to discharge and tumor regression was noted in three animals.

    Hepatic Dearterialization for Nonresectable Liver Tumors in Five Dogs and Two Cats · 2025 · DOI

  • Hypertension is documented in dogs with cancer receiving toceranib, but no studies have evaluated left ventricular (LV) systolic function and biomarkers of endothelial function.

    Effect of the Vascular Endothelial Growth Factor Inhibitor Toceranib on Cardiac Function and Endothelial Dysfunction Biomarkers in Dogs With Cancer · 2025 · DOI

  • The safety of oral cannabidiol (CBD) and cannabidiolic acid (CBDA)-rich hemp oil supplementation in dogs with cancer receiving chemotherapy has not been investigated.

    Safety, Efficacy and Doxorubicin Pharmacokinetics During Cannabidiol/Cannabidiolic Acid Rich Hemp Oil Use in Dogs With Lymphoma Undergoing CHOP Chemotherapy · 2025 · DOI

  • The need for further research on the role of the gut microbiota in the pathogenesis of chronic inflammatory enteropathies.

    Updating the Classification of Chronic Inflammatory Enteropathies in Dogs · 2024 · DOI

  • There is a lack of data regarding the true prevalence of chronic enteropathies in dogs. Current diagnostic methods for IBD may not be cost-effective or easily accessible. There is a need for easy-to-obtain and cost-effective hematological parameters for the diagnosis of IBD.

    Monocytes Count, NLR, MLR and PLR in Canine Inflammatory Bowel Disease · 2024 · DOI

  • The lack of standardized studies that correlate clinicopathologic and neuroimaging data for many brain tumor variants, particularly in cats, - The limited availability of antemortem biopsy, - The need for accurate non-invasive diagnostic techniques.

    An Illustrated Scoping Review of the Magnetic Resonance Imaging Characteristics of Canine and Feline Brain Tumors · 2024 · DOI

  • There is a need for earlier differentiation and characterization of chronic inflammatory enteropathies. Current methods for classification are based on treatment trials. There is a lack of non-invasive indicators of intestinal health to differentiate between CIEs.

    Faecal Short-Chain, Long-Chain, and Branched-Chain Fatty Acids as Markers of Different Chronic Inflammatory Enteropathies in Dogs · 2024 · DOI

  • There is a lack of data on tumor prevalence and behavior in cats, particularly in non-Western regions. Research in cats has been more limited, leading to a comparatively smaller dataset and fewer insights into feline oncology. There is a need for larger, multicenter datasets that incorporate environmental, genetic, and lifestyle factors.

    Regional Variations in and Key Predictors of Feline Tumor Malignancy: A Decade-Long Retrospective Study in Korea · 2024 · DOI

  • Kynurenine 3-monooxygenase (KMO) and Ki-67 are tumor biomarkers, but few studies have described the clinical value of KMO and Ki-67 in veterinary medicine.

    Evaluation of plasma kynurenine 3-monooxygenase and Ki-67 as screening biomarkers for neoplasia in dogs · 2026 · DOI

  • Despite being inexpensive and readily available, NLR, NMR, and LMR alone are insufficient to differentiate between CE phenotypes, particularly SRE and SCL, and cannot…

    Blood Leukocyte Ratios as Predictive Markers of Chronic Enteropathy Phenotypes in Cats · 2025 · DOI

  • The true prevalence of CIEs in dogs is unknown, - The evidence for prebiotics' efficacy in humans with IBD is low, - The study on β-glucans and mannan oligosaccharides…

    Updating the Classification of Chronic Inflammatory Enteropathies in Dogs · 2024 · DOI

  • Considerable variability in data inclusion and reporting, - low case numbers, - sample size limitations will likely remain a significant practical obstacle to the design of robustly powered radiomic studies, - all radiomic studies having QUADAS-2 scores ≤6, and thus were considered to provide low-level…

    An Illustrated Scoping Review of the Magnetic Resonance Imaging Characteristics of Canine and Feline Brain Tumors · 2024 · DOI

Most-cited papers in Veterinary Oncology Research

Most recent work

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This page shows what the Veterinary Oncology Research literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 7.9M-paper local library and writes the gaps from its rows.

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Open questions raised by papers listed on this page include: (1) Substantial work is needed before proteomics can be routinely applied in clinical veterinary practice (“Proteomics in Gastrointestinal Diseases of Companion Animals: Current State and…”, 2026); (2) The framework was applied to a single animal cancer registry, and therefore its performance has not been evaluated under different organizational and epidemiological situations (“A framework for assessing quality indicators in animal cancer registries: a…”, 2026); (3) Most available data on MLO are based on tumors arising from the skull, and little is known about the clinical behavior and prognosis of rib-origin MLO (“Surgical Management of Recurrent Rib-Origin Multilobular Osteochondrosarcoma…”, 2026); (4) Clinical trials are needed to determine whether these vitamin supplements are useful for improving the prognosis of dogs with CE and PLE (“Chronic Enteropathy and Vitamins in Dogs”, 2025); (5) Large-scale, prospective, randomized clinical trials specifically in both human and veterinary medicine are lacking for many repurposed drugs, leading to variable evidence (“Drug Repurposing in Veterinary Oncology: Myth or Reality?”, 2025). 534 gap statements have been mined from Veterinary Oncology Research papers in our 7.9M-paper local library, which holds 1,622 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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